Model Mathematics

Component: environment

Component: membrane

dd time V =- 1.0 Cm i_Na + i_Ca + i_K + i_K_A + i_K_Ca + i_L

Component: sodium_channel

i_Na = g_Na m 3.0 h V - E_Na

Component: sodium_channel_m_gate

alpha_m = -0.6 V + 30.0 -0.1 V + 30.0 - 1.0 beta_m = 20.0 - V + 55.0 18.0 dd time m = alpha_m 1.0 - m - beta_m m

Component: sodium_channel_h_gate

alpha_h = 0.4 - V + 50.0 20.0 beta_h = 6.0 -0.1 V + 20.0 + 1.0 dd time h = alpha_h 1.0 - h - beta_h h

Component: calcium_channel

i_Ca = g_Ca c 3.0 V - E_Ca E_Ca = R T 2.0 F ln Ca_e Ca_i

Component: calcium_channel_c_gate

alpha_c = -0.3 V + 13.0 -0.1 V + 13.0 - 1.0 beta_c = 10.0 - V + 38.0 18.0 dd time c = alpha_c 1.0 - c - beta_c c

Component: delayed_rectifier_potassium_channel

i_K = g_K n 4.0 V - E_K

Component: delayed_rectifier_potassium_channel_n_gate

alpha_n = -0.02 V + 40.0 -0.1 V + 40.0 - 1.0 beta_n = 0.4 - V + 50.0 80.0 dd time n = alpha_n 1.0 - n - beta_n n

Component: A_type_potassium_channel

i_K_A = g_K_A a 3.0 h V - E_K

Component: A_type_potassium_channel_a_gate

alpha_a = -0.006 V + 90.0 -0.1 V + 90.0 - 1.0 beta_a = 0.1 - V + 30.0 10.0 dd time a = alpha_a 1.0 - a - beta_a a

Component: A_type_potassium_channel_h_gate

alpha_h = 0.04 - V + 70.0 20.0 beta_h = 0.6 -0.1 V + 40.0 + 1.0 dd time h = alpha_h 1.0 - h - beta_h h

Component: calcium_activated_potassium_channel

i_K_Ca = g_K_Ca V - E_K g_K_Ca_gate = g_K_Ca Ca_i Ca_diss 2.0 1.0 + Ca_i Ca_diss 2.0

Component: leakage_channel

i_L = g_L V - E_L

Component: parameters

dd time Ca_i = -3.0 i_Ca 2.0 F r - Ca_i - Ca_res tau_Ca