Noble, Noble, 1984

Model Status

This model has been curated by Penny Noble of Oxford University and is known to run in PCEnv and COR and reproduce the results published in the paper it is based on.

Model Structure

In 1984 D. Noble and S.J. Noble published a mathematical model which describes electrical activity in the sino-atrial node. Their model is based on the Purkinje fibre model developed by D. DiFrancesco and D. Noble (please see the CellML version of the DiFrancesco-Noble Purkinje Fibre Model, 1985). Most of the equations of this cardiac cell model remain unchanged. However, based on the results of experimental work, where necessary, certain parameters have been modified in order to make the model appropriate to a sino-atrial node.

The complete original paper reference is cited below:

A Model of Sino-Atrial Node Electrical Activity Based on a Modification of the DiFrancesco-Noble (1984) Equations, D. Noble and S.J. Noble,Proceedings of the Royal Society of London. Series B, Biological Sciences, 222, 295-304. PubMed ID: 6149553

A schematic diagram describing the current flows across the cell membrane that are captured in the NN SAN model.

The network defined in the CellML description of the Noble-Noble SAN model. For simplicity, not all the variables are shown.