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Fallon, Lauffenburger, 2000
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Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response
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Model Mathematics
Component based math viewer is available
Component: environment
Component: Rs
d
d
time
Rs
=
kr
+
ksyn
Cs
+
Vs
-
kf
L
Rs
+
kt
Rs
Component: Cs
d
d
time
Cs
=
kf
L
Rs
-
kr
+
ke
Cs
Component: Ri
d
d
time
Ri
=
kre
Ci
+
kt
Rs
-
kfe
Li
Ri
+
kh
Ri
Component: Ci
d
d
time
Ci
=
kfe
Li
Ri
+
ke
Cs
-
kre
+
kh
Ci
Component: Li
d
d
time
Li
=
kre
Ci
-
kfe
Li
Ri
Ve
NA
-
kx
Li
Component: Ld
d
d
time
Ld
=
kh
Ci
Component: L
d
d
time
L
=
kr
Cs
+
kx
Li
Ve
NA
-
kf
L
Rs
Y
NA
Component: Y
d
d
time
Y
=
600
Cs
250
+
Cs
-
200
1
e
3
if
600
Cs
250
+
Cs
-
200
>
0
0
otherwise
Component: model_parameters
kf
=
kr
11.1
if
IL2
=
1
kr
8.2
otherwise
kre
=
kr
8
if
IL2
=
1
kr
5
otherwise
kfe
=
kre
1000
if
IL2
=
1
kre
3000
otherwise
Source
Derived from workspace
Fallon, Lauffenburger, 2000
at changeset
ea0210d2ea87
.
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License
This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response