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Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors

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The kinetics of 18 amino acids, ammonia (NH3) and urea (UREA) in 18 liver cell bioreactor runs were analyzed and simulated by a two-compartment model consisting of a system of 42 differential equations. The model parameters, most of them representing enzymatic activities, were identified and their values discussed with respect to the different liver cell bioreactor performance levels. The nitrogen balance based model was used as a tool to quantify the variability of runs and to describe different kinetic patterns of the amino acid metabolism, in particular with respect to glutamate (GLU) and aspartate (ASP). This is the amended version of guthke_2006 based on a follow up paper.
Hanne Nielsen <>
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Filename Size Date Options 1056229 2011-08-23 [browse]
guthke_2006.png 23190 2011-08-23 [browse]
guthke_2006.svg 18880 2011-08-23 [browse]
guthke_2006.xul 26511 2011-08-23 [browse]
guthke_amended_2006.html 1778 2011-08-23 [browse]
guthke_amendment_2006.cellml 187207 2011-08-23 [browse]
guthke_amendment_2006.session.xml 17662 2011-08-23 [browse] [run]