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• Exposures
  • Proctor, Tsiringotis, Gray, 2007
    • An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
  • Proctor, Soti, Boys, Gillespie, Shanley, Wilkinson, Kirkwood, 2005
    • Modelling the actions of chaperones and their role in ageing.
  • Vempati, Karagiannis, Popel, 2007
    • A Biochemical Model of Matrix Metalloproteinase 9 Activation and Inhibition
  • Ueda, Hagiwara, Kitano, 2001
    • Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
  • The Renal Nephron
  • Huang, Ferrell, 1996
    • Ultrasensitivity in the mitogen-activated protein kinase cascade
  • Mikane, Suga, Araki, Kohno, Nakayama, Suzuki, Shimuzi, Matsubara, Hirakawa, Takaki, 1997
    • Mechanism of Constant Contractile Efficiency Under Cooling Intropy of Myocardium: Simulation
  • Saucerman, Brunton, Michailova, McCulloch, 2003
    • Modeling beta-adrenergic control of cardiac myocyte contractility in silico
  • Mitchell, Schaeffer, 2003
    • A two-current model for the dynamics of cardiac membrane
  • Terkildsen, Niederer, Crampin, Hunter, Smith, 2008
    • Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction
  • Boyett, Zhang, Garny, Holden, 2001
    • Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling
  • Bondarenko, Szigeti, Bett, Kim, Rasmusson, 2004
    • Computer model of action potential of mouse ventricular myocytes (Apical Cell Description)
    • Computer model of action potential of mouse ventricular myocytes (Septal Cell Description)
  • Ventricular mechanics in diastole: material parameter sensitivity.
    • Ventricular mechanics in diastole: material parameter sensitivity.
  • Iancu, Jones, Harvey, 2007
    • Compartmentation of cAMP signaling in cardiac myocytes: a computational study
  • Mathematical model of geometry and fibrous structure of the heart.
    • Mathematical model of geometry and fibrous structure of the heart.
  • Wang, Huang, Huang, 2006
    • A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations
  • Cheng, Brown, Loeb, 2000
    • Virtual muscle: a computational approach to understanding the effects of muscle properties on motor control
  • Tham, Wang, Soo, Lee, Lee, Yong, Goh, Holford, 2008
    • A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients
  • Sarkar, Lauffenburger, 2003
    • Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
  • Hund, Rudy, 2004
    • Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model (Basic Model)
    • Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model (Tissue Model)
  • Pedersen, Bertram, Sherman, 2005
    • Intra- and inter-islet synchronization of metabolically driven insulin secretion
  • Wolf, Sohn, Heinrich, Kuriyama, 2001
    • Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisae
  • Qu, MacLellan, Weiss, 2003
    • Dynamics of the Cell Cycle: Checkpoints, Sizers, and Timers
  • Warren, Tawhai, Crampin, 2010
    • Mathematical modelling of calcium wave propagation in mammalian airway epithelium: evidence for regenerative ATP release
  • Nowak, Bangham, 1996
    • Population dynamics of immune responses to persistent viruses (Model 1)
    • Population dynamics of immune responses to persistent viruses (Model 2)
  • Seemann, Sachse, Weib, Dossel, 2003
    • Quantitative Reconstruction of Cardiac Electromechanics in Human Myocardium: Regional Heterogeneity
  • Bingzheng, Zhenye, Liansong, 1990
    • A mathematical model of the regulation system of the secretion of glucocorticoids
  • Zhang, Holden, Kodama, Honjo, Lei, Varghese, Boyett, 2000
    • Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.
  • Chen, Popel, 2007
    • Vascular and perivascular nitric oxide release and transport (Fe3 = 0.6 micromolar)
    • Vascular and perivascular nitric oxide release and transport (Fe3 = 0.9 micromolar)
  • McAllister, Noble, Tsien, 1975
    • Reconstruction of the electrical activity of cardiac Purkinje fibres.
    • Reconstruction of the electrical activity of cardiac Purkinje fibres.
  • Stern, Song, Sham, Yang, Boheler, Rios, 1999
    • Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors
  • Bornheimer, Maurya, Farquhar, Subramaniam, 2004
    • Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction
  • Sobie, Dilly, dos Santos Cruz, Lederer, Jafri, 2002
    • Termination of Cardiac Ca2+ Sparks: An Investigative Mathematical Model of Calcium-Induced Calcium Release
  • Lindblad, Murphey, Clark, Giles, 1996
    • A Model of the Action Potential and Underlying Membrane Currents in a Rabbit Atrial Cell
  • Revilla, Garcia-Ramos, 2003
    • Revilla and Garcia-Ramos's 2003 dynamic model for HIV-1 therapy.
  • Jafri, Rice, Winslow, 1998
    • Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load (Basic Model)
    • Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load (Extended Model)
  • Li, Bertram, Rinzel, 1996
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons
  • Stewart, Aslanidi, Noble, Noble, Boyett, Zhang, 2009
    • Mathematical models of the electrical action potential of Purkinje fibre cells
  • Grandi, Pasqualini, Bers, 2009
    • A novel computational model of the human ventricular action potential and Ca transient
    • Envelope Stimulus Protocol
    • IV Stimulus Protocol
    • No Stimulus Protocol
    • Pace1 Stimulus Protocol
    • Pace2 Stimulus Protocol
    • Pace4 Stimulus Protocol
    • PaceNew Stimulus Protocol
    • Recovery Stimulus Protocol
    • Voltage Clamp Stimulus Protocol
    • Complete Model in CellML 1.0
  • Bugbuster Systems Model
  • Beard, 2005
    • A biophysical model of the mitochondrial respiratory system and oxidative phosphorylation
  • Dupont, Goldbeter, 1992
    • Protein phosphorylation driven by intracellular calcium oscillations: A kinetic analysis (Model A)
    • Protein phosphorylation driven by intracellular calcium oscillations: A kinetic analysis (Model B)
  • Potter, Zager, Barton, 2006
    • Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats.
  • Vaseghi, Baumeister, Rizzi, Reuss, 1999
    • In Vivo Dynamics of the Pentose Phosphate Pathway in Saccharomyces cerevisiae
  • Itskov, Ehret, Mavrilas, 2006
    • A Polyconvex Anisotropic Strain-Energy Function for Soft Collagenous Tissues
  • Leloup, Goldbeter,
    • A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Continuous Darkness Model)
    • A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Light-Dark Cycle Model)
  • Novak, Pataki, Ciliberto, Tyson, 2001
    • Mathematical model of the cell division cycle of fission yeast
  • Ostby, Omholt, Oyehaug, Einevoll, Nagelhus, Plahte, Zeuthen, Voipio, Lloyd, Ottersen, 2008
    • Astrocytic processes explaining neural-activity-induced shrinkage of extraneuronal space
  • Gonzalez-Heydrich, Steingard, Kohane, 1994
    • A computer simulation of the hypothalamic-pituitary-adrenal axis
  • Kongas, van Beek, 2001
    • Creatine kinase in energy metabolic signaling in muscle
  • Fallon, Lauffenburger, 2000
    • Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response
  • Weinstein, 1998
    • A mathematical model of the inner medullary collecting duct of the rat: acid/base transport
    • A mathematical model of the inner medullary collecting duct of the rat: acid/base transport
  • Vinnakota, Kemp, Kushmeric, 2006
    • Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics (Experiment 29, 0.2% Glycogen Phosphorylase A)
    • Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics (Experiment 29, 40% Glycogen Phosphorylase A)
    • Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics (Experiment 45)
  • Pandit, Giles, Demir, 2003
    • A Mathematical Model of the Electrophysiological Alterations in Rat Ventricular Myocytes in Type-I Diabetes
  • Bertram, Pedersen, Luciani, Sherman, 2006
    • A simplified model for mitochondrial ATP production
  • Farhy, Bowers, Veldhuis, 2007
    • Model-projected mechanistic bases for sex differences in growth hormone regulation in humans.
    • Model-projected mechanistic bases for sex differences in growth hormone regulation in humans.
  • Iribe, Kohl, Noble, 2006
    • Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval-force relations: a modelling study.
  • Huang, Ferrell, 1996
    • Ultrasensitivity in the mitogen-activated protein kinase cascade
  • Borghans, Dupont, Goldbeter, 1997
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms (Model A)
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms (Model B)
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms (Model C)
  • Bindschadler, Sneyd, 2001
    • A Bifurcation Analysis of Two Coupled Calcium Oscillators
  • Dupont, Berridge, Goldbetter, 1991
    • Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release (Model A)
    • Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release (Model B)
  • Goldbeter, Dupont, Berridge, 1990
    • Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation
  • Vendelin, Kongas, Saks, 2000
    • Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer
  • Shorten, O'Callaghan, Davidson, Soboleva, 2007
    • A mathematical model of fatigue in skeletal muscle force contraction: fast-twitch muscle
    • A mathematical model of fatigue in skeletal muscle force contraction: slow-twitch muscle
  • Westermark, Lansner, 2003
    • A Model of Phosphofructokinase and Glycolytic Oscillations in the Pancreatic Beta-cell
  • Hai, Murphy, 1988
    • Cross-bridge phosphorylation and regulation of latch state in smooth muscle
  • Goodwin, 1965
    • Oscillatory behavior in enzymatic control processes (Model 1)
    • Oscillatory behavior in enzymatic control processes (Model 2)
    • Oscillatory behavior in enzymatic control processes (Model 3)
  • Wu, Jeneson, Beard, 2006
    • Oxidative ATP Synthesis in Skeletal Muscle is Controlled by Substrate Feedback
  • Terkildsen, Niederer, Crampin, Hunter, Smith, 2008
    • Using Physiome standards to couple cellular functions for rat cardiac excitation-contraction
  • Shorten, O'Callaghan, Davidson, Soboleva, 2007
    • A mathematical model of fatigue in skeletal muscle force contraction: fast-twitch muscle
    • A mathematical model of fatigue in skeletal muscle force contraction: slow-twitch muscle
  • Yamaguchi, Takaki, Matsubara, Yasuhara, Suga, 1996
    • Constancy and variability of contractile efficiency as a function of calcium and cross-bridge kinetics: simulation
  • Smith, Chase, Nokes, Shaw, Wake, 2004
    • Minimal haemodynamic system model including ventricular interaction and valve dynamics.
  • Guyton, Volume Receptors, 2008
    • Description of Guyton volume receptors module
    • Description of Guyton volume receptors module
  • Hynne, Dano, Sorensen, 2001
    • Full-scale model of glycolysis in Saccharomyces cerevisiae
  • Oomens, Maenhout, van Oijen, Drost, Baaijens, 2003
    • Finite element modelling of contracting skeletal muscle
  • Demiray, 1981
    • Large deformation analysis of some soft biological tissues
  • Razumova, Bukatina, Campbell, 2000
    • Different Myofilament Nearest-Neighbor Interactions Have Distinctive Effects on Contractile Behavior
  • Yamaguchi, Takaki, Matsubara, Yasuhara, Suga, 1996
    • Constancy and variability of contractile efficiency as a function of calcium and cross-bridge kinetics: simulation
  • Pasek, Simurda, Orchard, Christe, 2008
    • A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system
  • Maleckar, Greenstein, Trayanova, Giles, 2009
    • Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium
  • Razumova, Bukatina, Campbell, 1999
    • Stiffness-distortion sacromere model for muscle stimulation
  • Fink, Noble, Virag, Varro, Giles, 2008
    • Contributions of HERG K+ current to repolarization of the human ventricular action potential
  • Schoeberl, Eichler-Jonsson, Gilles, Muller, 2002
    • Computational Modeling of the Dynamics of the MAP Kinase Cascade Activated by Surface and Internalized EGF Receptors.
  • Modelling Hypertrophic IP3 Transients in the Cardiac Myocyte (Cooling, Hunter, Crampin, 2007)
    • Modelling Hypertrophic IP3 Transients in the Cardiac Myocyte (Cooling, Hunter, Crampin, 2007)
  • Mijailovich, Butler, Fredburg, 2000
    • Perturbed Equilibria of Myosin Binding in Airway Smooth Muscle: Bond-Length Distributions, Mechanics and ATP Metabolism
  • Bertram, Satin, Zhang, Smolen, Sherman, 2004
    • Calcium and Glycolysis Mediate Multiple Bursting Modes in Pancreatic Islets (glycolytic bursting model)
    • Calcium and Glycolysis Mediate Multiple Bursting Modes in Pancreatic Islets (compound bursting model)
  • Mijailovich, Butler, Fredburg, 2000
    • Perturbed Equilibria of Myosin Binding in Airway Smooth Muscle: Bond-Length Distributions, Mechanics and ATP Metabolism
  • Cooling, Hunter, Crampin, 2009. Tomida Calcium Protocol
    • Cooling, Hunter, Crampin, 2009. Tomida Calcium Protocol
  • Inada, Hancox, Zhang, Boyett, 2009
    • One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells (Atrio-Nodal Cell)
    • One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells (Nodal-His Cell)
    • One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells (Nodal Cell)
  • Dupont, Berridge, Goldbetter, 1991
    • Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release
    • Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release
  • Rice, Winslow, Jafri, 1999
    • Modeling Gain and Gradedness of Ca2+ Release in the Functional Unit of the Cardiac Diadic Space
  • van Beek, 2007
    • Adenine nucleotide-creatine-phosphate module in myocardial metabolic system explains fast phase of dynamic regulation of oxidative phosphorylation
  • Borghans, Dupont, Goldbeter, 1997
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
  • Yates, Stark, Klein, Antia, Callard, 2007
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection (Model 1)
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection (Model 2)
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection (Model 3)
  • Moore, Li, 2004
    • A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction
  • Goldbeter, Dupont, Berridge, 1990
    • Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation
  • Obeyesekere, Zimmerman, Tecarro, Auchmuty, 1999
    • A model of cell cycle behavior dominated by kinetics of a pathway stimulated by growth factors
  • Bertram, Arnot, Zamponi, 2002
    • Role for G protein G-beta-gamma isoform specificity in synaptic signal processing: a computational study
    • Role for G protein G-beta-gamma isoform specificity in synaptic signal processing: a computational study
  • Borghans, Dupont, Goldbeter, 1997
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
    • Complex intracellular calcium oscillations. A theoretical exploration of possible mechanisms
  • Iribe, Kohl, Noble, 2006
    • Modulatory effect of calmodulin-dependent kinase II (CaMKII) on sarcoplasmic reticulum Ca2+ handling and interval-force relations: a modelling study.
  • Mittler, Sulzer, Neumann, Perelson, 1998
    • Influence of delayed viral production on viral dynamics in HIV-1 infected patients
  • Warashina, Ogura, 2004
    • Modeling of simulation-secretion coupling in a chromaffin cell
  • Cooling, Hunter, Crampin, 2009
    • Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes
  • Courtemanche, Ramirez, Nattel, 1998
    • Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model
  • Proctor, Soti, Boys, Gillespie, Shanley, Wilkinson, Kirkwood, 2005
    • Modelling the actions of chaperones and their role in ageing.
  • Chen, Calzone, Csikasz-Nagy, Cross, Novak, Tyson, 2004
    • Integrative Analysis of Cell Cycle Control in Budding Yeast
  • Hinch, Greenstein, Tanskanen, Xu, Winslow, 2004
    • A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes
  • Aslanidi, Boyett, Dobrzynski, Li, Zhang, 2009
    • Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy
  • Bugbuster Systems Model
  • Bertram, Previte, Sherman, Kinard, Satin, 2000
    • The Phantom Burster Model for Pancreatic Beta Cells (fast bursting model)
    • The Phantom Burster Model for Pancreatic Beta Cells (medium bursting model)
    • The Phantom Burster Model for Pancreatic Beta Cells (slow bursting model)
  • Novak, Tyson, 2004
    • A model for restriction point control of the mammalian cell cycle
  • Novak, Tyson, 1997
    • Original CellML version of the model
    • SBML Version of the Novak-Tyson 1997 Model
  • Grange, Holford, Guentert, 2001
    • A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats
    • A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats
  • Smith, 1980
    • Hypothalamic regulation of pituitary secretion of luteinizing hormone. II. Feedback control of gonadotropin secretion
  • De Vries, Sherman, 2000
    • Channel Sharing in Pancreatic Beta-Cells Revisited: Enhancement of Emergent Bursting by Noise
  • Wodarz, 2003
    • Evolution of Immunological Memory and the Regulation of Competition between Pathogens
  • Wang, Sobie, 2008
    • Mathematical model of the neonatal mouse ventricular action potential
  • MacGregor, Leng, 2005
    • Modelling the hypothalamic control of growth hormone secretion.
    • Modelling the hypothalamic control of growth hormone secretion.
    • Modelling the hypothalamic control of growth hormone secretion.
    • Modelling the hypothalamic control of growth hormone secretion.
  • Tolic, Mosekilde, Sturis, 2000
    • Modelling the Insulin-Glucose Feedback System: The Significance of Pulsatile Insulin Secretion
  • Friel, 1995
    • [Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model
  • Qu, MacLellan, Weiss, 2003
    • Dynamics of the Cell Cycle: Checkpoints, Sizers, and Timers
  • Rice, Winslow, Hunter, 1999
    • Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses
    • Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses
    • Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses
    • Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses
    • Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses
  • MacGregor, Leng, 2005
    • Modelling the hypothalamic control of growth hormone secretion: pituitary model only
    • Modelling the hypothalamic control of growth hormone secretion: the full pituitary + hypothalamic model
  • Cloutier, Wellstead, 2009
    • The control systems structures of energy metabolism (Version A)
    • The control systems structures of energy metabolism (Version B)
    • The control systems structures of energy metabolism (Version C)
    • The control systems structures of energy metabolism (Version D)
    • The control systems structures of energy metabolism (Version E)
    • The control systems structures of energy metabolism (Version F)
  • Guyton, Atrial Natriuretic Peptide, 2008
    • Description of Guyton atrial natriuretic peptide module
    • Description of Guyton atrial natriuretic peptide module
  • Noble, Noble, 1984
    • A Model of Sino-Atrial Node Electrical Activity Based on a Modification of the DiFrancesco-Noble (1984) Equations
  • Boyett, Zhang, Garny, Holden, 2001
    • Control of the pacemaker activity of the sinoatrial node by intracellular Ca2+. Experiments and modelling
  • Priebe, Beuckelmann, 1998
    • Simulation Study of Cellular Electrical Properties in Heart Failure
  • Tolic, Mosekilde, Sturis, 2000
    • Modelling the Insulin-Glucose Feedback System: The Significance of Pulsatile Insulin Secretion
  • Clancy, Rudy, 2001
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (Wild Type Epicardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (IKrN629D Mutant Epicardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (IKr629D Mutant Midmyocardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (IKrR56Q Mutant Epicardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (IKrR56Q Mutant Midmyocardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (IKrT474I Mutant Epicardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (IKrT474I Mutant Midmyocardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (INaKPQ Mutant Epicardial Cell)
    • Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death (Wild Type Midmyocardial Cell)
  • Cooling, Hunter, Crampin, 2009. Tomida Calcium Protocol
  • Fox, McHarg, Gilmour, 2002
    • Ionic mechanism of electrical alternans
  • Ten Tusscher, Noble, Noble, Panfilov, 2004
    • A model for human ventricular tissue
    • A model for human ventricular tissue
    • A model for human ventricular tissue
  • Michailova, McCulloch, 2001
    • Model study of ATP and ADP buffering, transport of Ca2+ and Mg2+, and regulation of ion pumps in ventricular myocyte
  • Gupta, Maurya, Stephens, Dennis, Subramaniam, 2009
    • An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis
  • Tham, Wang, Soo, Lee, Lee, Yong, Goh, Holford, 2008
    • A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients
  • Bonhoeffer, Rembiszewski, Ortiz, Nixon, 2000
    • Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection
    • Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection
    • Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection
    • Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection
  • Demir, Clark, Giles, Murphey, 1994
    • A Mathematical Model of a Rabbit Sinoatrial Node Cell
  • Goldbeter, 1991
    • A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase
    • A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase (Model with MIRIAM annotations)
  • Fink, Slepchenko, Loew, 1999
    • Determination of time-dependent inositol-1,4,5-triphosphate concentrations during calcium release in a smooth muscle cell
  • Wodarz, Sierro, Klenerman, 2007
    • Dynamics of killer T cell inflation in viral infections
    • Dynamics of killer T cell inflation in viral infections
    • Dynamics of killer T cell inflation in viral infections
  • Keizer, Levine, 1996
    • Ryanodine Receptor Adaptation and Ca2+-Induced Ca2+ Release-Dependent Ca2+ Oscillations
  • Thomas, 2000
    • Inner medullary lactate production and accumulation: a vasa recta model
  • Lenbury, Ruktamatakul, Amornsamarnkul, 2001
    • Modeling insulin kinetics: responses to a single oral glucose administration or ambulatory-fed conditions
    • Extended Model
  • Goldbeter, 1995
    • A model for circadian oscillations in the Drosophila period protein (PER)
  • Cui, Kaandorp, Lloyd, 2008
    • Model does not include the zinc-buffering effects of TPEN
    • Model includes the zinc-buffering effects of TPEN
  • Kesmir, De Boer, 1999
    • A Mathematical Model on Germinal Center Kinetics and Termination
  • Nagano, Gerritsen, 2001
    • Effects of Neuromuscular Strength Training on Vertical Jumping Performance - A Computer Simulation Study
  • Skouibine, Trayanova, Moore, 1999
    • Anode/cathode make and break phenomena in a model of defibrillation
  • Pasek, Simurda, Christe, 2006
    • CellML 1.0 version of the model which stabilises at 1Hz
    • CellML 1.0 version of the model which stabilises at 5Hz
    • CellML 1.1 version of the model
  • A Primer on Modular Mass Action Modelling with CellML
  • Wang, Li, Kuang, 2007
    • Mathematical modeling and qualitative analysis of insulin therapies
  • Komarova, 2005
    • Mathematical model of paracrine interactions between osteoclasts and osteoblasts predicts anabolic action of parathyroid hormone on bone
  • Calzone, Thieffry, Tyson, Novak, 2007
    • Dynamical modeling of syncytial mitotic cycles in Drosophila embryos
  • Cheng, Brown, Loeb, 2000
    • Virtual muscle: a computational approach to understanding the effects of muscle properties on motor control
  • Faber, Rudy, 2000
    • Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study (Original model in steady state)
    • Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study (Updated model with an added Ito current and and updated Irel current)
  • Cronwright, Rohwer, Prior, 2002
    • Metabolic Control Analysis of Glycerol Synthesis in Saccharomyces cerevisiae
  • Pedersen, Bertram, Sherman, 2005
    • Intra- and inter-islet synchronization of metabolically driven insulin secretion
  • Neumann, Lam, Dahari, Gretch, Wiley, Layden, Perelson, 1998
    • Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-alpha Therapy
  • Schneider, Shimayoshi, Amano, Matsuda, 2006
    • Mechanism of the Frank-Starling law-- A simulation study with a novel cardiac muscle contraction model that includes titin and tropomyosin
  • Salem, Saidel, Stanley, Cabrera, 2002
    • Mechanistic Model of Myocardial Energy Metabolism Under Normal and Ischemic Conditions
  • Hatzimanikatis, Lee, Bailey, 1999
    • A mathematical description of regulation of the G1-S transition of the mammalian cell cycle
  • Dupont, Berridge, Goldbetter, 1991
    • Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release (Model A)
    • Signal-induced Ca2+ oscillations: Properties of a model based on (Ca2+)-induced Ca2+ release (Model B)
  • Ciliberto, Novak, Tyson, 2003
    • Mathematical Model of the Morphogenesis Checkpoint in Budding Yeast
  • Sobie, Dilly, dos Santos Cruz, Lederer, Jafri, 2002
    • Termination of Cardiac Ca2+ Sparks: An Investigative Mathematical Model of Calcium-Induced Calcium Release
  • Li, Bertram, Rinzel, 1996
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons (simple model based on the equations in the published paper)
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons (complex model based on the equations in the published paper)
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons (simple model based on the equations in the original code)
  • Lumped-parameter model for the systemic circulation
    • Lumped-parameter model for the systemic circulation
    • EAtrium.cellml
    • EVentricle.cellml
    • ModelLeftHeart.cellml
    • ModelSys.cellml
    • ParaLeftHeart.cellml
    • ParaSys.cellml
    • TempCDa.cellml
    • TempCDv.cellml
    • TempR.cellml
    • TempRC.cellml
    • TempRLC.cellml
    • Units.cellml
  • Leloup, Gonze, Goldbeter, 1999
    • Limit Cycle Model for Circadian Rhythms in Drosophila and Neurospora (Drosophila model)
    • Limit Cycle Model for Circadian Rhythms in Drosophila and Neurospora (Neurospora model)
  • Ostby, Omholt, Oyehaug, Einevoll, Nagelhus, Plahte, Zeuthen, Voipio, Lloyd, Ottersen, 2008
    • Astrocytic processes explaining neural-activity-induced shrinkage of extraneuronal space
  • Novak, Tyson, 1993
    • Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos: parameter values have been taken from the original published paper to reproduce figure 4A.
    • Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos: parameter values have been taken from the SBML model in the BioModels Database and the model simulates the synthesis and degradation of cyclin.
  • Decker, Heijman, Silva, Hund, Rudy, 2009
    • Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium
  • Komarova, Wodarz, 2003
    • Evolutionary Dynamics of Mutator Phenotypes in Cancer: Implications for Chemotherapy
  • Brown, Choe, Shanahan, Czeisler, 1997
    • A mathematical model of diurnal variations in human plasma melatonin levels
  • Creating a Systems Model from SVPs - a Tutorial
  • Chang, Fujita, 1999
    • A kinetic model of the thiazide-sensitive Na-Cl cotransporter
  • Rong, Perelson, 2009
    • Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy
  • Huang, Ferrell, 1996
    • Ultrasensitivity in the mitogen-activated protein kinase cascade
  • Goldbeter, 1991
    • A Minimal Cascade Model for the Mitotic Oscillator Involving Cyclin and cdc2 Kinase
  • Baylor, Hollingworth, Chandler, 2002
    • Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction A)
    • Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction B)
    • Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction C)
    • Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction D)
    • Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction E)
    • Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction F)
  • Martinov, Vitvitsky, Mosharov, Banerjee, Ataullakhanov, 2000
    • A Substrate Switch: A New Mode of Regulation in the Methionine Metabolic Pathway
  • Van der Pol, Van der Mark, 1928
    • The Heartbeat Considered as a Relaxation Oscillation, and an Electrical Model of the Heart.
  • Chay, 1997
    • Effects of extracellular calcium on electrical bursting and intracellular and luminal calcium oscillations in insulin secreting pancreatic beta-cells
  • Ostby, Omholt, Oyehaug, Einevoll, Nagelhus, Plahte, Zeuthen, Voipio, Lloyd, Ottersen, 2008
    • Astrocytic processes explaining neural-activity-induced shrinkage of extraneuronal space
  • Marhl, Schuster, Brumen, Heinrich, 1997
    • Modelling the interrelations between calcium oscillations and ER membrane potential oscillations
  • Cooling, Hunter, Crampin, 2009. Shen Calcium Protocol
    • Cooling, Hunter, Crampin, 2009. Shen Calcium Protocol
  • Guyton, Electrolytes, 2008
    • Description of Guyton electrolytes module
    • Description of Guyton electrolytes module
  • Yi, Fogelson, Keener, Peskin, 2003
    • A Mathematical Study of Volume Shifts and Ionic Concentration Changes during Ischemia and Hypoxia
  • Heyd, Drew, 2003
    • A Mathematical Model for Elongation of a Peptide Chain
  • Earm, Noble, 1990
    • A Model of the Single Atrial Cell: Relation between Calcium Current and Calcium Release
  • Bakker, Michels, Opperdoes, Westerhoff, 1997
    • Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes
  • Wodarz, Nowak, 1999
    • Specific therapy regimes could lead to long-term immunological control of HIV
  • Lambeth, Kushmerick, 2002
    • A computational model for glycogenolysis in skeletal muscle
  • Cloutier, Bolger, Lowry, Wellstead, 2009
    • An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements
  • Palecek, Horwitz, Lauffenburger, 1999
    • Kinetic Model for Integrin-mediated Adhesion Release During Cell Migration
    • [···]
  • Espinosa, 1998
    • L'Echange Na+ /Ca2+ dans l'Hypertrophie Ventriculaire D'Altitude chez le Rat: Etude Electrophysiologique et Utilisation du Modele "Oxsoft Heart"
  • Gupta, Aslakson, Gurbaxani, Vernon, 2007
    • Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability
    • Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability
  • Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2006
    • Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores
  • Wierschem, Bertram,
    • Complex bursting in pancreatic islets: a potential glycolytic mechanism
  • Noble, Noble, Bett, Earm, Ho, So, 1991
    • The Role of Sodium-Calcium Exchange During the Cardiac Action Potential
  • Leloup, Goldbeter,
    • A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins
    • A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins
  • Li, Bertram, Rinzel, 1996
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons (Simple Model)
    • Modeling N-methyl-D-aspartate-induced bursting in dopamine neurons (Complex Model)
  • Bingzheng, Zhenye, Liansong, 1990
    • A mathematical model of the regulation system of the secretion of glucocorticoids
  • Butera, Rinzel, Smith, 1999
    • Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons: model 1 (which does not include a slow potassium current)
    • Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons: model 2 (which includes a slow potassium current)
  • A Primer on Modular Mass Action Modelling with CellML
    • A Primer on Modular Mass Action Modelling with CellML
    • BestPractice_Cdecoupled.cellml
    • BidirectionalExample.cellml
    • CombinedExample.cellml
    • CompletedImportExample.cellml
    • ImportExample1.cellml
    • ImportExample2.cellml
    • MultienvironmentExample.cellml
  • Sneyd, Dufour, 2002
    • A dynamic model of the type-2 inositol triphosphate receptor
  • Katsnelson, Nikitina, Chemla, Solovyova, Coirault, Lecarpentier, Markhasin, 2004
    • Time is expressed in milliseconds, calcium variables and parameters are normalised to total TnC concentration.
    • Time is expressed in seconds, calcium variables and parameters are expressed in absolute values.
    • Time is expressed in seconds, calcium variables and parameters are normalised to total TnC concentration.
  • Noble, Varghese, Kohl, Noble, 1998
    • Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Basic Model)
    • Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Extended Model)
    • Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Stretch Model)
  • Gilbert, Heiner, Rosser, Fulton, Gu, Trybilo, 2007
    • A Case Study in Model-driven Synthetic Biology
  • Liu, Hu, Peng, Liu, 1999
    • A dynamical model for the pulsatile secretion of the hypothalamo-pituitary-adrenal axis
  • Teusink, Westerhoff, Snoep, Passarge, Reijenga, Esgalhado, van der Weijden, Schepper, Walsh, Bakker, van Dam, 2000
    • Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.
  • Chang, Fujita, 2001
    • A numerical model of acid-base transport in rat distal tubule
    • A numerical model of acid-base transport in rat distal tubule
    • A numerical model of acid-base transport in rat distal tubule
    • A numerical model of acid-base transport in rat distal tubule
  • Noble, Varghese, Kohl, Noble, 1998
    • Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.
    • Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.
  • Noble, Noble, 2001
    • Remodelling of Calcium Dynamics in Guinea-Pig Ventricular Cells
  • Purvis, Smith, Koizumi, Butera, 2007
    • Intrinsic Bursters Increase the Robustness of Rythm Generation in an Excitatory Network: Single Pacemaker Cell
    • Intrinsic Bursters Increase the Robustness of Rythm Generation in an Excitatory Network: Single Non-Pacemaker Cell
  • Noble, Noble, 1984
    • A Model of Sino-Atrial Node Electrical Activity Based on a Modification of the DiFrancesco-Noble (1984) Equations
  • Overgaard, Holford, Rytved, Madsen, 2007
    • PKPD model of interleukin-21 effects on thermoregulation in monkeys--application and evaluation of stochastic differential equations
    • PKPD model of interleukin-21 effects on thermoregulation in monkeys--application and evaluation of stochastic differential equations
  • Cooling, Hunter, Crampin, 2009. Shen Calcium Protocol
    • Cooling, Hunter, Crampin, 2009. Shen Calcium Protocol
  • Wodarz, Nowak, 1999
    • Specific therapy regimes could lead to long-term immunological control of HIV
  • Aguda, 1999
    • A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system
  • Luo, Rudy, 1991
    • A Model of the Ventricular Cardiac Action Potential. Depolarization, repolarization and their interaction
  • Jelic, Cupic, Kolar-Anic, 2005
    • Mathematical modeling of the hypothalamic-pituitary-adrenal system activity
  • Moore, Li, 2004
    • A Mathematical Model for Chronic Myelogenous Leukemia (CML) and T Cell Interaction (Decreasing CML Variant)
    • A Mathematical Model for Chronic Myelogenous Leukemia (CML) and T Cell Interaction (Increasing CML Variant)
    • A Mathematical Model for Chronic Myelogenous Leukemia (CML) and T Cell Interaction (CML Recovery Variant)
  • Rattananakul, Lenbury, Krishnamara, Wollkind, 2003
    • Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy
    • Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy
    • Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy
  • Chen, Popel, 2006
    • Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
  • Sneyd, Tsaneva-Atanasova, Yule, Thompson, Shuttleworth, 2004
    • Sneyd et al.'s 2004 mathematical model for Ca2+ oscillations and their control by membrane fluxes.
  • Yates, Stark, Klein, Antia, Callard, 2007
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection
  • Guyton, Antidiuretic Hormone, 2008
    • Description of Guyton antidiuretic hormone module
    • Description of Guyton antidiuretic hormone module
  • Aslanidi, Boyett, Dobrzynski, Li, Zhang, 2009
    • Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy
  • Maltsev, Lakatta, 2009
    • Non-steady state model translated from the published paper
    • Steady state model adapted from the author's orignal code
  • Saucerman, Brunton, Michailova, McCulloch, 2003
    • Modeling beta-adrenergic control of cardiac myocyte contractility in silico
  • Sakmann, Spindler, Bryant, Linz, Noble, 2000
    • Distribution of a persistent sodium current across the ventricular wall in guinea pigs (Epicardial Cell)
    • Distribution of a persistent sodium current across the ventricular wall in guinea pigs (Endocardial Cell)
    • Distribution of a persistent sodium current across the ventricular wall in guinea pigs (Midmyocardial Cell)
  • Kneller, Ramirez, Chartier, Courtemanche, Nattel, 2002
    • Time-dependent transients in an ionically based mathematical model of the canine atrial action potential
  • Lemaire, Tobin, Greller, Cho, Suva, 2004
    • Modeling the interactions between osteoblast and osteoclast activities in bone remodeling: Main Model
    • Main Model + Adding Osteoblasts
    • Main Model + Adding Responding Osteoblasts
    • Main Model + Adding Responding Osteoclasts
    • Main Model + Removing Responding Osteoblasts
    • Main Model + Removing Osteoblasts
    • Main Model + Removing Osteoclasts
    • Main Model + Adding PTH
    • Main Model + Adding Osteoprotegerin
    • Main Model + Adding RANKL and Osteoprotegerin
  • Bakker, Mensonides, Teusink, van Hoek, Michels, Westerhoff, 2000
    • Compartmentation protects trypanosomes from the dangerous design of glycolysis
  • Corrias, Buist, 2008
    • Quantitative cellular description of gastric slow wave activity
  • Heinze, Keener, Midgley, 1998
    • A mathematical model of luteinizing hormone release from ovine pituitary cells in perifusion
    • A mathematical model of luteinizing hormone release from ovine pituitary cells in perifusion
    • A mathematical model of luteinizing hormone release from ovine pituitary cells in perifusion
  • Grossman, Feinberg, Kuznetsov, Dimitrov, Paul, 1998
    • HIV infection: how effective is drug combination treatment?
  • ten Tusscher, Panfilov, 2006
    • Alternans and spiral breakup in a human ventricular tissue model (Epicardial Model)
    • Alternans and spiral breakup in a human ventricular tissue model (Endocardial Model)
    • Alternans and spiral breakup in a human ventricular tissue model (Midmyocardial Model)
  • Demir, Clark, Giles, 1999
    • Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model
  • Sachse, Glanzel, Seemann, 2003
    • Modeling of Protein Interactions Involved in Cardiac Tension Development
  • Grange, Holford, Guentert, 2001
    • A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats (L-dopa)
    • A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats (L-dopa + Benserazide)
  • A Primer on Modular Mass Action Modelling with CellML
    • PMR2_metadata.cellml
    • BestPractice_Cdecoupled.cellml
    • BidirectionalExample.cellml
    • CombinedExample.cellml
    • CompletedImportExample.cellml
    • ImportExample1.cellml
    • ImportExample2.cellml
    • MultienvironmentExample.cellml
  • A Tutorial on Creating a Systems Model from SVPs
    • A Tutorial on Creating a Systems Model from SVPs
  • Martinov, Vitvitsky, Mosharov, Banerjee, Ataullakhanov, 2000
    • A Substrate Switch: A New Mode of Regulation in the Methionine Metabolic Pathway
  • Wodarz, 2003
    • Evolution of Immunological Memory and the Regulation of Competition between Pathogens
  • Goldbeter, Pourquie, 2008
    • Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways
    • Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways
  • Cooling, Hunter, Crampin, 2009. Tomida Calcium Protocol
    • Cooling, Hunter, Crampin, 2009. Tomida Calcium Protocol
  • Novak, Tyson, 1997
    • Original CellML version of the model
    • Novak and Tyson 1997 SBML model
  • Sriram, Bernot, Kepes, 2007
    • A minimal mathematical model combining several regulatory cycles from the budding yeast cell cycle
  • ten Tusscher, Panfilov, 2006
    • Alternans and spiral breakup in a human ventricular tissue model.
    • Alternans and spiral breakup in a human ventricular tissue model.
    • Alternans and spiral breakup in a human ventricular tissue model.
  • Wu, Yang, Vinnakota, Beard, 2007
    • Computer Modeling of Mitochondrial Tricarboxylic Acid Cycle, Oxidative Phosphorylation, Metabolite Transport, and Electrophysiology
  • Fink, Slepchenko, Moraru, Watras, Schaff, Loew, 2000
    • An image-based model of calcium waves in differentiated neuroblastoma cells
  • Herz, Bonhoeffer, Anderson, May, Nowak, 1996
    • Viral Dynamics in vivo: Limitations on estimates of intracellular delay and virus decay
  • Sneyd, Tsaneva-Atanasova, Bruce, Straub, Giovannucci, Yule, 2003
    • A Model of Calcium Waves in Pancreatic and Parotid Acinar Cells
  • Enciso, Sontag, 2004
    • On the stability of a model of testosterone dynamics
  • Matsuoka, Sarai, Kuratomi, Ono, Noma, 2003
    • Role of individual ionic current systems in ventricular cells hypothesized by a model study
  • Zhang, Holden, Kodama, Honjo, Lei, Varghese, Boyett, 2000
    • Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node.
  • Moore, Li, 2004
    • A Mathematical Model for Chronic Myelogenous Leukemia (CML) and T Cell Interaction (Decreasing CML Variant)
    • A Mathematical Model for Chronic Myelogenous Leukemia (CML) and T Cell Interaction (Increasing CML Variant)
    • A Mathematical Model for Chronic Myelogenous Leukemia (CML) and T Cell Interaction (CML Recovery Variant)
  • Shi, Korakianitis, Bowles, 2007
    • Numerical simulation of cardiovascular dynamics with different types of VAD assistance
    • EAtrium.cellml
    • EVentricle.cellml
    • ModelDPump.cellml
    • ModelLeftHeartT.cellml
    • ModelSysT.cellml
    • ParaDPump.cellml
    • ParaHeartP.cellml
    • ParaSys.cellml
    • TJoint.cellml
    • TempCDa.cellml
    • TempCDv.cellml
    • TempDPump.cellml
    • TempR.cellml
    • TempRC.cellml
    • TempRLC.cellml
    • Units.cellml
  • Moss, Kazmierczak, Kirley, Harris, 2009
    • A computational model for emergent dynamics in the kidney
  • Korakianitis, Shi, 2006
    • A concentrated parameter model for the human cardiovascular system including heart valve dynamics and atrioventricular interaction
    • EAtrium.cellml
    • EVentricle.cellml
    • ModelDPump.cellml
    • ModelLeftHeartT.cellml
    • ModelSysT.cellml
    • ParaDPump.cellml
    • ParaHeartP.cellml
    • ParaSys.cellml
    • TJoint.cellml
    • TempCDa.cellml
    • TempCDv.cellml
    • TempDPump.cellml
    • TempR.cellml
    • TempRC.cellml
    • TempRLC.cellml
    • Units.cellml
  • Schlosser, Selgrade, 2000
    • A model of gonadotropin regulation during the menstrual cycle in women: qualitative features
  • Schlosser, Selgrade, 2000
    • A model of gonadotropin regulation during the menstrual cycle in women: qualitative features
  • Teusink, Westerhoff, Snoep, Passarge, Reijenga, Esgalhado, van der Weijden, Schepper, Walsh, Bakker, van Dam, 2000
    • Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.
  • Matsuoka, Sarai, Kuratomi, Ono, Noma, 2003
    • Role of individual ionic current systems in ventricular cells hypothesized by a model study
  • Yates, Stark, Klein, Antia, Callard, 2007
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection (Model 1)
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection (Model 2)
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection (Model 3)
  • Noble, Noble, 2001
    • Remodelling of Calcium Dynamics in Guinea-Pig Ventricular Cells
  • Lenbury, Pornsawad, 2005
    • A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans
  • Wang, Lin, Lin, Wu, 2008
    • Effect of riluzole on action potential in cultured human skeletal muscle cells
  • Chassagnole, Rais, Quentin, Fell, Mazat, 2001
    • An integrated study of Threonine-pathway enzyme kinetics in Escherichia coli
  • Hodgkin, Huxley, 1952
    • A quantitative description of membrane current and its application to conductance and excitation in nerve
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
  • Bertram, Satin, Pedersen, Luciani, Sherman, 2007
    • Intra- and inter-islet synchronization of metabolically driven insulin secretion
  • Bornheimer, Maurya, Farquhar, Subramaniam, 2004
    • Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction
  • Leloup, Goldbeter, 2003
    • Toward a detailed computational model for the mammalian circadian clock
  • Maltsev, Lakatta, 2009
    • Non-steady state model translated from the published paper
    • Steady state model adapted from the author's orignal code
  • Korakianitis, Shi, 2006
    • Zero dimensional (lumped parameter) modelling of native human cardiovascular dynamics
  • Heyd, Drew, 2003
    • A mathematical model for elongation of a peptide chain
  • Dixit, Perelson, 2004
    • Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay
  • Haugh, 2004
    • Mathematical model of human growth hormone (hGH)-stimulated cell proliferation explains the efficacy of hGH variants as receptor agonists or antagonists
  • Koivumaki, Takalo, Korhonen, Tavi, Weckstrom, 2009
    • Modelling Sarcoplasmic Reticulum Calcium APTase and its Regulation in Cardiac Myocytes
    • Modelling Sarcoplasmic Reticulum Calcium APTase and its Regulation in Cardiac Myocytes
    • Modelling Sarcoplasmic Reticulum Calcium APTase and its Regulation in Cardiac Myocytes
  • Sarai, Matsuoka, Kuratomi, Ono, Noma, 2003
    • Role of individual ionic current systems in the SA node hypothesized by a model study
  • Cartwright, Husain, 1986
    • A model for the control of testosterone secretion
  • Greenstein, Wu, Po, Tomaselli, Winslow, 2000
    • Role of the Calcium-Independent Transient Outward Current Ito1 in Shaping Action Potential Morphology and Duration
  • Espinosa, 1998
    • L'Echange Na+/Ca2+ dans l'Hypertrophie Ventriculaire D'Altitude chez le Rat: Etude Electrophysiologique et Utilisation du Modele "Oxsoft Heart": normal heart cell model
    • L'Echange Na+/Ca2+ dans l'Hypertrophie Ventriculaire D'Altitude chez le Rat: Etude Electrophysiologique et Utilisation du Modele "Oxsoft Heart": hypertrophic heart cell model
  • Hunter, Smaill, Hunter, 1995
    • A pole-zero constitutive law for myocardium
  • Butera, Rinzel, Smith, 1999
    • Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons: model 1 (which does not include a slow potassium current)
    • Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons: model 2 (which includes a slow potassium current)
  • Colegrove, Albrecht, Friel, 2000
    • Quantitive Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations
  • Nowak, Bangham, 1996
    • Population dynamics of immune responses to persistent viruses
    • Population dynamics of immune responses to persistent viruses
  • Dupont, Goldbeter, 1992
    • Protein phosphorylation driven by intracellular calcium oscillations: A kinetic analysis
    • Protein phosphorylation driven by intracellular calcium oscillations: A kinetic analysis
  • Olsen, Hauser, Kummer, 2003
    • Mechanism of protection of peroxidase activity by oscillatory dynamics
  • Nelson, Perelson, 1995
    • Modeling defective interfering virus therapy for AIDS: conditions for DIV survival (No DIV Interference)
    • Modeling defective interfering virus therapy for AIDS: conditions for DIV survival (DIV Interference)
  • Corrias, Buist, 2008
    • Quantitative cellular description of gastric slow wave activity
  • Endresen, 1996
    • Chaos in Weakly-coupled Pacemaker Cells
  • Lumped-parameter cardiovascular model with Windkessel after-load
    • Lumped-parameter cardiovascular model with Windkessel after-load
    • EAtrium.cellml
    • EVentricle.cellml
    • ModelLeftHeart.cellml
    • ModelWindKessel.cellml
    • ParaLeftHeart.cellml
    • ParaSys.cellml
    • ParaWindKessel.cellml
    • TempCDa.cellml
    • TempCDv.cellml
    • TempRC.cellml
    • Units.cellml
  • Goldbeter, 1995
    • A model for circadian oscillations in the Drosophila period protein (PER)
  • Ralser, Lehrach, Krobitsch, Wamelink, Kowald, Gerisch, Heeren, Struys, Klipp, Jakobs, Breitenbach, 2007
    • Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
  • Eskandari, Wright, Loo,
    • Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter
  • Nelson, Murray, Perelson, 2000
    • A model of HIV-1 pathogenesis that includes an intracellular delay
    • A model of HIV-1 pathogenesis that includes an intracellular delay
  • Guyton, Muscle Oxygen Delivery, 2008
    • Description of Guyton muscle oxygen delivery module
    • Description of Guyton muscle oxygen delivery module
  • Gupta, Aslakson, Gurbaxani, Vernon, 2007
    • Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability
    • Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability
  • Favile, Pullan, Sanders, Koh, Lloyd, Smith, 2009
    • Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis
  • Sachse, Moreno, Abildskov, 2008
    • Electrophysiological Modeling of Fibroblasts and Their Interaction with Myocytes (Coupled Fibroblast-Myocyte Model)
    • Electrophysiological Modeling of Fibroblasts and Their Interaction with Myocytes (Fibroblast Model)
  • Chen, Calzone, Csikasz-Nagy, Cross, Novak, Tyson, 2004
    • Integrative Analysis of Cell Cycle Control in Budding Yeast
  • Swanson, True, Lin, Buhler, Vessella, Murray, 2001
    • A Quantitative Model for the Dynamics of Serum Prostate-Specific Antigen as a Marker for Cancerous Growth
  • Li, Kuang, Mason, 2006
    • Modeling the glucose-insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays
  • Leloup, Goldbeter,
    • A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Continuous Darkness Model)
    • A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins (Light-Dark Cycle Model)
  • Goforth, Bertram, Khan, Zhang, Sherman, Satin, 2002
    • Calcium-activated K+ Channels of Mouse Beta Cells are Controlled by Both Store and Cytoplasmic Ca2+: Experimental and Theoretical Studies
  • Barberis, Klipp, Vanoni, Alberghina, 2007
    • Cell Size at S Phase Initiation: An Emergent Property of the G1/S Network
  • Luo, Rudy, 1994
    • A Dynamic Model of the Cardiac Ventricular Action Potential I. Simulations of Ionic Currents and Concentration Changes
  • Cui, Kaandorp, Lloyd, 2008
    • Model does not include the zinc-buffering effects of TPEN
    • Model includes the zinc-buffering effects of TPEN
  • Korakianitis, Shi, 2006
    • Lumped-parameter model of the systemic circulation with impeller pump VAD support
    • EAtrium.cellml
    • EVentricle.cellml
    • ModelIPump.cellml
    • ModelLeftHeartT.cellml
    • ModelSysT.cellml
    • ParaHeartP.cellml
    • ParaIPump.cellml
    • ParaSys.cellml
    • TJoint.cellml
    • TempCDa.cellml
    • TempCDv.cellml
    • TempIPump.cellml
    • TempR.cellml
    • TempRC.cellml
    • TempRLC.cellml
    • Units.cellml
  • Enciso, Sontag, 2004
    • On the stability of a model of testosterone dynamics
  • Dokos, Celler, Lovell, 1996
    • Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model
  • Kholodenko, Demin, Moehren, Hoek, 1999
    • Quantification of short term signalling by the epidermal growth
  • Karagiannis, Popel, 2004
    • A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
  • Bertram, Smolen, Sherman, Mears, Atwater, Martin, Soria, 1995
    • A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells