Model Mathematics

Component: environment

Component: NGF

Component: pro_TrkA

Component: TrkA

dd time TrkA = k2_NGF_TrkA NGF_TrkA + TrkA_turnover pro_TrkA - TrkA - k1_NGF_TrkA NGF TrkA

Component: NGF_TrkA

dd time NGF_TrkA = k1_NGF_TrkA NGF TrkA - k2_NGF_TrkA NGF_TrkA + k1_TrkA_phosphorylation NGF_TrkA

Component: pTrkA

dd time pTrkA = k1_TrkA_phosphorylation NGF_TrkA + k1_Akt_phosphorylation pTrkA_Akt + k2_pTrkA_Akt pTrkA_Akt - k1_pTrkA_degradation pTrkA + k1_pTrkA_Akt pTrkA Akt

Component: pTrkA_Akt

dd time pTrkA_Akt = k1_pTrkA_Akt pTrkA Akt - k2_pTrkA_Akt pTrkA_Akt + k1_Akt_phosphorylation pTrkA_Akt

Component: Akt

dd time Akt = k2_pTrkA_Akt pTrkA_Akt + k1_pAkt_dephosphorylation pAkt - k1_pTrkA_Akt pTrkA Akt

Component: pAkt

dd time pAkt = k1_Akt_phosphorylation pTrkA_Akt + k2_pAkt_S6 pAkt_S6 + k1_S6_phosphorylation pAkt_S6 - k1_pAkt_dephosphorylation pAkt + k1_pAkt_S6 pAkt S6

Component: pAkt_S6

dd time pAkt_S6 = k1_pAkt_S6 pAkt S6 - k2_pAkt_S6 pAkt_S6 + k1_S6_phosphorylation pAkt_S6

Component: S6

dd time S6 = k2_pAkt_S6 pAkt_S6 + k1_pS6_dephosphorylation pS6 - k1_pAkt_S6 pAkt S6

Component: pS6

dd time pS6 = k1_S6_phosphorylation pAkt_S6 - k1_pS6_dephosphorylation pS6

Component: pTrkA_total

pTrkA_total = pTrkA + pTrkA_Akt pTrkA_scalefactor

Component: pAkt_total

pAkt_total = pAkt + pAkt_S6 pAkt_scalefactor

Component: pS6_total

pS6_total = pS6 pS6_scalefactor

Component: model_parameters