- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2010-09-03 11:01:30+12:00
- Desc:
- Added xul and session file
- Permanent Source URI:
- https://models.cellml.org/workspace/wang_huang_huang_2006/rawfile/207a885a9ac99906e7fb1612ae5a31d52bd698af/wang_2006.cellml
<?xml version="1.0"?>
<!--
This CellML file was generated on 21/08/2009 at 9:19:39 at a.m. using:
COR (0.9.31.1309)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="wang_2006" name="wang_2006">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model runs in both OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca(2+) oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca(2+) oscillations are mainly due to interaction of Ca(2+) release from the endoplasmic reticulum (ER) and the ATP-dependent Ca(2+) pump back into the ER, and the oscillations are prolonged by extracellular Ca(2+) entry that maintains the constant Ca(2+) supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca(2+) oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca(2+) release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca(2+) oscillations characteristics such as duration, peak [Ca(2+)](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells.
</para>
<para>
The original paper is cited below:
</para>
<para>
A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. J. Wang, X. Huang and W. Huang, 2006, Journal of Theoretical Biology, 245, 510-519. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17188305&query_hl=1&itool=pubmed_docsum">PubMed ID: 17188305</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>Diagram of model</title>
</objectinfo>
<imagedata fileref="wang_2006.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the pathway described by the mathematical model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="micromolar">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="per_micromolar">
<unit exponent="-1" units="micromolar"/>
</units>
<units name="per_micromole">
<unit exponent="-1" prefix="micro" units="mole"/>
</units>
<units name="flux">
<unit units="micromolar"/>
<unit exponent="-1" units="second"/>
</units>
<units name="per_second">
<unit exponent="-1" units="second"/>
</units>
<units name="per_micromolar_per_second">
<unit exponent="-1" units="micromolar"/>
<unit units="per_second"/>
</units>
<units name="micromolar_square_per_second">
<unit exponent="2" units="micromolar"/>
<unit units="per_second"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="second"/>
</component>
<component name="Constants">
<variable initial_value="1e-4" name="k_0" public_interface="out" units="flux"/>
<variable initial_value="3.4" name="k_1" public_interface="out" units="per_second"/>
<variable initial_value="4" name="k_2" public_interface="out" units="per_second"/>
<variable initial_value="4.5" name="k_3" public_interface="out" units="per_second"/>
<variable initial_value="1.2" name="k_4" public_interface="out" units="per_second"/>
<variable initial_value="0.12" name="k_5" public_interface="out" units="per_second"/>
<variable initial_value="14" name="k_6" public_interface="out" units="per_second"/>
<variable initial_value="2" name="k_7" public_interface="out" units="per_second"/>
<variable initial_value="10.5" name="k_8" public_interface="out" units="flux"/>
<variable initial_value="0.6" name="k_9" public_interface="out" units="flux"/>
<variable initial_value="3" name="k_10" public_interface="out" units="flux"/>
<variable initial_value="0.26" name="k_11" public_interface="out" units="flux"/>
<variable initial_value="0.01" name="C_PLC_T" public_interface="out" units="micromolar"/>
<variable initial_value="0.01" name="K_D" public_interface="out" units="micromolar"/>
<variable initial_value="0.004" name="K_P" public_interface="out" units="micromolar"/>
<variable initial_value="0.2" name="K_R" public_interface="out" units="micromolar"/>
<variable initial_value="0.025" name="K_G" public_interface="out" units="micromolar"/>
<variable initial_value="0.025" name="K_S" public_interface="out" units="micromolar"/>
<variable initial_value="0.075" name="K_ER" public_interface="out" units="micromolar"/>
<variable initial_value="1" name="K_C1" public_interface="out" units="micromolar"/>
<variable initial_value="2" name="K_C2" public_interface="out" units="micromolar"/>
<variable initial_value="0.05" name="beta" public_interface="out" units="dimensionless"/>
<variable initial_value="0.001" name="lambda" public_interface="out" units="dimensionless"/>
<variable initial_value="0.2" name="rho" public_interface="out" units="dimensionless"/>
<variable initial_value="4" name="n" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="m" public_interface="out" units="dimensionless"/>
<variable initial_value="3" name="w" public_interface="out" units="dimensionless"/>
</component>
<component name="R_values">
<variable name="R_APLC" public_interface="out" units="dimensionless"/>
<variable name="R_PKC" public_interface="out" units="dimensionless"/>
<variable name="R_G" public_interface="out" units="dimensionless"/>
<variable name="R_DG" public_interface="out" units="dimensionless"/>
<variable name="R_IP_3" public_interface="out" units="dimensionless"/>
<variable name="R_Cyt1" public_interface="out" units="dimensionless"/>
<variable name="R_Cyt2" public_interface="out" units="dimensionless"/>
<variable name="R_ER" public_interface="out" units="dimensionless"/>
<variable name="APLC" public_interface="in" units="micromolar"/>
<variable name="DG" public_interface="in" units="micromolar"/>
<variable name="C_cyt" public_interface="in" units="micromolar"/>
<variable name="G" public_interface="in" units="micromolar"/>
<variable name="IP_3" public_interface="in" units="micromolar"/>
<variable name="C_ER" public_interface="in" units="micromolar"/>
<variable name="K_P" public_interface="in" units="micromolar"/>
<variable name="K_D" public_interface="in" units="micromolar"/>
<variable name="K_R" public_interface="in" units="micromolar"/>
<variable name="K_G" public_interface="in" units="micromolar"/>
<variable name="K_S" public_interface="in" units="micromolar"/>
<variable name="K_C1" public_interface="in" units="micromolar"/>
<variable name="K_C2" public_interface="in" units="micromolar"/>
<variable name="K_ER" public_interface="in" units="micromolar"/>
<variable name="n" public_interface="in" units="dimensionless"/>
<variable name="m" public_interface="in" units="dimensionless"/>
<variable name="w" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>R_APLC</ci>
<apply>
<divide/>
<ci>APLC</ci>
<apply>
<plus/>
<ci>K_P</ci>
<ci>APLC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_PKC</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>DG</ci>
<apply>
<plus/>
<ci>K_D</ci>
<ci>DG</ci>
</apply>
</apply>
<ci>C_cyt</ci>
</apply>
<apply>
<plus/>
<ci>K_R</ci>
<ci>C_cyt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_G</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>G</ci>
<ci>n</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_G</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>G</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_DG</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>DG</ci>
<ci>m</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_D</ci>
<ci>m</ci>
</apply>
<apply>
<power/>
<ci>DG</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_IP_3</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>IP_3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_S</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>IP_3</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_Cyt1</ci>
<apply>
<divide/>
<ci>C_cyt</ci>
<apply>
<plus/>
<ci>K_C1</ci>
<ci>C_cyt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_Cyt2</ci>
<apply>
<divide/>
<ci>C_cyt</ci>
<apply>
<plus/>
<ci>K_C2</ci>
<ci>C_cyt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>R_ER</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>C_ER</ci>
<ci>w</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_ER</ci>
<ci>w</ci>
</apply>
<apply>
<power/>
<ci>C_ER</ci>
<ci>w</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_GTP">
<variable cmeta:id="G_GTP_G" initial_value="0.001" name="G" public_interface="out" units="micromolar"/>
<variable name="k_0" public_interface="in" units="flux"/>
<variable name="k_1" public_interface="in" units="per_second"/>
<variable name="k_2" public_interface="in" units="per_second"/>
<variable name="k_3" public_interface="in" units="per_second"/>
<variable name="R_APLC" public_interface="in" units="dimensionless"/>
<variable name="R_PKC" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>G</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>k_0</ci>
<apply>
<times/>
<ci>k_1</ci>
<ci>G</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_2</ci>
<ci>R_APLC</ci>
<ci>G</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_3</ci>
<ci>R_PKC</ci>
<ci>G</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="APLC">
<variable initial_value="0.001" name="APLC" public_interface="out" units="micromolar"/>
<variable cmeta:id="APLC_PLC" name="PLC" units="micromolar"/>
<variable name="C_PLC_T" public_interface="in" units="micromolar"/>
<variable name="k_4" public_interface="in" units="per_second"/>
<variable name="k_5" public_interface="in" units="per_second"/>
<variable name="R_G" public_interface="in" units="dimensionless"/>
<variable name="R_DG" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PLC</ci>
<apply>
<minus/>
<ci>C_PLC_T</ci>
<ci>APLC</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>APLC</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_4</ci>
<ci>R_G</ci>
<ci>R_DG</ci>
<ci>PLC</ci>
</apply>
<apply>
<times/>
<ci>k_5</ci>
<ci>APLC</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IP_3">
<variable cmeta:id="IP_3_IP_3" initial_value="0.001" name="IP_3" public_interface="out" units="micromolar"/>
<variable name="k_6" public_interface="in" units="per_second"/>
<variable name="k_7" public_interface="in" units="per_second"/>
<variable name="APLC" public_interface="in" units="micromolar"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IP_3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_6</ci>
<ci>APLC</ci>
</apply>
<apply>
<times/>
<ci>k_7</ci>
<ci>IP_3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="DG">
<variable cmeta:id="DG_DG" name="DG" public_interface="out" units="micromolar"/>
<variable name="IP_3" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>DG</ci>
<ci>IP_3</ci>
</apply>
</math>
</component>
<component name="C_cyt">
<variable cmeta:id="C_cyt_C_cyt" initial_value="0.2" name="C_cyt" public_interface="out" units="micromolar"/>
<variable name="beta" public_interface="in" units="dimensionless"/>
<variable name="rho" public_interface="in" units="dimensionless"/>
<variable name="k_8" public_interface="in" units="flux"/>
<variable name="k_9" public_interface="in" units="flux"/>
<variable name="k_10" public_interface="in" units="flux"/>
<variable name="k_11" public_interface="in" units="flux"/>
<variable name="R_IP_3" public_interface="in" units="dimensionless"/>
<variable name="R_ER" public_interface="in" units="dimensionless"/>
<variable name="R_Cyt1" public_interface="in" units="dimensionless"/>
<variable name="R_Cyt2" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_cyt</ci>
</apply>
<apply>
<times/>
<ci>beta</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>rho</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_8</ci>
<ci>R_IP_3</ci>
<ci>R_ER</ci>
</apply>
<apply>
<times/>
<ci>k_9</ci>
<ci>R_Cyt1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_10</ci>
<ci>R_Cyt2</ci>
</apply>
</apply>
<ci>k_11</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C_ER">
<variable cmeta:id="C_ER_C_ER" initial_value="1" name="C_ER" public_interface="out" units="micromolar"/>
<variable name="lambda" public_interface="in" units="dimensionless"/>
<variable name="k_8" public_interface="in" units="flux"/>
<variable name="k_9" public_interface="in" units="flux"/>
<variable name="R_IP_3" public_interface="in" units="dimensionless"/>
<variable name="R_ER" public_interface="in" units="dimensionless"/>
<variable name="R_Cyt1" public_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_ER</ci>
</apply>
<apply>
<times/>
<ci>lambda</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>k_8</ci>
</apply>
<ci>R_IP_3</ci>
<ci>R_ER</ci>
</apply>
<apply>
<times/>
<ci>k_9</ci>
<ci>R_Cyt1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="G_GTP"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="APLC"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="IP_3"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="C_cyt"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="C_ER"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="Constants"/>
<map_variables variable_1="K_P" variable_2="K_P"/>
<map_variables variable_1="K_D" variable_2="K_D"/>
<map_variables variable_1="K_G" variable_2="K_G"/>
<map_variables variable_1="K_R" variable_2="K_R"/>
<map_variables variable_1="K_S" variable_2="K_S"/>
<map_variables variable_1="K_ER" variable_2="K_ER"/>
<map_variables variable_1="K_C1" variable_2="K_C1"/>
<map_variables variable_1="K_C2" variable_2="K_C2"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="w" variable_2="w"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="G_GTP"/>
<map_variables variable_1="G" variable_2="G"/>
<map_variables variable_1="R_APLC" variable_2="R_APLC"/>
<map_variables variable_1="R_PKC" variable_2="R_PKC"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="APLC"/>
<map_variables variable_1="APLC" variable_2="APLC"/>
<map_variables variable_1="R_G" variable_2="R_G"/>
<map_variables variable_1="R_DG" variable_2="R_DG"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="IP_3"/>
<map_variables variable_1="IP_3" variable_2="IP_3"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="DG"/>
<map_variables variable_1="DG" variable_2="DG"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="C_cyt"/>
<map_variables variable_1="C_cyt" variable_2="C_cyt"/>
<map_variables variable_1="R_IP_3" variable_2="R_IP_3"/>
<map_variables variable_1="R_ER" variable_2="R_ER"/>
<map_variables variable_1="R_Cyt1" variable_2="R_Cyt1"/>
<map_variables variable_1="R_Cyt2" variable_2="R_Cyt2"/>
</connection>
<connection>
<map_components component_1="R_values" component_2="C_ER"/>
<map_variables variable_1="C_ER" variable_2="C_ER"/>
<map_variables variable_1="R_IP_3" variable_2="R_IP_3"/>
<map_variables variable_1="R_ER" variable_2="R_ER"/>
<map_variables variable_1="R_Cyt1" variable_2="R_Cyt1"/>
</connection>
<connection>
<map_components component_1="G_GTP" component_2="Constants"/>
<map_variables variable_1="k_0" variable_2="k_0"/>
<map_variables variable_1="k_1" variable_2="k_1"/>
<map_variables variable_1="k_2" variable_2="k_2"/>
<map_variables variable_1="k_3" variable_2="k_3"/>
</connection>
<connection>
<map_components component_1="APLC" component_2="Constants"/>
<map_variables variable_1="C_PLC_T" variable_2="C_PLC_T"/>
<map_variables variable_1="k_4" variable_2="k_4"/>
<map_variables variable_1="k_5" variable_2="k_5"/>
</connection>
<connection>
<map_components component_1="APLC" component_2="IP_3"/>
<map_variables variable_1="APLC" variable_2="APLC"/>
</connection>
<connection>
<map_components component_1="IP_3" component_2="Constants"/>
<map_variables variable_1="k_6" variable_2="k_6"/>
<map_variables variable_1="k_7" variable_2="k_7"/>
</connection>
<connection>
<map_components component_1="IP_3" component_2="DG"/>
<map_variables variable_1="IP_3" variable_2="IP_3"/>
</connection>
<connection>
<map_components component_1="C_cyt" component_2="Constants"/>
<map_variables variable_1="beta" variable_2="beta"/>
<map_variables variable_1="rho" variable_2="rho"/>
<map_variables variable_1="k_8" variable_2="k_8"/>
<map_variables variable_1="k_9" variable_2="k_9"/>
<map_variables variable_1="k_10" variable_2="k_10"/>
<map_variables variable_1="k_11" variable_2="k_11"/>
</connection>
<connection>
<map_components component_1="C_ER" component_2="Constants"/>
<map_variables variable_1="lambda" variable_2="lambda"/>
<map_variables variable_1="k_8" variable_2="k_8"/>
<map_variables variable_1="k_9" variable_2="k_9"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<!--
The following RDF block contains metadata that applies to this document
as a whole, as indicated by the empty about attribute on the
<rdf:Description> element.
-->
<rdf:Description rdf:about="">
<!--
The Model Builder Metadata. The Dublin Core "creator" element is used
to indicate the person who translated the model into CellML.
-->
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Liu</vCard:Family>
<vCard:Given>Wei</vCard:Given>
</vCard:N>
<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<rdf:value>wliu052@aucklanduni.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
</vCard:ORG>
</dc:creator>
<!--
The Creation Date metadata. This is the date on which the model
was translated into CellML.
-->
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource">
<dcterms:W3CDTF>2009-09-29</dcterms:W3CDTF>
</dcterms:created>
<!--
The Modification History metadata. This lists the changes that have been
made to the document, who made the changes, and when they were made.
-->
</rdf:Description>
<!--
The following metadata refers to the model itself, as indicated by the
reference to the ID "wang_2006", which is
declared on the <model> element.
-->
<rdf:Description rdf:about="#wang_2006">
<!-- A human readable name for the model. -->
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
The Wang et al. 2006 model of ATP-induced intracellular calcium oscillations
</dc:title>
<!-- A comment regarding the model. -->
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This is the CellML description of Wang et al.'s mathematical model of ATP-induced intracellular calcium oscillations
</rdf:value>
<!-- The creator of the comment. -->
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<!-- Keyword(s) -->
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>calcium dynamics</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource">
<bqs:Pubmed_id>17188305</bqs:Pubmed_id>
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Seq>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Wang</vCard:Family>
<vCard:Given>J</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Huang</vCard:Family>
<vCard:Given>X</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:parseType="Resource">
<vCard:Family>Huang</vCard:Family>
<vCard:Given>W</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">
A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations
</dc:title>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:parseType="Resource">
<dcterms:W3CDTF>2006-04-07</dcterms:W3CDTF>
</dcterms:issued>
<bqs:Journal rdf:parseType="Resource">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Journal of Theoretical Biology</dc:title>
</bqs:Journal>
<bqs:volume>245</bqs:volume>
<bqs:first_page>510</bqs:first_page>
<bqs:last_page>519</bqs:last_page>
</bqs:JournalArticle>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>