- Info
Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors
-
Latest Exposure
If you are a new user to the repository, you may wish to view the
exposure for this workspace. An exposure will show the summarized
information for the content contained here.
Workspace Summary
- Description
- The kinetics of 18 amino acids, ammonia (NH3) and urea (UREA) in 18 liver cell bioreactor runs were analyzed and simulated by a two-compartment model consisting of a system of 42 differential equations. The model parameters, most of them representing enzymatic activities, were identified and their values discussed with respect to the different liver cell bioreactor performance levels. The nitrogen balance based model was used as a tool to quantify the variability of runs and to describe different kinetic patterns of the amino acid metabolism, in particular with respect to glutamate (GLU) and aspartate (ASP). This is the amended version of guthke_2006 based on a follow up paper.
- Owner
- Hanne Nielsen <hnie010@aucklanduni.ac.nz>
- URI for git clone/pull/push
- https://models.cellml.org/w/hnielsen/guthke_amended_2006
Files