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/* There are a total of 3 entries in the algebraic variable array. There are a total of 2 entries in each of the rate and state variable arrays. There are a total of 14 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is v0 in component parameters (micromolar_s). * CONSTANTS[1] is v1 in component parameters (micromolar_s). * ALGEBRAIC[0] is v2 in component parameters (micromolar_s). * ALGEBRAIC[1] is v3 in component parameters (micromolar_s). * ALGEBRAIC[2] is beta in component beta_pulse (dimensionless). * CONSTANTS[2] is VM2 in component parameters (micromolar_s). * CONSTANTS[3] is VM3 in component parameters (micromolar_s). * CONSTANTS[4] is KR in component parameters (micromolar). * CONSTANTS[5] is KA in component parameters (micromolar). * CONSTANTS[6] is kf in component parameters (per_second). * CONSTANTS[7] is k in component parameters (per_second). * CONSTANTS[8] is K2 in component parameters (micromolar). * CONSTANTS[9] is n in component parameters (dimensionless). * CONSTANTS[10] is m in component parameters (dimensionless). * CONSTANTS[11] is p in component parameters (dimensionless). * STATES[0] is Z in component cytosol (micromolar). * STATES[1] is Y in component insensitive_pool (micromolar). * CONSTANTS[12] is betaf in component beta_pulse (dimensionless). * CONSTANTS[13] is tp in component beta_pulse (second). * RATES[0] is d/dt Z in component cytosol (micromolar). * RATES[1] is d/dt Y in component insensitive_pool (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1; CONSTANTS[1] = 7.3; CONSTANTS[2] = 65; CONSTANTS[3] = 500; CONSTANTS[4] = 2; CONSTANTS[5] = 0.9; CONSTANTS[6] = 1; CONSTANTS[7] = 10; CONSTANTS[8] = 1; CONSTANTS[9] = 2; CONSTANTS[10] = 2; CONSTANTS[11] = 4; STATES[0] = 0.1; STATES[1] = 0.64; CONSTANTS[12] = 0.96; CONSTANTS[13] = 4; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[2]*pow(STATES[0], CONSTANTS[9]))/(pow(CONSTANTS[8], CONSTANTS[9])+pow(STATES[0], CONSTANTS[9])); ALGEBRAIC[1] = CONSTANTS[3]*(pow(STATES[1], CONSTANTS[10])/(pow(CONSTANTS[4], CONSTANTS[10])+pow(STATES[1], CONSTANTS[10])))*(pow(STATES[0], CONSTANTS[11])/(pow(CONSTANTS[5], CONSTANTS[11])+pow(STATES[0], CONSTANTS[11]))); RATES[1] = (ALGEBRAIC[0] - ALGEBRAIC[1]) - CONSTANTS[6]*STATES[1]; ALGEBRAIC[2] = (VOI<CONSTANTS[13] ? 0.00000 : VOI>=CONSTANTS[13] ? CONSTANTS[12]*exp( -0.200000*(VOI - CONSTANTS[13])) : 0.0/0.0); RATES[0] = (((CONSTANTS[0]+ CONSTANTS[1]*ALGEBRAIC[2]) - ALGEBRAIC[0])+ALGEBRAIC[1]+ CONSTANTS[6]*STATES[1]) - CONSTANTS[7]*STATES[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = ( CONSTANTS[2]*pow(STATES[0], CONSTANTS[9]))/(pow(CONSTANTS[8], CONSTANTS[9])+pow(STATES[0], CONSTANTS[9])); ALGEBRAIC[1] = CONSTANTS[3]*(pow(STATES[1], CONSTANTS[10])/(pow(CONSTANTS[4], CONSTANTS[10])+pow(STATES[1], CONSTANTS[10])))*(pow(STATES[0], CONSTANTS[11])/(pow(CONSTANTS[5], CONSTANTS[11])+pow(STATES[0], CONSTANTS[11]))); ALGEBRAIC[2] = (VOI<CONSTANTS[13] ? 0.00000 : VOI>=CONSTANTS[13] ? CONSTANTS[12]*exp( -0.200000*(VOI - CONSTANTS[13])) : 0.0/0.0); }