Luo, Rudy, 1991

Model Status

This model has been curated and unit checked and is known to replicate the published results in OpenCell and COR.

Model Structure

In 1991, Ching-hsing Luo and Yoram Rudy published a mathematical model of the ventricular cardiac action potential. This original model is the first of the two Luo-Rudy models, and it has subsequently come to be known as the Luo-Rudy I model. It is a significant update of the Beeler-Reuter mammalian ventricular model (1977) (see the figure below), and like the the Beeler-Reuter model, the Luo-Rudy I model uses Hodgkin-Huxley type equations to calculate ionic currents.

The complete original paper reference is cited below:

A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction, Ching-hsing Luo and Yoram Rudy, 1991 Circulation Research, 68, 1501-1526. PubMed ID: 1709839

A schematic diagram describing the current flows across the cell membrane that are captured in the LR-I model.