- Author:
- Tommy Yu <tommy.yu@auckland.ac.nz>
- Date:
- 2015-02-12 19:28:32+13:00
- Desc:
- Merging to remove the extra head
- Since the title is changed and in the interest of maintaining the
current structure we keep it as is.
- Permanent Source URI:
- https://models.cellml.org/w/matthiaskoenig/MetabolicComponentLibrary/rawfile/e0e2c28e2dfdfe37ea2cae3390a6ae26c28a3393/examples/Koenig2012_Hepatic_Glucose.cellml
<?xml version="1.0"?>
<!--
This CellML file was generated on 3/20/2013 at 2:02:41 at AM using:
COR (0.9.31.1409)
Copyright 2002-2013 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
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<ci>gamma</ci>
</apply>
<ci>v_native</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>v_phospho</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v9_GP">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_glyglc" public_interface="in" units="dimensionless"/>
<variable name="gamma" public_interface="in" units="dimensionless"/>
<variable name="glyglc" public_interface="in" units="mM"/>
<variable name="glc" public_interface="in" units="mM"/>
<variable name="amp" public_interface="in" units="mM"/>
<variable name="p" public_interface="in" units="mM"/>
<variable name="glc1p" public_interface="in" units="mM"/>
<variable name="keq" units="per_mM"/>
<variable name="k_glyc_native" units="mM"/>
<variable name="k_glyc_phospho" units="mM"/>
<variable name="k_glc1p_native" units="mM"/>
<variable name="k_glc1p_phospho" units="mM"/>
<variable name="k_p_native" units="mM"/>
<variable name="k_p_phospho" units="mM"/>
<variable name="ki_glc_phospho" units="mM"/>
<variable name="ka_amp_native" units="mM"/>
<variable name="base_amp_native" units="dimensionless"/>
<variable name="max_amp_native" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<variable name="C" units="mM"/>
<variable name="k1_max" units="dimensionless"/>
<variable name="fmax" units="dimensionless"/>
<variable name="vmax_native" units="mM_per_second"/>
<variable name="v_native" units="mM_per_second"/>
<variable name="vmax_phospho" units="mM_per_second"/>
<variable name="v_phospho" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mM">0.211826505793075</cn>
</apply>
<apply>
<eq/>
<ci>k_glyc_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">4.8</cn>
</apply>
<apply>
<eq/>
<ci>k_glyc_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">2.7</cn>
</apply>
<apply>
<eq/>
<ci>k_glc1p_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">120</cn>
</apply>
<apply>
<eq/>
<ci>k_glc1p_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">2</cn>
</apply>
<apply>
<eq/>
<ci>k_p_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">300</cn>
</apply>
<apply>
<eq/>
<ci>k_p_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">5</cn>
</apply>
<apply>
<eq/>
<ci>ki_glc_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">5</cn>
</apply>
<apply>
<eq/>
<ci>ka_amp_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<apply>
<eq/>
<ci>base_amp_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.03</cn>
</apply>
<apply>
<eq/>
<ci>max_amp_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.3</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">6.8</cn>
</apply>
<apply>
<eq/>
<ci>C</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">500</cn>
</apply>
<apply>
<eq/>
<ci>k1_max</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
</apply>
<apply>
<eq/>
<ci>fmax</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>k1_max</ci>
</apply>
<ci>glyglc</ci>
</apply>
<apply>
<plus/>
<ci>glyglc</ci>
<apply>
<times/>
<ci>k1_max</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vmax_native</ci>
<apply>
<times/>
<ci>scale_glyglc</ci>
<ci>Vmax</ci>
<ci>fmax</ci>
<apply>
<plus/>
<ci>base_amp_native</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>max_amp_native</ci>
<ci>base_amp_native</ci>
</apply>
<ci>amp</ci>
</apply>
<apply>
<plus/>
<ci>amp</ci>
<ci>ka_amp_native</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_native</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>vmax_native</ci>
<apply>
<times/>
<ci>k_glyc_native</ci>
<ci>k_p_native</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>glyglc</ci>
<ci>p</ci>
</apply>
<apply>
<divide/>
<ci>glc1p</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>glyglc</ci>
<ci>k_glyc_native</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>p</ci>
<ci>k_p_native</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>glc1p</ci>
<ci>k_glc1p_native</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>vmax_phospho</ci>
<apply>
<times/>
<ci>scale_glyglc</ci>
<ci>Vmax</ci>
<ci>fmax</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<log/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>ki_glc_phospho</ci>
</apply>
<ci>glc</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_phospho</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>vmax_phospho</ci>
<apply>
<times/>
<ci>k_glyc_phospho</ci>
<ci>k_p_phospho</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>glyglc</ci>
<ci>p</ci>
</apply>
<apply>
<divide/>
<ci>glc1p</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>glyglc</ci>
<ci>k_glyc_phospho</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>p</ci>
<ci>k_p_phospho</ci>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>glc1p</ci>
<ci>k_glc1p_phospho</ci>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>gamma</ci>
</apply>
<ci>v_native</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>v_phospho</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v10_NDK_GTP">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="atp" public_interface="in" units="mM"/>
<variable name="gdp" public_interface="in" units="mM"/>
<variable name="adp" public_interface="in" units="mM"/>
<variable name="gtp" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="km_atp" units="mM"/>
<variable name="km_adp" units="mM"/>
<variable name="km_gtp" units="mM"/>
<variable name="km_gdp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>km_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1.33</cn>
</apply>
<apply>
<eq/>
<ci>km_adp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.042</cn>
</apply>
<apply>
<eq/>
<ci>km_gtp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.15</cn>
</apply>
<apply>
<eq/>
<ci>km_gdp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.031</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>km_atp</ci>
<ci>km_gdp</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>atp</ci>
<ci>gdp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>adp</ci>
<ci>gtp</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>atp</ci>
<ci>km_atp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gdp</ci>
<ci>km_gdp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>adp</ci>
<ci>km_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gtp</ci>
<ci>km_gtp</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v11_NDK_UTP">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_glyglc" public_interface="in" units="dimensionless"/>
<variable name="atp" public_interface="in" units="mM"/>
<variable name="udp" public_interface="in" units="mM"/>
<variable name="adp" public_interface="in" units="mM"/>
<variable name="utp" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="km_atp" units="mM"/>
<variable name="km_adp" units="mM"/>
<variable name="km_utp" units="mM"/>
<variable name="km_udp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>km_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1.33</cn>
</apply>
<apply>
<eq/>
<ci>km_adp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.042</cn>
</apply>
<apply>
<eq/>
<ci>km_utp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">16</cn>
</apply>
<apply>
<eq/>
<ci>km_udp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.19</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">2940</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_glyglc</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>km_atp</ci>
<ci>km_udp</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>atp</ci>
<ci>udp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>adp</ci>
<ci>utp</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>atp</ci>
<ci>km_atp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>udp</ci>
<ci>km_udp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>adp</ci>
<ci>km_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>utp</ci>
<ci>km_utp</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v12_AKAT">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="atp" public_interface="in" units="mM"/>
<variable name="adp" public_interface="in" units="mM"/>
<variable name="amp" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="km_atp" units="mM"/>
<variable name="km_amp" units="mM"/>
<variable name="km_adp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.247390074904985</cn>
</apply>
<apply>
<eq/>
<ci>km_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.09</cn>
</apply>
<apply>
<eq/>
<ci>km_amp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.08</cn>
</apply>
<apply>
<eq/>
<ci>km_adp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.11</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>km_atp</ci>
<ci>km_amp</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>atp</ci>
<ci>amp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>adp</ci>
<ci>adp</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>atp</ci>
<ci>km_atp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>amp</ci>
<ci>km_amp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>adp</ci>
<ci>km_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>adp</ci>
<ci>km_adp</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v13_PFK2">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="gamma" public_interface="in" units="dimensionless"/>
<variable name="fru6p" public_interface="in" units="mM"/>
<variable name="atp" public_interface="in" units="mM"/>
<variable name="n_native" units="dimensionless"/>
<variable name="n_phospho" units="dimensionless"/>
<variable name="k_fru6p_native" units="mM"/>
<variable name="k_fru6p_phospho" units="mM"/>
<variable name="k_atp_native" units="mM"/>
<variable name="k_atp_phospho" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<variable name="v_native" units="mM_per_second"/>
<variable name="v_phospho" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>n_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.3</cn>
</apply>
<apply>
<eq/>
<ci>n_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.1</cn>
</apply>
<apply>
<eq/>
<ci>k_fru6p_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.016</cn>
</apply>
<apply>
<eq/>
<ci>k_fru6p_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.05</cn>
</apply>
<apply>
<eq/>
<ci>k_atp_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.28</cn>
</apply>
<apply>
<eq/>
<ci>k_atp_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.65</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0.0042</cn>
</apply>
<apply>
<eq/>
<ci>v_native</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<apply>
<power/>
<ci>fru6p</ci>
<ci>n_native</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>fru6p</ci>
<ci>n_native</ci>
</apply>
<apply>
<power/>
<ci>k_fru6p_native</ci>
<ci>n_native</ci>
</apply>
</apply>
</apply>
<ci>atp</ci>
</apply>
<apply>
<plus/>
<ci>atp</ci>
<ci>k_atp_native</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_phospho</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<apply>
<power/>
<ci>fru6p</ci>
<ci>n_phospho</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>fru6p</ci>
<ci>n_phospho</ci>
</apply>
<apply>
<power/>
<ci>k_fru6p_phospho</ci>
<ci>n_phospho</ci>
</apply>
</apply>
</apply>
<ci>atp</ci>
</apply>
<apply>
<plus/>
<ci>atp</ci>
<ci>k_atp_phospho</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>gamma</ci>
</apply>
<ci>v_native</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>v_phospho</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v14_FBP2">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="gamma" public_interface="in" units="dimensionless"/>
<variable name="fru6p" public_interface="in" units="mM"/>
<variable name="fru26bp" public_interface="in" units="mM"/>
<variable name="km_fru26bp_native" units="mM"/>
<variable name="ki_fru6p_native" units="mM"/>
<variable name="km_fru26bp_phospho" units="mM"/>
<variable name="ki_fru6p_phospho" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<variable name="v_native" units="mM_per_second"/>
<variable name="v_phospho" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km_fru26bp_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.01</cn>
</apply>
<apply>
<eq/>
<ci>ki_fru6p_native</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0035</cn>
</apply>
<apply>
<eq/>
<ci>km_fru26bp_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0005</cn>
</apply>
<apply>
<eq/>
<ci>ki_fru6p_phospho</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.01</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0.126</cn>
</apply>
<apply>
<eq/>
<ci>v_native</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fru6p</ci>
<ci>ki_fru6p_native</ci>
</apply>
</apply>
</apply>
<ci>fru26bp</ci>
</apply>
<apply>
<plus/>
<ci>km_fru26bp_native</ci>
<ci>fru26bp</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_phospho</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fru6p</ci>
<ci>ki_fru6p_phospho</ci>
</apply>
</apply>
</apply>
<ci>fru26bp</ci>
</apply>
<apply>
<plus/>
<ci>km_fru26bp_phospho</ci>
<ci>fru26bp</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>gamma</ci>
</apply>
<ci>v_native</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>v_phospho</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v15_PFK1">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="fru26bp" public_interface="in" units="mM"/>
<variable name="fru6p" public_interface="in" units="mM"/>
<variable name="atp" public_interface="in" units="mM"/>
<variable name="km_atp" units="mM"/>
<variable name="km_fru6p" units="mM"/>
<variable name="ki_fru6p" units="mM"/>
<variable name="ka_fru26bp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.111</cn>
</apply>
<apply>
<eq/>
<ci>km_fru6p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.077</cn>
</apply>
<apply>
<eq/>
<ci>ki_fru6p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.012</cn>
</apply>
<apply>
<eq/>
<ci>ka_fru26bp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.001</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">7.182</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fru26bp</ci>
<ci>ka_fru26bp</ci>
</apply>
</apply>
</apply>
</apply>
<ci>fru6p</ci>
<ci>atp</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>ki_fru6p</ci>
<ci>km_atp</ci>
</apply>
<apply>
<times/>
<ci>km_fru6p</ci>
<ci>atp</ci>
</apply>
<apply>
<times/>
<ci>km_atp</ci>
<ci>fru6p</ci>
</apply>
<apply>
<times/>
<ci>atp</ci>
<ci>fru6p</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v16_FBP1">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="fru26bp" public_interface="in" units="mM"/>
<variable name="fru16bp" public_interface="in" units="mM"/>
<variable name="ki_fru26bp" units="mM"/>
<variable name="km_fru16bp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ki_fru26bp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.001</cn>
</apply>
<apply>
<eq/>
<ci>km_fru16bp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0013</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">4.326</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fru26bp</ci>
<ci>ki_fru26bp</ci>
</apply>
</apply>
</apply>
<ci>fru16bp</ci>
</apply>
<apply>
<plus/>
<ci>fru16bp</ci>
<ci>km_fru16bp</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v17_ALD">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="fru16bp" public_interface="in" units="mM"/>
<variable name="grap" public_interface="in" units="mM"/>
<variable name="dhap" public_interface="in" units="mM"/>
<variable name="keq" units="mM"/>
<variable name="km_fru16bp" units="mM"/>
<variable name="km_dhap" units="mM"/>
<variable name="km_grap" units="mM"/>
<variable name="ki1_grap" units="mM"/>
<variable name="ki2_grap" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">9.76298897362969 <sep/>
-5</cn>
</apply>
<apply>
<eq/>
<ci>km_fru16bp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0071</cn>
</apply>
<apply>
<eq/>
<ci>km_dhap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0364</cn>
</apply>
<apply>
<eq/>
<ci>km_grap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0071</cn>
</apply>
<apply>
<eq/>
<ci>ki1_grap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0572</cn>
</apply>
<apply>
<eq/>
<ci>ki2_grap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.176</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">420</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<ci>km_fru16bp</ci>
</apply>
<apply>
<minus/>
<ci>fru16bp</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>grap</ci>
<ci>dhap</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>fru16bp</ci>
<ci>km_fru16bp</ci>
</apply>
<apply>
<divide/>
<ci>grap</ci>
<ci>ki1_grap</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>dhap</ci>
<apply>
<plus/>
<ci>grap</ci>
<ci>km_grap</ci>
</apply>
</apply>
<apply>
<times/>
<ci>km_dhap</ci>
<ci>ki1_grap</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>fru16bp</ci>
<ci>grap</ci>
</apply>
<apply>
<times/>
<ci>km_fru16bp</ci>
<ci>ki2_grap</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v18_TPI">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="grap" public_interface="in" units="mM"/>
<variable name="dhap" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="km_dhap" units="mM"/>
<variable name="km_grap" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.054476985386756</cn>
</apply>
<apply>
<eq/>
<ci>km_dhap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.59</cn>
</apply>
<apply>
<eq/>
<ci>km_grap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.42</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">420</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<ci>km_dhap</ci>
</apply>
<apply>
<minus/>
<ci>dhap</ci>
<apply>
<divide/>
<ci>grap</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>dhap</ci>
<ci>km_dhap</ci>
</apply>
<apply>
<divide/>
<ci>grap</ci>
<ci>km_grap</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v19_GAPDH">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="nad" public_interface="in" units="mM"/>
<variable name="grap" public_interface="in" units="mM"/>
<variable name="p" public_interface="in" units="mM"/>
<variable name="bpg13" public_interface="in" units="mM"/>
<variable name="nadh" public_interface="in" units="mM"/>
<variable name="keq" units="per_mM"/>
<variable name="k_nad" units="mM"/>
<variable name="k_grap" units="mM"/>
<variable name="k_p" units="mM"/>
<variable name="k_nadh" units="mM"/>
<variable name="k_bpg13" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mM">0.086779866194594</cn>
</apply>
<apply>
<eq/>
<ci>k_nad</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.05</cn>
</apply>
<apply>
<eq/>
<ci>k_grap</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.005</cn>
</apply>
<apply>
<eq/>
<ci>k_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">3.9</cn>
</apply>
<apply>
<eq/>
<ci>k_nadh</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0083</cn>
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<apply>
<eq/>
<ci>k_bpg13</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0035</cn>
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<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">420</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_nad</ci>
<ci>k_grap</ci>
<ci>k_p</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>nad</ci>
<ci>grap</ci>
<ci>p</ci>
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<apply>
<divide/>
<apply>
<times/>
<ci>bpg13</ci>
<ci>nadh</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>nad</ci>
<ci>k_nad</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>grap</ci>
<ci>k_grap</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>p</ci>
<ci>k_p</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>nadh</ci>
<ci>k_nadh</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>bpg13</ci>
<ci>k_bpg13</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v20_PGK">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="adp" public_interface="in" units="mM"/>
<variable name="bpg13" public_interface="in" units="mM"/>
<variable name="atp" public_interface="in" units="mM"/>
<variable name="pg3" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_adp" units="mM"/>
<variable name="k_atp" units="mM"/>
<variable name="k_bpg13" units="mM"/>
<variable name="k_pg3" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.958644052488538</cn>
</apply>
<apply>
<eq/>
<ci>k_adp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.35</cn>
</apply>
<apply>
<eq/>
<ci>k_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.48</cn>
</apply>
<apply>
<eq/>
<ci>k_bpg13</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.002</cn>
</apply>
<apply>
<eq/>
<ci>k_pg3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1.2</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">420</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_adp</ci>
<ci>k_bpg13</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>adp</ci>
<ci>bpg13</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>atp</ci>
<ci>pg3</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>adp</ci>
<ci>k_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>bpg13</ci>
<ci>k_bpg13</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>atp</ci>
<ci>k_atp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pg3</ci>
<ci>k_pg3</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v21_PGM">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pg3" public_interface="in" units="mM"/>
<variable name="pg2" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_pg3" units="mM"/>
<variable name="k_pg2" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.181375378837397</cn>
</apply>
<apply>
<eq/>
<ci>k_pg3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">5</cn>
</apply>
<apply>
<eq/>
<ci>k_pg2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">420</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<apply>
<minus/>
<ci>pg3</ci>
<apply>
<divide/>
<ci>pg2</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>pg3</ci>
<apply>
<times/>
<ci>k_pg3</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pg2</ci>
<ci>k_pg2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v22_ENO">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pep" public_interface="in" units="mM"/>
<variable name="pg2" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_pep" units="mM"/>
<variable name="k_pg2" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.054476985386756</cn>
</apply>
<apply>
<eq/>
<ci>k_pep</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<apply>
<eq/>
<ci>k_pg2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">35.994</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<apply>
<minus/>
<ci>pg2</ci>
<apply>
<divide/>
<ci>pep</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>pg2</ci>
<apply>
<times/>
<ci>k_pg2</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pep</ci>
<ci>k_pep</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v23_PK">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="gamma" public_interface="in" units="dimensionless"/>
<variable name="pep" public_interface="in" units="mM"/>
<variable name="fru16bp" public_interface="in" units="mM"/>
<variable name="adp" public_interface="in" units="mM"/>
<variable name="n" units="dimensionless"/>
<variable name="n_p" units="dimensionless"/>
<variable name="n_fbp" units="dimensionless"/>
<variable name="n_fbp_p" units="dimensionless"/>
<variable name="alpha" units="dimensionless"/>
<variable name="alpha_p" units="dimensionless"/>
<variable name="alpha_end" units="dimensionless"/>
<variable name="k_fbp" units="mM"/>
<variable name="k_fbp_p" units="mM"/>
<variable name="k_pep" units="mM"/>
<variable name="k_pep_p" units="mM"/>
<variable name="k_pep_end" units="mM"/>
<variable name="k_adp" units="mM"/>
<variable name="base_act" units="dimensionless"/>
<variable name="base_act_p" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<variable name="f" units="dimensionless"/>
<variable name="f_p" units="dimensionless"/>
<variable name="alpha_inp" units="dimensionless"/>
<variable name="alpha_p_inp" units="dimensionless"/>
<variable name="pep_inp" units="mM"/>
<variable name="pep_p_inp" units="mM"/>
<variable name="v_native" units="mM_per_second"/>
<variable name="v_phospho" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>n</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.5</cn>
</apply>
<apply>
<eq/>
<ci>n_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.5</cn>
</apply>
<apply>
<eq/>
<ci>n_fbp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.8</cn>
</apply>
<apply>
<eq/>
<ci>n_fbp_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.8</cn>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>alpha_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.1</cn>
</apply>
<apply>
<eq/>
<ci>alpha_end</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>k_fbp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">0.16 <sep/>
-3</cn>
</apply>
<apply>
<eq/>
<ci>k_fbp_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">0.35 <sep/>
-3</cn>
</apply>
<apply>
<eq/>
<ci>k_pep</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.58</cn>
</apply>
<apply>
<eq/>
<ci>k_pep_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1.1</cn>
</apply>
<apply>
<eq/>
<ci>k_pep_end</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.08</cn>
</apply>
<apply>
<eq/>
<ci>k_adp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">2.3</cn>
</apply>
<apply>
<eq/>
<ci>base_act</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.08</cn>
</apply>
<apply>
<eq/>
<ci>base_act_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.04</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">46.2</cn>
</apply>
<apply>
<eq/>
<ci>f</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>fru16bp</ci>
<ci>n_fbp</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>k_fbp</ci>
<ci>n_fbp</ci>
</apply>
<apply>
<power/>
<ci>fru16bp</ci>
<ci>n_fbp</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_p</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>fru16bp</ci>
<ci>n_fbp_p</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>k_fbp_p</ci>
<ci>n_fbp_p</ci>
</apply>
<apply>
<power/>
<ci>fru16bp</ci>
<ci>n_fbp_p</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_inp</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f</ci>
</apply>
<apply>
<minus/>
<ci>alpha</ci>
<ci>alpha_end</ci>
</apply>
</apply>
<ci>alpha_end</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_p_inp</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_p</ci>
</apply>
<apply>
<minus/>
<ci>alpha_p</ci>
<ci>alpha_end</ci>
</apply>
</apply>
<ci>alpha_end</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>pep_inp</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f</ci>
</apply>
<apply>
<minus/>
<ci>k_pep</ci>
<ci>k_pep_end</ci>
</apply>
</apply>
<ci>k_pep_end</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>pep_p_inp</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>f_p</ci>
</apply>
<apply>
<minus/>
<ci>k_pep_p</ci>
<ci>k_pep_end</ci>
</apply>
</apply>
<ci>k_pep_end</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_native</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<ci>alpha_inp</ci>
<apply>
<power/>
<ci>pep</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>pep_inp</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>pep</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
<ci>adp</ci>
</apply>
<apply>
<plus/>
<ci>adp</ci>
<ci>k_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>base_act</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>base_act</ci>
</apply>
<ci>f</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_phospho</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<ci>alpha_p_inp</ci>
<apply>
<power/>
<ci>pep</ci>
<ci>n_p</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>pep_p_inp</ci>
<ci>n_p</ci>
</apply>
<apply>
<power/>
<ci>pep</ci>
<ci>n_p</ci>
</apply>
</apply>
</apply>
<ci>adp</ci>
</apply>
<apply>
<plus/>
<ci>adp</ci>
<ci>k_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>base_act_p</ci>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>base_act_p</ci>
</apply>
<ci>f_p</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>gamma</ci>
</apply>
<ci>v_native</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>v_phospho</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v24_PEPCK">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pep" public_interface="in" units="mM"/>
<variable name="oaa" public_interface="in" units="mM"/>
<variable name="gtp" public_interface="in" units="mM"/>
<variable name="gdp" public_interface="in" units="mM"/>
<variable name="co2" public_interface="in" units="mM"/>
<variable name="keq" units="mM"/>
<variable name="k_pep" units="mM"/>
<variable name="k_gdp" units="mM"/>
<variable name="k_co2" units="mM"/>
<variable name="k_oaa" units="mM"/>
<variable name="k_gtp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">3.369565215864287 <sep/>
2</cn>
</apply>
<apply>
<eq/>
<ci>k_pep</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.237</cn>
</apply>
<apply>
<eq/>
<ci>k_gdp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0921</cn>
</apply>
<apply>
<eq/>
<ci>k_co2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">25.5</cn>
</apply>
<apply>
<eq/>
<ci>k_oaa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0055</cn>
</apply>
<apply>
<eq/>
<ci>k_gtp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0222</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_oaa</ci>
<ci>k_gtp</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>oaa</ci>
<ci>gtp</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>pep</ci>
<ci>gdp</ci>
<ci>co2</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>oaa</ci>
<ci>k_oaa</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gtp</ci>
<ci>k_gtp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pep</ci>
<ci>k_pep</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gdp</ci>
<ci>k_gdp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>co2</ci>
<ci>k_co2</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v25_PEPCKM">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pep_mito" public_interface="in" units="mM"/>
<variable name="oaa_mito" public_interface="in" units="mM"/>
<variable name="gtp_mito" public_interface="in" units="mM"/>
<variable name="gdp_mito" public_interface="in" units="mM"/>
<variable name="co2_mito" public_interface="in" units="mM"/>
<variable name="keq" units="mM"/>
<variable name="k_pep" units="mM"/>
<variable name="k_gdp" units="mM"/>
<variable name="k_co2" units="mM"/>
<variable name="k_oaa" units="mM"/>
<variable name="k_gtp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="mM">3.369565215864287 <sep/>
2</cn>
</apply>
<apply>
<eq/>
<ci>k_pep</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.237</cn>
</apply>
<apply>
<eq/>
<ci>k_gdp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0921</cn>
</apply>
<apply>
<eq/>
<ci>k_co2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">25.5</cn>
</apply>
<apply>
<eq/>
<ci>k_oaa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0055</cn>
</apply>
<apply>
<eq/>
<ci>k_gtp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.0222</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">546</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_oaa</ci>
<ci>k_gtp</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>oaa_mito</ci>
<ci>gtp_mito</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>pep_mito</ci>
<ci>gdp_mito</ci>
<ci>co2_mito</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>oaa_mito</ci>
<ci>k_oaa</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gtp_mito</ci>
<ci>k_gtp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pep_mito</ci>
<ci>k_pep</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gdp_mito</ci>
<ci>k_gdp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>co2_mito</ci>
<ci>k_co2</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v26_PC">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pyr_mito" public_interface="in" units="mM"/>
<variable name="atp_mito" public_interface="in" units="mM"/>
<variable name="co2_mito" public_interface="in" units="mM"/>
<variable name="acoa_mito" public_interface="in" units="mM"/>
<variable name="k_atp" units="mM"/>
<variable name="k_pyr" units="mM"/>
<variable name="k_co2" units="mM"/>
<variable name="k_acoa" units="mM"/>
<variable name="n" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.22</cn>
</apply>
<apply>
<eq/>
<ci>k_pyr</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.22</cn>
</apply>
<apply>
<eq/>
<ci>k_co2</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">3.2</cn>
</apply>
<apply>
<eq/>
<ci>k_acoa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.015</cn>
</apply>
<apply>
<eq/>
<ci>n</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.5</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">168</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<ci>atp_mito</ci>
</apply>
<apply>
<plus/>
<ci>k_atp</ci>
<ci>atp_mito</ci>
</apply>
</apply>
<ci>pyr_mito</ci>
</apply>
<apply>
<plus/>
<ci>k_pyr</ci>
<ci>pyr_mito</ci>
</apply>
</apply>
<ci>co2_mito</ci>
</apply>
<apply>
<plus/>
<ci>k_co2</ci>
<ci>co2_mito</ci>
</apply>
</apply>
<apply>
<power/>
<ci>acoa_mito</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>acoa_mito</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>k_acoa</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v27_LDH">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pyr" public_interface="in" units="mM"/>
<variable name="nadh" public_interface="in" units="mM"/>
<variable name="lac" public_interface="in" units="mM"/>
<variable name="nad" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_pyr" units="mM"/>
<variable name="k_lac" units="mM"/>
<variable name="k_nad" units="mM"/>
<variable name="k_nadh" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">2.78321076004752 <sep/>
-4</cn>
</apply>
<apply>
<eq/>
<ci>k_pyr</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.495</cn>
</apply>
<apply>
<eq/>
<ci>k_lac</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">31.98</cn>
</apply>
<apply>
<eq/>
<ci>k_nad</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.984</cn>
</apply>
<apply>
<eq/>
<ci>k_nadh</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.027</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">12.6</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_pyr</ci>
<ci>k_nadh</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>pyr</ci>
<ci>nadh</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>lac</ci>
<ci>nad</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>nadh</ci>
<ci>k_nadh</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pyr</ci>
<ci>k_pyr</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>lac</ci>
<ci>k_lac</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>nad</ci>
<ci>k_nad</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v28_LACT">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="lac" public_interface="in" units="mM"/>
<variable name="lac_ext" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_lac" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>k_lac</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.8</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">5.418</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<ci>k_lac</ci>
</apply>
<apply>
<minus/>
<ci>lac_ext</ci>
<apply>
<divide/>
<ci>lac</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>lac_ext</ci>
<ci>k_lac</ci>
</apply>
<apply>
<divide/>
<ci>lac</ci>
<ci>k_lac</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v29_PYRT">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pyr" public_interface="in" units="mM"/>
<variable name="pyr_mito" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_pyr" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>k_pyr</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.1</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">42</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<ci>k_pyr</ci>
</apply>
<apply>
<minus/>
<ci>pyr</ci>
<apply>
<divide/>
<ci>pyr_mito</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pyr</ci>
<ci>k_pyr</ci>
</apply>
<apply>
<divide/>
<ci>pyr_mito</ci>
<ci>k_pyr</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v30_PEPT">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="pep" public_interface="in" units="mM"/>
<variable name="pep_mito" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_pep" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>k_pep</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.1</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">33.6</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<ci>k_pep</ci>
</apply>
<apply>
<minus/>
<ci>pep_mito</ci>
<apply>
<divide/>
<ci>pep</ci>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>pep</ci>
<ci>k_pep</ci>
</apply>
<apply>
<divide/>
<ci>pep_mito</ci>
<ci>k_pep</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v31_PDH">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="gamma" public_interface="in" units="dimensionless"/>
<variable name="pyr_mito" public_interface="in" units="mM"/>
<variable name="nad_mito" public_interface="in" units="mM"/>
<variable name="nadh_mito" public_interface="in" units="mM"/>
<variable name="coa_mito" public_interface="in" units="mM"/>
<variable name="acoa_mito" public_interface="in" units="mM"/>
<variable name="k_pyr" units="mM"/>
<variable name="k_coa" units="mM"/>
<variable name="k_nad" units="mM"/>
<variable name="ki_acoa" units="mM"/>
<variable name="ki_nadh" units="mM"/>
<variable name="alpha_nat" units="dimensionless"/>
<variable name="alpha_p" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<variable name="v_base" units="mM_per_second"/>
<variable name="v_nat" units="mM_per_second"/>
<variable name="v_p" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>k_pyr</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.025</cn>
</apply>
<apply>
<eq/>
<ci>k_coa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.013</cn>
</apply>
<apply>
<eq/>
<ci>k_nad</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.05</cn>
</apply>
<apply>
<eq/>
<ci>ki_acoa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.035</cn>
</apply>
<apply>
<eq/>
<ci>ki_nadh</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.036</cn>
</apply>
<apply>
<eq/>
<ci>alpha_nat</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<ci>alpha_p</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">13.44</cn>
</apply>
<apply>
<eq/>
<ci>v_base</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
<ci>pyr_mito</ci>
</apply>
<apply>
<plus/>
<ci>pyr_mito</ci>
<ci>k_pyr</ci>
</apply>
</apply>
<ci>nad_mito</ci>
</apply>
<apply>
<plus/>
<ci>nad_mito</ci>
<apply>
<times/>
<ci>k_nad</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>nadh_mito</ci>
<ci>ki_nadh</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>coa_mito</ci>
</apply>
<apply>
<plus/>
<ci>coa_mito</ci>
<apply>
<times/>
<ci>k_coa</ci>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>acoa_mito</ci>
<ci>ki_acoa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_nat</ci>
<apply>
<times/>
<ci>v_base</ci>
<ci>alpha_nat</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v_p</ci>
<apply>
<times/>
<ci>v_base</ci>
<ci>alpha_p</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>gamma</ci>
</apply>
<ci>v_nat</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>v_p</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v32_CS">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="coa_mito" public_interface="in" units="mM"/>
<variable name="acoa_mito" public_interface="in" units="mM"/>
<variable name="oaa_mito" public_interface="in" units="mM"/>
<variable name="cit_mito" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_oaa" units="mM"/>
<variable name="k_acoa" units="mM"/>
<variable name="k_cit" units="mM"/>
<variable name="k_coa" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">2.665990308427589 <sep/>
5</cn>
</apply>
<apply>
<eq/>
<ci>k_oaa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.002</cn>
</apply>
<apply>
<eq/>
<ci>k_acoa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.016</cn>
</apply>
<apply>
<eq/>
<ci>k_cit</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.42</cn>
</apply>
<apply>
<eq/>
<ci>k_coa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.07</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">4.2</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_oaa</ci>
<ci>k_acoa</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>acoa_mito</ci>
<ci>oaa_mito</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>cit_mito</ci>
<ci>coa_mito</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>acoa_mito</ci>
<ci>k_acoa</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>oaa_mito</ci>
<ci>k_oaa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>cit_mito</ci>
<ci>k_cit</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>coa_mito</ci>
<ci>k_coa</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v33_NDKMG">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="atp_mito" public_interface="in" units="mM"/>
<variable name="adp_mito" public_interface="in" units="mM"/>
<variable name="gtp_mito" public_interface="in" units="mM"/>
<variable name="gdp_mito" public_interface="in" units="mM"/>
<variable name="keq" units="dimensionless"/>
<variable name="k_atp" units="mM"/>
<variable name="k_adp" units="mM"/>
<variable name="k_gtp" units="mM"/>
<variable name="k_gdp" units="mM"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>keq</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<eq/>
<ci>k_atp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1.33</cn>
</apply>
<apply>
<eq/>
<ci>k_adp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.042</cn>
</apply>
<apply>
<eq/>
<ci>k_gtp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.15</cn>
</apply>
<apply>
<eq/>
<ci>k_gdp</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.031</cn>
</apply>
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">420</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
<apply>
<times/>
<ci>k_atp</ci>
<ci>k_gdp</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>atp_mito</ci>
<ci>gdp_mito</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>adp_mito</ci>
<ci>gtp_mito</ci>
</apply>
<ci>keq</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>atp_mito</ci>
<ci>k_atp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gdp_mito</ci>
<ci>k_gdp</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>adp_mito</ci>
<ci>k_adp</ci>
</apply>
</apply>
<apply>
<plus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>gtp_mito</ci>
<ci>k_gtp</ci>
</apply>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="v34_OAA_FLUX">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
</apply>
</math>
</component>
<component name="v35_ACOA_FLUX">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
</apply>
</math>
</component>
<component name="v36_CIT_FLUX">
<variable name="v" public_interface="out" units="mM_per_second"/>
<variable name="scale_gly" public_interface="in" units="dimensionless"/>
<variable name="Vmax" units="mM_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vmax</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<ci>v</ci>
<apply>
<times/>
<ci>scale_gly</ci>
<ci>Vmax</ci>
</apply>
</apply>
</math>
</component>
<component name="GlucoseMetabolism">
<variable name="t" units="second"/>
<variable name="gamma" private_interface="in" public_interface="out" units="dimensionless"/>
<variable initial_value="2.8" name="atp" public_interface="out" units="mM"/>
<variable initial_value="0.8" name="adp" public_interface="out" units="mM"/>
<variable initial_value="0.16" name="amp" public_interface="out" units="mM"/>
<variable initial_value="0.27" name="utp" public_interface="out" units="mM"/>
<variable initial_value="0.09" name="udp" public_interface="out" units="mM"/>
<variable initial_value="0.29" name="gtp" public_interface="out" units="mM"/>
<variable initial_value="0.1" name="gdp" public_interface="out" units="mM"/>
<variable initial_value="1.22" name="nad" public_interface="out" units="mM"/>
<variable initial_value="0.56e-3" name="nadh" public_interface="out" units="mM"/>
<variable initial_value="5" name="p" public_interface="out" units="mM"/>
<variable initial_value="0.008" name="pp" public_interface="out" units="mM"/>
<variable initial_value="5" name="co2" public_interface="out" units="mM"/>
<variable initial_value="0.38" name="udpglc" public_interface="out" units="mM"/>
<variable initial_value="250" name="glyglc" public_interface="out" units="mM"/>
<variable initial_value="5" name="glc" public_interface="out" units="mM"/>
<variable initial_value="0.012" name="glc1p" public_interface="out" units="mM"/>
<variable initial_value="0.12" name="glc6p" public_interface="out" units="mM"/>
<variable initial_value="0.05" name="fru6p" public_interface="out" units="mM"/>
<variable initial_value="0.02" name="fru16bp" public_interface="out" units="mM"/>
<variable initial_value="0.004" name="fru26bp" public_interface="out" units="mM"/>
<variable initial_value="0.1" name="grap" public_interface="out" units="mM"/>
<variable initial_value="0.03" name="dhap" public_interface="out" units="mM"/>
<variable initial_value="0.3" name="bpg13" public_interface="out" units="mM"/>
<variable initial_value="0.27" name="pg3" public_interface="out" units="mM"/>
<variable initial_value="0.03" name="pg2" public_interface="out" units="mM"/>
<variable initial_value="0.15" name="pep" public_interface="out" units="mM"/>
<variable initial_value="0.1" name="pyr" public_interface="out" units="mM"/>
<variable initial_value="0.01" name="oaa" public_interface="out" units="mM"/>
<variable initial_value="0.5" name="lac" public_interface="out" units="mM"/>
<variable initial_value="3" name="glc_ext" private_interface="out" public_interface="out" units="mM"/>
<variable initial_value="1.2" name="lac_ext" public_interface="out" units="mM"/>
<variable initial_value="5" name="co2_mito" public_interface="out" units="mM"/>
<variable initial_value="5" name="p_mito" units="mM"/>
<variable initial_value="0.01" name="oaa_mito" public_interface="out" units="mM"/>
<variable initial_value="0.15" name="pep_mito" public_interface="out" units="mM"/>
<variable initial_value="0.04" name="acoa_mito" public_interface="out" units="mM"/>
<variable initial_value="0.1" name="pyr_mito" public_interface="out" units="mM"/>
<variable initial_value="0.32" name="cit_mito" public_interface="out" units="mM"/>
<variable initial_value="2.8" name="atp_mito" public_interface="out" units="mM"/>
<variable initial_value="0.8" name="adp_mito" public_interface="out" units="mM"/>
<variable initial_value="0.29" name="gtp_mito" public_interface="out" units="mM"/>
<variable initial_value="0.1" name="gdp_mito" public_interface="out" units="mM"/>
<variable initial_value="0.055" name="coa_mito" public_interface="out" units="mM"/>
<variable initial_value="0.24" name="nadh_mito" public_interface="out" units="mM"/>
<variable initial_value="0.98" name="nad_mito" public_interface="out" units="mM"/>
<variable initial_value="12.5" name="scale_gly" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="scale_glyglc" public_interface="out" units="dimensionless"/>
<variable name="v1" public_interface="in" units="mM_per_second"/>
<variable name="v2" public_interface="in" units="mM_per_second"/>
<variable name="v3" public_interface="in" units="mM_per_second"/>
<variable name="v4" public_interface="in" units="mM_per_second"/>
<variable name="v5" public_interface="in" units="mM_per_second"/>
<variable name="v6" public_interface="in" units="mM_per_second"/>
<variable name="v7" public_interface="in" units="mM_per_second"/>
<variable name="v8" public_interface="in" units="mM_per_second"/>
<variable name="v9" public_interface="in" units="mM_per_second"/>
<variable name="v10" public_interface="in" units="mM_per_second"/>
<variable name="v11" public_interface="in" units="mM_per_second"/>
<variable name="v12" public_interface="in" units="mM_per_second"/>
<variable name="v13" public_interface="in" units="mM_per_second"/>
<variable name="v14" public_interface="in" units="mM_per_second"/>
<variable name="v15" public_interface="in" units="mM_per_second"/>
<variable name="v16" public_interface="in" units="mM_per_second"/>
<variable name="v17" public_interface="in" units="mM_per_second"/>
<variable name="v18" public_interface="in" units="mM_per_second"/>
<variable name="v19" public_interface="in" units="mM_per_second"/>
<variable name="v20" public_interface="in" units="mM_per_second"/>
<variable name="v21" public_interface="in" units="mM_per_second"/>
<variable name="v22" public_interface="in" units="mM_per_second"/>
<variable name="v23" public_interface="in" units="mM_per_second"/>
<variable name="v24" public_interface="in" units="mM_per_second"/>
<variable name="v25" public_interface="in" units="mM_per_second"/>
<variable name="v26" public_interface="in" units="mM_per_second"/>
<variable name="v27" public_interface="in" units="mM_per_second"/>
<variable name="v28" public_interface="in" units="mM_per_second"/>
<variable name="v29" public_interface="in" units="mM_per_second"/>
<variable name="v30" public_interface="in" units="mM_per_second"/>
<variable name="v31" public_interface="in" units="mM_per_second"/>
<variable name="v32" public_interface="in" units="mM_per_second"/>
<variable name="v33" public_interface="in" units="mM_per_second"/>
<variable name="v34" public_interface="in" units="mM_per_second"/>
<variable name="v35" public_interface="in" units="mM_per_second"/>
<variable name="v36" public_interface="in" units="mM_per_second"/>
<variable name="Vol_mc" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vol_mc</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>atp</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>adp</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>amp</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>utp</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v6</ci>
</apply>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>udp</ci>
</apply>
<apply>
<minus/>
<ci>v8</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>gtp</ci>
</apply>
<apply>
<minus/>
<ci>v10</ci>
<ci>v24</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>gdp</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v10</ci>
</apply>
<ci>v24</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>nad</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>nadh</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>p</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pp</ci>
</apply>
<apply>
<minus/>
<ci>v6</ci>
<ci>v7</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>co2</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>glc1p</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v5</ci>
</apply>
<ci>v6</ci>
</apply>
<ci>v9</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>udpglc</ci>
</apply>
<apply>
<minus/>
<ci>v6</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>glyglc</ci>
</apply>
<apply>
<minus/>
<ci>v8</ci>
<ci>v9</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>glc</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>v1</ci>
<ci>v2</ci>
</apply>
<ci>v3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>glc6p</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v2</ci>
<ci>v3</ci>
</apply>
<ci>v4</ci>
</apply>
<ci>v5</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
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<ci>fru6p</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v4</ci>
<ci>v13</ci>
</apply>
<ci>v14</ci>
</apply>
<ci>v15</ci>
</apply>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
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</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v15</ci>
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</apply>
<ci>v17</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>fru26bp</ci>
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<apply>
<minus/>
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</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>grap</ci>
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<apply>
<minus/>
<apply>
<plus/>
<ci>v17</ci>
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</apply>
<ci>v19</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>dhap</ci>
</apply>
<apply>
<minus/>
<ci>v17</ci>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>bpg13</ci>
</apply>
<apply>
<minus/>
<ci>v19</ci>
<ci>v20</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pg3</ci>
</apply>
<apply>
<minus/>
<ci>v20</ci>
<ci>v21</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pg2</ci>
</apply>
<apply>
<minus/>
<ci>v21</ci>
<ci>v22</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pep</ci>
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<apply>
<plus/>
<apply>
<minus/>
<ci>v22</ci>
<ci>v23</ci>
</apply>
<ci>v24</ci>
<ci>v30</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pyr</ci>
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<apply>
<minus/>
<apply>
<minus/>
<ci>v23</ci>
<ci>v27</ci>
</apply>
<ci>v29</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>oaa</ci>
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<apply>
<minus/>
<ci>v24</ci>
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</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>lac</ci>
</apply>
<apply>
<plus/>
<ci>v27</ci>
<ci>v28</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>glc_ext</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>lac_ext</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>co2_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>p_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>oaa_mito</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>Vol_mc</ci>
</apply>
<ci>v25</ci>
</apply>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v26</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v32</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v34</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pep_mito</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v25</ci>
</apply>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v30</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>acoa_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pyr_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>cit_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>atp_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>adp_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>gtp_mito</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>Vol_mc</ci>
</apply>
<ci>v25</ci>
</apply>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v33</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>gdp_mito</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v25</ci>
</apply>
<apply>
<times/>
<ci>Vol_mc</ci>
<ci>v33</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>coa_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>nadh_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>nad_mito</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_second">0</cn>
</apply>
</math>
</component>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="Gamma"/>
<map_variables variable_1="glc_ext" variable_2="glc"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v1_GLUT2"/>
<map_variables variable_1="v1" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="glc_ext" variable_2="glc_ext"/>
<map_variables variable_1="glc" variable_2="glc"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v2_GK"/>
<map_variables variable_1="v2" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="glc" variable_2="glc"/>
<map_variables variable_1="fru6p" variable_2="fru6p"/>
<map_variables variable_1="atp" variable_2="atp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v3_G6PASE"/>
<map_variables variable_1="v3" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="glc6p" variable_2="glc6p"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v4_GPI"/>
<map_variables variable_1="v4" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="glc6p" variable_2="glc6p"/>
<map_variables variable_1="fru6p" variable_2="fru6p"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v5_G1PI"/>
<map_variables variable_1="v5" variable_2="v"/>
<map_variables variable_1="scale_glyglc" variable_2="scale_glyglc"/>
<map_variables variable_1="glc6p" variable_2="glc6p"/>
<map_variables variable_1="glc1p" variable_2="glc1p"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v6_UPGASE"/>
<map_variables variable_1="v6" variable_2="v"/>
<map_variables variable_1="scale_glyglc" variable_2="scale_glyglc"/>
<map_variables variable_1="utp" variable_2="utp"/>
<map_variables variable_1="glc1p" variable_2="glc1p"/>
<map_variables variable_1="udpglc" variable_2="udpglc"/>
<map_variables variable_1="pp" variable_2="pp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v7_PPASE"/>
<map_variables variable_1="v7" variable_2="v"/>
<map_variables variable_1="scale_glyglc" variable_2="scale_glyglc"/>
<map_variables variable_1="pp" variable_2="pp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v8_GS"/>
<map_variables variable_1="v8" variable_2="v"/>
<map_variables variable_1="scale_glyglc" variable_2="scale_glyglc"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="glyglc" variable_2="glyglc"/>
<map_variables variable_1="glc6p" variable_2="glc6p"/>
<map_variables variable_1="udpglc" variable_2="udpglc"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v9_GP"/>
<map_variables variable_1="v9" variable_2="v"/>
<map_variables variable_1="scale_glyglc" variable_2="scale_glyglc"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="glyglc" variable_2="glyglc"/>
<map_variables variable_1="glc" variable_2="glc"/>
<map_variables variable_1="amp" variable_2="amp"/>
<map_variables variable_1="p" variable_2="p"/>
<map_variables variable_1="glc1p" variable_2="glc1p"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v10_NDK_GTP"/>
<map_variables variable_1="v10" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="atp" variable_2="atp"/>
<map_variables variable_1="adp" variable_2="adp"/>
<map_variables variable_1="gtp" variable_2="gtp"/>
<map_variables variable_1="gdp" variable_2="gdp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v11_NDK_UTP"/>
<map_variables variable_1="v11" variable_2="v"/>
<map_variables variable_1="scale_glyglc" variable_2="scale_glyglc"/>
<map_variables variable_1="atp" variable_2="atp"/>
<map_variables variable_1="adp" variable_2="adp"/>
<map_variables variable_1="utp" variable_2="utp"/>
<map_variables variable_1="udp" variable_2="udp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v12_AKAT"/>
<map_variables variable_1="v12" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="atp" variable_2="atp"/>
<map_variables variable_1="adp" variable_2="adp"/>
<map_variables variable_1="amp" variable_2="amp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v13_PFK2"/>
<map_variables variable_1="v13" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="atp" variable_2="atp"/>
<map_variables variable_1="fru6p" variable_2="fru6p"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v14_FBP2"/>
<map_variables variable_1="v14" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="fru6p" variable_2="fru6p"/>
<map_variables variable_1="fru26bp" variable_2="fru26bp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v15_PFK1"/>
<map_variables variable_1="v15" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="fru6p" variable_2="fru6p"/>
<map_variables variable_1="fru26bp" variable_2="fru26bp"/>
<map_variables variable_1="atp" variable_2="atp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v16_FBP1"/>
<map_variables variable_1="v16" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="fru16bp" variable_2="fru16bp"/>
<map_variables variable_1="fru26bp" variable_2="fru26bp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v17_ALD"/>
<map_variables variable_1="v17" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="fru16bp" variable_2="fru16bp"/>
<map_variables variable_1="grap" variable_2="grap"/>
<map_variables variable_1="dhap" variable_2="dhap"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v18_TPI"/>
<map_variables variable_1="v18" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="grap" variable_2="grap"/>
<map_variables variable_1="dhap" variable_2="dhap"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v19_GAPDH"/>
<map_variables variable_1="v19" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="nad" variable_2="nad"/>
<map_variables variable_1="grap" variable_2="grap"/>
<map_variables variable_1="p" variable_2="p"/>
<map_variables variable_1="bpg13" variable_2="bpg13"/>
<map_variables variable_1="nadh" variable_2="nadh"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v20_PGK"/>
<map_variables variable_1="v20" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="atp" variable_2="atp"/>
<map_variables variable_1="adp" variable_2="adp"/>
<map_variables variable_1="bpg13" variable_2="bpg13"/>
<map_variables variable_1="pg3" variable_2="pg3"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v21_PGM"/>
<map_variables variable_1="v21" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pg3" variable_2="pg3"/>
<map_variables variable_1="pg2" variable_2="pg2"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v22_ENO"/>
<map_variables variable_1="v22" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pep" variable_2="pep"/>
<map_variables variable_1="pg2" variable_2="pg2"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v23_PK"/>
<map_variables variable_1="v23" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="pep" variable_2="pep"/>
<map_variables variable_1="fru16bp" variable_2="fru16bp"/>
<map_variables variable_1="adp" variable_2="adp"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v24_PEPCK"/>
<map_variables variable_1="v24" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pep" variable_2="pep"/>
<map_variables variable_1="oaa" variable_2="oaa"/>
<map_variables variable_1="gtp" variable_2="gtp"/>
<map_variables variable_1="gdp" variable_2="gdp"/>
<map_variables variable_1="co2" variable_2="co2"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v25_PEPCKM"/>
<map_variables variable_1="v25" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pep_mito" variable_2="pep_mito"/>
<map_variables variable_1="oaa_mito" variable_2="oaa_mito"/>
<map_variables variable_1="gtp_mito" variable_2="gtp_mito"/>
<map_variables variable_1="gdp_mito" variable_2="gdp_mito"/>
<map_variables variable_1="co2_mito" variable_2="co2_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v26_PC"/>
<map_variables variable_1="v26" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pyr_mito" variable_2="pyr_mito"/>
<map_variables variable_1="atp_mito" variable_2="atp_mito"/>
<map_variables variable_1="co2_mito" variable_2="co2_mito"/>
<map_variables variable_1="acoa_mito" variable_2="acoa_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v27_LDH"/>
<map_variables variable_1="v27" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pyr" variable_2="pyr"/>
<map_variables variable_1="nadh" variable_2="nadh"/>
<map_variables variable_1="lac" variable_2="lac"/>
<map_variables variable_1="nad" variable_2="nad"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v28_LACT"/>
<map_variables variable_1="v28" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="lac" variable_2="lac"/>
<map_variables variable_1="lac_ext" variable_2="lac_ext"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v29_PYRT"/>
<map_variables variable_1="v29" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pyr" variable_2="pyr"/>
<map_variables variable_1="pyr_mito" variable_2="pyr_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v30_PEPT"/>
<map_variables variable_1="v30" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="pep" variable_2="pep"/>
<map_variables variable_1="pep_mito" variable_2="pep_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v31_PDH"/>
<map_variables variable_1="v31" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="pyr_mito" variable_2="pyr_mito"/>
<map_variables variable_1="nad_mito" variable_2="nad_mito"/>
<map_variables variable_1="nadh_mito" variable_2="nadh_mito"/>
<map_variables variable_1="coa_mito" variable_2="coa_mito"/>
<map_variables variable_1="acoa_mito" variable_2="acoa_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v32_CS"/>
<map_variables variable_1="v32" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="coa_mito" variable_2="coa_mito"/>
<map_variables variable_1="acoa_mito" variable_2="acoa_mito"/>
<map_variables variable_1="cit_mito" variable_2="cit_mito"/>
<map_variables variable_1="oaa_mito" variable_2="oaa_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v33_NDKMG"/>
<map_variables variable_1="v33" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
<map_variables variable_1="atp_mito" variable_2="atp_mito"/>
<map_variables variable_1="adp_mito" variable_2="adp_mito"/>
<map_variables variable_1="gtp_mito" variable_2="gtp_mito"/>
<map_variables variable_1="gdp_mito" variable_2="gdp_mito"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v34_OAA_FLUX"/>
<map_variables variable_1="v34" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v35_ACOA_FLUX"/>
<map_variables variable_1="v35" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
</connection>
<connection>
<map_components component_1="GlucoseMetabolism" component_2="v36_CIT_FLUX"/>
<map_variables variable_1="v36" variable_2="v"/>
<map_variables variable_1="scale_gly" variable_2="scale_gly"/>
</connection>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="Koenig2012_Gamma.cellml">
<component component_ref="Gamma" name="Gamma"/>
</import>
<group><relationship_ref relationship="encapsulation"/><component_ref component="GlucoseMetabolism"><component_ref component="Gamma"/></component_ref></group></model>
