Location: Metabolic Component Library @ f963a33d3d8f / examples / Koenig2012_HormoneGlucoseResponseDecreasing.cellml

Author:
Matthias K?nig <matthias.koenig@charite.de>
Date:
2013-04-21 20:13:13+02:00
Desc:
Nazaret 2009 example implemented and integratable. Results between normal and MCL implementation not identical ! Problems with original model implementation (no steady state)!
Permanent Source URI:
https://models.cellml.org/w/matthiaskoenig/MetabolicComponentLibrary/rawfile/f963a33d3d8fb4ce27a9e04729b5038282db7623/examples/Koenig2012_HormoneGlucoseResponseDecreasing.cellml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="HormoneGlucoseResponseDecreasing" name="HormoneGlucoseResponseDecreasing"> 
   <component name="HormoneGlucoseResponseDecreasing">
      <variable name="h" public_interface="out" units="pM"/>
      <variable name="glc" public_interface="in" units="mM"/>
      <variable name="h_max" public_interface="in" units="pM"/>
      <variable name="h_base" public_interface="in" units="pM"/>
      <variable name="h_km" public_interface="in" units="pM"/>
      <variable name="h_n" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>h</ci>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>h_max</ci>
                  <ci>h_base</ci>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <ci>glc</ci>
                        <ci>h_n</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>glc</ci>
                           <ci>h_n</ci>
                        </apply>
                        <apply>
                           <power/>
                           <ci>h_km</ci>
                           <ci>h_n</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
</model>