Model Mathematics

Component: environment

Component: total_cytoplasmic_Ca_flux

J_ICa = I_Ca 2.0 F v_i k_i

Component: Ca_extrusion_across_the_plasma_membrane

J_pm = J_extru + J_ICa J_extru = k_leak Ca_i - Ca_o + Vmax_extru 1.0 + EC50_extru Ca_i n_extru

Component: Ca_uptake_by_SR_Ca_ATPase

J_SERCA = Vmax_SERCA 1.0 + EC50_SERCA Ca_i n_SERCA

Component: ER_Ca_release

J_release = P_ER Ca_i - Ca_ER J_ER = J_SERCA + J_release P_ER = P_basal + Pmax_RyR 1.0 + EC50_RyR Ca_i n_RyR

Component: cytoplasmic_calcium

dd time Ca_i =- J_i J_i = J_pm + J_ER

Component: intraluminal_calcium

dd time Ca_ER = J_ER gamma_ER gamma_ER = v_ER k_ER v_i k_i