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<!--
This CellML file was generated on 5/01/2009 at 11:18:19 at a.m. using:
COR (0.9.31.1125)
Copyright 2002-2009 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
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<article>
<articleinfo>
<title>Modelling the Budding Yeast Cell Cycle</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML version of the model has been checked in COR and OpenCell and the model runs to replicate the results in the original published paper. The units have been checked and they are consistent.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: The molecular machinery of cell cycle control is known in more detail for budding yeast, Saccharomyces cerevisiae, than for any other eukaryotic organism. In recent years, many elegant experiments on budding yeast have dissected the roles of cyclin molecules (Cln1-3 and Clb1-6) in coordinating the events of DNA synthesis, bud emergence, spindle formation, nuclear division, and cell separation. These experimental clues suggest a mechanism for the principal molecular interactions controlling cyclin synthesis and degradation. Using standard techniques of biochemical kinetics, we convert the mechanism into a set of differential equations, which describe the time courses of three major classes of cyclin-dependent kinase activities. Model in hand, we examine the molecular events controlling "Start" (the commitment step to a new round of chromosome replication, bud formation, and mitosis) and "Finish" (the transition from metaphase to anaphase, when sister chromatids are pulled apart and the bud separates from the mother cell) in wild-type cells and 50 mutants. The model accounts for many details of the physiology, biochemistry, and genetics of cell cycle control in budding yeast.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Kinetic Analysis of a Molecular Model of the Budding Yeast Cell Cycle, Katherine C. Chen, Attila Csikasz-Nagy, Bela Gyorffy, John Val, Bela Novak, and John J. Tyson, 2000,
<emphasis>Molecular Biology of the Cell</emphasis>
, 11, 369-391. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed?term=10637314">PubMed ID: 10637314</ulink>
</para>
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<title>reaction diagram</title>
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<caption>Molecular model of the control of CDK activities during the budding yeast cell cycle.</caption>
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</sect1>
</article>
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<apply>
<geq/>
<ci>ORI</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</piece>
<piece>
<ci>ki_20</ci>
<apply>
<geq/>
<ci>SPN</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="first_order_rate_constant">0.1</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="Hct1">
<variable cmeta:id="Hct1_Hct1" initial_value="0.9946" name="Hct1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.04" name="ka_t1" units="first_order_rate_constant"/>
<variable initial_value="2" name="ka_t1_" units="first_order_rate_constant"/>
<variable initial_value="0" name="ki_t1" units="first_order_rate_constant"/>
<variable initial_value="0.64" name="ki_t1_" units="first_order_rate_constant"/>
<variable name="Vi_t1" units="first_order_rate_constant"/>
<variable initial_value="0.05" name="Ji_t1" units="dimensionless"/>
<variable initial_value="0.05" name="Ja_t1" units="dimensionless"/>
<variable initial_value="1" name="epsiloni_t1_n2" units="dimensionless"/>
<variable initial_value="0.5" name="epsiloni_t1_b5" units="dimensionless"/>
<variable initial_value="1" name="epsiloni_t1_b2" units="dimensionless"/>
<variable name="Cdc20" public_interface="in" units="dimensionless"/>
<variable name="Hct1_T" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Hct1</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>ka_t1</ci>
<apply>
<times/>
<ci>ka_t1_</ci>
<ci>Cdc20</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Hct1_T</ci>
<ci>Hct1</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_t1</ci>
<ci>Hct1_T</ci>
</apply>
<ci>Hct1</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vi_t1</ci>
<ci>Hct1</ci>
</apply>
<apply>
<plus/>
<ci>Ji_t1</ci>
<ci>Hct1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vi_t1</ci>
<apply>
<plus/>
<ci>ki_t1</ci>
<apply>
<times/>
<ci>ki_t1_</ci>
<apply>
<plus/>
<ci>Cln3</ci>
<apply>
<times/>
<ci>epsiloni_t1_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsiloni_t1_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsiloni_t1_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="mass">
<variable initial_value="0.6608" name="mass" public_interface="out" units="dimensionless"/>
<variable initial_value="0.005776" name="mu" units="first_order_rate_constant"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>mass</ci>
</apply>
<apply>
<times/>
<ci>mu</ci>
<ci>mass</ci>
</apply>
</apply>
</math>
</component>
<component name="ORI">
<variable initial_value="0" name="ORI" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="ks_ori" units="first_order_rate_constant"/>
<variable initial_value="0.06" name="kd_ori" units="first_order_rate_constant"/>
<variable initial_value="0.4" name="epsilonori_b2" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ORI</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ks_ori</ci>
<apply>
<plus/>
<ci>Clb5</ci>
<apply>
<times/>
<ci>epsilonori_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kd_ori</ci>
<ci>ORI</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="BUD">
<variable initial_value="0" name="BUD" units="dimensionless"/>
<variable initial_value="0.3" name="ks_bud" units="first_order_rate_constant"/>
<variable initial_value="0.06" name="kd_bud" units="first_order_rate_constant"/>
<variable initial_value="1" name="epsilonbud_b5" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BUD</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ks_bud</ci>
<apply>
<plus/>
<ci>Cln2</ci>
<ci>Cln3</ci>
<apply>
<times/>
<ci>epsilonbud_b5</ci>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kd_bud</ci>
<ci>BUD</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SPN">
<variable initial_value="0" name="SPN" public_interface="out" units="dimensionless"/>
<variable initial_value="0.08" name="ks_spn" units="first_order_rate_constant"/>
<variable initial_value="0.06" name="kd_spn" units="first_order_rate_constant"/>
<variable initial_value="0.2" name="J_spn" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SPN</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>ks_spn</ci>
<ci>Clb2</ci>
</apply>
<apply>
<plus/>
<ci>J_spn</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_spn</ci>
<ci>SPN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SBF">
<variable cmeta:id="SBF_SBF" name="SBF" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="ka_sbf" units="first_order_rate_constant"/>
<variable initial_value="0.5" name="ki_sbf" units="first_order_rate_constant"/>
<variable initial_value="6" name="ki_sbf_" units="first_order_rate_constant"/>
<variable name="Va_sbf" units="first_order_rate_constant"/>
<variable initial_value="0.01" name="Ji_sbf" units="dimensionless"/>
<variable initial_value="0.01" name="Ja_sbf" units="dimensionless"/>
<variable initial_value="75" name="epsilonsbf_n3" units="dimensionless"/>
<variable initial_value="0.5" name="epsilonsbf_b5" units="dimensionless"/>
<variable name="Bck2" public_interface="in" units="dimensionless"/>
<variable name="Cln3" public_interface="in" units="dimensionless"/>
<variable name="Clb5" public_interface="in" units="dimensionless"/>
<variable name="Cln2" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>SBF</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>Va_sbf</ci>
<ci>Ji_sbf</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_sbf</ci>
<apply>
<times/>
<ci>ki_sbf_</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>Va_sbf</ci>
<ci>Ji_sbf</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>ki_sbf</ci>
<apply>
<times/>
<ci>ki_sbf_</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Ja_sbf</ci>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_sbf</ci>
<apply>
<times/>
<ci>ki_sbf_</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>Va_sbf</ci>
<ci>Ji_sbf</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>ki_sbf</ci>
<apply>
<times/>
<ci>ki_sbf_</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Ja_sbf</ci>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>Va_sbf</ci>
<ci>Ji_sbf</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_sbf</ci>
<apply>
<times/>
<ci>ki_sbf_</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Va_sbf</ci>
<apply>
<times/>
<ci>ka_sbf</ci>
<apply>
<plus/>
<ci>Cln2</ci>
<apply>
<times/>
<ci>epsilonsbf_n3</ci>
<apply>
<plus/>
<ci>Cln3</ci>
<ci>Bck2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>epsilonsbf_b5</ci>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="MBF">
<variable cmeta:id="MBF_MBF" name="MBF" public_interface="out" units="dimensionless"/>
<variable name="SBF" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>MBF</ci>
<ci>SBF</ci>
</apply>
</math>
</component>
<component name="Mcm1">
<variable cmeta:id="Mcm1_Mcm1" name="Mcm1" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="ka_mcm" units="first_order_rate_constant"/>
<variable initial_value="0.15" name="ki_mcm" units="first_order_rate_constant"/>
<variable initial_value="1" name="Ji_mcm" units="dimensionless"/>
<variable initial_value="1" name="Ja_mcm" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mcm1</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
<ci>Ji_mcm</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
<ci>Ji_mcm</ci>
</apply>
<apply>
<times/>
<ci>ki_mcm</ci>
<ci>Ja_mcm</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
<ci>Ji_mcm</ci>
</apply>
<apply>
<times/>
<ci>ki_mcm</ci>
<ci>Ja_mcm</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
<ci>Ji_mcm</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5">
<variable cmeta:id="Swi5_Swi5" name="Swi5" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="ka_swi" units="first_order_rate_constant"/>
<variable initial_value="0.3" name="ki_swi" units="first_order_rate_constant"/>
<variable initial_value="0.2" name="ki_swi_" units="first_order_rate_constant"/>
<variable initial_value="0.1" name="Ji_swi" units="dimensionless"/>
<variable initial_value="0.1" name="Ja_swi" units="dimensionless"/>
<variable name="Cdc20" public_interface="in" units="dimensionless"/>
<variable name="Clb2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Swi5</ci>
<apply>
<divide/>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
<ci>Ji_swi</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_swi</ci>
<apply>
<times/>
<ci>ki_swi_</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
<ci>Ji_swi</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>ki_swi</ci>
<apply>
<times/>
<ci>ki_swi_</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Ja_swi</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
</apply>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_swi</ci>
<apply>
<times/>
<ci>ki_swi_</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
<ci>Ji_swi</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>ki_swi</ci>
<apply>
<times/>
<ci>ki_swi_</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Ja_swi</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_swi</ci>
<apply>
<times/>
<ci>ki_swi_</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
</apply>
</apply>
<ci>ka_swi</ci>
<ci>Cdc20</ci>
<ci>Ji_swi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="parameters">
<variable initial_value="0.01" name="kd1_c1" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.08" name="kd_20" public_interface="out" units="first_order_rate_constant"/>
<variable initial_value="0.05" name="Jd2_c1" public_interface="out" units="dimensionless"/>
</component>
<connection>
<map_components component_1="Cln2" component_2="SBF"/>
<map_variables variable_1="SBF" variable_2="SBF"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Cln2" component_2="Vd2_c1"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Cln2" component_2="Hct1"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Cln2" component_2="BUD"/>
<map_variables variable_1="Cln2" variable_2="Cln2"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="Clb2"/>
<map_variables variable_1="Clb2_T" variable_2="Clb2_T"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="Mcm1"/>
<map_variables variable_1="Mcm1" variable_2="Mcm1"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="Cdc20"/>
<map_variables variable_1="Cdc20" variable_2="Cdc20"/>
</connection>
<connection>
<map_components component_1="Clb2_T" component_2="Hct1"/>
<map_variables variable_1="Hct1" variable_2="Hct1"/>
<map_variables variable_1="Hct1_T" variable_2="Hct1_T"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="Clb5"/>
<map_variables variable_1="Clb5_T" variable_2="Clb5_T"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="Clb5_Sic1"/>
<map_variables variable_1="Vd_b5" variable_2="Vd_b5"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="MBF"/>
<map_variables variable_1="MBF" variable_2="MBF"/>
</connection>
<connection>
<map_components component_1="Clb5_T" component_2="Cdc20"/>
<map_variables variable_1="Cdc20" variable_2="Cdc20"/>
</connection>
<connection>
<map_components component_1="Bck2" component_2="Vd2_c1"/>
<map_variables variable_1="Bck2" variable_2="Bck2"/>
</connection>
<connection>
<map_components component_1="Bck2" component_2="SBF"/>
<map_variables variable_1="Bck2" variable_2="Bck2"/>
</connection>
<connection>
<map_components component_1="Cln3" component_2="Vd2_c1"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Cln3" component_2="SBF"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Cln3" component_2="Hct1"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Cln3" component_2="BUD"/>
<map_variables variable_1="Cln3" variable_2="Cln3"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Clb2_Sic1"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
<map_variables variable_1="Clb2_Sic1" variable_2="Clb2_Sic1"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Cdc20_T"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Hct1"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="ORI"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="SPN"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="BUD"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="SBF"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Mcm1"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
</connection>
<connection>
<map_components component_1="Clb2" component_2="Swi5"/>
<map_variables variable_1="Clb2" variable_2="Clb2"/>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jeelean</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Lim</vCard:Family>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Bela</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Novak</vCard:Family>
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<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">John</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Val</vCard:Family>
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<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2009-05-29T16:27:30+12:00</dcterms:W3CDTF>
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<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#ba5f90a9-4e65-4420-8bf9-8fd770a4995c"/>
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<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">The University of Auckland</vCard:Orgname>
<vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Auckland Bioengineering Institute</vCard:Orgunit>
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<dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#41bc80a1-6542-496c-b3f9-d6254b5d9dc0"/>
<rdf:value>Added cmeta id to several variables</rdf:value>
<cmeta:modifier rdf:resource="rdf:#ebf7660f-7ac8-40af-bb9b-1a2178c475b5"/>
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<rdf:Description rdf:about="rdf:#41bc80a1-6542-496c-b3f9-d6254b5d9dc0">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2009-02-13T11:58:59+13:00</dcterms:W3CDTF>
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<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#193e778d-2f6a-42d3-bb6a-41a7772add3b"/>
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</rdf:RDF>
</model>
