Model Mathematics

Component: Environment

FonRT=FTempR

Component: cell

vcell=1000πraral ageo=2πrara+2πral Acap=ageo2 vmyo=vcell0.68 vmito=vcell0.24 vsr=vcell0.06 vnsr=vcell0.0552 vjsr=vcell0.0048 vss=vcell0.02 AF=AcapF past=timestim_periodstim_period i_Stim=stim_amplitudeiftime-paststim_offsettime-paststim_offset+stim_duration0otherwise caiont=ilca+icab+ipca-2inaca+icat naiont=ina+inab+3inaca+ilcana+3inak kiont=ikr+iks+IK1+ikp+ilcak-2inak+i_Stim ddtimeV=-naiont+kiont+caiont

Component: INa

ina=GNammmHJV-ENa a=1-11+-V+400.024 aH=a0.13580+V-6.8 bH=1-a0.131+V+10.66-11.1+a3.560.079V+3.11e50.35V aj=a-1.2714e50.2444V-3.474e-5-0.04391V1V+37.781+0.311V+79.23 bj=1-a0.3-2.535e-7V1+-0.1V+32+a0.1212-0.01052V1+-0.1378V+40.14 am=0.321V+47.131--0.1V+47.13 bm=0.08-V11 ddtimeH=aH1-H-bHH ddtimem=am1-m-bmm ddtimeJ=aj1-J-bjJ

Component: ICaL

dss0=11+-V+106.24 taud=dss011--V+106.240.035V+10 dss1=11+-V+600.024 dss=dss0dss1 fss=11+V+328+0.61+50-V20 tauf=10.0197-0.0337V+102+0.02 ibarca=pca4VFFonRTgacaiCa_i2VFonRT-gacaoCa_o2VFonRT-1 ibarna=pnaVFFonRTganaiNa_iVFonRT-ganaoNa_oVFonRT-1 ibark=pkVFFonRTgakiK_iVFonRT-gakoK_oVFonRT-1 fca=11+Ca_ikmca ilca=dffcaibarca ilcana=dffcaibarna ilcak=dffcaibark ddtimed=dss-dtaud ddtimef=fss-ftauf

Component: IK1

GK1_=GK1maxK_o5.4 ak1=1.021+0.2385V-EK-59.215 bk1=0.491240.08032V-EK+5.476+10.06175V-EK-594.311+-0.5143V-EK+4.753 gK1=GK1_ak1ak1+bk1 IK1=gK1V-EK

Component: IKr

r=11+V+922.4 ikr=gkrmaxK_o5.4xrrV-EK xrss=11+-V+10.0854.25 tauxr=10.00138V+14.21--0.123V+14.2+0.00061V+38.90.145V+38.9-1 ddtimexr=xrss-xrtauxr

Component: IKs

gks=GKsmax1+0.61+3.8e-5Ca_i1.4 xss=11+-V-1.516.7 tauxs=10.0000719V+301--0.148V+30+0.000131V+300.0687V+30-1 iks=gksxs1xs2V-EKs ddtimexs1=xss-xs1tauxs ddtimexs2=xss-xs2tauxs4

Component: INaK

sigma=Na_o67.3-17 fnak=11+0.1245-0.1VFonRT+0.0365sigma-VFonRT inak=ibarnakfnak1+kmnaiNa_i21+kmkoK_o

Component: INaCa

inaca=c1gammas-1VFonRTVFonRTNa_i3Ca_o-Na_o3Ca_i1+c2gammas-1VFonRTVFonRTNa_i3Ca_o+Na_o3Ca_i

Component: IKp

ikp=GKpmaxV-EK1+7.488-V5.98

Component: IpCa

ipca=ibarpcaCa_ikmpca+Ca_i

Component: ICab

icab=gcabV-lnCa_oCa_i2FonRT

Component: INab

inab=GNabV-ENa

Component: ICaT

icat=gcatbbgV-ECa bss=11+-V+1410.8 taub=3.7+6.11+V+254.5 gss=11+V+605.6 aa=1-11+-V0.0024 taug=aa1-0.875V+12+121-aa ddtimeb=bss-btaub ddtimeg=gss-gtaug

Component: reversal_potentials

ENa=lnNa_oNa_iFonRT ECa=lnCa_oCa_i2FonRT EK=lnK_oK_iFonRT EKs=lnK_o+prnakNa_oK_i+prnakNa_iFonRT

Component: Irel

alpha_Rel=taukappa bbb=csqnbar+kmcsqn-Ca_JSR_T c=Ca_JSR_Tkmcsqn Ca_JSR_free=-bbb2+bbb2+4c2 Rel_ss=ilcaalpha_Rel1+K_RelssCa_JSR_freeqn tau_Rel=tau1+0.0123Ca_JSR_free ddtimeRel=-Rel_ss+Reltau_Rel

Component: Iup_Ileak

iup=iupbarCa_iCa_i+kmup ileak=iupbarCa_NSRnsrbar

Component: Itr

itr=Ca_NSR-Ca_JSR_freetautr

Component: Na

ddtimeNa_i=-naiontAFvmyo

Component: K

ddtimeK_i=-kiontAFvmyo

Component: Ca

bmyo=cmdnbar+trpnbar-Ca_T+kmtrpn+kmcmdn cmyo=kmcmdnkmtrpn-Ca_Tkmtrpn+kmcmdn+trpnbarkmcmdn+cmdnbarkmtrpn dmyo=-kmtrpnkmcmdnCa_T Ca_i=2bmyobmyo-3cmyo3cosarccos9bmyocmyo-2bmyobmyobmyo-27dmyo2bmyobmyo-3cmyo1.53-bmyo3 ddtimeOver=0 ddtimeCa_T=-caiontAFvmyo2+ileak-iupvnsrvmyo+Relvjsrvmyo ddtimeCa_NSR=iup-itrvjsrvnsr-ileak ddtimeCa_JSR_T=itr-Rel

Component: intracellular_currents

Component: transmembrane_currents

Component: Ions_n_reversal_potentials