Colegrove, Albrecht, Friel, 2000
This model can not be solved as it is unsuitably constrained.
ValidateCellML verifies this model as valid CellML with consistent units.
One of the central goals in the study of calcium signalling is to understand the basis of [Ca2+] dynamics. This is complicated by the fact that Ca2+ is present in several membrane-bound intracellular compartments, each of which uses a distinct Ca2+ transport system and the rate of Ca2+ transport between these compartments can exhibit a complex non-linear dependence on free [Ca2+].
In their 2000 model, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel have studied how mitochondrial Ca2+ transport contributes to the redistribution of intracellular Ca2+ during and after depolarisation-evoked Ca2+ entry in sympathetic neurons. The total Ca2+ flux during the recovery phase following membrane depolarisation was divided into three components (see the figure below): one representing net Ca2+ extrusion across the plasma membrane (Jextru), one representing mitochondrial Ca2+ uptake via the uniporter (Juni) and one representing mitochondrial Ca2+ release via the Na+/Ca2+ exchanger (JNaCa). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in .
The complete original paper reference is cited below:
Quantitative Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations , Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel, 2000, The Journal Of General Physiology , 115, 371-388. PubMed ID: 10694264
|Schematic of the model indicating Ca2+ compartmentalization in the extracellular matrix, cytosol and the mitochondrial matrix and pathways for Ca2+ ion movement between the compartments.|