Exposures

Below is a listing of model exposures (100 per page | full list)

A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology
An analysis of deformation-dependent electromechanical coupling in the mouse heart
Davies ISAP 2012
Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells
Simulations of the effects of inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase activities on Ca2+ oscillations
[Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model
A model for pacemaking in substantia nigra neurons (A simple model based on a spherical geometry)
A Primer on Modular Mass Action Modelling with CellML
A single compartment model of pacemaking in dissasociated Substantia nigra neurons with hyperbolic tetrahedral geometry
A Tutorial on Creating a Systems Model from SVPs
Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: a Theoretical Study
Adrian, Chandler, Hodgkin, 1970
Voltage clamp experiments in striated muscle fibres
Aguda, 1999
A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system
Aguda, Tang, 1999
The kinetic origins of the restriction point in the mammalian cell cycle
Albrecht, Colegrove, Friel, 2002
Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release
Albrecht, Colegrove, Hongpaisan, Pivovarova, Andrews, Friel, 2001
Multiple Modes of Calcium-induced Calcium Release in Sympathetic Neurons I: Attenuation of Endoplasmic Reticulum Ca2+ Accumulation at Low [Ca2+]i during Weak Depolarisation
Alexander, Wahl, 2010
Self-tolerance and Autoimmunity in a Regulatory T Cell Model
An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis
An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation.
Andre playing with nested tasks in SED-ML
Andre's Hodgkin & Huxley with CellML
Andre's Hodgkin & Huxley with CellML
Aon, Cortassa, 2002
Coherent and robust modulation of a metabolic network by cytoskeletal organization and dynamics
Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation
Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation
Aslanidi, Boyett, Dobrzynski, Li, Zhang, 2009
Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy
Aslanidi, Stewart, Boyett, Zhang, 2009
Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction
Asthagiri, Lauffenburger, 2001
A Compuational Study of Feedback Effects on Signal Dynamics in a Mitogen-Activated Protein Kinase (MAPK) Pathway Model
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2006
Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores
Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008
Computational insights on the competing effects of nitric oxide in regulating apoptosis
Bakker, Mensonides, Teusink, van Hoek, Michels, Westerhoff, 2000
Compartmentation protects trypanosomes from the dangerous design of glycolysis
Bakker, Michels, Opperdoes, Westerhoff, 1997
Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes
Barberis, Klipp, Vanoni, Alberghina, 2007
Cell Size at S Phase Initiation: An Emergent Property of the G1/S Network
Baylor, Hollingworth, Chandler, 2002
Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog
Beard, 2005
A biophysical model of the mitochondrial respiratory system and oxidative phosphorylation
Ben-Tal, 2006
Simplified models for gas exchange in the human lungs
Benson, Aslanidi, Zhang, Holden, 2008
The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis
Bernus, Wilders, Zemlin, Verschelde, Panfilov, 2002
A computationally efficient electrophysiological model of human ventricular cells
Bertram, Arnot, Zamponi, 2002
Role for G protein G-beta-gamma isoform specificity in synaptic signal processing: a computational study
Bertram, Pedersen, Luciani, Sherman, 2006
A simplified model for mitochondrial ATP production
Bertram, Previte, Sherman, Kinard, Satin, 2000
The Phantom Burster Model for Pancreatic Beta Cells
Bertram, Rhoads, Cimbora, 2008
A phantom bursting mechanism for episodic bursting
Bertram, Satin, Pedersen, Luciani, Sherman, 2007
Intra- and inter-islet synchronization of metabolically driven insulin secretion
Bertram, Satin, Zhang, Smolen, Sherman, 2004
Calcium and Glycolysis Mediate Multiple Bursting Modes in Pancreatic Islets
Bertram, Sherman, 2004
A Calcium-based Phantom Bursting Model for Pancreatic Islets
Bertram, Smolen, Sherman, Mears, Atwater, Martin, Soria, 1995
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells
Bhalla, Iyengar, 1999
Emergent Properties of Networks of Biological Signaling Pathways
Bifurcation analysis of the regulatory modules of the mammalian G1/S transition
Bindschadler, Sneyd, 2001
A Bifurcation Analysis of Two Coupled Calcium Oscillators
Bingzheng, Zhenye, Liansong, 1990
A mathematical model of the regulation system of the secretion of glucocorticoids
Bondarenko, Szigeti, Bett, Kim, Rasmusson, 2004
Computer model of action potential of mouse ventricular myocytes
Bonhoeffer, Rembiszewski, Ortiz, Nixon, 2000
Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection
Borghans, Dupont, Goldbeter, 1997
Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
Bornheimer, Maurya, Farquhar, Subramaniam, 2004
Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction
Boyett, Zhang, Garny, Holden, 2001
Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling
Brightman, Fell, 2000
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells.
Brown, Choe, Shanahan, Czeisler, 1997
A mathematical model of diurnal variations in human plasma melatonin levels
Bueno, 2007
Mathematical modeling and spectral simulation of genetic diseases in the human heart
Bugbuster Systems Model
Bugenhagen 2010
Bugenhagen 2010
Model of the overall baroreflex heart rate control system.
Butera, Rinzel, Smith, 1999
Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. II. Populations of Coupled Pacemaker Neurons
Butera, Rinzel, Smith, 1999
Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons
Butera, Rinzel, Smith, 1999
Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. II. Populations of Coupled Pacemaker Neurons
Calzone, Thieffry, Tyson, Novak, 2007
Dynamical modeling of syncytial mitotic cycles in Drosophila embryos
Campbell, Chandra, 2006
Functions of Stretch Activation in Heart Muscle
Carro, Rodriguez, Laguna, Pueyo (2011)
In this study, several modifications were introduced to a recently proposed human ventricular action potential (AP) model so as to render it suitable for the study of ventricular arrhythmias. These modifications were driven by new sets of experimental data available from the literature and the analysis of several well-established cellular arrhythmic risk biomarkers, namely AP duration at 90 per cent repolarization (APD90), AP triangulation, calcium dynamics, restitution properties, APD90 adaptation to abrupt heart rate changes, and rate dependence of intracellular sodium and calcium concentrations. The proposed methodology represents a novel framework for the development of cardiac cell models. Five stimulation protocols were applied to the original model and the ventricular AP model developed here to compute the described arrhythmic risk biomarkers. In addition, those models were tested in a one-dimensional fibre in which hyperkalaemia was simulated by increasing the extracellular potassium concentration, [K+]o. The effective refractory period (ERP), conduction velocity (CV) and the occurrence of APD alternans were investigated. Results show that modifications improved model behaviour as verified by: (i) AP triangulation well within experimental limits (the difference between APD at 50 and 90 per cent repolarization being 78.1 ms); (ii) APD90 rate adaptation dynamics characterized by fast and slow time constants within physiological ranges (10.1 and 105.9 ms); and (iii) maximum S1S2 restitution slope in accordance with experimental data (SS1S2=1.0). In simulated tissues under hyperkalaemic conditions, APD90 progressively shortened with the degree of hyperkalaemia, whereas ERP increased once a threshold in [K+]o was reached ([K+]o= 6 mM). CV decreased with [K+]o, and conduction was blocked for [K+]o>10.4 mM. APD90 alternans were observed for [K+]o>9.8 mM. Those results adequately reproduce experimental observations. This study demonstrated the value of basing the development of AP models on the computation of arrhythmic risk biomarkers, as opposed to joining together independently derived ion channel descriptions to produce a whole-cell AP model, with the new framework providing a better picture of the model performance under a variety of stimulation conditions. On top of replicating experimental data at single-cell level, the model developed here was able to predict the occurrence of APD90 alternans and areas of conduction block associated with high [K+]o in tissue, which is of relevance for the investigation of the arrhythmogenic substrate in ischaemic hearts.
Cartwright, Husain, 1986
A model for the control of testosterone secretion
Chang, Fujita, 1999
A kinetic model of the thiazide-sensitive Na-Cl cotransporter
Chang, Fujita, 1999
A numerical model of the renal distal tubule
Chang, Fujita, 2001
A numerical model of acid-base transport in rat distal tubule
Chassagnole, Rais, Quentin, Fell, Mazat, 2001
An integrated study of Threonine-pathway enzyme kinetics in Escherichia coli
Chay, 1997
Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells
Chay, Lee, Fan, 1995
Appearance of Phase-locked Wenchbach-like Rhythms, Devil's Staircase and Universality in Intracellular Calcium Spikes in Non-excitable Cell Models
Chen, Calzone, Csikasz-Nagy, Cross, Novak, Tyson, 2004
Integrative Analysis of Cell Cycle Control in Budding Yeast
Chen, Csikasz-Nagy, Gyorffy, Val, Novak, Tyson, 2000
Kinetic Analysis of a Molecular Model of the Budding Yeast Cell Cycle
Chen, Popel, 2006
Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
Chen, Popel, 2007
Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)
Cheng, Brown, Loeb, 2000
Virtual muscle: a computational approach to understanding the effects of muscle properties on motor control
Ciliberto, Novak, Tyson, 2003
Mathematical Model of the Morphogenesis Checkpoint in Budding Yeast
Ciliberto, Petrus, Tyson, Sible, 2003
A kinetic model of the cyclin E/Cdk2 developmental timer in Xenopus
Ciliberto, Tyson, 2000
Mathematical Model for Early Development of the Sea Urchin Embryo
Clancy, Rudy, 2001
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death
Clancy, Rudy, 2002
Na Channel Mutation That Causes Both Brugada Syndrome and Long-QT Syndrome Phenotypes: A Simulation Study of Mechanism
Cloutier, Bolger, Lowry, Wellstead, 2009
An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements
Cloutier, Wellstead, 2009
The control systems structures of energy metabolism
Colegrove, Albrecht, Friel, 2000
Quantitive Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations
Collier et al (1996) Delta-Notch model
Computational Mechanics of the Heart
Computational models of ventricular- and atrial-like human induced pluripotent stem cell derived cardiomyocytes
Computational models of ventricular- and atrial-like human induced pluripotent stem cell derived cardiomyocytes
Conradie, Bruggeman, Ciliberto, Csikasz-Nagy, Novak, Westerhoff, Snoep,
Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex
Cooling, Hunter, Crampin, 2008
Cooling, Hunter, Crampin, 2009. Dual Calcium Protocol
Cooling, Hunter, Crampin, 2009. Shen Calcium Protocol
Cooling, Hunter, Crampin, 2009. Tomida Calcium Protocol
Corrias, Buist, 2007
Corrias, Buist, 2007
Corrias, Buist, 2008
Quantitative cellular description of gastric slow wave activity
Cortassa et al. (2006) ECME model
Cortassa, Aon, Marban, Winslow, O'Rourke, 2003
An Integrated Model of Cardiac Mitrochondrial Energy Metabolism and Calcium Dynamics