Magnus, Keizer, 1997
This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.
In 1997 Gerhard Magnus and Joel Keizer published a minimal mathematical model to describe Ca2+ handling by mitochondria in the pancreatic beta-cell. Their kinetic model includes six transport mechanisms in the inner mitochondrial membrane, including proton pumping via respiration and proton pumping by the F0F1-ATPase, a proton leak, adenine nucleotide exchange, the Ca2+ uniporter and Na+/Ca2+ exchange (see the figure below).
The complete original paper reference is cited below:
The raw CellML description of the mitochondrial Ca2+ handling model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.
|A schematic representation of the ion fluxes through the mitochondrial inner membrane that are included in the Magnus-Keizer minimal model.|
|The network defined in the CellML description of the mitochondrial Ca2+ handling model.|