Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. II. Populations of Coupled Pacemaker Neurons: Single Cell Model
Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. II. Populations of Coupled Pacemaker Neurons
Model Status
This CellML model represents a single neuron in a network of cells. This cell model is based on "model 1" published in a preceding paper (Butera et al. 1999) which is also described in CellML as a stand alone CellML 1.0 model. To model inter-cellular coupling a synaptic input current Isyn_e has been added to the model.
Model Structure
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| The single cell neuron model is based on a single-compartment Hodgkin-Huxley type formalism. It is composed of five ionic currents across the plasma membrane: a fast sodium current, INa; a delayed rectifier potassium current, IK; a persistent sodium current, INaP; a passive leakage current, IL; and a tonic current, Itonic_e In addition for the multicellular model a synaptic current (Isyn_e) has been added to connect the cells in the network. |
The original paper reference is cited below:
Models of respiratory rhythm generation in the Pre-Botzinger complex. II. Populations Of coupled pacemaker neurons, Butera RJ Jr, Rinzel J, Smith JC, 1999, Journal of Neurophysiology, 82, 398-415. PubMed ID: 10400967