SLC transporters

Energy-based bond graph models of glucose transport with SLC transporters

We present the parameterized bond graph models for facilitated diffusion with SLC2A2 (GLUT2) and electrogenic cotransport with SLC5A1 (SGLT1) transporters. The bond graph models are placed in the folders <Facilitated transporter> and <Electrogenic cotransporter>, respectively.

Facilitated transporter

The main CellML files are:

• The bond graph model GLUT2_BG.cellml parameterized to the kinetic data in Lowe and Walmsley (1986),
• The steady-state model derived from the bond graph with the variation of intracellular concentration of glucose GLUT2_ss_io.cellml,
• The steady-state model derived from the bond graph with the variation of extracellular concentration of glucose GLUT2_ss_oi.cellml,
• The steady-state kinetic models GLUT2_kinetic.cellml defined in Lowe and Walmsley (1986),
• The parameter file for the bond graph params_BG.cellml,
• The unit definition file units.cellml.

Electrogenic cotransporter

The main CellML files are:

• The bond graph model SGLT1_BG.cellml parameterized to the kinetic data in Parent et al (1992),
• The bond graph model with fast binding/unbinding parameters SGLT1_BG_fast.cellml,
• The steady-state model derived from the bond graph SGLT1_ss.cellml,
• The steady-state model with fast binding/unbinding parameters SGLT1_ss_fast.cellml,
• The parameter file for the bond graph model params_BG.cellml,
• The parameter file for the bond graph model with fast binding/unbinding parameters params_BG_fast.cellml,
• The unit definition file units.cellml.

The corresponding SED-ML files can be used to run simulations in OpenCOR.