Generated Code

The following is python code generated by the CellML API from this CellML file. (Back to language selection)

The raw code is available.

# Size of variable arrays:
sizeAlgebraic = 70
sizeStates = 19
sizeConstants = 49
from math import *
from numpy import *

def createLegends():
    legend_states = [""] * sizeStates
    legend_rates = [""] * sizeStates
    legend_algebraic = [""] * sizeAlgebraic
    legend_voi = ""
    legend_constants = [""] * sizeConstants
    legend_voi = "time in component environment (millisecond)"
    legend_states[0] = "V in component membrane (millivolt)"
    legend_constants[0] = "R in component membrane (joule_per_mole_kelvin)"
    legend_constants[1] = "T in component membrane (kelvin)"
    legend_constants[2] = "F in component membrane (coulomb_per_millimole)"
    legend_constants[3] = "Cm in component membrane (microF)"
    legend_constants[4] = "V_c in component membrane (micrometre3)"
    legend_algebraic[47] = "i_K1 in component inward_rectifier_potassium_current (picoA_per_picoF)"
    legend_algebraic[54] = "i_to in component transient_outward_current (picoA_per_picoF)"
    legend_algebraic[48] = "i_Kr in component rapid_time_dependent_potassium_current (picoA_per_picoF)"
    legend_algebraic[49] = "i_Ks in component slow_time_dependent_potassium_current (picoA_per_picoF)"
    legend_algebraic[52] = "i_CaL in component L_type_Ca_current (picoA_per_picoF)"
    legend_algebraic[55] = "i_NaK in component sodium_potassium_pump_current (picoA_per_picoF)"
    legend_algebraic[50] = "i_Na in component fast_sodium_current (picoA_per_picoF)"
    legend_algebraic[51] = "i_b_Na in component sodium_background_current (picoA_per_picoF)"
    legend_algebraic[56] = "i_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF)"
    legend_algebraic[53] = "i_b_Ca in component calcium_background_current (picoA_per_picoF)"
    legend_algebraic[58] = "i_p_K in component potassium_pump_current (picoA_per_picoF)"
    legend_algebraic[57] = "i_p_Ca in component calcium_pump_current (picoA_per_picoF)"
    legend_algebraic[12] = "i_Stim in component membrane (picoA_per_picoF)"
    legend_algebraic[25] = "E_Na in component reversal_potentials (millivolt)"
    legend_algebraic[33] = "E_K in component reversal_potentials (millivolt)"
    legend_algebraic[41] = "E_Ks in component reversal_potentials (millivolt)"
    legend_algebraic[43] = "E_Ca in component reversal_potentials (millivolt)"
    legend_constants[5] = "P_kna in component reversal_potentials (dimensionless)"
    legend_constants[6] = "K_o in component potassium_dynamics (millimolar)"
    legend_constants[7] = "Na_o in component sodium_dynamics (millimolar)"
    legend_states[1] = "K_i in component potassium_dynamics (millimolar)"
    legend_states[2] = "Na_i in component sodium_dynamics (millimolar)"
    legend_constants[8] = "Ca_o in component calcium_dynamics (millimolar)"
    legend_states[3] = "Ca_i in component calcium_dynamics (millimolar)"
    legend_constants[9] = "g_K1 in component inward_rectifier_potassium_current (nanoS_per_picoF)"
    legend_algebraic[46] = "xK1_inf in component inward_rectifier_potassium_current (dimensionless)"
    legend_algebraic[44] = "alpha_K1 in component inward_rectifier_potassium_current (dimensionless)"
    legend_algebraic[45] = "beta_K1 in component inward_rectifier_potassium_current (dimensionless)"
    legend_constants[10] = "g_Kr in component rapid_time_dependent_potassium_current (nanoS_per_picoF)"
    legend_states[4] = "Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless)"
    legend_states[5] = "Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless)"
    legend_algebraic[0] = "xr1_inf in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless)"
    legend_algebraic[13] = "alpha_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless)"
    legend_algebraic[26] = "beta_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless)"
    legend_algebraic[34] = "tau_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (millisecond)"
    legend_algebraic[1] = "xr2_inf in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless)"
    legend_algebraic[14] = "alpha_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless)"
    legend_algebraic[27] = "beta_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless)"
    legend_algebraic[35] = "tau_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (millisecond)"
    legend_constants[11] = "g_Ks in component slow_time_dependent_potassium_current (nanoS_per_picoF)"
    legend_states[6] = "Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless)"
    legend_algebraic[2] = "xs_inf in component slow_time_dependent_potassium_current_Xs_gate (dimensionless)"
    legend_algebraic[15] = "alpha_xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless)"
    legend_algebraic[28] = "beta_xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless)"
    legend_algebraic[36] = "tau_xs in component slow_time_dependent_potassium_current_Xs_gate (millisecond)"
    legend_constants[12] = "g_Na in component fast_sodium_current (nanoS_per_picoF)"
    legend_states[7] = "m in component fast_sodium_current_m_gate (dimensionless)"
    legend_states[8] = "h in component fast_sodium_current_h_gate (dimensionless)"
    legend_states[9] = "j in component fast_sodium_current_j_gate (dimensionless)"
    legend_algebraic[3] = "m_inf in component fast_sodium_current_m_gate (dimensionless)"
    legend_algebraic[16] = "alpha_m in component fast_sodium_current_m_gate (dimensionless)"
    legend_algebraic[29] = "beta_m in component fast_sodium_current_m_gate (dimensionless)"
    legend_algebraic[37] = "tau_m in component fast_sodium_current_m_gate (millisecond)"
    legend_algebraic[4] = "h_inf in component fast_sodium_current_h_gate (dimensionless)"
    legend_algebraic[17] = "alpha_h in component fast_sodium_current_h_gate (per_millisecond)"
    legend_algebraic[30] = "beta_h in component fast_sodium_current_h_gate (per_millisecond)"
    legend_algebraic[38] = "tau_h in component fast_sodium_current_h_gate (millisecond)"
    legend_algebraic[5] = "j_inf in component fast_sodium_current_j_gate (dimensionless)"
    legend_algebraic[18] = "alpha_j in component fast_sodium_current_j_gate (per_millisecond)"
    legend_algebraic[31] = "beta_j in component fast_sodium_current_j_gate (per_millisecond)"
    legend_algebraic[39] = "tau_j in component fast_sodium_current_j_gate (millisecond)"
    legend_constants[13] = "g_bna in component sodium_background_current (nanoS_per_picoF)"
    legend_constants[14] = "g_CaL in component L_type_Ca_current (litre_per_farad_second)"
    legend_states[10] = "Ca_ss in component calcium_dynamics (millimolar)"
    legend_states[11] = "d in component L_type_Ca_current_d_gate (dimensionless)"
    legend_states[12] = "f in component L_type_Ca_current_f_gate (dimensionless)"
    legend_states[13] = "f2 in component L_type_Ca_current_f2_gate (dimensionless)"
    legend_states[14] = "fCass in component L_type_Ca_current_fCass_gate (dimensionless)"
    legend_algebraic[6] = "d_inf in component L_type_Ca_current_d_gate (dimensionless)"
    legend_algebraic[19] = "alpha_d in component L_type_Ca_current_d_gate (dimensionless)"
    legend_algebraic[32] = "beta_d in component L_type_Ca_current_d_gate (dimensionless)"
    legend_algebraic[40] = "gamma_d in component L_type_Ca_current_d_gate (millisecond)"
    legend_algebraic[42] = "tau_d in component L_type_Ca_current_d_gate (millisecond)"
    legend_algebraic[7] = "f_inf in component L_type_Ca_current_f_gate (dimensionless)"
    legend_algebraic[20] = "tau_f in component L_type_Ca_current_f_gate (millisecond)"
    legend_algebraic[8] = "f2_inf in component L_type_Ca_current_f2_gate (dimensionless)"
    legend_algebraic[21] = "tau_f2 in component L_type_Ca_current_f2_gate (millisecond)"
    legend_algebraic[9] = "fCass_inf in component L_type_Ca_current_fCass_gate (dimensionless)"
    legend_algebraic[22] = "tau_fCass in component L_type_Ca_current_fCass_gate (millisecond)"
    legend_constants[15] = "g_bca in component calcium_background_current (nanoS_per_picoF)"
    legend_constants[16] = "g_to in component transient_outward_current (nanoS_per_picoF)"
    legend_states[15] = "s in component transient_outward_current_s_gate (dimensionless)"
    legend_states[16] = "r in component transient_outward_current_r_gate (dimensionless)"
    legend_algebraic[10] = "s_inf in component transient_outward_current_s_gate (dimensionless)"
    legend_algebraic[23] = "tau_s in component transient_outward_current_s_gate (millisecond)"
    legend_algebraic[11] = "r_inf in component transient_outward_current_r_gate (dimensionless)"
    legend_algebraic[24] = "tau_r in component transient_outward_current_r_gate (millisecond)"
    legend_constants[17] = "P_NaK in component sodium_potassium_pump_current (picoA_per_picoF)"
    legend_constants[18] = "K_mk in component sodium_potassium_pump_current (millimolar)"
    legend_constants[19] = "K_mNa in component sodium_potassium_pump_current (millimolar)"
    legend_constants[20] = "K_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF)"
    legend_constants[21] = "K_sat in component sodium_calcium_exchanger_current (dimensionless)"
    legend_constants[22] = "alpha in component sodium_calcium_exchanger_current (dimensionless)"
    legend_constants[23] = "gamma in component sodium_calcium_exchanger_current (dimensionless)"
    legend_constants[24] = "Km_Ca in component sodium_calcium_exchanger_current (millimolar)"
    legend_constants[25] = "Km_Nai in component sodium_calcium_exchanger_current (millimolar)"
    legend_constants[26] = "g_pCa in component calcium_pump_current (picoA_per_picoF)"
    legend_constants[27] = "K_pCa in component calcium_pump_current (millimolar)"
    legend_constants[28] = "g_pK in component potassium_pump_current (nanoS_per_picoF)"
    legend_states[17] = "Ca_SR in component calcium_dynamics (millimolar)"
    legend_algebraic[67] = "i_rel in component calcium_dynamics (millimolar_per_millisecond)"
    legend_algebraic[59] = "i_up in component calcium_dynamics (millimolar_per_millisecond)"
    legend_algebraic[60] = "i_leak in component calcium_dynamics (millimolar_per_millisecond)"
    legend_algebraic[61] = "i_xfer in component calcium_dynamics (millimolar_per_millisecond)"
    legend_algebraic[66] = "O in component calcium_dynamics (dimensionless)"
    legend_states[18] = "R_prime in component calcium_dynamics (dimensionless)"
    legend_algebraic[64] = "k1 in component calcium_dynamics (per_millimolar2_per_millisecond)"
    legend_algebraic[65] = "k2 in component calcium_dynamics (per_millimolar_per_millisecond)"
    legend_constants[29] = "k1_prime in component calcium_dynamics (per_millimolar2_per_millisecond)"
    legend_constants[30] = "k2_prime in component calcium_dynamics (per_millimolar_per_millisecond)"
    legend_constants[31] = "k3 in component calcium_dynamics (per_millisecond)"
    legend_constants[32] = "k4 in component calcium_dynamics (per_millisecond)"
    legend_constants[33] = "EC in component calcium_dynamics (millimolar)"
    legend_constants[34] = "max_sr in component calcium_dynamics (dimensionless)"
    legend_constants[35] = "min_sr in component calcium_dynamics (dimensionless)"
    legend_algebraic[62] = "kcasr in component calcium_dynamics (dimensionless)"
    legend_constants[36] = "V_rel in component calcium_dynamics (per_millisecond)"
    legend_constants[37] = "V_xfer in component calcium_dynamics (per_millisecond)"
    legend_constants[38] = "K_up in component calcium_dynamics (millimolar)"
    legend_constants[39] = "V_leak in component calcium_dynamics (per_millisecond)"
    legend_constants[40] = "Vmax_up in component calcium_dynamics (millimolar_per_millisecond)"
    legend_algebraic[63] = "Ca_i_bufc in component calcium_dynamics (dimensionless)"
    legend_algebraic[68] = "Ca_sr_bufsr in component calcium_dynamics (dimensionless)"
    legend_algebraic[69] = "Ca_ss_bufss in component calcium_dynamics (dimensionless)"
    legend_constants[41] = "Buf_c in component calcium_dynamics (millimolar)"
    legend_constants[42] = "K_buf_c in component calcium_dynamics (millimolar)"
    legend_constants[43] = "Buf_sr in component calcium_dynamics (millimolar)"
    legend_constants[44] = "K_buf_sr in component calcium_dynamics (millimolar)"
    legend_constants[45] = "Buf_ss in component calcium_dynamics (millimolar)"
    legend_constants[46] = "K_buf_ss in component calcium_dynamics (millimolar)"
    legend_constants[47] = "V_sr in component calcium_dynamics (micrometre3)"
    legend_constants[48] = "V_ss in component calcium_dynamics (micrometre3)"
    legend_rates[0] = "d/dt V in component membrane (millivolt)"
    legend_rates[4] = "d/dt Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless)"
    legend_rates[5] = "d/dt Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless)"
    legend_rates[6] = "d/dt Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless)"
    legend_rates[7] = "d/dt m in component fast_sodium_current_m_gate (dimensionless)"
    legend_rates[8] = "d/dt h in component fast_sodium_current_h_gate (dimensionless)"
    legend_rates[9] = "d/dt j in component fast_sodium_current_j_gate (dimensionless)"
    legend_rates[11] = "d/dt d in component L_type_Ca_current_d_gate (dimensionless)"
    legend_rates[12] = "d/dt f in component L_type_Ca_current_f_gate (dimensionless)"
    legend_rates[13] = "d/dt f2 in component L_type_Ca_current_f2_gate (dimensionless)"
    legend_rates[14] = "d/dt fCass in component L_type_Ca_current_fCass_gate (dimensionless)"
    legend_rates[15] = "d/dt s in component transient_outward_current_s_gate (dimensionless)"
    legend_rates[16] = "d/dt r in component transient_outward_current_r_gate (dimensionless)"
    legend_rates[18] = "d/dt R_prime in component calcium_dynamics (dimensionless)"
    legend_rates[3] = "d/dt Ca_i in component calcium_dynamics (millimolar)"
    legend_rates[17] = "d/dt Ca_SR in component calcium_dynamics (millimolar)"
    legend_rates[10] = "d/dt Ca_ss in component calcium_dynamics (millimolar)"
    legend_rates[2] = "d/dt Na_i in component sodium_dynamics (millimolar)"
    legend_rates[1] = "d/dt K_i in component potassium_dynamics (millimolar)"
    return (legend_states, legend_algebraic, legend_voi, legend_constants)

def initConsts():
    constants = [0.0] * sizeConstants; states = [0.0] * sizeStates;
    states[0] = -86.709
    constants[0] = 8314.472
    constants[1] = 310
    constants[2] = 96485.3415
    constants[3] = 0.185
    constants[4] = 0.016404
    constants[5] = 0.03
    constants[6] = 5.4
    constants[7] = 140
    states[1] = 138.4
    states[2] = 10.355
    constants[8] = 2
    states[3] = 0.00013
    constants[9] = 5.405
    constants[10] = 0.153
    states[4] = 0.00448
    states[5] = 0.476
    constants[11] = 0.392
    states[6] = 0.0087
    constants[12] = 14.838
    states[7] = 0.00155
    states[8] = 0.7573
    states[9] = 0.7225
    constants[13] = 0.00029
    constants[14] = 0.0000398
    states[10] = 0.00036
    states[11] = 3.164e-5
    states[12] = 0.8009
    states[13] = 0.9778
    states[14] = 0.9953
    constants[15] = 0.000592
    constants[16] = 0.073
    states[15] = 0.3212
    states[16] = 2.235e-8
    constants[17] = 2.724
    constants[18] = 1
    constants[19] = 40
    constants[20] = 1000
    constants[21] = 0.1
    constants[22] = 2.5
    constants[23] = 0.35
    constants[24] = 1.38
    constants[25] = 87.5
    constants[26] = 0.1238
    constants[27] = 0.0005
    constants[28] = 0.0146
    states[17] = 3.715
    states[18] = 0.9068
    constants[29] = 0.15
    constants[30] = 0.045
    constants[31] = 0.06
    constants[32] = 0.005
    constants[33] = 1.5
    constants[34] = 2.5
    constants[35] = 1
    constants[36] = 0.102
    constants[37] = 0.0038
    constants[38] = 0.00025
    constants[39] = 0.00036
    constants[40] = 0.006375
    constants[41] = 0.2
    constants[42] = 0.001
    constants[43] = 10
    constants[44] = 0.3
    constants[45] = 0.4
    constants[46] = 0.00025
    constants[47] = 0.001094
    constants[48] = 0.00005468
    return (states, constants)

def computeRates(voi, states, constants):
    rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic
    algebraic[7] = 1.00000/(1.00000+exp((states[0]+20.0000)/7.00000))
    algebraic[20] = 1102.50*exp(-(power(states[0]+27.0000, 2.00000))/225.000)+200.000/(1.00000+exp((13.0000-states[0])/10.0000))+180.000/(1.00000+exp((states[0]+30.0000)/10.0000))+20.0000
    rates[12] = (algebraic[7]-states[12])/algebraic[20]
    algebraic[8] = 0.670000/(1.00000+exp((states[0]+35.0000)/7.00000))+0.330000
    algebraic[21] = 562.000*exp(-(power(states[0]+27.0000, 2.00000))/240.000)+31.0000/(1.00000+exp((25.0000-states[0])/10.0000))+80.0000/(1.00000+exp((states[0]+30.0000)/10.0000))
    rates[13] = (algebraic[8]-states[13])/algebraic[21]
    algebraic[9] = 0.600000/(1.00000+power(states[10]/0.0500000, 2.00000))+0.400000
    algebraic[22] = 80.0000/(1.00000+power(states[10]/0.0500000, 2.00000))+2.00000
    rates[14] = (algebraic[9]-states[14])/algebraic[22]
    algebraic[10] = 1.00000/(1.00000+exp((states[0]+28.0000)/5.00000))
    algebraic[23] = 1000.00*exp(-(power(states[0]+67.0000, 2.00000))/1000.00)+8.00000
    rates[15] = (algebraic[10]-states[15])/algebraic[23]
    algebraic[11] = 1.00000/(1.00000+exp((20.0000-states[0])/6.00000))
    algebraic[24] = 9.50000*exp(-(power(states[0]+40.0000, 2.00000))/1800.00)+0.800000
    rates[16] = (algebraic[11]-states[16])/algebraic[24]
    algebraic[0] = 1.00000/(1.00000+exp((-26.0000-states[0])/7.00000))
    algebraic[13] = 450.000/(1.00000+exp((-45.0000-states[0])/10.0000))
    algebraic[26] = 6.00000/(1.00000+exp((states[0]+30.0000)/11.5000))
    algebraic[34] = 1.00000*algebraic[13]*algebraic[26]
    rates[4] = (algebraic[0]-states[4])/algebraic[34]
    algebraic[1] = 1.00000/(1.00000+exp((states[0]+88.0000)/24.0000))
    algebraic[14] = 3.00000/(1.00000+exp((-60.0000-states[0])/20.0000))
    algebraic[27] = 1.12000/(1.00000+exp((states[0]-60.0000)/20.0000))
    algebraic[35] = 1.00000*algebraic[14]*algebraic[27]
    rates[5] = (algebraic[1]-states[5])/algebraic[35]
    algebraic[2] = 1.00000/(1.00000+exp((-5.00000-states[0])/14.0000))
    algebraic[15] = 1400.00/(power(1.00000+exp((5.00000-states[0])/6.00000), 1.0/2))
    algebraic[28] = 1.00000/(1.00000+exp((states[0]-35.0000)/15.0000))
    algebraic[36] = 1.00000*algebraic[15]*algebraic[28]+80.0000
    rates[6] = (algebraic[2]-states[6])/algebraic[36]
    algebraic[3] = 1.00000/(power(1.00000+exp((-56.8600-states[0])/9.03000), 2.00000))
    algebraic[16] = 1.00000/(1.00000+exp((-60.0000-states[0])/5.00000))
    algebraic[29] = 0.100000/(1.00000+exp((states[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((states[0]-50.0000)/200.000))
    algebraic[37] = 1.00000*algebraic[16]*algebraic[29]
    rates[7] = (algebraic[3]-states[7])/algebraic[37]
    algebraic[4] = 1.00000/(power(1.00000+exp((states[0]+71.5500)/7.43000), 2.00000))
    algebraic[17] = custom_piecewise([less(states[0] , -40.0000), 0.0570000*exp(-(states[0]+80.0000)/6.80000) , True, 0.00000])
    algebraic[30] = custom_piecewise([less(states[0] , -40.0000), 2.70000*exp(0.0790000*states[0])+310000.*exp(0.348500*states[0]) , True, 0.770000/(0.130000*(1.00000+exp((states[0]+10.6600)/-11.1000)))])
    algebraic[38] = 1.00000/(algebraic[17]+algebraic[30])
    rates[8] = (algebraic[4]-states[8])/algebraic[38]
    algebraic[5] = 1.00000/(power(1.00000+exp((states[0]+71.5500)/7.43000), 2.00000))
    algebraic[18] = custom_piecewise([less(states[0] , -40.0000), (((-25428.0*exp(0.244400*states[0])-6.94800e-06*exp(-0.0439100*states[0]))*(states[0]+37.7800))/1.00000)/(1.00000+exp(0.311000*(states[0]+79.2300))) , True, 0.00000])
    algebraic[31] = custom_piecewise([less(states[0] , -40.0000), (0.0242400*exp(-0.0105200*states[0]))/(1.00000+exp(-0.137800*(states[0]+40.1400))) , True, (0.600000*exp(0.0570000*states[0]))/(1.00000+exp(-0.100000*(states[0]+32.0000)))])
    algebraic[39] = 1.00000/(algebraic[18]+algebraic[31])
    rates[9] = (algebraic[5]-states[9])/algebraic[39]
    algebraic[6] = 1.00000/(1.00000+exp((-8.00000-states[0])/7.50000))
    algebraic[19] = 1.40000/(1.00000+exp((-35.0000-states[0])/13.0000))+0.250000
    algebraic[32] = 1.40000/(1.00000+exp((states[0]+5.00000)/5.00000))
    algebraic[40] = 1.00000/(1.00000+exp((50.0000-states[0])/20.0000))
    algebraic[42] = 1.00000*algebraic[19]*algebraic[32]+algebraic[40]
    rates[11] = (algebraic[6]-states[11])/algebraic[42]
    algebraic[55] = ((((constants[17]*constants[6])/(constants[6]+constants[18]))*states[2])/(states[2]+constants[19]))/(1.00000+0.124500*exp((-0.100000*states[0]*constants[2])/(constants[0]*constants[1]))+0.0353000*exp((-states[0]*constants[2])/(constants[0]*constants[1])))
    algebraic[25] = ((constants[0]*constants[1])/constants[2])*log(constants[7]/states[2])
    algebraic[50] = constants[12]*(power(states[7], 3.00000))*states[8]*states[9]*(states[0]-algebraic[25])
    algebraic[51] = constants[13]*(states[0]-algebraic[25])
    algebraic[56] = (constants[20]*(exp((constants[23]*states[0]*constants[2])/(constants[0]*constants[1]))*(power(states[2], 3.00000))*constants[8]-exp(((constants[23]-1.00000)*states[0]*constants[2])/(constants[0]*constants[1]))*(power(constants[7], 3.00000))*states[3]*constants[22]))/((power(constants[25], 3.00000)+power(constants[7], 3.00000))*(constants[24]+constants[8])*(1.00000+constants[21]*exp(((constants[23]-1.00000)*states[0]*constants[2])/(constants[0]*constants[1]))))
    rates[2] = ((-1.00000*(algebraic[50]+algebraic[51]+3.00000*algebraic[55]+3.00000*algebraic[56]))/(1.00000*constants[4]*constants[2]))*constants[3]
    algebraic[33] = ((constants[0]*constants[1])/constants[2])*log(constants[6]/states[1])
    algebraic[44] = 0.100000/(1.00000+exp(0.0600000*((states[0]-algebraic[33])-200.000)))
    algebraic[45] = (3.00000*exp(0.000200000*((states[0]-algebraic[33])+100.000))+exp(0.100000*((states[0]-algebraic[33])-10.0000)))/(1.00000+exp(-0.500000*(states[0]-algebraic[33])))
    algebraic[46] = algebraic[44]/(algebraic[44]+algebraic[45])
    algebraic[47] = constants[9]*algebraic[46]*(power(constants[6]/5.40000, 1.0/2))*(states[0]-algebraic[33])
    algebraic[54] = constants[16]*states[16]*states[15]*(states[0]-algebraic[33])
    algebraic[48] = constants[10]*(power(constants[6]/5.40000, 1.0/2))*states[4]*states[5]*(states[0]-algebraic[33])
    algebraic[41] = ((constants[0]*constants[1])/constants[2])*log((constants[6]+constants[5]*constants[7])/(states[1]+constants[5]*states[2]))
    algebraic[49] = constants[11]*(power(states[6], 2.00000))*(states[0]-algebraic[41])
    algebraic[52] = (((constants[14]*states[11]*states[12]*states[13]*states[14]*4.00000*(states[0]-15.0000)*(power(constants[2], 2.00000)))/(constants[0]*constants[1]))*(0.250000*states[10]*exp((2.00000*(states[0]-15.0000)*constants[2])/(constants[0]*constants[1]))-constants[8]))/(exp((2.00000*(states[0]-15.0000)*constants[2])/(constants[0]*constants[1]))-1.00000)
    algebraic[43] = ((0.500000*constants[0]*constants[1])/constants[2])*log(constants[8]/states[3])
    algebraic[53] = constants[15]*(states[0]-algebraic[43])
    algebraic[58] = (constants[28]*(states[0]-algebraic[33]))/(1.00000+exp((25.0000-states[0])/5.98000))
    algebraic[57] = (constants[26]*states[3])/(states[3]+constants[27])
    algebraic[12] = custom_piecewise([greater_equal(voi , 100.000) & less_equal(voi , 101.000), -52.0000 , True, 0.00000])
    rates[0] = (-1.00000/1.00000)*(algebraic[47]+algebraic[54]+algebraic[48]+algebraic[49]+algebraic[52]+algebraic[55]+algebraic[50]+algebraic[51]+algebraic[56]+algebraic[53]+algebraic[58]+algebraic[57]+algebraic[12])
    rates[1] = ((-1.00000*((algebraic[47]+algebraic[54]+algebraic[48]+algebraic[49]+algebraic[58]+algebraic[12])-2.00000*algebraic[55]))/(1.00000*constants[4]*constants[2]))*constants[3]
    algebraic[59] = constants[40]/(1.00000+(power(constants[38], 2.00000))/(power(states[3], 2.00000)))
    algebraic[60] = constants[39]*(states[17]-states[3])
    algebraic[61] = constants[37]*(states[10]-states[3])
    algebraic[63] = 1.00000/(1.00000+(constants[41]*constants[42])/(power(states[3]+constants[42], 2.00000)))
    rates[3] = algebraic[63]*((((algebraic[60]-algebraic[59])*constants[47])/constants[4]+algebraic[61])-(1.00000*((algebraic[53]+algebraic[57])-2.00000*algebraic[56])*constants[3])/(2.00000*1.00000*constants[4]*constants[2]))
    algebraic[62] = constants[34]-(constants[34]-constants[35])/(1.00000+power(constants[33]/states[17], 2.00000))
    algebraic[65] = constants[30]*algebraic[62]
    rates[18] = -algebraic[65]*states[10]*states[18]+constants[32]*(1.00000-states[18])
    algebraic[64] = constants[29]/algebraic[62]
    algebraic[66] = (algebraic[64]*(power(states[10], 2.00000))*states[18])/(constants[31]+algebraic[64]*(power(states[10], 2.00000)))
    algebraic[67] = constants[36]*algebraic[66]*(states[17]-states[10])
    algebraic[68] = 1.00000/(1.00000+(constants[43]*constants[44])/(power(states[17]+constants[44], 2.00000)))
    rates[17] = algebraic[68]*(algebraic[59]-(algebraic[67]+algebraic[60]))
    algebraic[69] = 1.00000/(1.00000+(constants[45]*constants[46])/(power(states[10]+constants[46], 2.00000)))
    rates[10] = algebraic[69]*(((-1.00000*algebraic[52]*constants[3])/(2.00000*1.00000*constants[48]*constants[2])+(algebraic[67]*constants[47])/constants[48])-(algebraic[61]*constants[4])/constants[48])
    return(rates)

def computeAlgebraic(constants, states, voi):
    algebraic = array([[0.0] * len(voi)] * sizeAlgebraic)
    states = array(states)
    voi = array(voi)
    algebraic[7] = 1.00000/(1.00000+exp((states[0]+20.0000)/7.00000))
    algebraic[20] = 1102.50*exp(-(power(states[0]+27.0000, 2.00000))/225.000)+200.000/(1.00000+exp((13.0000-states[0])/10.0000))+180.000/(1.00000+exp((states[0]+30.0000)/10.0000))+20.0000
    algebraic[8] = 0.670000/(1.00000+exp((states[0]+35.0000)/7.00000))+0.330000
    algebraic[21] = 562.000*exp(-(power(states[0]+27.0000, 2.00000))/240.000)+31.0000/(1.00000+exp((25.0000-states[0])/10.0000))+80.0000/(1.00000+exp((states[0]+30.0000)/10.0000))
    algebraic[9] = 0.600000/(1.00000+power(states[10]/0.0500000, 2.00000))+0.400000
    algebraic[22] = 80.0000/(1.00000+power(states[10]/0.0500000, 2.00000))+2.00000
    algebraic[10] = 1.00000/(1.00000+exp((states[0]+28.0000)/5.00000))
    algebraic[23] = 1000.00*exp(-(power(states[0]+67.0000, 2.00000))/1000.00)+8.00000
    algebraic[11] = 1.00000/(1.00000+exp((20.0000-states[0])/6.00000))
    algebraic[24] = 9.50000*exp(-(power(states[0]+40.0000, 2.00000))/1800.00)+0.800000
    algebraic[0] = 1.00000/(1.00000+exp((-26.0000-states[0])/7.00000))
    algebraic[13] = 450.000/(1.00000+exp((-45.0000-states[0])/10.0000))
    algebraic[26] = 6.00000/(1.00000+exp((states[0]+30.0000)/11.5000))
    algebraic[34] = 1.00000*algebraic[13]*algebraic[26]
    algebraic[1] = 1.00000/(1.00000+exp((states[0]+88.0000)/24.0000))
    algebraic[14] = 3.00000/(1.00000+exp((-60.0000-states[0])/20.0000))
    algebraic[27] = 1.12000/(1.00000+exp((states[0]-60.0000)/20.0000))
    algebraic[35] = 1.00000*algebraic[14]*algebraic[27]
    algebraic[2] = 1.00000/(1.00000+exp((-5.00000-states[0])/14.0000))
    algebraic[15] = 1400.00/(power(1.00000+exp((5.00000-states[0])/6.00000), 1.0/2))
    algebraic[28] = 1.00000/(1.00000+exp((states[0]-35.0000)/15.0000))
    algebraic[36] = 1.00000*algebraic[15]*algebraic[28]+80.0000
    algebraic[3] = 1.00000/(power(1.00000+exp((-56.8600-states[0])/9.03000), 2.00000))
    algebraic[16] = 1.00000/(1.00000+exp((-60.0000-states[0])/5.00000))
    algebraic[29] = 0.100000/(1.00000+exp((states[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((states[0]-50.0000)/200.000))
    algebraic[37] = 1.00000*algebraic[16]*algebraic[29]
    algebraic[4] = 1.00000/(power(1.00000+exp((states[0]+71.5500)/7.43000), 2.00000))
    algebraic[17] = custom_piecewise([less(states[0] , -40.0000), 0.0570000*exp(-(states[0]+80.0000)/6.80000) , True, 0.00000])
    algebraic[30] = custom_piecewise([less(states[0] , -40.0000), 2.70000*exp(0.0790000*states[0])+310000.*exp(0.348500*states[0]) , True, 0.770000/(0.130000*(1.00000+exp((states[0]+10.6600)/-11.1000)))])
    algebraic[38] = 1.00000/(algebraic[17]+algebraic[30])
    algebraic[5] = 1.00000/(power(1.00000+exp((states[0]+71.5500)/7.43000), 2.00000))
    algebraic[18] = custom_piecewise([less(states[0] , -40.0000), (((-25428.0*exp(0.244400*states[0])-6.94800e-06*exp(-0.0439100*states[0]))*(states[0]+37.7800))/1.00000)/(1.00000+exp(0.311000*(states[0]+79.2300))) , True, 0.00000])
    algebraic[31] = custom_piecewise([less(states[0] , -40.0000), (0.0242400*exp(-0.0105200*states[0]))/(1.00000+exp(-0.137800*(states[0]+40.1400))) , True, (0.600000*exp(0.0570000*states[0]))/(1.00000+exp(-0.100000*(states[0]+32.0000)))])
    algebraic[39] = 1.00000/(algebraic[18]+algebraic[31])
    algebraic[6] = 1.00000/(1.00000+exp((-8.00000-states[0])/7.50000))
    algebraic[19] = 1.40000/(1.00000+exp((-35.0000-states[0])/13.0000))+0.250000
    algebraic[32] = 1.40000/(1.00000+exp((states[0]+5.00000)/5.00000))
    algebraic[40] = 1.00000/(1.00000+exp((50.0000-states[0])/20.0000))
    algebraic[42] = 1.00000*algebraic[19]*algebraic[32]+algebraic[40]
    algebraic[55] = ((((constants[17]*constants[6])/(constants[6]+constants[18]))*states[2])/(states[2]+constants[19]))/(1.00000+0.124500*exp((-0.100000*states[0]*constants[2])/(constants[0]*constants[1]))+0.0353000*exp((-states[0]*constants[2])/(constants[0]*constants[1])))
    algebraic[25] = ((constants[0]*constants[1])/constants[2])*log(constants[7]/states[2])
    algebraic[50] = constants[12]*(power(states[7], 3.00000))*states[8]*states[9]*(states[0]-algebraic[25])
    algebraic[51] = constants[13]*(states[0]-algebraic[25])
    algebraic[56] = (constants[20]*(exp((constants[23]*states[0]*constants[2])/(constants[0]*constants[1]))*(power(states[2], 3.00000))*constants[8]-exp(((constants[23]-1.00000)*states[0]*constants[2])/(constants[0]*constants[1]))*(power(constants[7], 3.00000))*states[3]*constants[22]))/((power(constants[25], 3.00000)+power(constants[7], 3.00000))*(constants[24]+constants[8])*(1.00000+constants[21]*exp(((constants[23]-1.00000)*states[0]*constants[2])/(constants[0]*constants[1]))))
    algebraic[33] = ((constants[0]*constants[1])/constants[2])*log(constants[6]/states[1])
    algebraic[44] = 0.100000/(1.00000+exp(0.0600000*((states[0]-algebraic[33])-200.000)))
    algebraic[45] = (3.00000*exp(0.000200000*((states[0]-algebraic[33])+100.000))+exp(0.100000*((states[0]-algebraic[33])-10.0000)))/(1.00000+exp(-0.500000*(states[0]-algebraic[33])))
    algebraic[46] = algebraic[44]/(algebraic[44]+algebraic[45])
    algebraic[47] = constants[9]*algebraic[46]*(power(constants[6]/5.40000, 1.0/2))*(states[0]-algebraic[33])
    algebraic[54] = constants[16]*states[16]*states[15]*(states[0]-algebraic[33])
    algebraic[48] = constants[10]*(power(constants[6]/5.40000, 1.0/2))*states[4]*states[5]*(states[0]-algebraic[33])
    algebraic[41] = ((constants[0]*constants[1])/constants[2])*log((constants[6]+constants[5]*constants[7])/(states[1]+constants[5]*states[2]))
    algebraic[49] = constants[11]*(power(states[6], 2.00000))*(states[0]-algebraic[41])
    algebraic[52] = (((constants[14]*states[11]*states[12]*states[13]*states[14]*4.00000*(states[0]-15.0000)*(power(constants[2], 2.00000)))/(constants[0]*constants[1]))*(0.250000*states[10]*exp((2.00000*(states[0]-15.0000)*constants[2])/(constants[0]*constants[1]))-constants[8]))/(exp((2.00000*(states[0]-15.0000)*constants[2])/(constants[0]*constants[1]))-1.00000)
    algebraic[43] = ((0.500000*constants[0]*constants[1])/constants[2])*log(constants[8]/states[3])
    algebraic[53] = constants[15]*(states[0]-algebraic[43])
    algebraic[58] = (constants[28]*(states[0]-algebraic[33]))/(1.00000+exp((25.0000-states[0])/5.98000))
    algebraic[57] = (constants[26]*states[3])/(states[3]+constants[27])
    algebraic[12] = custom_piecewise([greater_equal(voi , 100.000) & less_equal(voi , 101.000), -52.0000 , True, 0.00000])
    algebraic[59] = constants[40]/(1.00000+(power(constants[38], 2.00000))/(power(states[3], 2.00000)))
    algebraic[60] = constants[39]*(states[17]-states[3])
    algebraic[61] = constants[37]*(states[10]-states[3])
    algebraic[63] = 1.00000/(1.00000+(constants[41]*constants[42])/(power(states[3]+constants[42], 2.00000)))
    algebraic[62] = constants[34]-(constants[34]-constants[35])/(1.00000+power(constants[33]/states[17], 2.00000))
    algebraic[65] = constants[30]*algebraic[62]
    algebraic[64] = constants[29]/algebraic[62]
    algebraic[66] = (algebraic[64]*(power(states[10], 2.00000))*states[18])/(constants[31]+algebraic[64]*(power(states[10], 2.00000)))
    algebraic[67] = constants[36]*algebraic[66]*(states[17]-states[10])
    algebraic[68] = 1.00000/(1.00000+(constants[43]*constants[44])/(power(states[17]+constants[44], 2.00000)))
    algebraic[69] = 1.00000/(1.00000+(constants[45]*constants[46])/(power(states[10]+constants[46], 2.00000)))
    return algebraic

def custom_piecewise(cases):
    """Compute result of a piecewise function"""
    return select(cases[0::2],cases[1::2])

def solve_model():
    """Solve model with ODE solver"""
    from scipy.integrate import ode
    # Initialise constants and state variables
    (init_states, constants) = initConsts()

    # Set timespan to solve over
    voi = linspace(0, 10, 500)

    # Construct ODE object to solve
    r = ode(computeRates)
    r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1)
    r.set_initial_value(init_states, voi[0])
    r.set_f_params(constants)

    # Solve model
    states = array([[0.0] * len(voi)] * sizeStates)
    states[:,0] = init_states
    for (i,t) in enumerate(voi[1:]):
        if r.successful():
            r.integrate(t)
            states[:,i+1] = r.y
        else:
            break

    # Compute algebraic variables
    algebraic = computeAlgebraic(constants, states, voi)
    return (voi, states, algebraic)

def plot_model(voi, states, algebraic):
    """Plot variables against variable of integration"""
    import pylab
    (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends()
    pylab.figure(1)
    pylab.plot(voi,vstack((states,algebraic)).T)
    pylab.xlabel(legend_voi)
    pylab.legend(legend_states + legend_algebraic, loc='best')
    pylab.show()

if __name__ == "__main__":
    (voi, states, algebraic) = solve_model()
    plot_model(voi, states, algebraic)