Generated Code
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/* There are a total of 16 entries in the algebraic variable array. There are a total of 8 entries in each of the rate and state variable arrays. There are a total of 37 entries in the constant variable array. */ /* * VOI is Time in component Environmental (second). * CONSTANTS[0] is S in component Parameters (hertz). * CONSTANTS[1] is Zeta in component Parameters (dimensionless). * CONSTANTS[2] is R0 in component Parameters (mm). * CONSTANTS[3] is Cwall in component Parameters (mm_per_mmHg). * CONSTANTS[4] is Kne in component Parameters (mmHg_per_mm). * CONSTANTS[5] is K1 in component Parameters (mmHg_per_mm). * CONSTANTS[6] is K2 in component Parameters (mmHg_per_mm). * CONSTANTS[7] is K3 in component Parameters (mmHg_per_mm). * CONSTANTS[8] is Bwall in component Parameters (mmHg_s_per_sq_mm). * CONSTANTS[9] is B1 in component Parameters (mmHg_s_per_mm). * CONSTANTS[10] is B2 in component Parameters (mmHg_s_per_mm). * CONSTANTS[11] is B3 in component Parameters (mmHg_s_per_mm). * CONSTANTS[12] is Tsmax in component Parameters (AU). * CONSTANTS[13] is Tpmax in component Parameters (AU). * CONSTANTS[14] is Tsmin in component Parameters (AU). * CONSTANTS[15] is Tpmin in component Parameters (AU). * CONSTANTS[16] is Gcns in component Parameters (dimensionless). * CONSTANTS[17] is Gs in component Parameters (per_Hertz). * CONSTANTS[18] is Gp in component Parameters (per_Hertz). * CONSTANTS[19] is tau_nor in component Parameters (second). * CONSTANTS[20] is tau_ach in component Parameters (second). * CONSTANTS[21] is tau_HR_nor in component Parameters (second). * CONSTANTS[22] is tau_HR_ach in component Parameters (second). * CONSTANTS[23] is HRo in component Parameters (Beats_per_min). * CONSTANTS[24] is HRmax in component Parameters (Beats_per_min). * CONSTANTS[25] is HRmin in component Parameters (Beats_per_min). * CONSTANTS[26] is Beta in component Parameters (dimensionless). * CONSTANTS[27] is delta_th in component Parameters (dimensionless). * CONSTANTS[28] is q_nor in component Parameters (per_s). * CONSTANTS[29] is q_ach in component Parameters (per_s). * CONSTANTS[30] is K_nor in component Parameters (AU). * CONSTANTS[31] is K_ach in component Parameters (AU). * CONSTANTS[32] is Gamma in component Parameters (dimensionless). * ALGEBRAIC[10] is alpha_cns in component Nervous_System (hertz). * ALGEBRAIC[8] is n in component Nervous_System (hertz). * ALGEBRAIC[6] is Delta in component Coupling_Dynamics (dimensionless). * CONSTANTS[33] is alpha_s0 in component Nervous_System (hertz). * CONSTANTS[34] is alpha_p0 in component Nervous_System (hertz). * STATES[0] is A in component Aortic_Wall (mm_sq). * ALGEBRAIC[0] is P in component Aortic_Wall (mmHg). * ALGEBRAIC[1] is R in component Aortic_Wall (mm). * STATES[1] is Eps_1 in component Coupling_Dynamics (dimensionless). * STATES[2] is Eps_2 in component Coupling_Dynamics (dimensionless). * STATES[3] is Eps_3 in component Coupling_Dynamics (dimensionless). * ALGEBRAIC[4] is Eps_wall in component Coupling_Dynamics (dimensionless). * ALGEBRAIC[12] is Ts in component PNS_tones (AU). * ALGEBRAIC[13] is Tp in component PNS_tones (AU). * STATES[4] is c_nor in component Norepinephrine (AU). * STATES[5] is C_ach in component Acetylcholine (AU). * ALGEBRAIC[2] is delta_HR_ss in component Heart_Response_Nor (Beats_per_min). * CONSTANTS[35] is delta_HR_smax in component Heart_Response_Nor (Beats_per_min). * STATES[6] is delta_HR_s in component Heart_Response_Nor (Beats_per_min). * ALGEBRAIC[3] is delta_HR_ps in component HR_ach (Beats_per_min). * CONSTANTS[36] is delta_HR_pmax in component HR_ach (Beats_per_min). * ALGEBRAIC[5] is delta_HR_pfast in component HR_ach (Beats_per_min). * STATES[7] is delta_HR_pslow in component HR_ach (Beats_per_min). * ALGEBRAIC[7] is delta_HR_p in component HR_ach (Beats_per_min). * ALGEBRAIC[14] is HR in component HR_Combined (Beats_per_min). * ALGEBRAIC[11] is HR_p in component HR_Combined (Beats_per_min). * ALGEBRAIC[9] is HR_s in component HR_Combined (Beats_per_min). * ALGEBRAIC[15] is Period in component HR_Combined (Sec_per_Beat). * RATES[0] is d/dt A in component Aortic_Wall (mm_sq). * RATES[1] is d/dt Eps_1 in component Coupling_Dynamics (dimensionless). * RATES[2] is d/dt Eps_2 in component Coupling_Dynamics (dimensionless). * RATES[3] is d/dt Eps_3 in component Coupling_Dynamics (dimensionless). * RATES[4] is d/dt c_nor in component Norepinephrine (AU). * RATES[5] is d/dt C_ach in component Acetylcholine (AU). * RATES[6] is d/dt delta_HR_s in component Heart_Response_Nor (Beats_per_min). * RATES[7] is d/dt delta_HR_pslow in component HR_ach (Beats_per_min). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 480; CONSTANTS[1] = 1; CONSTANTS[2] = 1.6; CONSTANTS[3] = 0.006; CONSTANTS[4] = 1; CONSTANTS[5] = 1.5; CONSTANTS[6] = 3.75; CONSTANTS[7] = 1.05; CONSTANTS[8] = 1; CONSTANTS[9] = 1; CONSTANTS[10] = 10; CONSTANTS[11] = 206.973; CONSTANTS[12] = 4.12; CONSTANTS[13] = 4.994; CONSTANTS[14] = 0.5; CONSTANTS[15] = 1.6; CONSTANTS[16] = 1; CONSTANTS[17] = 0.178; CONSTANTS[18] = 0.492; CONSTANTS[19] = 9.1; CONSTANTS[20] = 0.2; CONSTANTS[21] = 2.1; CONSTANTS[22] = 2.5; CONSTANTS[23] = 282.648; CONSTANTS[24] = 483.218; CONSTANTS[25] = 226.238; CONSTANTS[26] = 0.175; CONSTANTS[27] = 0; CONSTANTS[28] = 0.1099; CONSTANTS[29] = 5; CONSTANTS[30] = 1.12; CONSTANTS[31] = 0.65; CONSTANTS[32] = 0.75; CONSTANTS[33] = 58.6; CONSTANTS[34] = 76.019; STATES[0] = 15.20531; STATES[1] = 0.2042; STATES[2] = 0.183; STATES[3] = 0.161; STATES[4] = 1.441; STATES[5] = 1.0; STATES[6] = 0; STATES[7] = 0; CONSTANTS[35] = CONSTANTS[24] - CONSTANTS[23]; CONSTANTS[36] = CONSTANTS[23] - CONSTANTS[25]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = 100.000+ 10.0000* sin( 5.00000*VOI); RATES[0] = (- ( pow((STATES[0]/ 3.14159265358979), 1.0 / 2) - CONSTANTS[2])/CONSTANTS[3]+ALGEBRAIC[0])/CONSTANTS[8]; ALGEBRAIC[2] = ( CONSTANTS[35]*pow(STATES[4], 2.00000))/(pow(CONSTANTS[30], 2.00000)+pow(STATES[4], 2.00000)); RATES[6] = (- STATES[6]+ALGEBRAIC[2])/CONSTANTS[21]; ALGEBRAIC[3] = ( CONSTANTS[36]*pow(STATES[5], 2.00000))/(pow(CONSTANTS[31], 2.00000)+pow(STATES[5], 2.00000)); RATES[7] = (- STATES[7]+ (1.00000 - CONSTANTS[32])*ALGEBRAIC[3])/CONSTANTS[22]; ALGEBRAIC[1] = pow(STATES[0]/ 3.14159265358979, 0.500000); ALGEBRAIC[4] = (ALGEBRAIC[1] - CONSTANTS[2])/CONSTANTS[2]; rootfind_0(VOI, CONSTANTS, RATES, STATES, ALGEBRAIC, pret); ALGEBRAIC[6] = ALGEBRAIC[4] - STATES[1]; ALGEBRAIC[8] = CONSTANTS[0]*(ALGEBRAIC[6] - CONSTANTS[1]*CONSTANTS[27]); ALGEBRAIC[10] = CONSTANTS[16]*ALGEBRAIC[8]; ALGEBRAIC[12] = CONSTANTS[14]+(CONSTANTS[12] - CONSTANTS[14])/(exp( CONSTANTS[17]*(ALGEBRAIC[10] - CONSTANTS[33]))+1.00000); RATES[4] = - (STATES[4]/CONSTANTS[19])+ CONSTANTS[28]*ALGEBRAIC[12]; ALGEBRAIC[13] = CONSTANTS[15]+(CONSTANTS[13] - CONSTANTS[15])/(exp( - CONSTANTS[18]*(ALGEBRAIC[10] - CONSTANTS[34]))+1.00000); RATES[5] = - (STATES[5]/CONSTANTS[20])+ CONSTANTS[29]*ALGEBRAIC[13]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = 100.000+ 10.0000* sin( 5.00000*VOI); ALGEBRAIC[2] = ( CONSTANTS[35]*pow(STATES[4], 2.00000))/(pow(CONSTANTS[30], 2.00000)+pow(STATES[4], 2.00000)); ALGEBRAIC[3] = ( CONSTANTS[36]*pow(STATES[5], 2.00000))/(pow(CONSTANTS[31], 2.00000)+pow(STATES[5], 2.00000)); ALGEBRAIC[1] = pow(STATES[0]/ 3.14159265358979, 0.500000); ALGEBRAIC[4] = (ALGEBRAIC[1] - CONSTANTS[2])/CONSTANTS[2]; ALGEBRAIC[6] = ALGEBRAIC[4] - STATES[1]; ALGEBRAIC[8] = CONSTANTS[0]*(ALGEBRAIC[6] - CONSTANTS[1]*CONSTANTS[27]); ALGEBRAIC[10] = CONSTANTS[16]*ALGEBRAIC[8]; ALGEBRAIC[12] = CONSTANTS[14]+(CONSTANTS[12] - CONSTANTS[14])/(exp( CONSTANTS[17]*(ALGEBRAIC[10] - CONSTANTS[33]))+1.00000); ALGEBRAIC[13] = CONSTANTS[15]+(CONSTANTS[13] - CONSTANTS[15])/(exp( - CONSTANTS[18]*(ALGEBRAIC[10] - CONSTANTS[34]))+1.00000); ALGEBRAIC[5] = CONSTANTS[32]*ALGEBRAIC[3]; ALGEBRAIC[7] = ALGEBRAIC[5]+STATES[7]; ALGEBRAIC[9] = CONSTANTS[23]+STATES[6]; ALGEBRAIC[11] = CONSTANTS[23] - ALGEBRAIC[7]; ALGEBRAIC[14] = ALGEBRAIC[11]+( (ALGEBRAIC[9] - CONSTANTS[23])*(ALGEBRAIC[11] - CONSTANTS[26]*CONSTANTS[25]))/(CONSTANTS[23] - CONSTANTS[26]*CONSTANTS[25]); ALGEBRAIC[15] = 60.0000/ALGEBRAIC[14]; } void objfunc_0(double *p, double *hx, int m, int n, void *adata) { struct rootfind_info* rfi = (struct rootfind_info*)adata; #define VOI rfi->aVOI #define CONSTANTS rfi->aCONSTANTS #define RATES rfi->aRATES #define STATES rfi->aSTATES #define ALGEBRAIC rfi->aALGEBRAIC #define pret rfi->aPRET RATES[1] = p[0]; RATES[2] = p[1]; RATES[3] = p[2]; hx[0] = RATES[1] - (( CONSTANTS[4]*(ALGEBRAIC[4] - STATES[1]) - CONSTANTS[5]*(STATES[1] - STATES[2]))/CONSTANTS[9]+RATES[2]); hx[1] = RATES[2] - (( CONSTANTS[5]*(STATES[1] - STATES[2]) - CONSTANTS[6]*(STATES[2] - STATES[3]))+ CONSTANTS[9]*RATES[1]+ CONSTANTS[10]*RATES[3])/(CONSTANTS[9]+CONSTANTS[10]); hx[2] = RATES[3] - (( CONSTANTS[6]*(STATES[2] - STATES[3]) - CONSTANTS[7]*STATES[3])+ CONSTANTS[10]*RATES[2])/(CONSTANTS[10]+CONSTANTS[11]); #undef VOI #undef CONSTANTS #undef RATES #undef STATES #undef ALGEBRAIC #undef pret } void rootfind_0(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC, int* pret) { static double p[3] = {0.1,0.1,0.1}; double bp[3], work[LM_DIF_WORKSZ(3, 3)]; struct rootfind_info rfi; rfi.aVOI = VOI; rfi.aCONSTANTS = CONSTANTS; rfi.aRATES = RATES; rfi.aSTATES = STATES; rfi.aALGEBRAIC = ALGEBRAIC; rfi.aPRET = pret; do_levmar(objfunc_0, p, bp, work, pret, 3, &rfi); RATES[1] = p[0]; RATES[2] = p[1]; RATES[3] = p[2]; }