Location: Wang, Huang, Huang, 2006 @ 207a885a9ac9 / wang_2006.cellml

Author:
Hanne <Hanne@hanne-nielsens-macbook.local>
Date:
2010-09-03 11:01:30+12:00
Desc:
Added xul and session file
Permanent Source URI:
https://models.cellml.org/workspace/wang_huang_huang_2006/rawfile/207a885a9ac99906e7fb1612ae5a31d52bd698af/wang_2006.cellml

<?xml version="1.0"?>
<!--
This CellML file was generated on 21/08/2009 at 9:19:39 at a.m. using:

COR (0.9.31.1309)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="wang_2006" name="wang_2006">

<documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <section id="sec_status">
        <title>Model Status</title>
        <para>
	This CellML model runs in both OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
          </para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        
		<para>ABSTRACT: A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca(2+) oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca(2+) oscillations are mainly due to interaction of Ca(2+) release from the endoplasmic reticulum (ER) and the ATP-dependent Ca(2+) pump back into the ER, and the oscillations are prolonged by extracellular Ca(2+) entry that maintains the constant Ca(2+) supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca(2+) oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca(2+) release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca(2+) oscillations characteristics such as duration, peak [Ca(2+)](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells.
        </para>
       
	<para>
	The original paper is cited below:
	</para>
	<para>
	A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. J. Wang, X. Huang and W. Huang, 2006, Journal of Theoretical Biology, 245, 510-519. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17188305&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 17188305</ulink>
	</para>

<informalfigure float="0" id="fig_reaction_diagram">
	<mediaobject>
		<imageobject>
			<objectinfo>
			<title>Diagram of model</title>
			</objectinfo>
			<imagedata fileref="wang_2006.png"/>
		</imageobject>
	</mediaobject>
<caption>A schematic diagram of the pathway described by the mathematical model.</caption>
</informalfigure>

      </sect1>
    </article>
  </documentation>  
  
  
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      <!-- A human readable name for the model. -->
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        The Wang et al. 2006 model of ATP-induced intracellular calcium oscillations
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          This is the CellML description of Wang et al.'s mathematical model of ATP-induced intracellular calcium oscillations
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           A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations
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