Rendering of the source text

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<!--
This CellML file was generated on 20/07/2009 at 14:53:30 using:

COR (0.9.31.1297)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="IyerHajjarArmoundas2007" name="IyerHajjarArmoundas2007">

<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<section id="sec_status">
				<title>Model Status</title>
				<para>            This CellML model is known to run in both COR and OpenCell to recreate the original results.  This model is valid CellML and has consistent units</para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
<para>
ABSTRACT: Catecholaminergic polymorphic ventricular tachycardia is a heritable arrhythmia unmasked by exertion or stress
and is characterized by triggered activity and sudden cardiac death. In this study, we simulated mutations in 2 genes
linked to catecholaminergic polymorphic ventricular tachycardia, the first located in calsequestrin (CSQN2) and the
second in the ryanodine receptor (RyR2). The aim of the study was to investigate the mechanistic basis for spontaneous
Ca2 release events that lead to delayed afterdepolarizations in affected patients. Sarcoplasmic reticulum (SR) luminal
Ca2 sensing was incorporated into a model of the human ventricular myocyte, and CSQN2 mutations were modeled
by simulating disrupted RyR2 luminal Ca2 sensing. In voltage-clamp mode, the mutant CSQN2 model recapitulated
the smaller calcium transients, smaller time to peak calcium transient, and accelerated recovery from inactivation seen
in experiments. In current clamp mode, in the presence of stimulation, we observed delayed afterdepolarizations,
suggesting that accelerated recovery of RyR2 induced by impaired luminal Ca2 sensing underlies the triggered activity
observed in mutant CSQN2-expressing myocytes. In current-clamp mode, in a model of mutant RyR2 that is
characterized by reduced FKBP12.6 binding to the RyR2 on stimulation, the impaired coupled gating characteristic
of these mutations was modeled by reducing cooperativity of RyR2 activation. In current-clamp mode, the mutant RyR2
model exhibited increased diastolic RyR2 open probability that resulted in formation of delayed afterdepolarizations. In
conclusion, these minimal order models of mutant CSQN2 and RyR2 provide plausible mechanisms by which defects
in RyR2 gating may lead to the cellular triggers for arrhythmia, with implications for the development of
targeted therapy. 
</para>

<informalfigure float="0" id="fig_reaction_diagram">
					<mediaobject>
						<imageobject>
							<objectinfo>
								<title>model diagram</title>
							</objectinfo>
							<imagedata fileref="iyer_2007.png"/>
						</imageobject>
					</mediaobject>
					<caption>Schematic diagram of the cell model.</caption>
				</informalfigure>

<para>
   Mechanisms of Abnormal Calcium Homeostasis in Mutations Responsible for Catecholaminergic Polymorphic Ventricular Tachycardia, Vivek Iyer, Roger J. Hajjar, Antonis A. Armoundas, 2007, <emphasis>Circulation Research</emphasis>, 100, e22-31. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17234962&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 17234962</ulink>.
</para>
			
			</sect1>
		</article>
	</documentation>

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                  <ci>Krb</ci>
               </apply>
               <ci>Nrb</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Jup</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>KSR</ci>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <ci>vmaxf</ci>
                              <ci>fb</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>vmaxr</ci>
                              <ci>rb</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>fb</ci>
                        <ci>rb</ci>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>iso</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        <ci>KSR</ci>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <ci>vmaxf</ci>
                              <ci>fb</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>vmaxr</ci>
                              <ci>rb</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>fb</ci>
                        <ci>rb</ci>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>Jrel</ci>
            <apply>
               <times/>
               <ci>v1</ci>
               <apply>
                  <plus/>
                  <ci>O1_RyR</ci>
                  <ci>O2_RyR</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>CaJSR</ci>
                  <ci>CaSS</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Jtr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>CaNSR</ci>
                  <ci>CaJSR</ci>
               </apply>
               <ci>tautr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Jxfer</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>CaSS</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>tauxfer</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS">
      <variable initial_value="0.07" name="LTRPNtot" units="mM"/>
      <variable initial_value="0.14" name="HTRPNtot" units="mM"/>
      <variable initial_value="20" name="khtrpn_plus" units="per_mM_per_ms"/>
      <variable initial_value="6.6e-5" name="khtrpn_minus" units="per_ms"/>
      <variable initial_value="40" name="kltrpn_plus" units="per_mM_per_ms"/>
      <variable initial_value="0.04" name="kltrpn_minus" units="per_ms"/>
      <variable initial_value="0.05" name="CMDNtot" units="mM"/>
      <variable name="CSQNtot" units="mM"/>
      <variable initial_value="0" name="EGTAtot" units="mM"/>
      <variable initial_value="0.00238" name="KmCMDN" units="mM"/>
      <variable initial_value="0.8" name="KmCSQN" units="mM"/>
      <variable initial_value="0.00015" name="KmEGTA" units="mM"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="dLTRPNCa" units="per_ms"/>
      <variable name="dHTRPNCa" units="per_ms"/>
      <variable name="Jtrpn" public_interface="out" units="mM_per_ms"/>
      <variable name="CaSS" public_interface="in" units="mM"/>
      <variable name="beta_SS" public_interface="out" units="dimensionless"/>
      <variable name="beta_JSR" public_interface="out" units="dimensionless"/>
      <variable name="beta_i" public_interface="out" units="dimensionless"/>
      <variable name="CaJSR" public_interface="in" units="mM"/>
      <variable initial_value="0.280466039150394" name="LTRPNCa" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.99347761599363" name="HTRPNCa" public_interface="out" units="dimensionless"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="CSQN2" public_interface="in" units="dimensionless"/>
      <variable name="RyR2" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>CSQNtot</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">15</cn>
                  <apply>
                     <eq/>
                     <ci>RyR2</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">15</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>dLTRPNCa</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kltrpn_plus</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>LTRPNCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kltrpn_minus</ci>
                  <ci>LTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dHTRPNCa</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>khtrpn_plus</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>HTRPNCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>khtrpn_minus</ci>
                  <ci>HTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LTRPNCa</ci>
            </apply>
            <ci>dLTRPNCa</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HTRPNCa</ci>
            </apply>
            <ci>dHTRPNCa</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Jtrpn</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>LTRPNtot</ci>
                  <ci>dLTRPNCa</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>HTRPNtot</ci>
                  <ci>dHTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_SS</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CMDNtot</ci>
                        <ci>KmCMDN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>CaSS</ci>
                           <ci>KmCMDN</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>EGTAtot</ci>
                        <ci>KmEGTA</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>CaSS</ci>
                           <ci>KmEGTA</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_JSR</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CSQNtot</ci>
                        <ci>KmCSQN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>CaJSR</ci>
                           <ci>KmCSQN</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CMDNtot</ci>
                        <ci>KmCMDN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Cai</ci>
                           <ci>KmCMDN</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>EGTAtot</ci>
                        <ci>KmEGTA</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Cai</ci>
                           <ci>KmEGTA</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES">
      <variable initial_value="0.01215" name="kaplus" units="per_uM4_per_ms"/>
      <variable initial_value="0.576" name="kaminus" units="per_ms"/>
      <variable initial_value="0.00405" name="kbplus" units="per_uM3_per_ms"/>
      <variable initial_value="1.93" name="kbminus" units="per_ms"/>
      <variable initial_value="0.1" name="kcplus" units="per_ms"/>
      <variable initial_value="0.0008" name="kcminus" units="per_ms"/>
      <variable initial_value="4" name="ncoop" units="dimensionless"/>
      <variable initial_value="3" name="mcoop" units="dimensionless"/>
      <variable initial_value="1" name="kryr" units="dimensionless"/>
      <variable name="klumenC1O1" units="dimensionless"/>
      <variable name="klumenO1C2" units="dimensionless"/>
      <variable name="klumenC2O1" units="dimensionless"/>
      <variable initial_value="0.5" name="HmaxC1O1" units="dimensionless"/>
      <variable name="HmaxO1C2" units="dimensionless"/>
      <variable initial_value="0.5" name="HmaxC2O1" units="dimensionless"/>
      <variable initial_value="5" name="Hmin" units="dimensionless"/>
      <variable initial_value="1" name="H50C1O1" units="mM"/>
      <variable initial_value="1" name="H50O1C2" units="mM"/>
      <variable name="H50C2O1" units="mM"/>
      <variable initial_value="2.5" name="HN" units="dimensionless"/>
      <variable name="CaSS" public_interface="in" units="mM"/>
      <variable name="CaJSR" public_interface="in" units="mM"/>
      <variable name="dC1_RyR" units="per_ms"/>
      <variable name="dO2_RyR" units="per_ms"/>
      <variable name="dC2_RyR" units="per_ms"/>
      <variable name="dO1_RyR" units="per_ms"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES_C1_RyR" initial_value="0.132070890861418" name="C1_RyR" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES_O2_RyR" initial_value="3.11350788541838e-7" name="O2_RyR" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES_C2_RyR" initial_value="0.866791951404883" name="C2_RyR" public_interface="out" units="dimensionless"/>
      <variable cmeta:id="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES_O1_RyR" initial_value="0.00113684728532807" name="O1_RyR" public_interface="out" units="dimensionless"/>
      <variable name="CSQN2" public_interface="in" units="dimensionless"/>
      <variable name="RyR2" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>HmaxO1C2</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                  <apply>
                     <eq/>
                     <ci>CSQN2</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>H50C2O1</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.5</cn>
                  <apply>
                     <eq/>
                     <ci>CSQN2</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>klumenC1O1</ci>
            <apply>
               <minus/>
               <ci>HmaxC1O1</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>HmaxC1O1</ci>
                     <ci>Hmin</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>H50C1O1</ci>
                           <ci>CaJSR</ci>
                        </apply>
                        <ci>HN</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>klumenO1C2</ci>
            <apply>
               <minus/>
               <ci>HmaxO1C2</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>HmaxO1C2</ci>
                     <ci>Hmin</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>H50O1C2</ci>
                           <ci>CaJSR</ci>
                        </apply>
                        <ci>HN</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>klumenC2O1</ci>
            <apply>
               <minus/>
               <ci>HmaxC2O1</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>HmaxC2O1</ci>
                     <ci>Hmin</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>H50C2O1</ci>
                           <ci>CaJSR</ci>
                        </apply>
                        <ci>HN</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dC1_RyR</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>kaplus</ci>
                  </apply>
                  <ci>klumenC1O1</ci>
                  <apply>
                     <power/>
                     <apply>
                        <times/>
                        <ci>CaSS</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="m2u">1000</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>ncoop</ci>
                        <ci>kryr</ci>
                     </apply>
                  </apply>
                  <ci>C1_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kaminus</ci>
                  <ci>O1_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dO2_RyR</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kbplus</ci>
                  <apply>
                     <power/>
                     <apply>
                        <times/>
                        <ci>CaSS</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="m2u">1000</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>mcoop</ci>
                        <ci>kryr</ci>
                     </apply>
                  </apply>
                  <ci>O1_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbminus</ci>
                  <ci>O2_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dC2_RyR</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>kcplus</ci>
                     <ci>klumenO1C2</ci>
                  </apply>
                  <ci>O1_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kcminus</ci>
                  <ci>klumenC2O1</ci>
                  <ci>C2_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dO1_RyR</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>dC1_RyR</ci>
                  <ci>dO2_RyR</ci>
                  <ci>dC2_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1_RyR</ci>
            </apply>
            <ci>dC1_RyR</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O2_RyR</ci>
            </apply>
            <ci>dO2_RyR</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2_RyR</ci>
            </apply>
            <ci>dC2_RyR</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O1_RyR</ci>
            </apply>
            <ci>dO1_RyR</ci>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES">
      <variable initial_value="0.3" name="fL" units="per_ms"/>
      <variable initial_value="4" name="gL" units="per_ms"/>
      <variable initial_value="2" name="bL" units="dimensionless"/>
      <variable initial_value="2" name="aL" units="dimensionless"/>
      <variable name="C0_to_C1" units="per_ms"/>
      <variable name="C1_to_C2" units="per_ms"/>
      <variable name="C2_to_C3" units="per_ms"/>
      <variable name="C3_to_C4" units="per_ms"/>
      <variable name="C1_to_C0" units="per_ms"/>
      <variable name="C2_to_C1" units="per_ms"/>
      <variable name="C3_to_C2" units="per_ms"/>
      <variable name="C4_to_C3" units="per_ms"/>
      <variable name="CCa0_to_CCa1" units="per_ms"/>
      <variable name="CCa1_to_CCa2" units="per_ms"/>
      <variable name="CCa2_to_CCa3" units="per_ms"/>
      <variable name="CCa3_to_CCa4" units="per_ms"/>
      <variable name="CCa1_to_CCa0" units="per_ms"/>
      <variable name="CCa2_to_CCa1" units="per_ms"/>
      <variable name="CCa3_to_CCa2" units="per_ms"/>
      <variable name="CCa4_to_CCa3" units="per_ms"/>
      <variable name="C0_to_CCa0" units="per_ms"/>
      <variable name="C1_to_CCa1" units="per_ms"/>
      <variable name="C2_to_CCa2" units="per_ms"/>
      <variable name="C3_to_CCa3" units="per_ms"/>
      <variable name="C4_to_CCa4" units="per_ms"/>
      <variable name="CCa0_to_C0" units="per_ms"/>
      <variable name="CCa1_to_C1" units="per_ms"/>
      <variable name="CCa2_to_C2" units="per_ms"/>
      <variable name="CCa3_to_C3" units="per_ms"/>
      <variable name="CCa4_to_C4" units="per_ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="alpha" units="per_ms"/>
      <variable name="beta" units="per_ms"/>
      <variable name="alpha_prime" units="per_ms"/>
      <variable name="beta_prime" units="per_ms"/>
      <variable name="gamma" units="per_ms"/>
      <variable name="omega" units="per_ms"/>
      <variable name="a1_Ca0" units="per_ms"/>
      <variable name="a2_Ca0" units="per_ms"/>
      <variable name="a1_Ca1" units="per_ms"/>
      <variable name="a2_Ca1" units="per_ms"/>
      <variable name="a1_Ca2" units="per_ms"/>
      <variable name="a2_Ca2" units="per_ms"/>
      <variable name="a1_Ca3" units="per_ms"/>
      <variable name="a2_Ca3" units="per_ms"/>
      <variable name="a1_Ca4" units="per_ms"/>
      <variable name="a2_Ca4" units="per_ms"/>
      <variable name="a1_C0" units="per_ms"/>
      <variable name="a2_C0" units="per_ms"/>
      <variable name="a1_C1" units="per_ms"/>
      <variable name="a2_C1" units="per_ms"/>
      <variable name="a1_C2" units="per_ms"/>
      <variable name="a2_C2" units="per_ms"/>
      <variable name="a1_C3" units="per_ms"/>
      <variable name="a2_C3" units="per_ms"/>
      <variable name="a1_C4" units="per_ms"/>
      <variable name="a2_C4" units="per_ms"/>
      <variable name="CaSS" public_interface="in" units="mM"/>
      <variable initial_value="0.465679150104636" name="C0" units="dimensionless"/>
      <variable initial_value="0.00834457719966281" name="C1" units="dimensionless"/>
      <variable initial_value="5.60736209083906e-5" name="C2" units="dimensionless"/>
      <variable initial_value="1.6747092904465e-7" name="C3" units="dimensionless"/>
      <variable initial_value="1.87571666668874e-10" name="C4" units="dimensionless"/>
      <variable initial_value="0.489846779190386" name="CCa0" units="dimensionless"/>
      <variable initial_value="0.035111008610982" name="CCa1" units="dimensionless"/>
      <variable initial_value="0.000943745917866092" name="CCa2" units="dimensionless"/>
      <variable initial_value="1.12741202215634e-5" name="CCa3" units="dimensionless"/>
      <variable initial_value="5.05056944609524e-8" name="CCa4" units="dimensionless"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable initial_value="1.40806027419488e-11" name="Open" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.995434385054729" name="yCa" public_interface="out" units="dimensionless"/>
      <variable name="a1_Cainf" units="dimensionless"/>
      <variable name="yCa_inf" units="dimensionless"/>
      <variable name="tau_yCa" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">4</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.2</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.416</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.012</cn>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">35</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">4</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.45</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.049</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.065</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">22</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_prime</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>alpha</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_prime</ci>
            <apply>
               <divide/>
               <ci>beta</ci>
               <ci>bL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gamma</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.6</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mM">0.09233</cn>
               <ci>CaSS</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>omega</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.25</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C0_to_C1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               <ci>alpha</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1_to_C2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               <ci>alpha</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C2_to_C3</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <ci>alpha</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C3_to_C4</ci>
            <ci>alpha</ci>
         </apply>
         <apply>
            <eq/>
            <ci>CCa0_to_CCa1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               <ci>alpha_prime</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa1_to_CCa2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               <ci>alpha_prime</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa2_to_CCa3</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <ci>alpha_prime</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa3_to_CCa4</ci>
            <ci>alpha_prime</ci>
         </apply>
         <apply>
            <eq/>
            <ci>C1_to_C0</ci>
            <ci>beta</ci>
         </apply>
         <apply>
            <eq/>
            <ci>C2_to_C1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <ci>beta</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C3_to_C2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               <ci>beta</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C4_to_C3</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               <ci>beta</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa1_to_CCa0</ci>
            <ci>beta_prime</ci>
         </apply>
         <apply>
            <eq/>
            <ci>CCa2_to_CCa1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <ci>beta_prime</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa3_to_CCa2</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               <ci>beta_prime</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa4_to_CCa3</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               <ci>beta_prime</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C0_to_CCa0</ci>
            <ci>gamma</ci>
         </apply>
         <apply>
            <eq/>
            <ci>C1_to_CCa1</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C0_to_CCa0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C2_to_CCa2</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C1_to_CCa1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C3_to_CCa3</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C2_to_CCa2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C4_to_CCa4</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C3_to_CCa3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa0_to_C0</ci>
            <ci>omega</ci>
         </apply>
         <apply>
            <eq/>
            <ci>CCa1_to_C1</ci>
            <apply>
               <divide/>
               <ci>CCa0_to_C0</ci>
               <ci>bL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa2_to_C2</ci>
            <apply>
               <divide/>
               <ci>CCa1_to_C1</ci>
               <ci>bL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa3_to_C3</ci>
            <apply>
               <divide/>
               <ci>CCa2_to_C2</ci>
               <ci>bL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>CCa4_to_C4</ci>
            <apply>
               <divide/>
               <ci>CCa3_to_C3</ci>
               <ci>bL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C0</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C0_to_C1</ci>
                  <ci>C0_to_CCa0</ci>
               </apply>
               <ci>C0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C0</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C1_to_C0</ci>
                  <ci>C1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa0_to_C0</ci>
                  <ci>CCa0</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C0</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C0</ci>
               <ci>a1_C0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C1_to_C0</ci>
                  <ci>C1_to_C2</ci>
                  <ci>C1_to_CCa1</ci>
               </apply>
               <ci>C1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C0_to_C1</ci>
                  <ci>C0</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C2_to_C1</ci>
                  <ci>C2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa1_to_C1</ci>
                  <ci>CCa1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C1</ci>
               <ci>a1_C1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C2_to_C1</ci>
                  <ci>C2_to_C3</ci>
                  <ci>C2_to_CCa2</ci>
               </apply>
               <ci>C2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C1_to_C2</ci>
                  <ci>C1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C3_to_C2</ci>
                  <ci>C3</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa2_to_C2</ci>
                  <ci>CCa2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C2</ci>
               <ci>a1_C2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C3</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C3_to_C2</ci>
                  <ci>C3_to_C4</ci>
                  <ci>C3_to_CCa3</ci>
               </apply>
               <ci>C3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C2_to_C3</ci>
                  <ci>C2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C4_to_C3</ci>
                  <ci>C4</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa3_to_C3</ci>
                  <ci>CCa3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C3</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C3</ci>
               <ci>a1_C3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C4</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C4_to_C3</ci>
                  <ci>fL</ci>
                  <ci>C4_to_CCa4</ci>
               </apply>
               <ci>C4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C4</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C3_to_C4</ci>
                  <ci>C3</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>gL</ci>
                  <ci>Open</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa4_to_C4</ci>
                  <ci>CCa4</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C4</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C4</ci>
               <ci>a1_C4</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Open</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>fL</ci>
                  <ci>C4</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>gL</ci>
                  <ci>Open</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Ca0</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CCa0_to_CCa1</ci>
                  <ci>CCa0_to_C0</ci>
               </apply>
               <ci>CCa0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Ca0</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CCa1_to_CCa0</ci>
                  <ci>CCa1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C0_to_CCa0</ci>
                  <ci>C0</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CCa0</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_Ca0</ci>
               <ci>a1_Ca0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Ca1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CCa1_to_CCa0</ci>
                  <ci>CCa1_to_CCa2</ci>
                  <ci>CCa1_to_C1</ci>
               </apply>
               <ci>CCa1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Ca1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CCa0_to_CCa1</ci>
                  <ci>CCa0</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa2_to_CCa1</ci>
                  <ci>CCa2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1_to_CCa1</ci>
                  <ci>C1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CCa1</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_Ca1</ci>
               <ci>a1_Ca1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Ca2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CCa2_to_CCa1</ci>
                  <ci>CCa2_to_CCa3</ci>
                  <ci>CCa2_to_C2</ci>
               </apply>
               <ci>CCa2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Ca2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CCa1_to_CCa2</ci>
                  <ci>CCa1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa3_to_CCa2</ci>
                  <ci>CCa3</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C2_to_CCa2</ci>
                  <ci>C2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CCa2</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_Ca2</ci>
               <ci>a1_Ca2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Ca3</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CCa3_to_CCa2</ci>
                  <ci>CCa3_to_CCa4</ci>
                  <ci>CCa3_to_C3</ci>
               </apply>
               <ci>CCa3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Ca3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CCa2_to_CCa3</ci>
                  <ci>CCa2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa4_to_CCa3</ci>
                  <ci>CCa4</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C3_to_CCa3</ci>
                  <ci>C3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CCa3</ci>
            </apply>
            <apply>
               <minus/>
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            <ci>a1_C0</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C0Kv14_to_C1Kv14</ci>
                  <ci>C0Kv14_to_CI0Kv14</ci>
               </apply>
               <ci>C0Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C0</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C1Kv14_to_C0Kv14</ci>
                  <ci>C1Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI0Kv14_to_C0Kv14</ci>
                  <ci>CI0Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C0Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C0</ci>
               <ci>a1_C0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C1Kv14_to_C2Kv14</ci>
                  <ci>C1Kv14_to_C0Kv14</ci>
                  <ci>C1Kv14_to_CI1Kv14</ci>
               </apply>
               <ci>C1Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C2Kv14_to_C1Kv14</ci>
                  <ci>C2Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI1Kv14_to_C1Kv14</ci>
                  <ci>CI1Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C0Kv14_to_C1Kv14</ci>
                  <ci>C0Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C1</ci>
               <ci>a1_C1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C2Kv14_to_C3Kv14</ci>
                  <ci>C2Kv14_to_C1Kv14</ci>
                  <ci>C2Kv14_to_CI2Kv14</ci>
               </apply>
               <ci>C2Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C3Kv14_to_C2Kv14</ci>
                  <ci>C3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI2Kv14_to_C2Kv14</ci>
                  <ci>CI2Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1Kv14_to_C2Kv14</ci>
                  <ci>C1Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C2</ci>
               <ci>a1_C2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C3</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C3Kv14_to_OKv14</ci>
                  <ci>C3Kv14_to_C2Kv14</ci>
                  <ci>C3Kv14_to_CI3Kv14</ci>
               </apply>
               <ci>C3Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>OKv14_to_C3Kv14</ci>
                  <ci>OKv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI3Kv14_to_C3Kv14</ci>
                  <ci>CI3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C2Kv14_to_C3Kv14</ci>
                  <ci>C2Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C3Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C3</ci>
               <ci>a1_C3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_O</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>OKv14_to_C3Kv14</ci>
                  <ci>OKv14_to_OIKv14</ci>
               </apply>
               <ci>OKv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_O</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C3Kv14_to_OKv14</ci>
                  <ci>C3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>OIKv14_to_OKv14</ci>
                  <ci>OIKv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OKv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_O</ci>
               <ci>a1_O</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_CI0</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI0Kv14_to_C0Kv14</ci>
                  <ci>CI0Kv14_to_CI1Kv14</ci>
               </apply>
               <ci>CI0Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_CI0</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C0Kv14_to_CI0Kv14</ci>
                  <ci>C0Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI1Kv14_to_CI0Kv14</ci>
                  <ci>CI1Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI0Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_CI0</ci>
               <ci>a1_CI0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_CI1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI1Kv14_to_CI2Kv14</ci>
                  <ci>CI1Kv14_to_C1Kv14</ci>
                  <ci>CI1Kv14_to_CI0Kv14</ci>
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               <ci>CI1Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_CI1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CI2Kv14_to_CI1Kv14</ci>
                  <ci>CI2Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1Kv14_to_CI1Kv14</ci>
                  <ci>C1Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI0Kv14_to_CI1Kv14</ci>
                  <ci>CI0Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI1Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_CI1</ci>
               <ci>a1_CI1</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_CI2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI2Kv14_to_CI3Kv14</ci>
                  <ci>CI2Kv14_to_C2Kv14</ci>
                  <ci>CI2Kv14_to_CI1Kv14</ci>
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               <ci>CI2Kv14</ci>
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         <apply>
            <eq/>
            <ci>a2_CI2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CI3Kv14_to_CI2Kv14</ci>
                  <ci>CI3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C2Kv14_to_CI2Kv14</ci>
                  <ci>C2Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI1Kv14_to_CI2Kv14</ci>
                  <ci>CI1Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI2Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_CI2</ci>
               <ci>a1_CI2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_CI3</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI3Kv14_to_OIKv14</ci>
                  <ci>CI3Kv14_to_C3Kv14</ci>
                  <ci>CI3Kv14_to_CI2Kv14</ci>
               </apply>
               <ci>CI3Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_CI3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>OIKv14_to_CI3Kv14</ci>
                  <ci>OIKv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C3Kv14_to_CI3Kv14</ci>
                  <ci>C3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI2Kv14_to_CI3Kv14</ci>
                  <ci>CI2Kv14</ci>
               </apply>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI3Kv14</ci>
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            <apply>
               <minus/>
               <ci>a2_CI3</ci>
               <ci>a1_CI3</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>a1_OI</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>OIKv14_to_OKv14</ci>
                  <ci>OIKv14_to_CI3Kv14</ci>
               </apply>
               <ci>OIKv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_OI</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>OKv14_to_OIKv14</ci>
                  <ci>OKv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI3Kv14_to_OIKv14</ci>
                  <ci>CI3Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OIKv14</ci>
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            <apply>
               <minus/>
               <ci>a2_OI</ci>
               <ci>a1_OI</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_REVERSAL_POTENTIALS">
      <variable name="ENa" public_interface="out" units="mV"/>
      <variable name="EK" public_interface="out" units="mV"/>
      <variable name="EKs" public_interface="out" units="mV"/>
      <variable name="ECa" public_interface="out" units="mV"/>
      <variable name="RT_over_F" public_interface="in" units="mV"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <variable name="Cao" public_interface="in" units="mM"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="a1" units="mM"/>
      <variable name="a2" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>ENa</ci>
            <apply>
               <times/>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>Nai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>EK</ci>
            <apply>
               <times/>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1</ci>
            <apply>
               <plus/>
               <ci>Ko</ci>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01833</cn>
                  <ci>Nao</ci>
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            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2</ci>
            <apply>
               <plus/>
               <ci>Ki</ci>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01833</cn>
                  <ci>Nai</ci>
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            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>EKs</ci>
            <apply>
               <times/>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>a1</ci>
                     <ci>a2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ECa</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
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               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
      <variable initial_value="0.0186" name="GKr" units="mS_per_uF"/>
      <variable initial_value="0.0035" name="GKs" units="mS_per_uF"/>
      <variable initial_value="0.125305126118808" name="GK1" units="mS_per_uF"/>
      <variable initial_value="56.32" name="GNa" units="mS_per_uF"/>
      <variable initial_value="0.001" name="GNab" units="mS_per_uF"/>
      <variable initial_value="0.872" name="KvScale" units="dimensionless"/>
      <variable initial_value="0.889" name="Kv43Frac" units="dimensionless"/>
      <variable name="GKv43" units="mS_per_uF"/>
      <variable name="PKv14" units="litre_per_farad_second"/>
      <variable name="OKv14" public_interface="in" units="dimensionless"/>
      <variable name="na6" public_interface="in" units="dimensionless"/>
      <variable name="na7" public_interface="in" units="dimensionless"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="ENa" public_interface="in" units="mV"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="OHerg" public_interface="in" units="dimensionless"/>
      <variable name="O1ks" public_interface="in" units="dimensionless"/>
      <variable name="O2ks" public_interface="in" units="dimensionless"/>
      <variable name="OKv43" public_interface="in" units="dimensionless"/>
      <variable name="RT_over_F" public_interface="in" units="mV"/>
      <variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <variable name="EK" public_interface="in" units="mV"/>
      <variable name="fKo" units="dimensionless"/>
      <variable name="VF_over_RT" units="dimensionless"/>
      <variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
      <variable name="a1_K" units="mM"/>
      <variable name="a2" units="dimensionless"/>
      <variable name="a1_Na" units="mM"/>
      <variable name="K1_inf" units="dimensionless"/>
      <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr" name="IKr" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs" name="IKs" public_interface="out" units="uA_per_uF"/>
      <variable name="IKv43" public_interface="out" units="uA_per_uF"/>
      <variable name="IKv14_K" public_interface="out" units="uA_per_uF"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="IKv14_Na" public_interface="out" units="uA_per_uF"/>
      <variable name="IKv14" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_Ito1" name="Ito1" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IK1" name="IK1" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INab" name="INab" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INa" name="INa" public_interface="out" units="uA_per_uF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <eq/>
            <ci>PKv14</ci>
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               <times/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>Kv43Frac</ci>
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               <ci>KvScale</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>GKv43</ci>
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               <times/>
               <ci>Kv43Frac</ci>
               <ci>KvScale</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mS_per_uF">0.1</cn>
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         <apply>
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            <ci>INa</ci>
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               <times/>
               <ci>GNa</ci>
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                  <plus/>
                  <ci>na6</ci>
                  <ci>na7</ci>
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               <apply>
                  <minus/>
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            <ci>fKo</ci>
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               <root/>
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                  <ci>Ko</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>IKr</ci>
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               <times/>
               <ci>GKr</ci>
               <ci>fKo</ci>
               <ci>OHerg</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>IKs</ci>
            <apply>
               <times/>
               <ci>GKs</ci>
               <apply>
                  <plus/>
                  <ci>O1ks</ci>
                  <ci>O2ks</ci>
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               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
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         <apply>
            <eq/>
            <ci>IKv43</ci>
            <apply>
               <times/>
               <ci>GKv43</ci>
               <ci>OKv43</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
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         <apply>
            <eq/>
            <ci>VF_over_RT</ci>
            <apply>
               <divide/>
               <ci>V</ci>
               <ci>RT_over_F</ci>
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         <apply>
            <eq/>
            <ci>VFsq_over_RT</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
               <ci>Faraday</ci>
               <ci>VF_over_RT</ci>
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         <apply>
            <eq/>
            <ci>a1_K</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Ki</ci>
                  <apply>
                     <exp/>
                     <ci>VF_over_RT</ci>
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               <ci>Ko</ci>
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         <apply>
            <eq/>
            <ci>a2</ci>
            <apply>
               <minus/>
               <apply>
                  <exp/>
                  <ci>VF_over_RT</ci>
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         <apply>
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            <ci>IKv14_K</ci>
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               <divide/>
               <apply>
                  <times/>
                  <ci>PKv14</ci>
                  <ci>OKv14</ci>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_K</ci>
               </apply>
               <ci>a2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Na</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Nai</ci>
                  <apply>
                     <exp/>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <ci>Nao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IKv14_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
                  <ci>PKv14</ci>
                  <ci>OKv14</ci>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_Na</ci>
               </apply>
               <ci>a2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IKv14</ci>
            <apply>
               <plus/>
               <ci>IKv14_K</ci>
               <ci>IKv14_Na</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ito1</ci>
            <apply>
               <plus/>
               <ci>IKv43</ci>
               <ci>IKv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.94</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.26</cn>
                           <ci>RT_over_F</ci>
                        </apply>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <ci>EK</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IK1</ci>
            <apply>
               <times/>
               <ci>GK1</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
                  </apply>
               </apply>
               <ci>K1_inf</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>INab</ci>
            <apply>
               <times/>
               <ci>GNab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>ENa</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_INaK_INaCa_ICab_IpCa">
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="ECa" public_interface="in" units="mV"/>
      <variable name="RT_over_F" public_interface="in" units="mV"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="Cao" public_interface="in" units="mM"/>
      <variable initial_value="0.44" name="kNaCa" units="uA_per_uF"/>
      <variable initial_value="87.5" name="KmNa" units="mM"/>
      <variable initial_value="1.38" name="KmCa" units="mM"/>
      <variable initial_value="0.2" name="ksat" units="dimensionless"/>
      <variable initial_value="0.35" name="eta" units="dimensionless"/>
      <variable initial_value="2.387" name="INaKmax" units="uA_per_uF"/>
      <variable initial_value="20" name="KmNai" units="mM"/>
      <variable initial_value="1.5" name="KmKo" units="mM"/>
      <variable initial_value="0.05" name="IpCamax" units="uA_per_uF"/>
      <variable initial_value="0.0005" name="KmpCa" units="mM"/>
      <variable initial_value="7.684e-5" name="GCab" units="mS_per_uF"/>
      <variable name="VF_over_RT" units="dimensionless"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="a1_Na" units="dimensionless"/>
      <variable name="a2_Na" units="dimensionless"/>
      <variable name="fNaK" units="dimensionless"/>
      <variable name="a1_K" units="dimensionless"/>
      <variable name="a2_K" units="dimensionless"/>
      <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaK" name="INaK" public_interface="out" units="uA_per_uF"/>
      <variable name="a1_ncx" units="mM4"/>
      <variable name="a2_ncx" units="mM4"/>
      <variable name="a3_ncx" units="dimensionless"/>
      <variable name="a4_ncx" units="mM"/>
      <variable name="a5_ncx" units="mM3"/>
      <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaCa" name="INaCa" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_ICab" name="ICab" public_interface="out" units="uA_per_uF"/>
      <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_IpCa" name="IpCa" public_interface="out" units="uA_per_uF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>ICab</ci>
            <apply>
               <times/>
               <ci>GCab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>ECa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IpCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>IpCamax</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>KmpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>VF_over_RT</ci>
            <apply>
               <divide/>
               <ci>V</ci>
               <ci>RT_over_F</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Na</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                        </apply>
                        <ci>VF_over_RT</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Na</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
               <ci>sigma</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.33</cn>
                     </apply>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>fNaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>a1_Na</ci>
                  <ci>a2_Na</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_K</ci>
            <apply>
               <divide/>
               <ci>Ko</ci>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>KmKo</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_K</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>KmNai</ci>
                     <ci>Nai</ci>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>INaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>INaKmax</ci>
                  <ci>fNaK</ci>
                  <ci>a1_K</ci>
               </apply>
               <ci>a2_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_ncx</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>eta</ci>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Nai</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Cao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_ncx</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>eta</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Nao</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Cai</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a3_ncx</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <times/>
                  <ci>ksat</ci>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>eta</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                        <ci>VF_over_RT</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a4_ncx</ci>
            <apply>
               <plus/>
               <ci>KmCa</ci>
               <ci>Cao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a5_ncx</ci>
            <apply>
               <divide/>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>KmNa</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Nao</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5000</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>INaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>kNaCa</ci>
                  <apply>
                     <minus/>
                     <ci>a1_ncx</ci>
                     <ci>a2_ncx</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>a4_ncx</ci>
                  <ci>a3_ncx</ci>
                  <ci>a5_ncx</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_ICa_ICaK">
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <variable name="RT_over_F" public_interface="in" units="mV"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="Cao" public_interface="in" units="mM"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="yCa" public_interface="in" units="dimensionless"/>
      <variable name="Open" public_interface="in" units="dimensionless"/>
      <variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="PKprime" units="litre_per_farad_second"/>
      <variable name="VF_over_RT" units="dimensionless"/>
      <variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
      <variable name="a1_Ca" units="mM"/>
      <variable name="a2_Ca" units="dimensionless"/>
      <variable name="a1_K" units="mM"/>
      <variable name="a2_K" units="dimensionless"/>
      <variable name="ICa" public_interface="out" units="uA_per_uF"/>
      <variable name="ICaK" public_interface="out" units="uA_per_uF"/>
      <variable name="ICamax" units="uA_per_uF"/>
      <variable name="Icabar" units="uA_per_uF"/>
      <variable name="PCa" units="litre_per_farad_second"/>
      <variable name="PK" units="litre_per_farad_second"/>
      <variable initial_value="-0.265" name="ICahalf" units="uA_per_uF"/>
      <variable initial_value="7" name="Pscale" units="dimensionless"/>
      <variable name="iso" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>PK</ci>
            <apply>
               <times/>
               <ci>Pscale</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second">4.574<sep/>-7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>PCa</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <ci>Pscale</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second">2.469<sep/>-4</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>iso</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                     <ci>Pscale</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_second">2.469<sep/>-4</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>VF_over_RT</ci>
            <apply>
               <divide/>
               <ci>V</ci>
               <ci>RT_over_F</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>VFsq_over_RT</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1000</cn>
               <ci>Faraday</ci>
               <ci>VF_over_RT</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Ca</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">1<sep/>-3</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>VF_over_RT</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Cao</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Ca</ci>
            <apply>
               <minus/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ICamax</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>PCa</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_Ca</ci>
               </apply>
               <ci>a2_Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ICa</ci>
            <apply>
               <times/>
               <ci>ICamax</ci>
               <ci>yCa</ci>
               <ci>Open</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Icabar</ci>
            <piecewise>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn>
                  <apply>
                     <geq/>
                     <ci>ICamax</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uA_per_uF">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <ci>ICamax</ci>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>PKprime</ci>
            <apply>
               <divide/>
               <ci>PK</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Icabar</ci>
                     <ci>ICahalf</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_K</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Ki</ci>
                  <apply>
                     <exp/>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <ci>Ko</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_K</ci>
            <apply>
               <minus/>
               <apply>
                  <exp/>
                  <ci>VF_over_RT</ci>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ICaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>PKprime</ci>
                  <ci>Open</ci>
                  <ci>yCa</ci>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_K</ci>
               </apply>
               <ci>a2_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="INa">
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="Temp_Scale" units="dimensionless"/>
      <variable name="alpha1" units="per_ms"/>
      <variable name="beta1" units="per_ms"/>
      <variable name="gamma1" units="per_ms"/>
      <variable name="Delta1" units="per_ms"/>
      <variable name="On" units="per_ms"/>
      <variable name="Of" units="per_ms"/>
      <variable name="GammaGamma" units="per_ms"/>
      <variable name="DeltaDelta" units="per_ms"/>
      <variable name="epsilon" units="per_ms"/>
      <variable name="omega_na" units="per_ms"/>
      <variable name="rho" units="per_ms"/>
      <variable name="mu" units="per_ms"/>
      <variable name="Cn" units="per_ms"/>
      <variable name="Cf" units="per_ms"/>
      <variable name="parameter_a" units="dimensionless"/>
      <variable name="k12" units="per_ms"/>
      <variable name="k23" units="per_ms"/>
      <variable name="k34" units="per_ms"/>
      <variable name="k45" units="per_ms"/>
      <variable name="k56" units="per_ms"/>
      <variable name="k67" units="per_ms"/>
      <variable name="k89" units="per_ms"/>
      <variable name="k910" units="per_ms"/>
      <variable name="k1011" units="per_ms"/>
      <variable name="k1112" units="per_ms"/>
      <variable name="k1213" units="per_ms"/>
      <variable name="k57" units="per_ms"/>
      <variable name="k21" units="per_ms"/>
      <variable name="k32" units="per_ms"/>
      <variable name="k43" units="per_ms"/>
      <variable name="k54" units="per_ms"/>
      <variable name="k65" units="per_ms"/>
      <variable name="k76" units="per_ms"/>
      <variable name="k98" units="per_ms"/>
      <variable name="k109" units="per_ms"/>
      <variable name="k1110" units="per_ms"/>
      <variable name="k1211" units="per_ms"/>
      <variable name="k1312" units="per_ms"/>
      <variable name="k75" units="per_ms"/>
      <variable name="k81" units="per_ms"/>
      <variable name="k92" units="per_ms"/>
      <variable name="k103" units="per_ms"/>
      <variable name="k114" units="per_ms"/>
      <variable name="k125" units="per_ms"/>
      <variable name="k136" units="per_ms"/>
      <variable name="k18" units="per_ms"/>
      <variable name="k29" units="per_ms"/>
      <variable name="k310" units="per_ms"/>
      <variable name="k411" units="per_ms"/>
      <variable name="k512" units="per_ms"/>
      <variable name="k613" units="per_ms"/>
      <variable initial_value="0.111284526171411" name="na1" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.0481019786429977" name="na2" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.00779692701457915" name="na3" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.000561699600929369" name="na4" public_interface="out" units="dimensionless"/>
      <variable initial_value="1.51746424723121e-5" name="na5" public_interface="out" units="dimensionless"/>
      <variable initial_value="1.02118700961583e-7" name="na6" public_interface="out" units="dimensionless"/>
      <variable initial_value="1.93499158844817e-8" name="na7" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.368582741846592" name="na8" public_interface="out" units="dimensionless"/>
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      <variable initial_value="0.000750073829883749" name="na12" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.0370604970714329" name="na13" public_interface="out" units="dimensionless"/>
      <variable initial_value="294.16" name="TNa" units="kelvin"/>
      <variable name="KToverH" units="per_ms"/>
      <variable name="FoverRT" units="per_mV"/>
      <variable name="RToverF" public_interface="in" units="mV"/>
      <variable name="RTNa" units="joule_per_mole"/>
      <variable name="RTNaF" units="mV"/>
      <variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
      <variable name="Rgas" public_interface="in" units="joule_per_mole_kelvin"/>
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         <apply>
            <eq/>
            <ci>FoverRT</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>RToverF</ci>
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            <eq/>
            <ci>KToverH</ci>
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               <divide/>
               <apply>
                  <times/>
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            <eq/>
            <ci>RTNaF</ci>
            <apply>
               <divide/>
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                  <times/>
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                  <ci>TNa</ci>
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               <ci>Faraday</ci>
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            <eq/>
            <ci>Temp_Scale</ci>
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         <apply>
            <eq/>
            <ci>alpha1</ci>
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                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">114007.462700232</cn>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">224.114</cn>
                        <ci>Rgas</ci>
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                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.286374268596235</cn>
                           <ci>V</ci>
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                        <ci>RTNaF</ci>
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                  </apply>
               </apply>
            </apply>
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         <apply>
            <eq/>
            <ci>beta1</ci>
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               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
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                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">272470.273489681</cn>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">708.146</cn>
                        <ci>Rgas</ci>
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                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.28528417586424</cn>
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                           <ci>V</ci>
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                  </apply>
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         <apply>
            <eq/>
            <ci>gamma1</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
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                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">196336.575735923</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">529.952</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.78084918596045</cn>
                           <ci>V</ci>
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                        <ci>RTNaF</ci>
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                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Delta1</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">133689.9304091</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">229.205</cn>
                        <ci>Rgas</ci>
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                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.55804214553883</cn>
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                           <ci>V</ci>
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                        <ci>RTNaF</ci>
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                  </apply>
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         <apply>
            <eq/>
            <ci>On</ci>
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               <ci>Temp_Scale</ci>
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                  <exp/>
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                     <plus/>
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                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">62123.0784380481</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">39.295</cn>
                        <ci>Rgas</ci>
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                        <divide/>
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                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.288816042743232</cn>
                           <ci>V</ci>
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            <ci>Of</ci>
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               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
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                  <exp/>
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                     <plus/>
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                        <divide/>
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                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">97657.8497137015</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">1.51</cn>
                        <ci>Rgas</ci>
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                        <divide/>
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                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0684861993100685</cn>
                           <ci>V</ci>
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                        <ci>RTNaF</ci>
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         <apply>
            <eq/>
            <ci>GammaGamma</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">116431.142142348</cn>
                        <ci>RTNa</ci>
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                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">578.317</cn>
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                        <ci>Rgas</ci>
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                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.764126011745707</cn>
                           <ci>V</ci>
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                        <ci>RTNaF</ci>
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         <apply>
            <eq/>
            <ci>DeltaDelta</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
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                        <divide/>
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                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">55700.6624658307</cn>
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                        <ci>RTNa</ci>
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                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">130.639</cn>
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                        <ci>Rgas</ci>
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                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.64981672927078</cn>
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         <apply>
            <eq/>
            <ci>epsilon</ci>
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               <ci>Temp_Scale</ci>
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               <apply>
                  <exp/>
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                     <plus/>
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                        <divide/>
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                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">85800.3675578326</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">70.078</cn>
                        <ci>Rgas</ci>
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         <apply>
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            <ci>omega_na</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
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                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">121955.166154864</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">225.175</cn>
                        <ci>Rgas</ci>
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                  </apply>
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         <apply>
            <eq/>
            <ci>rho</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">147813.990005035</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">338.915</cn>
                        <ci>Rgas</ci>
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                     <apply>
                        <divide/>
                        <apply>
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                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.1360043702126</cn>
                           <ci>V</ci>
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                        <ci>RTNaF</ci>
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         <apply>
            <eq/>
            <ci>mu</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">121322.143275242</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">193.265</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.74290267020903</cn>
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                           <ci>V</ci>
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         <apply>
            <eq/>
            <ci>Cn</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
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                  <apply>
                     <plus/>
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                        <divide/>
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                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">287913.446530953</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">786.217</cn>
                        <ci>Rgas</ci>
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         <apply>
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            <ci>Cf</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
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                  <exp/>
                  <apply>
                     <plus/>
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                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole">59565.2236284584</cn>
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                        <ci>RTNa</ci>
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                        <divide/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="joule_per_mole_kelvin">0.00711</cn>
                        <ci>Rgas</ci>
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            <ci>parameter_a</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.40042625477401</cn>
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            <ci>k12</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               <ci>alpha1</ci>
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            <ci>k23</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               <ci>alpha1</ci>
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            <ci>k34</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               <ci>alpha1</ci>
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            <eq/>
            <ci>k45</ci>
            <ci>alpha1</ci>
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            <ci>k56</ci>
            <ci>gamma1</ci>
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            <eq/>
            <ci>k67</ci>
            <ci>epsilon</ci>
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            <ci>k89</ci>
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               <ci>k12</ci>
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            <ci>k910</ci>
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               <ci>k23</ci>
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            <ci>k1011</ci>
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               <ci>k34</ci>
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            <ci>k1112</ci>
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               <ci>k45</ci>
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         <apply>
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            <ci>k1213</ci>
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            <eq/>
            <ci>k57</ci>
            <ci>rho</ci>
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            <ci>k21</ci>
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            <ci>k32</ci>
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               <ci>beta1</ci>
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            <ci>k43</ci>
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               <ci>beta1</ci>
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               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
               <ci>beta1</ci>
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            <ci>k1110</ci>
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            <ci>k1211</ci>
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            </apply>
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            <apply>
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               <apply>
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               </apply>
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            </apply>
         </apply>
         <apply>
            <eq/>
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            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>IH_to_C3H</ci>
                  <ci>IH_to_OH</ci>
               </apply>
               <ci>IHerg</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
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               <diff/>
               <bvar>
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               <ci>IHerg</ci>
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            <apply>
               <minus/>
               <ci>a1_I</ci>
               <ci>a2_I</ci>
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         </apply>
      </math>
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      <variable name="C0ks_C1ks" units="per_ms"/>
      <variable name="C1ks_O1ks" units="per_ms"/>
      <variable name="O1ks_O2ks" units="per_ms"/>
      <variable name="O1ks_C1ks" units="per_ms"/>
      <variable name="O2ks_O1ks" units="per_ms"/>
      <variable name="C1ks_C0ks" units="per_ms"/>
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      <variable initial_value="0.0360525668093578" name="C1ks" public_interface="out" units="dimensionless"/>
      <variable initial_value="5.65460174551007e-7" name="O1ks" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.0258818770122187" name="O2ks" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
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            <eq/>
            <ci>C0ks_C1ks</ci>
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            <eq/>
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               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00767254363063</cn>
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                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.08662945914655</cn>
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         <apply>
            <eq/>
            <ci>O1ks_C1ks</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00700806628929</cn>
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                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.14999754700285</cn>
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                     <ci>V</ci>
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               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>O2ks_O1ks</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.00379737998368</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.01425668126881</cn>
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                     <ci>V</ci>
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            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1ks_C0ks</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.2162557589585</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.00001889123021</cn>
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                     <ci>V</ci>
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         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C0ks</ci>
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            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>C0ks_C1ks</ci>
                  </apply>
                  <ci>C0ks</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1ks_C0ks</ci>
                  <ci>C1ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1ks</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>C0ks_C1ks</ci>
                     <ci>C0ks</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <plus/>
                        <ci>C1ks_C0ks</ci>
                        <ci>C1ks_O1ks</ci>
                     </apply>
                     <ci>C1ks</ci>
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               </apply>
               <apply>
                  <times/>
                  <ci>O1ks_C1ks</ci>
                  <ci>O1ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O1ks</ci>
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            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>C1ks_O1ks</ci>
                     <ci>C1ks</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <plus/>
                        <ci>O1ks_C1ks</ci>
                        <ci>O1ks_O2ks</ci>
                     </apply>
                     <ci>O1ks</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>O2ks_O1ks</ci>
                  <ci>O2ks</ci>
               </apply>
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         </apply>
         <apply>
            <eq/>
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               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O2ks</ci>
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            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>O1ks_O2ks</ci>
                  <ci>O1ks</ci>
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               <apply>
                  <times/>
                  <ci>O2ks_O1ks</ci>
                  <ci>O2ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
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   <connection>
      <map_components component_1="environment" component_2="IKs"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES"/>
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   <connection>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
      <map_variables variable_1="time" variable_2="time"/>
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      <map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
      <map_variables variable_1="time" variable_2="time"/>
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      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="CSQN2" variable_2="CSQN2"/>
      <map_variables variable_1="RyR2" variable_2="RyR2"/>
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   <connection>
      <map_components component_1="environment" component_2="I_stimulus"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_ICa_ICaK"/>
      <map_variables variable_1="iso" variable_2="iso"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES"/>
      <map_variables variable_1="iso" variable_2="iso"/>
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      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKs"/>
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   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKr"/>
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   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="INa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="RT_over_F" variable_2="RToverF"/>
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   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
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      <map_variables variable_1="INaK" variable_2="INaK"/>
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      <map_variables variable_1="INab" variable_2="INab"/>
      <map_variables variable_1="IKr" variable_2="IKr"/>
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      <map_variables variable_1="IKs" variable_2="IKs"/>
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   <connection>
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      <map_variables variable_1="beta_SS" variable_2="beta_SS"/>
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      <map_variables variable_1="CaJSR" variable_2="CaJSR"/>
      <map_variables variable_1="CaSS" variable_2="CaSS"/>
      <map_variables variable_1="Jxfer" variable_2="Jxfer"/>
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   <connection>
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   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="I_stimulus"/>
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   <connection>
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      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
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   <connection>
      <map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="INa"/>
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   <connection>
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   <connection>
      <map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="COMPUTE_REVERSAL_POTENTIALS"/>
      <map_variables variable_1="ENa" variable_2="ENa"/>
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   <connection>
      <map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="IKr"/>
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   <connection>
      <map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="IKs"/>
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   <connection>
      <map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
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   <connection>
      <map_components component_1="COMPUTE_ICa_ICaK" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES"/>
      <map_variables variable_1="yCa" variable_2="yCa"/>
      <map_variables variable_1="Open" variable_2="Open"/>
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