Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors

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Description: The kinetics of 18 amino acids, ammonia (NH3) and urea (UREA) in 18 liver cell bioreactor runs were analyzed and simulated by a two-compartment model consisting of a system of 42 differential equations. The model parameters, most of them representing enzymatic activities, were identified and their values discussed with respect to the different liver cell bioreactor performance levels. The nitrogen balance based model was used as a tool to quantify the variability of runs and to describe different kinetic patterns of the amino acid metabolism, in particular with respect to glutamate (GLU) and aspartate (ASP). This is the amended version of guthke_2006 based on a follow up paper.
Owner: Hanne Nielsen <hnie010@aucklanduni.ac.nz>
URI for git clone/pull/push: https://models.cellml.org/w/hnielsen/guthke_amended_2006

Filename	Size	Date	Options
guthke_2006.ai	1056229	2011-08-23	[browse]
guthke_2006.png	23190	2011-08-23	[browse]
guthke_2006.svg	18880	2011-08-23	[browse]
guthke_2006.xul	26511	2011-08-23	[browse]
guthke_amended_2006.html	1778	2011-08-23	[browse]
guthke_amendment_2006.cellml	187207	2011-08-23	[browse]
guthke_amendment_2006.session.xml	17662	2011-08-23	[browse] [run]