Lindblad, Murphey, Clark, Giles, 1996

Model Status

This model has been curated and is known to run in PCEnv and COR and reproduce the results published in the publication on which it is based.

Model Structure

This model is based on the paper:

"A Model of the Action Potential and Underlying Membrane Currents in a Rabbit Atrial Cell"

by D. S. Lindblad, C. R. Murphey, J. W. Clark and W. R. Giles

AJP - Heart and Circulatory Physiology, Vol 271, Issue 4 1666-H1696

ABSTRACT:

We have developed a mathematical model of the rabbit atrial myocyte and have used it in an examination of the ionic basis of the atrial action potential. Available biophysical data have been incorporated into the model to quantify the specific ultrastructural morphology, intracellular ion buffering, and time- and voltage-dependent currents and transport mechanisms of the rabbit atrial cell. When possible, mathematical expressions describing ionic currents identified in rabbit atrium are based on whole cell voltage-clamp data from enzymatically isolated rabbit atrial myocytes. This membrane model is coupled to equations describing Na+, K+, and Ca2+ homeostasis, including the uptake and release of Ca2+ by the sarcoplasmic reticulum and Ca2+ buffering. The resulting formulation can accurately simulate the whole cell voltage-clamp data on which it is based and provides fits to a family of rabbit atrial cell action potentials obtained at 35 degrees C over a range of stimulus rates (0.2-3.0 Hz). The model is utilized to provide a qualitative prediction of the intracellular Ca2+ concentration transient during the action potential and to illustrate the interactions between membrane currents that underlie repolarization in the rabbit atrial myocyte.

A schematic representation of the Linblad et al 1996 model.

The complete original paper reference is cited below:

A model of the action potential and underlying membrane currents in a rabbit atrial cell, D. S. Lindblad, C. R. Murphey, J. W. Clark and W. R. Giles, 1996 PubMed ID: 8897964