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/* There are a total of 7 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 17 entries in the constant variable array. */ /* * VOI is time in component environment (second). * ALGEBRAIC[0] is Ca_Pr in component total_calcium (micromolar). * CONSTANTS[0] is Ca_tot in component total_calcium (micromolar). * CONSTANTS[1] is rho_ER in component ER_calcium (dimensionless). * CONSTANTS[2] is beta_ER in component ER_calcium (dimensionless). * CONSTANTS[3] is rho_m in component mitochondrial_calcium (dimensionless). * CONSTANTS[4] is beta_m in component mitochondrial_calcium (dimensionless). * STATES[0] is Ca_cyt in component cytosolic_calcium (micromolar). * STATES[1] is Ca_ER in component ER_calcium (micromolar). * STATES[2] is Ca_m in component mitochondrial_calcium (micromolar). * ALGEBRAIC[1] is Pr in component total_protein (micromolar). * CONSTANTS[5] is Pr_tot in component total_protein (micromolar). * CONSTANTS[6] is k_plus in component cytosolic_calcium (second_order_rate_constant). * CONSTANTS[7] is k_minus in component cytosolic_calcium (first_order_rate_constant). * ALGEBRAIC[3] is J_ch in component Ca_efflux_from_the_ER (flux). * ALGEBRAIC[4] is J_leak in component Ca_leak_flux_from_the_ER (flux). * ALGEBRAIC[2] is J_pump in component ATP_dependent_Ca_uptake_into_the_ER (flux). * ALGEBRAIC[6] is J_out in component mitochondrial_Ca_release (flux). * ALGEBRAIC[5] is J_in in component mitochondrial_Ca_uptake (flux). * CONSTANTS[8] is k_pump in component ATP_dependent_Ca_uptake_into_the_ER (first_order_rate_constant). * CONSTANTS[9] is k_ch in component Ca_efflux_from_the_ER (first_order_rate_constant). * CONSTANTS[10] is K1 in component Ca_efflux_from_the_ER (micromolar). * CONSTANTS[11] is k_leak in component Ca_leak_flux_from_the_ER (first_order_rate_constant). * CONSTANTS[12] is k_in in component mitochondrial_Ca_uptake (flux). * CONSTANTS[13] is K2 in component mitochondrial_Ca_uptake (micromolar). * CONSTANTS[14] is k_out in component mitochondrial_Ca_release (first_order_rate_constant). * CONSTANTS[15] is k_m in component mitochondrial_Ca_release (first_order_rate_constant). * CONSTANTS[16] is K3 in component mitochondrial_Ca_release (micromolar). * RATES[0] is d/dt Ca_cyt in component cytosolic_calcium (micromolar). * RATES[1] is d/dt Ca_ER in component ER_calcium (micromolar). * RATES[2] is d/dt Ca_m in component mitochondrial_calcium (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 90.0; CONSTANTS[1] = 0.01; CONSTANTS[2] = 0.0025; CONSTANTS[3] = 0.01; CONSTANTS[4] = 0.0025; STATES[0] = 0.05; STATES[1] = 1.0; STATES[2] = 0.4; CONSTANTS[5] = 120.0; CONSTANTS[6] = 0.1; CONSTANTS[7] = 0.01; CONSTANTS[8] = 20.0; CONSTANTS[9] = 4100.0; CONSTANTS[10] = 5.0; CONSTANTS[11] = 0.05; CONSTANTS[12] = 300.0; CONSTANTS[13] = 0.8; CONSTANTS[14] = 125.0; CONSTANTS[15] = 0.00625; CONSTANTS[16] = 5.0; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = CONSTANTS[9]*(pow(STATES[0], 2.00000)/(pow(CONSTANTS[10], 2.00000)+pow(STATES[0], 2.00000)))*(STATES[1] - STATES[0]); ALGEBRAIC[4] = CONSTANTS[11]*(STATES[1] - STATES[0]); ALGEBRAIC[2] = CONSTANTS[8]*STATES[0]; RATES[1] = (CONSTANTS[2]/CONSTANTS[1])*(ALGEBRAIC[2] - (ALGEBRAIC[3]+ALGEBRAIC[4])); ALGEBRAIC[0] = CONSTANTS[0] - (STATES[0]+ (CONSTANTS[1]/CONSTANTS[2])*STATES[1]+ (CONSTANTS[3]/CONSTANTS[4])*STATES[2]); ALGEBRAIC[1] = CONSTANTS[5] - ALGEBRAIC[0]; ALGEBRAIC[6] = ( CONSTANTS[14]*(pow(STATES[0], 2.00000)/(pow(CONSTANTS[16], 2.00000)+pow(STATES[0], 2.00000)))+CONSTANTS[15])*STATES[2]; ALGEBRAIC[5] = CONSTANTS[12]*(pow(STATES[0], 8.00000)/(pow(CONSTANTS[13], 8.00000)+pow(STATES[0], 8.00000))); RATES[0] = (ALGEBRAIC[3]+ALGEBRAIC[4]+ALGEBRAIC[6]+ CONSTANTS[7]*ALGEBRAIC[0]) - (ALGEBRAIC[2]+ALGEBRAIC[5]+ CONSTANTS[6]*STATES[0]*ALGEBRAIC[1]); RATES[2] = (CONSTANTS[4]/CONSTANTS[3])*(ALGEBRAIC[5] - ALGEBRAIC[6]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = CONSTANTS[9]*(pow(STATES[0], 2.00000)/(pow(CONSTANTS[10], 2.00000)+pow(STATES[0], 2.00000)))*(STATES[1] - STATES[0]); ALGEBRAIC[4] = CONSTANTS[11]*(STATES[1] - STATES[0]); ALGEBRAIC[2] = CONSTANTS[8]*STATES[0]; ALGEBRAIC[0] = CONSTANTS[0] - (STATES[0]+ (CONSTANTS[1]/CONSTANTS[2])*STATES[1]+ (CONSTANTS[3]/CONSTANTS[4])*STATES[2]); ALGEBRAIC[1] = CONSTANTS[5] - ALGEBRAIC[0]; ALGEBRAIC[6] = ( CONSTANTS[14]*(pow(STATES[0], 2.00000)/(pow(CONSTANTS[16], 2.00000)+pow(STATES[0], 2.00000)))+CONSTANTS[15])*STATES[2]; ALGEBRAIC[5] = CONSTANTS[12]*(pow(STATES[0], 8.00000)/(pow(CONSTANTS[13], 8.00000)+pow(STATES[0], 8.00000))); }