A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes

A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes

Model Status

This version was created by Penny Noble of Oxford University and represents the EPICARDIAL CELL VARIANT. This version is known to read in COR and an error (incorrectly defined variables, as far as PCEnv is concerned,) was fixed by James Lawson on 18/04/07 so that the file now reads in PCEnv.

Model Structure

Over the past decade electrophysiological studies have revealed transmural heterogeneity, or differences in the action potential waveforms recorded in cells isolated from the epicardial and the endocardial tissues in the left ventricles of mammalian hearts.

The adult rat has been widely used as an experimental model to investigate the electrical heterogeneity in the left ventricle under normal conditions and pathophysiological states. From this biophysical, experimental data, derived from patch clamp experiments, Sandeep V. Pandit, Robert B. Clark, Wayne R. Giles and Semahat S. Demir have developed a mathematical model of action potential heterogeneity in adult rat left ventricular myocytes (see the figure below). The mathematical models for the epicardial and endocardial cells of the rat left ventricle are based on the classical formulation of Hodgkin and Huxley (see The Hodgkin-Huxley Squid Axon Model, 1952), and are therefore similar to previous computational work carried out by this research group (see Demir et al. Sinoatrial Node Model 1994 and Demir et al. Sinoatrial Node Model 1999). The endocardial cell model is based on the epicardial formulation with only slight modifications in certain parameters and equations.

The complete original paper reference is cited below:

A Mathematical Model of Action Potential Heterogeneity in Adult Rat Left Ventricular Myocytes, , Sandeep V. Pandit, Robert B. Clark, Wayne R. Giles and Semahat S. Demir, 2001, Biophysical Journal , 81, 3029-3051. (Full text and PDF versions of the article are available for Journal Members on the Biophysical Journal website.) PubMed ID: 11720973

The raw CellML description of the Pandit et al 2001 model of action potential heterogeneity in adult rat left ventricular myocytes can be downloaded in various formats as described in .

A fluid compartment model of the rat epicardial/endocardial ventricular cell.
Source
Derived from workspace Pandit, Clark, Giles, Demir, 2001 at changeset 893c872ca63f.
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License

This work is licensed under a Creative Commons Attribution 3.0 Unported License.