Model Mathematics

Component: environment

Component: parameters

Component: membrane

ddtimeV=-i_Na+i_K+i_leak-i_appCm

Component: stimulus_protocol

i_app=IstimAmplitudeiftimeIstimStarttimeIstimEndtime-IstimStart-time-IstimStartIstimPeriodIstimPeriodIstimPulseDuration0otherwise

Component: sodium_current

i_Na=120x_infinity31-nV-120 x_infinity=alpha_xalpha_x+beta_x alpha_x=0.2V+401-1-V+4010 beta_x=81-V+6518

Component: potassium_current

i_K=36n4V+771

Component: potassium_current_n_gate

ddtimen=alpha_n1-n-beta_nn alpha_n=0.02V+551--V+5510 beta_n=0.25-V+6580

Component: leak_current

i_leak=0.3V+54

Component: transmitter_release

ddtimeR=kr_plusCa1-R-kr_minusR T=T_barR

Component: calcium_concentration

Ca_open=sigma2Dcrπ sigma=-5.182i_V i_V=g_CaP2FVR_gas_constTempCa_ex1-2FVR_gas_constTemp Ca=OCa_open+0.1

Component: rate_constants

alpha=0.45V22 alpha_=alpha8 beta=0.015-V14 beta_=beta8 ddtimea=ka_plusT1-a-ka_minusa kG_plus=3a680+320a

Component: C1

ddtimeC1=betaC2+kG_minusC_G1-C14alpha+kG_plus

Component: C2

ddtimeC2=4alphaC1+2betaC3+kG2_minusC_G2-C2beta+3alpha+kG_plus

Component: C3

ddtimeC3=3alphaC2+3betaC4+kG3_minusC_G3-C32beta+2alpha+kG_plus

Component: C4

ddtimeC4=2alphaC3+4betaO-C43beta+alpha

Component: O

O=1-C1-C2-C3-C4-C_G1-C_G2-C_G3 C_G=C_G1+C_G2+C_G3

Component: C_G1

ddtimeC_G1=beta_C_G2+kG_plusC1-C_G14alpha_+kG_minus

Component: C_G2

ddtimeC_G2=4alpha_C_G1+2beta_C_G3+kG_plusC2-C_G2beta_+3alpha_+kG2_minus

Component: C_G3

ddtimeC_G3=3alpha_C_G2+kG_plusC3-C_G32beta_+kG3_minus