<?xml version="1.0"?>
<!--
This CellML file was generated on 21/08/2009 at 9:19:39 at a.m. using:
COR (0.9.31.1309)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="wang_2006" name="wang_2006">
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<article>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model runs in both OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca(2+) oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca(2+) oscillations are mainly due to interaction of Ca(2+) release from the endoplasmic reticulum (ER) and the ATP-dependent Ca(2+) pump back into the ER, and the oscillations are prolonged by extracellular Ca(2+) entry that maintains the constant Ca(2+) supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca(2+) oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca(2+) release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca(2+) oscillations characteristics such as duration, peak [Ca(2+)](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells.
</para>
<para>
The original paper is cited below:
</para>
<para>
A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. J. Wang, X. Huang and W. Huang, 2006, Journal of Theoretical Biology, 245, 510-519. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17188305&query_hl=1&itool=pubmed_docsum">PubMed ID: 17188305</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>Diagram of model</title>
</objectinfo>
<imagedata fileref="wang_2006.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the pathway described by the mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource">
<dcterms:W3CDTF>2009-09-29</dcterms:W3CDTF>
</dcterms:created>
<!--
The Modification History metadata. This lists the changes that have been
made to the document, who made the changes, and when they were made.
-->
</rdf:Description>
<!--
The following metadata refers to the model itself, as indicated by the
reference to the ID "wang_2006", which is
declared on the <model> element.
-->
<rdf:Description rdf:about="#wang_2006">
<!-- A human readable name for the model. -->
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
The Wang et al. 2006 model of ATP-induced intracellular calcium oscillations
</dc:title>
<!-- A comment regarding the model. -->
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This is the CellML description of Wang et al.'s mathematical model of ATP-induced intracellular calcium oscillations
</rdf:value>
<!-- The creator of the comment. -->
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<!-- Keyword(s) -->
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<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>calcium dynamics</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource">
<bqs:Pubmed_id>17188305</bqs:Pubmed_id>
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">
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<rdf:li rdf:parseType="Resource">
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<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Wang</vCard:Family>
<vCard:Given>J</vCard:Given>
</vCard:N>
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</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Huang</vCard:Family>
<vCard:Given>X</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Huang</vCard:Family>
<vCard:Given>W</vCard:Given>
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</bqs:Person>
</rdf:li>
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</dc:creator>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations
</dc:title>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource">
<dcterms:W3CDTF>2006-04-07</dcterms:W3CDTF>
</dcterms:issued>
<bqs:Journal rdf:parseType="Resource">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Journal of Theoretical Biology</dc:title>
</bqs:Journal>
<bqs:volume>245</bqs:volume>
<bqs:first_page>510</bqs:first_page>
<bqs:last_page>519</bqs:last_page>
</bqs:JournalArticle>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>
