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C C There are a total of 11 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 21 entries in the constant variable array. C C C VOI is time in component environment (hour). C ALGBRC(1) is Metin in component environment (flux). C STATES(1) is Met in component Met (micromolar). C ALGBRC(8) is V_MS in component V_MS (flux). C ALGBRC(11) is V_BHMT in component V_BHMT (flux). C ALGBRC(2) is V_MATI in component V_MATI (flux). C ALGBRC(4) is V_MATIII in component V_MATIII (flux). C STATES(2) is AdoMet in component AdoMet (micromolar). C ALGBRC(7) is V_METH in component V_METH (flux). C ALGBRC(5) is V_GNMT in component V_GNMT (flux). C STATES(3) is AdoHcy in component AdoHcy (micromolar). C ALGBRC(9) is V_AH in component V_AH (flux). C STATES(4) is Hcy in component Hcy (micromolar). C ALGBRC(10) is V_CBS in component V_CBS (flux). C CONSTS(1) is V_MATImax in component V_MATI (flux). C CONSTS(2) is Km_MATI in component V_MATI (micromolar). C CONSTS(3) is Ki_MATI in component V_MATI (micromolar). C CONSTS(4) is V_MATIIImax in component V_MATIII (flux). C ALGBRC(3) is Km1_MATIII in component V_MATIII (micromolar). C CONSTS(5) is Km2_MATIII in component V_MATIII (micromolar). C CONSTS(6) is V_GNMTmax in component V_GNMT (flux). C CONSTS(7) is Km_GNMT in component V_GNMT (micromolar). C CONSTS(8) is Ki_GNMT in component V_GNMT (micromolar). C CONSTS(9) is V_METHmax in component V_METH (flux). C ALGBRC(6) is Km1_METH in component V_METH (micromolar). C CONSTS(10) is Km2_METH_A in component V_METH (dimensionless). C CONSTS(11) is five_mTHF in component V_MS (micromolar). C CONSTS(12) is V_MSmax in component V_MS (flux). C CONSTS(13) is Kd_MS in component V_MS (micromolar). C CONSTS(14) is Km_Hcy_MS in component V_MS (micromolar). C CONSTS(15) is Km_five_mTHF_MS in component V_MS (micromolar). C CONSTS(16) is alpha1 in component V_AH (first_order_rate_constant). C CONSTS(17) is alpha2 in component V_AH (dimensionless). C CONSTS(18) is beta1 in component V_CBS (second_order_rate_constant). C CONSTS(19) is beta2 in component V_CBS (first_order_rate_constant). C CONSTS(20) is V_BHMTmax in component V_BHMT (flux). C CONSTS(21) is Km_BHMT in component V_BHMT (micromolar). C RATES(1) is d/dt Met in component Met (micromolar). C RATES(2) is d/dt AdoMet in component AdoMet (micromolar). C RATES(3) is d/dt AdoHcy in component AdoHcy (micromolar). C RATES(4) is d/dt Hcy in component Hcy (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 53.5 STATES(2) = 137.6 STATES(3) = 13.2 STATES(4) = 0.88 CONSTS(1) = 561 CONSTS(2) = 41 CONSTS(3) = 50 CONSTS(4) = 22870 CONSTS(5) = 21.1 CONSTS(6) = 10600 CONSTS(7) = 4500 CONSTS(8) = 20 CONSTS(9) = 4521 CONSTS(10) = 10 CONSTS(11) = 5.2 CONSTS(12) = 500 CONSTS(13) = 1 CONSTS(14) = 0.1 CONSTS(15) = 25 CONSTS(16) = 100 CONSTS(17) = 10 CONSTS(18) = 1.7 CONSTS(19) = 30 CONSTS(20) = 2500 CONSTS(21) = 12 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(1)/(1.00000+ (CONSTS(2)/STATES(1))*(1.00000+STATES(2)/CONSTS(3))) ALGBRC(3) = 20000.0/(1.00000+ 5.70000*STATES(2)/(STATES(2)+600.000) ** 2.00000) ALGBRC(4) = CONSTS(4)/(1.00000+( ALGBRC(3)*CONSTS(5))/(STATES(1) ** 2.00000+ STATES(1)*CONSTS(5))) ALGBRC(6) = 1.00000*(1.00000+STATES(3)/4.00000) ALGBRC(7) = CONSTS(9)/(1.00000+ALGBRC(6)/STATES(2)+CONSTS(10)+( CONSTS(10)*ALGBRC(6))/STATES(2)) ALGBRC(5) = ( (CONSTS(6)/(1.00000+CONSTS(7)/STATES(2) ** 2.30000))*1.00000)/(1.00000+STATES(3)/CONSTS(8)) RATES(2) = (ALGBRC(2)+ALGBRC(4)) - (ALGBRC(7)+ALGBRC(5)) ALGBRC(9) = CONSTS(16)*(STATES(3) - CONSTS(17)*STATES(4)) RATES(3) = (ALGBRC(7)+ALGBRC(5)) - ALGBRC(9) ALGBRC(1) = TERNRY(VOI.LT.2.00000.OR.VOI.GE.8.00000, 200.000, TERNRY(VOI.GE.2.00000.AND.VOI.LT.5.00000, 300.000, TERNRY(VOI.GE.5.00000.AND.VOI.LT.8.00000, 100.000, 200.000) ALGBRC(8) = ( CONSTS(12)*CONSTS(11)*STATES(4))/( CONSTS(13)*CONSTS(14)+ CONSTS(14)*CONSTS(11)+ CONSTS(15)*STATES(4)+ CONSTS(11)*STATES(4)) ALGBRC(11) = ( (0.700000 - 0.0250000*((STATES(2)+STATES(3)) - 150.000))*CONSTS(20)*STATES(4))/(CONSTS(21)+STATES(4)) RATES(1) = (ALGBRC(8)+ALGBRC(11)+ALGBRC(1)) - (ALGBRC(2)+ALGBRC(4)) ALGBRC(10) = ( CONSTS(18)*(STATES(2)+STATES(3)) - CONSTS(19))*STATES(4) RATES(4) = ALGBRC(9) - (ALGBRC(10)+ALGBRC(8)+ALGBRC(11)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(1)/(1.00000+ (CONSTS(2)/STATES(1))*(1.00000+STATES(2)/CONSTS(3))) ALGBRC(3) = 20000.0/(1.00000+ 5.70000*STATES(2)/(STATES(2)+600.000) ** 2.00000) ALGBRC(4) = CONSTS(4)/(1.00000+( ALGBRC(3)*CONSTS(5))/(STATES(1) ** 2.00000+ STATES(1)*CONSTS(5))) ALGBRC(6) = 1.00000*(1.00000+STATES(3)/4.00000) ALGBRC(7) = CONSTS(9)/(1.00000+ALGBRC(6)/STATES(2)+CONSTS(10)+( CONSTS(10)*ALGBRC(6))/STATES(2)) ALGBRC(5) = ( (CONSTS(6)/(1.00000+CONSTS(7)/STATES(2) ** 2.30000))*1.00000)/(1.00000+STATES(3)/CONSTS(8)) ALGBRC(9) = CONSTS(16)*(STATES(3) - CONSTS(17)*STATES(4)) ALGBRC(1) = TERNRY(VOI.LT.2.00000.OR.VOI.GE.8.00000, 200.000, TERNRY(VOI.GE.2.00000.AND.VOI.LT.5.00000, 300.000, TERNRY(VOI.GE.5.00000.AND.VOI.LT.8.00000, 100.000, 200.000) ALGBRC(8) = ( CONSTS(12)*CONSTS(11)*STATES(4))/( CONSTS(13)*CONSTS(14)+ CONSTS(14)*CONSTS(11)+ CONSTS(15)*STATES(4)+ CONSTS(11)*STATES(4)) ALGBRC(11) = ( (0.700000 - 0.0250000*((STATES(2)+STATES(3)) - 150.000))*CONSTS(20)*STATES(4))/(CONSTS(21)+STATES(4)) ALGBRC(10) = ( CONSTS(18)*(STATES(2)+STATES(3)) - CONSTS(19))*STATES(4) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END