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Raposo, Sobrinho, Ferreira, 2002
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A minimal mathematical model of calcium homeostasis
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Model Mathematics
Component based math viewer is available
Component: environment
Component: Q_Ca_p
d
d
time
Q_Ca_p
=
J_bp_Ca
+
J_ip_Ca
-
J_pb_Ca
+
J_pu_Ca
Component: Q_P_p
d
d
time
Q_P_p
=
J_bp_P
+
J_ip_P
+
J_cp_P
-
J_pb_P
+
J_pu_P
+
J_pc_P
Component: Q_P_c
d
d
time
Q_P_c
=
J_pc_P
-
J_cp_P
Component: Q_PTH_p
d
d
time
Q_PTH_p
=
S_PTH
-
k_PTH
1.0
C_PTH_p
Component: Q_Ca_b
d
d
time
Q_Ca_b
=
J_pb_Ca
-
J_bp_Ca
Component: Q_P_b
d
d
time
Q_P_b
=
J_pb_P
-
J_bp_P
Component: Q_E_k
d
d
time
Q_E_k
=
S_E
-
k_E
Q_E_k
Component: Q_D_p
d
d
time
Q_D_p
=
1.0
Q_E_k
-
k_D
Q_D_p
Component: Q_TCa_i
d
d
time
Q_TCa_i
=
1.0
-
Q_TCa_i
k1_D
-
Q_TCa_i
k2_D
Component: Q_C_PT
d
d
time
Q_C_PT
=
1.0
-
Q_C_PT
k3_D
-
Q_C_PT
k4_D
Component: Q_TP_k
d
d
time
Q_TP_k
=
1.0
-
Q_TP_k
k1_P
-
Q_TP_k
k2_P
Component: model_fluxes
J_pb_Ca
=
k_Ca_b
Q_Ca_b
J_bp_P
=
Stoic_Ca_P
J_bp_Ca
J_pb_P
=
Stoic_Ca_P
J_pb_Ca
J_ip_Ca
=
Y_Ca_i_2plus
1.0
-
Q_TCa_i
1.0
k1_D
+
k_Ca_i
1.0
C_Ca_i
-
C_Ca_p
-
Q_TCa_i
k2_D
J_ip_P
=
J_P_ing
S_PTH
=
1.0
Y_Ca_p_1minus
k3_D
1.0
-
Q_C_PT
-
k4_D
Q_C_PT
J_pc_P
=
k4_P
1.0
C_P_p
J_cp_P
=
k3_P
Q_P_c
Component: model_parameters
Ca_thr
=
1.95
+
Y_PTH_p_2plus
Ca_T
=
Ca_thr
C_Ca_p
P_thr
=
Y_PTH_p_2minus
Q_TP_k
P_T
=
P_thr
C_P_p
k1_D
=
Y_i_D_p_1plus
k2_D
=
Y_i_D_p_1minus
k3_D
=
Y_PT_D_p_1plus
k4_D
=
Y_PT_D_p_1minus
k1_P
=
Y_k_Jext_1plus
Y_i_D_p_1plus
=
Y_i_D_p_1plus_minus_Max
a
1.0
+
tanh
b_i_D
C_D_p
-
X_R_i_D
+
d
Y_PT_D_p_1plus
=
Y_PT_D_p_1plus_minus_Max
a
1.0
+
tanh
b_PTH_D
C_D_p
-
X_R_PTH_D
+
d
Y_k_Jext_1plus
=
Y_k_Jext_1plus_minus_Max
a
1.0
+
tanh
b_E_PTH
1.0
C_P_p
-
X_R_E_PTH
+
d
Y_Ca_p_1minus
=
Y_Ca_p_1plus_minus_Max
a
1.0
-
tanh
b_PTH_Ca
C_Ca_p
-
X_R_PTH_Ca
+
d
Y_i_D_p_1minus
=
Y_i_D_p_1plus_minus_Max
a
1.0
-
tanh
b_i_D
C_D_p
-
X_R_i_D
+
d
Y_PT_D_p_1minus
=
Y_PT_D_p_1plus_minus_Max
a
1.0
-
tanh
b_PTH_D
C_D_p
-
X_R_PTH_D
+
d
Y_Ca_i_2plus
=
Y_Ca_i_2plus_Max
C_Ca_i
C_Ca_i
+
X_R_i_Ca
Y_PTH_p_2plus
=
Y_PTH_p_2plus_Max
C_PTH_p
C_PTH_p
+
1.0
X_R_P_k_PTH
Y_PTH_p_2minus
=
Y_PTH_p_2minus_Max
X_R_P_k_PTH
1.0
C_PTH_p
+
X_R_P_k_PTH
Source
Derived from workspace
Raposo, Sobrinho and Ferreira, 2002
at changeset
3dcc0383f024
.
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A minimal mathematical model of calcium homeostasis