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Fujita, Toyoshima, Uda, Ozaki, Kubota, Kuroda, 2010
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Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics: NGF-dependent Akt pathway model
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Model Mathematics
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Component: environment
Component: NGF
Component: pro_TrkA
Component: TrkA
d
d
time
TrkA
=
k2_NGF_TrkA
NGF_TrkA
+
TrkA_turnover
pro_TrkA
-
TrkA
-
k1_NGF_TrkA
NGF
TrkA
Component: NGF_TrkA
d
d
time
NGF_TrkA
=
k1_NGF_TrkA
NGF
TrkA
-
k2_NGF_TrkA
NGF_TrkA
+
k1_TrkA_phosphorylation
NGF_TrkA
Component: pTrkA
d
d
time
pTrkA
=
k1_TrkA_phosphorylation
NGF_TrkA
+
k1_Akt_phosphorylation
pTrkA_Akt
+
k2_pTrkA_Akt
pTrkA_Akt
-
k1_pTrkA_degradation
pTrkA
+
k1_pTrkA_Akt
pTrkA
Akt
Component: pTrkA_Akt
d
d
time
pTrkA_Akt
=
k1_pTrkA_Akt
pTrkA
Akt
-
k2_pTrkA_Akt
pTrkA_Akt
+
k1_Akt_phosphorylation
pTrkA_Akt
Component: Akt
d
d
time
Akt
=
k2_pTrkA_Akt
pTrkA_Akt
+
k1_pAkt_dephosphorylation
pAkt
-
k1_pTrkA_Akt
pTrkA
Akt
Component: pAkt
d
d
time
pAkt
=
k1_Akt_phosphorylation
pTrkA_Akt
+
k2_pAkt_S6
pAkt_S6
+
k1_S6_phosphorylation
pAkt_S6
-
k1_pAkt_dephosphorylation
pAkt
+
k1_pAkt_S6
pAkt
S6
Component: pAkt_S6
d
d
time
pAkt_S6
=
k1_pAkt_S6
pAkt
S6
-
k2_pAkt_S6
pAkt_S6
+
k1_S6_phosphorylation
pAkt_S6
Component: S6
d
d
time
S6
=
k2_pAkt_S6
pAkt_S6
+
k1_pS6_dephosphorylation
pS6
-
k1_pAkt_S6
pAkt
S6
Component: pS6
d
d
time
pS6
=
k1_S6_phosphorylation
pAkt_S6
-
k1_pS6_dephosphorylation
pS6
Component: pTrkA_total
pTrkA_total
=
pTrkA
+
pTrkA_Akt
pTrkA_scalefactor
Component: pAkt_total
pAkt_total
=
pAkt
+
pAkt_S6
pAkt_scalefactor
Component: pS6_total
pS6_total
=
pS6
pS6_scalefactor
Component: model_parameters
Source
Derived from workspace
Fujita, Toyoshima, Uda, Ozaki, Kubota and Kuroda 2010
at changeset
e404cee704e9
.
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This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics: NGF-dependent Akt pathway model
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