<?xml version="1.0"?>
<!--
This CellML file was generated on 18/07/2008 at 11:24:29 at a.m. using:
COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:base="" cmeta:id="reidl_borowski_sensse_starke_zapotocky_eiswirth_2006" name="reidl_borowski_sensse_starke_zapotocky_eiswirth_2006">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model is known to run in both PCEnv and COR. It recreates the published results, and is currently set up for a dual pulse experiment, with duration of 100 milliseconds. The model is relatively stiff, so maximum step size and number of steps might have to be adjusted to obtain discernible changes.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Abstract: We present a mathematical model for calcium oscillations in the cilia of olfactory sensory neurons. The underlying mechanism is based on direct negative regulation of cyclic nucleotide-gated channels by calcium/calmodulin and does not require any autocatalysis such as calcium-induced calcium release. The model is in quantitative agreement with available experimental data, both with respect to oscillations and to fast adaptation. We give predictions for the ranges of parameters in which oscillations should be observable. Relevance of the model to calcium oscillations in other systems is discussed.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia, J. Reidl, P. Borowski, A. Sensse, J. Starke, M. Zapotocky, and M. Eiswirth, 2006, Biophysical Journal, 90, 1147-1155. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16326896&dopt=Abstract">PubMed ID: 16326896 </ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
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<title>model diagram</title>
</objectinfo>
<imagedata fileref="reidl_2006.png"/>
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<caption>Schematic diagram of the model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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