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/* There are a total of 9 entries in the algebraic variable array. There are a total of 22 entries in each of the rate and state variable arrays. There are a total of 45 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is T2 in component T2 (micromolar). * ALGEBRAIC[0] is Vmax in component T2 (flux). * CONSTANTS[37] is KR in component T2 (molar). * STATES[1] is LT2 in component LT2 (micromolar). * STATES[2] is T2R in component T2R (micromolar). * CONSTANTS[0] is R in component R (micromolar). * STATES[3] is T3 in component T3 (micromolar). * CONSTANTS[1] is L in component L (micromolar). * STATES[4] is Bp in component Bp (micromolar). * STATES[5] is T2p in component T2p (micromolar). * CONSTANTS[2] is Y0 in component Y0 (micromolar). * STATES[6] is Yp in component Yp (micromolar). * CONSTANTS[3] is B0 in component B0 (micromolar). * CONSTANTS[4] is k5 in component model_parameters (second_order_rate_constant). * CONSTANTS[5] is k_5 in component model_parameters (first_order_rate_constant). * CONSTANTS[6] is k8 in component model_parameters (first_order_rate_constant). * CONSTANTS[7] is k_1 in component model_parameters (second_order_rate_constant). * CONSTANTS[8] is ky in component model_parameters (second_order_rate_constant). * CONSTANTS[9] is kb in component model_parameters (second_order_rate_constant). * CONSTANTS[10] is k1a in component model_parameters (first_order_rate_constant). * CONSTANTS[11] is k1b in component model_parameters (second_order_rate_constant). * CONSTANTS[12] is k1c in component model_parameters (first_order_rate_constant). * ALGEBRAIC[1] is Vmax in component T3 (flux). * CONSTANTS[38] is KR in component T3 (molar). * STATES[7] is LT3 in component LT3 (micromolar). * STATES[8] is T3R in component T3R (micromolar). * STATES[9] is T4 in component T4 (micromolar). * STATES[10] is T3p in component T3p (micromolar). * CONSTANTS[13] is k6 in component model_parameters (second_order_rate_constant). * CONSTANTS[14] is k_6 in component model_parameters (first_order_rate_constant). * CONSTANTS[15] is k9 in component model_parameters (first_order_rate_constant). * CONSTANTS[16] is k_2 in component model_parameters (second_order_rate_constant). * CONSTANTS[17] is k2a in component model_parameters (first_order_rate_constant). * CONSTANTS[18] is k2b in component model_parameters (second_order_rate_constant). * CONSTANTS[19] is k2c in component model_parameters (first_order_rate_constant). * STATES[11] is LT4 in component LT4 (micromolar). * STATES[12] is T4p in component T4p (micromolar). * CONSTANTS[20] is k7 in component model_parameters (second_order_rate_constant). * CONSTANTS[21] is k_7 in component model_parameters (first_order_rate_constant). * CONSTANTS[22] is k10 in component model_parameters (first_order_rate_constant). * ALGEBRAIC[2] is Vmax in component T2p (flux). * CONSTANTS[39] is KR in component T2p (molar). * STATES[13] is LT2p in component LT2p (micromolar). * STATES[14] is T2pR in component T2pR (micromolar). * ALGEBRAIC[3] is Vmax in component T3p (flux). * CONSTANTS[40] is KR in component T3p (molar). * STATES[15] is LT3p in component LT3p (micromolar). * STATES[16] is T3pR in component T3pR (micromolar). * STATES[17] is LT4p in component LT4p (micromolar). * ALGEBRAIC[4] is Vmax in component LT2 (flux). * CONSTANTS[41] is KR in component LT2 (molar). * STATES[18] is LT2R in component LT2R (micromolar). * CONSTANTS[23] is k11 in component model_parameters (first_order_rate_constant). * CONSTANTS[24] is k_3 in component model_parameters (second_order_rate_constant). * CONSTANTS[25] is k3a in component model_parameters (first_order_rate_constant). * CONSTANTS[26] is k3b in component model_parameters (second_order_rate_constant). * CONSTANTS[27] is k3c in component model_parameters (first_order_rate_constant). * ALGEBRAIC[5] is Vmax in component LT3 (flux). * CONSTANTS[42] is KR in component LT3 (molar). * STATES[19] is LT3R in component LT3R (micromolar). * CONSTANTS[28] is k12 in component model_parameters (first_order_rate_constant). * CONSTANTS[29] is k_4 in component model_parameters (second_order_rate_constant). * CONSTANTS[30] is k4a in component model_parameters (first_order_rate_constant). * CONSTANTS[31] is k4b in component model_parameters (second_order_rate_constant). * CONSTANTS[32] is k4c in component model_parameters (first_order_rate_constant). * CONSTANTS[33] is k13 in component model_parameters (first_order_rate_constant). * ALGEBRAIC[6] is Vmax in component LT2p (flux). * CONSTANTS[43] is KR in component LT2p (molar). * STATES[20] is LT2pR in component LT2pR (micromolar). * ALGEBRAIC[7] is Vmax in component LT3p (flux). * CONSTANTS[44] is KR in component LT3p (molar). * STATES[21] is LT3pR in component LT3pR (micromolar). * ALGEBRAIC[8] is P in component P (micromolar). * CONSTANTS[34] is Z in component Z (micromolar). * CONSTANTS[35] is k_y in component model_parameters (second_order_rate_constant). * CONSTANTS[36] is k_b in component model_parameters (first_order_rate_constant). * RATES[0] is d/dt T2 in component T2 (micromolar). * RATES[3] is d/dt T3 in component T3 (micromolar). * RATES[9] is d/dt T4 in component T4 (micromolar). * RATES[5] is d/dt T2p in component T2p (micromolar). * RATES[10] is d/dt T3p in component T3p (micromolar). * RATES[12] is d/dt T4p in component T4p (micromolar). * RATES[1] is d/dt LT2 in component LT2 (micromolar). * RATES[7] is d/dt LT3 in component LT3 (micromolar). * RATES[11] is d/dt LT4 in component LT4 (micromolar). * RATES[13] is d/dt LT2p in component LT2p (micromolar). * RATES[15] is d/dt LT3p in component LT3p (micromolar). * RATES[17] is d/dt LT4p in component LT4p (micromolar). * RATES[6] is d/dt Yp in component Yp (micromolar). * RATES[4] is d/dt Bp in component Bp (micromolar). * RATES[2] is d/dt T2R in component T2R (micromolar). * RATES[8] is d/dt T3R in component T3R (micromolar). * RATES[14] is d/dt T2pR in component T2pR (micromolar). * RATES[16] is d/dt T3pR in component T3pR (micromolar). * RATES[18] is d/dt LT2R in component LT2R (micromolar). * RATES[19] is d/dt LT3R in component LT3R (micromolar). * RATES[20] is d/dt LT2pR in component LT2pR (micromolar). * RATES[21] is d/dt LT3pR in component LT3pR (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.01; STATES[1] = 0.01; STATES[2] = 0.01; CONSTANTS[0] = 0.3; STATES[3] = 0.01; CONSTANTS[1] = 3.0; STATES[4] = 0.01; STATES[5] = 0.01; CONSTANTS[2] = 20.0; STATES[6] = 0.01; CONSTANTS[3] = 1.7; CONSTANTS[4] = 7E7; CONSTANTS[5] = 70.0; CONSTANTS[6] = 15.0; CONSTANTS[7] = 4E5; CONSTANTS[8] = 3E7; CONSTANTS[9] = 8E5; CONSTANTS[10] = 10; CONSTANTS[11] = 17; CONSTANTS[12] = 0.17; STATES[7] = 0.01; STATES[8] = 0.01; STATES[9] = 0.01; STATES[10] = 0.01; CONSTANTS[13] = 7E7; CONSTANTS[14] = 70.0; CONSTANTS[15] = 45.0; CONSTANTS[16] = 3E4; CONSTANTS[17] = 10; CONSTANTS[18] = 17; CONSTANTS[19] = 0.017; STATES[11] = 0.01; STATES[12] = 0.01; CONSTANTS[20] = 7E7; CONSTANTS[21] = 70.0; CONSTANTS[22] = 48.0; STATES[13] = 0.01; STATES[14] = 0.01; STATES[15] = 0.01; STATES[16] = 0.01; STATES[17] = 0.01; STATES[18] = 0.01; CONSTANTS[23] = 0.0; CONSTANTS[24] = 4E5; CONSTANTS[25] = 10; CONSTANTS[26] = 17; CONSTANTS[27] = 5.1; STATES[19] = 0.01; CONSTANTS[28] = 16.5; CONSTANTS[29] = 3E4; CONSTANTS[30] = 10; CONSTANTS[31] = 17; CONSTANTS[32] = 0.51; CONSTANTS[33] = 34.56; STATES[20] = 0.01; STATES[21] = 0.01; CONSTANTS[34] = 40.0; CONSTANTS[35] = 5E5; CONSTANTS[36] = 0.35; CONSTANTS[37] = (CONSTANTS[10]+CONSTANTS[12])/CONSTANTS[11]; CONSTANTS[38] = (CONSTANTS[17]+CONSTANTS[19])/CONSTANTS[18]; CONSTANTS[39] = (CONSTANTS[10]+CONSTANTS[12])/CONSTANTS[11]; CONSTANTS[40] = (CONSTANTS[17]+CONSTANTS[19])/CONSTANTS[18]; CONSTANTS[41] = (CONSTANTS[25]+CONSTANTS[27])/CONSTANTS[26]; CONSTANTS[42] = (CONSTANTS[30]+CONSTANTS[32])/CONSTANTS[31]; CONSTANTS[43] = (CONSTANTS[25]+CONSTANTS[27])/CONSTANTS[26]; CONSTANTS[44] = (CONSTANTS[30]+CONSTANTS[32])/CONSTANTS[31]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[9] = ( CONSTANTS[21]*STATES[11]+ CONSTANTS[8]*STATES[12]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[12]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[20]*CONSTANTS[1]*STATES[9]+ CONSTANTS[22]*STATES[9]); RATES[12] = ( CONSTANTS[21]*STATES[17]+ CONSTANTS[8]*STATES[9]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[9]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[20]*CONSTANTS[1]*STATES[12]+ CONSTANTS[22]*STATES[12]); RATES[11] = ( CONSTANTS[21]*STATES[9]+ CONSTANTS[8]*STATES[17]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[17]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[20]*CONSTANTS[1]*STATES[11]+ CONSTANTS[33]*STATES[11]); RATES[17] = ( CONSTANTS[21]*STATES[12]+ CONSTANTS[8]*STATES[17]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[17]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[20]*CONSTANTS[1]*STATES[17]+ CONSTANTS[33]*STATES[17]); RATES[2] = CONSTANTS[11]*STATES[0]*CONSTANTS[0] - ( CONSTANTS[10]*STATES[2]+ CONSTANTS[12]*STATES[2]); RATES[8] = CONSTANTS[18]*STATES[3]*CONSTANTS[0] - ( CONSTANTS[17]*STATES[8]+ CONSTANTS[19]*STATES[8]); RATES[14] = CONSTANTS[11]*STATES[5]*CONSTANTS[0] - ( CONSTANTS[10]*STATES[14]+ CONSTANTS[12]*STATES[14]); RATES[16] = CONSTANTS[18]*STATES[10]*CONSTANTS[0] - ( CONSTANTS[17]*STATES[16]+ CONSTANTS[19]*STATES[16]); RATES[18] = CONSTANTS[26]*STATES[1]*CONSTANTS[0] - ( CONSTANTS[25]*STATES[18]+ CONSTANTS[27]*STATES[18]); RATES[19] = CONSTANTS[31]*STATES[7]*CONSTANTS[0] - ( CONSTANTS[30]*STATES[19]+ CONSTANTS[32]*STATES[19]); RATES[20] = CONSTANTS[26]*STATES[13]*CONSTANTS[0] - ( CONSTANTS[25]*STATES[20]+ CONSTANTS[27]*STATES[20]); RATES[21] = CONSTANTS[31]*STATES[15]*CONSTANTS[0] - ( CONSTANTS[30]*STATES[21]+ CONSTANTS[32]*STATES[21]); ALGEBRAIC[0] = CONSTANTS[12]*(CONSTANTS[0]+STATES[2]); RATES[0] = ( CONSTANTS[5]*STATES[1]+ CONSTANTS[7]*STATES[4]*STATES[3]+ CONSTANTS[8]*STATES[5]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[5]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[4]*CONSTANTS[1]*STATES[0]+ CONSTANTS[6]*STATES[0]+ ALGEBRAIC[0]*(STATES[0]/(CONSTANTS[37]+STATES[0]))); ALGEBRAIC[1] = CONSTANTS[19]*(CONSTANTS[0]+STATES[8]); RATES[3] = ( CONSTANTS[14]*STATES[7]+ CONSTANTS[16]*STATES[4]*STATES[9]+ CONSTANTS[8]*STATES[10]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[10]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[13]*CONSTANTS[1]*STATES[3]+ CONSTANTS[15]*STATES[3]+ ALGEBRAIC[1]*(STATES[3]/(CONSTANTS[38]+STATES[3]))); ALGEBRAIC[2] = CONSTANTS[12]*(CONSTANTS[0]+STATES[14]); RATES[5] = ( CONSTANTS[5]*STATES[13]+ CONSTANTS[7]*STATES[4]*STATES[10]+ CONSTANTS[8]*STATES[0]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[0]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[4]*CONSTANTS[1]*STATES[5]+ CONSTANTS[6]*STATES[5]+ ALGEBRAIC[2]*(STATES[5]/(CONSTANTS[39]+STATES[5]))); ALGEBRAIC[3] = CONSTANTS[19]*(CONSTANTS[0]+STATES[16]); RATES[10] = ( CONSTANTS[14]*STATES[15]+ CONSTANTS[16]*STATES[4]*STATES[12]+ CONSTANTS[8]*STATES[3]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[3]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[13]*CONSTANTS[1]*STATES[10]+ CONSTANTS[15]*STATES[10]+ ALGEBRAIC[3]*(STATES[10]/(CONSTANTS[40]+STATES[10]))); ALGEBRAIC[4] = CONSTANTS[27]*(CONSTANTS[0]+STATES[18]); RATES[1] = ( CONSTANTS[5]*STATES[0]+ CONSTANTS[24]*STATES[4]*STATES[7]+ CONSTANTS[8]*STATES[13]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[13]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[4]*CONSTANTS[1]*STATES[1]+ CONSTANTS[23]*STATES[1]+ ALGEBRAIC[4]*(STATES[1]/(CONSTANTS[41]+STATES[1]))); ALGEBRAIC[5] = CONSTANTS[32]*(CONSTANTS[0]+STATES[19]); RATES[7] = ( CONSTANTS[14]*STATES[3]+ CONSTANTS[29]*STATES[4]*STATES[11]+ CONSTANTS[8]*STATES[15]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[15]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[13]*CONSTANTS[1]*STATES[7]+ CONSTANTS[28]*STATES[7]+ ALGEBRAIC[5]*(STATES[7]/(CONSTANTS[42]+STATES[7]))); ALGEBRAIC[6] = CONSTANTS[27]*(CONSTANTS[0]+STATES[20]); RATES[13] = ( CONSTANTS[5]*STATES[5]+ CONSTANTS[24]*STATES[4]*STATES[15]+ CONSTANTS[8]*STATES[1]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[1]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[4]*CONSTANTS[1]*STATES[13]+ CONSTANTS[23]*STATES[13]+ ALGEBRAIC[6]*(STATES[13]/(CONSTANTS[43]+STATES[13]))); ALGEBRAIC[7] = CONSTANTS[32]*(CONSTANTS[0]+STATES[21]); RATES[15] = ( CONSTANTS[14]*STATES[10]+ CONSTANTS[29]*STATES[4]*STATES[17]+ CONSTANTS[8]*STATES[7]*(CONSTANTS[2] - STATES[6])+ CONSTANTS[9]*STATES[7]*(CONSTANTS[3] - STATES[4])) - ( CONSTANTS[13]*CONSTANTS[1]*STATES[15]+ CONSTANTS[28]*STATES[15]+ ALGEBRAIC[7]*(STATES[15]/(CONSTANTS[44]+STATES[15]))); ALGEBRAIC[8] = STATES[5]+STATES[13]+STATES[10]+STATES[15]+STATES[12]+STATES[17]; RATES[6] = CONSTANTS[8]*ALGEBRAIC[8]*(CONSTANTS[2] - STATES[6]) - CONSTANTS[35]*CONSTANTS[34]*STATES[6]; RATES[4] = CONSTANTS[9]*ALGEBRAIC[8]*(CONSTANTS[3] - STATES[4]) - CONSTANTS[36]*STATES[4]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[12]*(CONSTANTS[0]+STATES[2]); ALGEBRAIC[1] = CONSTANTS[19]*(CONSTANTS[0]+STATES[8]); ALGEBRAIC[2] = CONSTANTS[12]*(CONSTANTS[0]+STATES[14]); ALGEBRAIC[3] = CONSTANTS[19]*(CONSTANTS[0]+STATES[16]); ALGEBRAIC[4] = CONSTANTS[27]*(CONSTANTS[0]+STATES[18]); ALGEBRAIC[5] = CONSTANTS[32]*(CONSTANTS[0]+STATES[19]); ALGEBRAIC[6] = CONSTANTS[27]*(CONSTANTS[0]+STATES[20]); ALGEBRAIC[7] = CONSTANTS[32]*(CONSTANTS[0]+STATES[21]); ALGEBRAIC[8] = STATES[5]+STATES[13]+STATES[10]+STATES[15]+STATES[12]+STATES[17]; }