Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 54 entries in the algebraic variable array.
There are a total of 26 entries in each of the rate and state variable arrays.
There are a total of 70 entries in the constant variable array.
*/
/*
* VOI is time in component environment (second).
* STATES[0] is V in component membrane (millivolt).
* CONSTANTS[0] is R in component membrane (millijoule_per_mole_kelvin).
* CONSTANTS[1] is T in component membrane (kelvin).
* CONSTANTS[2] is F in component membrane (coulomb_per_mole).
* CONSTANTS[3] is Cm in component membrane (microF).
* ALGEBRAIC[25] is i_Na in component sodium_current (nanoA).
* ALGEBRAIC[26] is i_Ca_L in component L_type_Ca_channel (nanoA).
* ALGEBRAIC[28] is i_t in component Ca_independent_transient_outward_K_current (nanoA).
* ALGEBRAIC[29] is i_ss in component steady_state_outward_K_current (nanoA).
* ALGEBRAIC[34] is i_f in component hyperpolarisation_activated_current (nanoA).
* ALGEBRAIC[31] is i_K1 in component inward_rectifier (nanoA).
* ALGEBRAIC[38] is i_B in component background_currents (nanoA).
* ALGEBRAIC[39] is i_NaK in component sodium_potassium_pump (nanoA).
* ALGEBRAIC[41] is i_NaCa in component Na_Ca_ion_exchanger_current (nanoA).
* ALGEBRAIC[40] is i_Ca_P in component sarcolemmal_calcium_pump_current (nanoA).
* ALGEBRAIC[13] is i_Stim in component membrane (nanoA).
* ALGEBRAIC[30] is i_K_slow in component slowly_inactivating_delayed_rectifier_K_current (nanoA).
* CONSTANTS[4] is stim_period in component membrane (second).
* CONSTANTS[5] is stim_duration in component membrane (second).
* CONSTANTS[6] is stim_amplitude in component membrane (nanoA).
* ALGEBRAIC[24] is E_Na in component sodium_current (millivolt).
* CONSTANTS[7] is g_Na in component sodium_current (microS).
* CONSTANTS[65] is g_Na_endo in component sodium_current (microS).
* STATES[1] is Na_i in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[8] is Na_o in component standard_ionic_concentrations (millimolar).
* STATES[2] is m in component sodium_current_m_gate (dimensionless).
* STATES[3] is h in component sodium_current_h_gate (dimensionless).
* STATES[4] is j in component sodium_current_j_gate (dimensionless).
* ALGEBRAIC[0] is m_infinity in component sodium_current_m_gate (dimensionless).
* ALGEBRAIC[14] is tau_m in component sodium_current_m_gate (second).
* ALGEBRAIC[1] is h_infinity in component sodium_current_h_gate (dimensionless).
* ALGEBRAIC[15] is tau_h in component sodium_current_h_gate (second).
* ALGEBRAIC[2] is j_infinity in component sodium_current_j_gate (dimensionless).
* ALGEBRAIC[16] is tau_j in component sodium_current_j_gate (second).
* CONSTANTS[9] is g_Ca_L in component L_type_Ca_channel (microS).
* CONSTANTS[10] is E_Ca_L in component L_type_Ca_channel (millivolt).
* STATES[5] is Ca_ss in component intracellular_ion_concentrations (millimolar).
* STATES[6] is d in component L_type_Ca_channel_d_gate (dimensionless).
* STATES[7] is f_11 in component L_type_Ca_channel_f_11_gate (dimensionless).
* STATES[8] is f_12 in component L_type_Ca_channel_f_12_gate (dimensionless).
* STATES[9] is Ca_inact in component L_type_Ca_channel_Ca_inact_gate (dimensionless).
* ALGEBRAIC[3] is d_infinity in component L_type_Ca_channel_d_gate (dimensionless).
* ALGEBRAIC[17] is tau_d in component L_type_Ca_channel_d_gate (second).
* ALGEBRAIC[4] is f_11_infinity in component L_type_Ca_channel_f_11_gate (dimensionless).
* ALGEBRAIC[18] is tau_f_11 in component L_type_Ca_channel_f_11_gate (second).
* ALGEBRAIC[5] is f_12_infinity in component L_type_Ca_channel_f_12_gate (dimensionless).
* ALGEBRAIC[19] is tau_f_12 in component L_type_Ca_channel_f_12_gate (second).
* CONSTANTS[11] is tau_Ca_inact in component L_type_Ca_channel_Ca_inact_gate (second).
* ALGEBRAIC[6] is Ca_inact_infinity in component L_type_Ca_channel_Ca_inact_gate (dimensionless).
* ALGEBRAIC[27] is E_K in component Ca_independent_transient_outward_K_current (millivolt).
* CONSTANTS[12] is g_t in component Ca_independent_transient_outward_K_current (microS).
* CONSTANTS[13] is K_o in component standard_ionic_concentrations (millimolar).
* STATES[10] is K_i in component intracellular_ion_concentrations (millimolar).
* STATES[11] is r in component Ca_independent_transient_outward_K_current_r_gate (dimensionless).
* STATES[12] is s in component Ca_independent_transient_outward_K_current_s_gate (dimensionless).
* ALGEBRAIC[20] is tau_r in component Ca_independent_transient_outward_K_current_r_gate (second).
* ALGEBRAIC[7] is r_infinity in component Ca_independent_transient_outward_K_current_r_gate (dimensionless).
* CONSTANTS[66] is tau_s in component Ca_independent_transient_outward_K_current_s_gate (second).
* ALGEBRAIC[8] is s_infinity in component Ca_independent_transient_outward_K_current_s_gate (dimensionless).
* CONSTANTS[14] is g_ss in component steady_state_outward_K_current (microS).
* STATES[13] is r_ss in component steady_state_outward_K_current_r_ss_gate (dimensionless).
* ALGEBRAIC[21] is tau_r_ss in component steady_state_outward_K_current_r_ss_gate (second).
* ALGEBRAIC[9] is r_ss_infinity in component steady_state_outward_K_current_r_ss_gate (dimensionless).
* CONSTANTS[15] is g_K_slow in component slowly_inactivating_delayed_rectifier_K_current (microS).
* STATES[14] is r_K_slow in component slowly_inactivating_delayed_rectifier_K_current_r_K_slow_gate (dimensionless).
* STATES[15] is s_K_slow in component slowly_inactivating_delayed_rectifier_K_current_s_K_slow_gate (dimensionless).
* ALGEBRAIC[22] is tau_r_K_slow in component slowly_inactivating_delayed_rectifier_K_current_r_K_slow_gate (second).
* ALGEBRAIC[10] is r_K_slow_infinity in component slowly_inactivating_delayed_rectifier_K_current_r_K_slow_gate (dimensionless).
* CONSTANTS[67] is tau_s_K_slow in component slowly_inactivating_delayed_rectifier_K_current_s_K_slow_gate (second).
* ALGEBRAIC[11] is s_K_slow_infinity in component slowly_inactivating_delayed_rectifier_K_current_s_K_slow_gate (dimensionless).
* CONSTANTS[16] is g_K1 in component inward_rectifier (microS).
* ALGEBRAIC[32] is i_f_Na in component hyperpolarisation_activated_current (nanoA).
* ALGEBRAIC[33] is i_f_K in component hyperpolarisation_activated_current (nanoA).
* CONSTANTS[17] is g_f in component hyperpolarisation_activated_current (microS).
* CONSTANTS[18] is f_Na in component hyperpolarisation_activated_current (dimensionless).
* CONSTANTS[68] is f_K in component hyperpolarisation_activated_current (dimensionless).
* STATES[16] is y in component hyperpolarisation_activated_current_y_gate (dimensionless).
* ALGEBRAIC[23] is tau_y in component hyperpolarisation_activated_current_y_gate (second).
* ALGEBRAIC[12] is y_infinity in component hyperpolarisation_activated_current_y_gate (dimensionless).
* ALGEBRAIC[35] is i_B_Na in component background_currents (nanoA).
* ALGEBRAIC[36] is i_B_Ca in component background_currents (nanoA).
* ALGEBRAIC[37] is i_B_K in component background_currents (nanoA).
* CONSTANTS[19] is g_B_Na in component background_currents (microS).
* CONSTANTS[20] is g_B_Ca in component background_currents (microS).
* CONSTANTS[21] is g_B_K in component background_currents (microS).
* CONSTANTS[22] is E_Ca in component background_currents (millivolt).
* CONSTANTS[23] is Ca_o in component standard_ionic_concentrations (millimolar).
* STATES[17] is Ca_i in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[24] is i_NaK_max in component sodium_potassium_pump (nanoA).
* CONSTANTS[25] is K_m_K in component sodium_potassium_pump (millimolar).
* CONSTANTS[26] is K_m_Na in component sodium_potassium_pump (millimolar).
* CONSTANTS[69] is sigma in component sodium_potassium_pump (dimensionless).
* CONSTANTS[27] is i_Ca_P_max in component sarcolemmal_calcium_pump_current (nanoA).
* CONSTANTS[28] is K_NaCa in component Na_Ca_ion_exchanger_current (millimolar_4).
* CONSTANTS[29] is d_NaCa in component Na_Ca_ion_exchanger_current (millimolar_4).
* CONSTANTS[30] is gamma_NaCa in component Na_Ca_ion_exchanger_current (dimensionless).
* ALGEBRAIC[42] is J_rel in component SR_Ca_release_channel (millimolar_per_second).
* CONSTANTS[31] is v1 in component SR_Ca_release_channel (per_second).
* CONSTANTS[32] is k_a_plus in component SR_Ca_release_channel (millimolar4_per_second).
* CONSTANTS[33] is k_a_minus in component SR_Ca_release_channel (per_second).
* CONSTANTS[34] is k_b_plus in component SR_Ca_release_channel (millimolar3_per_second).
* CONSTANTS[35] is k_b_minus in component SR_Ca_release_channel (per_second).
* CONSTANTS[36] is k_c_plus in component SR_Ca_release_channel (per_second).
* CONSTANTS[37] is k_c_minus in component SR_Ca_release_channel (per_second).
* STATES[18] is P_O1 in component SR_Ca_release_channel (dimensionless).
* STATES[19] is P_O2 in component SR_Ca_release_channel (dimensionless).
* STATES[20] is P_C1 in component SR_Ca_release_channel (dimensionless).
* STATES[21] is P_C2 in component SR_Ca_release_channel (dimensionless).
* CONSTANTS[38] is n in component SR_Ca_release_channel (dimensionless).
* CONSTANTS[39] is m in component SR_Ca_release_channel (dimensionless).
* STATES[22] is Ca_JSR in component intracellular_ion_concentrations (millimolar).
* ALGEBRAIC[45] is J_up in component SERCA2a_pump (millimolar_per_second).
* CONSTANTS[40] is K_fb in component SERCA2a_pump (millimolar).
* CONSTANTS[41] is K_rb in component SERCA2a_pump (millimolar).
* ALGEBRAIC[43] is fb in component SERCA2a_pump (dimensionless).
* ALGEBRAIC[44] is rb in component SERCA2a_pump (dimensionless).
* CONSTANTS[42] is Vmaxf in component SERCA2a_pump (millimolar_per_second).
* CONSTANTS[43] is Vmaxr in component SERCA2a_pump (millimolar_per_second).
* CONSTANTS[44] is K_SR in component SERCA2a_pump (dimensionless).
* CONSTANTS[45] is N_fb in component SERCA2a_pump (dimensionless).
* CONSTANTS[46] is N_rb in component SERCA2a_pump (dimensionless).
* STATES[23] is Ca_NSR in component intracellular_ion_concentrations (millimolar).
* ALGEBRAIC[47] is J_tr in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* ALGEBRAIC[46] is J_xfer in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* ALGEBRAIC[52] is J_trpn in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* CONSTANTS[47] is tau_tr in component intracellular_and_SR_Ca_fluxes (second).
* CONSTANTS[48] is tau_xfer in component intracellular_and_SR_Ca_fluxes (second).
* STATES[24] is HTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar).
* STATES[25] is LTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar).
* ALGEBRAIC[48] is J_HTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* ALGEBRAIC[51] is J_LTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* CONSTANTS[49] is HTRPN_tot in component intracellular_and_SR_Ca_fluxes (millimolar).
* CONSTANTS[50] is LTRPN_tot in component intracellular_and_SR_Ca_fluxes (millimolar).
* CONSTANTS[51] is k_htrpn_plus in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* CONSTANTS[52] is k_htrpn_minus in component intracellular_and_SR_Ca_fluxes (per_second).
* CONSTANTS[53] is k_ltrpn_plus in component intracellular_and_SR_Ca_fluxes (millimolar_per_second).
* CONSTANTS[54] is k_ltrpn_minus in component intracellular_and_SR_Ca_fluxes (per_second).
* CONSTANTS[55] is V_myo in component intracellular_ion_concentrations (micro_litre).
* CONSTANTS[56] is V_JSR in component intracellular_ion_concentrations (micro_litre).
* CONSTANTS[57] is V_NSR in component intracellular_ion_concentrations (micro_litre).
* CONSTANTS[58] is V_SS in component intracellular_ion_concentrations (micro_litre).
* CONSTANTS[59] is K_mCMDN in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[60] is K_mCSQN in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[61] is K_mEGTA in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[62] is CMDN_tot in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[63] is CSQN_tot in component intracellular_ion_concentrations (millimolar).
* CONSTANTS[64] is EGTA_tot in component intracellular_ion_concentrations (millimolar).
* ALGEBRAIC[53] is beta_i in component intracellular_ion_concentrations (millimolar).
* ALGEBRAIC[49] is beta_SS in component intracellular_ion_concentrations (millimolar).
* ALGEBRAIC[50] is beta_JSR in component intracellular_ion_concentrations (millimolar).
* RATES[0] is d/dt V in component membrane (millivolt).
* RATES[2] is d/dt m in component sodium_current_m_gate (dimensionless).
* RATES[3] is d/dt h in component sodium_current_h_gate (dimensionless).
* RATES[4] is d/dt j in component sodium_current_j_gate (dimensionless).
* RATES[6] is d/dt d in component L_type_Ca_channel_d_gate (dimensionless).
* RATES[7] is d/dt f_11 in component L_type_Ca_channel_f_11_gate (dimensionless).
* RATES[8] is d/dt f_12 in component L_type_Ca_channel_f_12_gate (dimensionless).
* RATES[9] is d/dt Ca_inact in component L_type_Ca_channel_Ca_inact_gate (dimensionless).
* RATES[11] is d/dt r in component Ca_independent_transient_outward_K_current_r_gate (dimensionless).
* RATES[12] is d/dt s in component Ca_independent_transient_outward_K_current_s_gate (dimensionless).
* RATES[13] is d/dt r_ss in component steady_state_outward_K_current_r_ss_gate (dimensionless).
* RATES[14] is d/dt r_K_slow in component slowly_inactivating_delayed_rectifier_K_current_r_K_slow_gate (dimensionless).
* RATES[15] is d/dt s_K_slow in component slowly_inactivating_delayed_rectifier_K_current_s_K_slow_gate (dimensionless).
* RATES[16] is d/dt y in component hyperpolarisation_activated_current_y_gate (dimensionless).
* RATES[20] is d/dt P_C1 in component SR_Ca_release_channel (dimensionless).
* RATES[18] is d/dt P_O1 in component SR_Ca_release_channel (dimensionless).
* RATES[19] is d/dt P_O2 in component SR_Ca_release_channel (dimensionless).
* RATES[21] is d/dt P_C2 in component SR_Ca_release_channel (dimensionless).
* RATES[24] is d/dt HTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar).
* RATES[25] is d/dt LTRPNCa in component intracellular_and_SR_Ca_fluxes (millimolar).
* RATES[17] is d/dt Ca_i in component intracellular_ion_concentrations (millimolar).
* RATES[1] is d/dt Na_i in component intracellular_ion_concentrations (millimolar).
* RATES[10] is d/dt K_i in component intracellular_ion_concentrations (millimolar).
* RATES[5] is d/dt Ca_ss in component intracellular_ion_concentrations (millimolar).
* RATES[22] is d/dt Ca_JSR in component intracellular_ion_concentrations (millimolar).
* RATES[23] is d/dt Ca_NSR in component intracellular_ion_concentrations (millimolar).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = -80.50146;
CONSTANTS[0] = 8314.5;
CONSTANTS[1] = 295;
CONSTANTS[2] = 96487;
CONSTANTS[3] = 0.0001;
CONSTANTS[4] = 1;
CONSTANTS[5] = 5e-3;
CONSTANTS[6] = -0.6;
CONSTANTS[7] = 1.064;
STATES[1] = 10.73519;
CONSTANTS[8] = 140;
STATES[2] = 0.004164108;
STATES[3] = 0.6735613;
STATES[4] = 0.6729362;
CONSTANTS[9] = 0.0341;
CONSTANTS[10] = 65;
STATES[5] = 0.00008737212;
STATES[6] = 0.000002171081;
STATES[7] = 0.9999529;
STATES[8] = 0.9999529;
STATES[9] = 0.9913102;
CONSTANTS[11] = 0.009;
CONSTANTS[12] = 0.033;
CONSTANTS[13] = 5.4;
STATES[10] = 139.2751;
STATES[11] = 0.002191519;
STATES[12] = 0.9842542;
CONSTANTS[14] = 0.005;
STATES[13] = 0.002907171;
CONSTANTS[15] = 0.014;
STATES[14] = 0.642;
STATES[15] = 0.314;
CONSTANTS[16] = 0.024;
CONSTANTS[17] = 0.00145;
CONSTANTS[18] = 0.2;
STATES[16] = 0.003578708;
CONSTANTS[19] = 0.00008015;
CONSTANTS[20] = 0.0000324;
CONSTANTS[21] = 0.000138;
CONSTANTS[22] = 65;
CONSTANTS[23] = 1.2;
STATES[17] = 0.00007901351;
CONSTANTS[24] = 0.08;
CONSTANTS[25] = 1.5;
CONSTANTS[26] = 10;
CONSTANTS[27] = 0.004;
CONSTANTS[28] = 0.000009984;
CONSTANTS[29] = 0.0001;
CONSTANTS[30] = 0.5;
CONSTANTS[31] = 1.8e3;
CONSTANTS[32] = 12.15e12;
CONSTANTS[33] = 576;
CONSTANTS[34] = 4.05e9;
CONSTANTS[35] = 1930;
CONSTANTS[36] = 100;
CONSTANTS[37] = 0.8;
STATES[18] = 0.0004327548;
STATES[19] = 0.000000000606254;
STATES[20] = 0.6348229;
STATES[21] = 0.3647471;
CONSTANTS[38] = 4;
CONSTANTS[39] = 3;
STATES[22] = 0.06607948;
CONSTANTS[40] = 0.000168;
CONSTANTS[41] = 3.29;
CONSTANTS[42] = 0.04;
CONSTANTS[43] = 0.9;
CONSTANTS[44] = 1;
CONSTANTS[45] = 1.2;
CONSTANTS[46] = 1;
STATES[23] = 0.06600742;
CONSTANTS[47] = 0.0005747;
CONSTANTS[48] = 0.0267;
STATES[24] = 1.394301e-1;
STATES[25] = 5.1619e-3;
CONSTANTS[49] = 0.14;
CONSTANTS[50] = 0.07;
CONSTANTS[51] = 200000;
CONSTANTS[52] = 0.066;
CONSTANTS[53] = 40000;
CONSTANTS[54] = 40;
CONSTANTS[55] = 0.00000936;
CONSTANTS[56] = 0.000000056;
CONSTANTS[57] = 0.000000504;
CONSTANTS[58] = 0.0000000012;
CONSTANTS[59] = 0.00238;
CONSTANTS[60] = 0.8;
CONSTANTS[61] = 0.00015;
CONSTANTS[62] = 0.05;
CONSTANTS[63] = 15;
CONSTANTS[64] = 0;
CONSTANTS[65] = 1.33000*CONSTANTS[7];
CONSTANTS[66] = 0.0572000;
CONSTANTS[67] = 1.17400;
CONSTANTS[68] = 1.00000 - CONSTANTS[18];
CONSTANTS[69] = (exp(CONSTANTS[8]/67.3000) - 1.00000)/7.00000;
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
RATES[20] = - CONSTANTS[32]*pow(STATES[5], CONSTANTS[38])*STATES[20]+ CONSTANTS[33]*STATES[18];
RATES[18] = ( CONSTANTS[32]*pow(STATES[5], CONSTANTS[38])*STATES[20] - ( CONSTANTS[33]*STATES[18]+ CONSTANTS[34]*pow(STATES[5], CONSTANTS[39])*STATES[18]+ CONSTANTS[36]*STATES[18]))+ CONSTANTS[35]*STATES[19]+ CONSTANTS[37]*STATES[21];
RATES[19] = CONSTANTS[34]*pow(STATES[5], CONSTANTS[39])*STATES[18] - CONSTANTS[35]*STATES[19];
RATES[21] = CONSTANTS[36]*STATES[18] - CONSTANTS[37]*STATES[21];
ALGEBRAIC[6] = 1.00000/(1.00000+STATES[5]/0.0100000);
RATES[9] = (ALGEBRAIC[6] - STATES[9])/CONSTANTS[11];
ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+24.8000)/3.50000));
RATES[12] = (ALGEBRAIC[8] - STATES[12])/CONSTANTS[66];
ALGEBRAIC[11] = 1.00000/(1.00000+exp((STATES[0]+37.6000)/5.90000));
RATES[15] = (ALGEBRAIC[11] - STATES[15])/CONSTANTS[67];
ALGEBRAIC[0] = 1.00000/(1.00000+exp((STATES[0]+45.0000)/- 6.50000));
ALGEBRAIC[14] = 0.00136000/(( 0.320000*(STATES[0]+47.1300))/(1.00000 - exp( - 0.100000*(STATES[0]+47.1300)))+ 0.0800000*exp(- STATES[0]/11.0000));
RATES[2] = (ALGEBRAIC[0] - STATES[2])/ALGEBRAIC[14];
ALGEBRAIC[1] = 1.00000/(1.00000+exp((STATES[0]+76.1000)/6.07000));
ALGEBRAIC[15] = (STATES[0]>=- 40.0000 ? 0.000453700*(1.00000+exp(- (STATES[0]+10.6600)/11.1000)) : 0.00349000/( 0.135000*exp(- (STATES[0]+80.0000)/6.80000)+ 3.56000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.350000*STATES[0])));
RATES[3] = (ALGEBRAIC[1] - STATES[3])/ALGEBRAIC[15];
ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+76.1000)/6.07000));
ALGEBRAIC[16] = (STATES[0]>=- 40.0000 ? ( 0.0116300*(1.00000+exp( - 0.100000*(STATES[0]+32.0000))))/exp( - 2.53500e-07*STATES[0]) : 0.00349000/( ((STATES[0]+37.7800)/(1.00000+exp( 0.311000*(STATES[0]+79.2300))))*( - 127140.*exp( 0.244400*STATES[0]) - 3.47400e-05*exp( - 0.0439100*STATES[0]))+( 0.121200*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400)))));
RATES[4] = (ALGEBRAIC[2] - STATES[4])/ALGEBRAIC[16];
ALGEBRAIC[3] = 1.00000/(1.00000+exp((STATES[0]+15.3000)/- 5.00000));
ALGEBRAIC[17] = 0.00305000*exp( - 0.00450000*pow(STATES[0]+7.00000, 2.00000))+ 0.00105000*exp( - 0.00200000*pow(STATES[0] - 18.0000, 2.00000))+0.000250000;
RATES[6] = (ALGEBRAIC[3] - STATES[6])/ALGEBRAIC[17];
ALGEBRAIC[4] = 1.00000/(1.00000+exp((STATES[0]+26.7000)/5.40000));
ALGEBRAIC[18] = 0.105000*exp(- pow((STATES[0]+45.0000)/12.0000, 2.00000))+0.0400000/(1.00000+exp((- STATES[0]+25.0000)/25.0000))+0.0150000/(1.00000+exp((STATES[0]+75.0000)/25.0000))+0.00170000;
RATES[7] = (ALGEBRAIC[4] - STATES[7])/ALGEBRAIC[18];
ALGEBRAIC[5] = 1.00000/(1.00000+exp((STATES[0]+26.7000)/5.40000));
ALGEBRAIC[19] = 0.0410000*exp(- pow((STATES[0]+47.0000)/12.0000, 2.00000))+0.0800000/(1.00000+exp((STATES[0]+55.0000)/- 5.00000))+0.0150000/(1.00000+exp((STATES[0]+75.0000)/25.0000))+0.00170000;
RATES[8] = (ALGEBRAIC[5] - STATES[8])/ALGEBRAIC[19];
ALGEBRAIC[20] = 1.00000/( 45.1600*exp( 0.0357700*(STATES[0]+50.0000))+ 98.9000*exp( - 0.100000*(STATES[0]+38.0000)));
ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0]+12.5000)/- 7.70000));
RATES[11] = (ALGEBRAIC[7] - STATES[11])/ALGEBRAIC[20];
ALGEBRAIC[21] = 3.00000/( 45.1600*exp( 0.0357700*(STATES[0]+50.0000))+ 98.9000*exp( - 0.100000*(STATES[0]+38.0000)));
ALGEBRAIC[9] = 1.00000/(1.00000+exp((STATES[0]+12.5000)/- 7.70000));
RATES[13] = (ALGEBRAIC[9] - STATES[13])/ALGEBRAIC[21];
ALGEBRAIC[22] = 1.00000/( 45.1600*exp( 0.0357700*(STATES[0]+50.0000))+ 98.9000*exp( - 0.100000*(STATES[0]+38.0000)));
ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+12.5000)/- 7.70000));
RATES[14] = (ALGEBRAIC[10] - STATES[14])/ALGEBRAIC[22];
ALGEBRAIC[23] = 1.00000/( 0.118850*exp((STATES[0]+80.0000)/28.3700)+ 0.562300*exp((STATES[0]+80.0000)/- 14.1900));
ALGEBRAIC[12] = 1.00000/(1.00000+exp((STATES[0]+138.600)/10.4800));
RATES[16] = (ALGEBRAIC[12] - STATES[16])/ALGEBRAIC[23];
ALGEBRAIC[27] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[13]/STATES[10]);
ALGEBRAIC[28] = CONSTANTS[12]*STATES[11]*STATES[12]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[29] = CONSTANTS[14]*STATES[13]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[31] = ( (48.0000/(exp((STATES[0]+37.0000)/25.0000)+exp((STATES[0]+37.0000)/- 25.0000))+10.0000)*0.00100000)/(1.00000+exp((STATES[0] - (ALGEBRAIC[27]+76.7700))/- 17.0000))+( CONSTANTS[16]*(STATES[0] - (ALGEBRAIC[27]+1.73000)))/( (1.00000+exp(( 1.61300*CONSTANTS[2]*(STATES[0] - (ALGEBRAIC[27]+1.73000)))/( CONSTANTS[0]*CONSTANTS[1])))*(1.00000+exp((CONSTANTS[13] - 0.998800)/- 0.124000)));
ALGEBRAIC[39] = ( (( (( CONSTANTS[24]*1.00000)/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0365000*CONSTANTS[69]*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))))*CONSTANTS[13])/(CONSTANTS[13]+CONSTANTS[25]))*1.00000)/(1.00000+pow(CONSTANTS[26]/STATES[1], 1.50000));
ALGEBRAIC[30] = CONSTANTS[15]*STATES[14]*STATES[15]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[33] = CONSTANTS[17]*STATES[16]*CONSTANTS[68]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[37] = CONSTANTS[21]*(STATES[0] - ALGEBRAIC[27]);
RATES[10] = ( - (ALGEBRAIC[29]+ALGEBRAIC[37]+ALGEBRAIC[28]+ALGEBRAIC[30]+ALGEBRAIC[31]+ALGEBRAIC[33]+ ALGEBRAIC[39]*- 2.00000)*1.00000)/( CONSTANTS[55]*CONSTANTS[2]);
ALGEBRAIC[24] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[8]/STATES[1]);
ALGEBRAIC[25] = CONSTANTS[7]*pow(STATES[2], 3.00000)*STATES[3]*STATES[4]*(STATES[0] - ALGEBRAIC[24]);
ALGEBRAIC[26] = CONSTANTS[9]*STATES[6]*( (0.900000+STATES[9]/10.0000)*STATES[7]+ (0.100000 - STATES[9]/10.0000)*STATES[8])*(STATES[0] - CONSTANTS[10]);
ALGEBRAIC[32] = CONSTANTS[17]*STATES[16]*CONSTANTS[18]*(STATES[0] - ALGEBRAIC[24]);
ALGEBRAIC[34] = ALGEBRAIC[32]+ALGEBRAIC[33];
ALGEBRAIC[35] = CONSTANTS[19]*(STATES[0] - ALGEBRAIC[24]);
ALGEBRAIC[36] = CONSTANTS[20]*(STATES[0] - CONSTANTS[22]);
ALGEBRAIC[38] = ALGEBRAIC[35]+ALGEBRAIC[36]+ALGEBRAIC[37];
ALGEBRAIC[41] = ( CONSTANTS[28]*( pow(STATES[1], 3.00000)*CONSTANTS[23]*exp( 0.0374300*STATES[0]*CONSTANTS[30]) - pow(CONSTANTS[8], 3.00000)*STATES[17]*exp( 0.0374300*STATES[0]*(CONSTANTS[30] - 1.00000))))/(1.00000+ CONSTANTS[29]*( STATES[17]*pow(CONSTANTS[8], 3.00000)+ CONSTANTS[23]*pow(STATES[1], 3.00000)));
ALGEBRAIC[40] = ( CONSTANTS[27]*STATES[17])/(STATES[17]+0.000400000);
ALGEBRAIC[13] = (VOI - floor(VOI/CONSTANTS[4])*CONSTANTS[4]>=0.00000&&VOI - floor(VOI/CONSTANTS[4])*CONSTANTS[4]<=CONSTANTS[5] ? CONSTANTS[6] : 0.00000);
RATES[0] = - (ALGEBRAIC[25]+ALGEBRAIC[26]+ALGEBRAIC[28]+ALGEBRAIC[29]+ALGEBRAIC[30]+ALGEBRAIC[34]+ALGEBRAIC[31]+ALGEBRAIC[38]+ALGEBRAIC[39]+ALGEBRAIC[41]+ALGEBRAIC[40]+ALGEBRAIC[13])/CONSTANTS[3];
RATES[1] = ( - (ALGEBRAIC[25]+ALGEBRAIC[35]+ ALGEBRAIC[41]*3.00000+ ALGEBRAIC[39]*3.00000+ALGEBRAIC[32])*1.00000)/( CONSTANTS[55]*CONSTANTS[2]);
ALGEBRAIC[43] = pow(STATES[17]/CONSTANTS[40], CONSTANTS[45]);
ALGEBRAIC[44] = pow(STATES[23]/CONSTANTS[41], CONSTANTS[46]);
ALGEBRAIC[45] = ( CONSTANTS[44]*( CONSTANTS[42]*ALGEBRAIC[43] - CONSTANTS[43]*ALGEBRAIC[44]))/(1.00000+ALGEBRAIC[43]+ALGEBRAIC[44]);
ALGEBRAIC[47] = (STATES[23] - STATES[22])/CONSTANTS[47];
RATES[23] = ( ALGEBRAIC[45]*CONSTANTS[55])/CONSTANTS[57] - ( ALGEBRAIC[47]*CONSTANTS[56])/CONSTANTS[57];
ALGEBRAIC[48] = CONSTANTS[51]*STATES[17]*(CONSTANTS[49] - STATES[24]) - CONSTANTS[52]*STATES[24];
RATES[24] = ALGEBRAIC[48];
ALGEBRAIC[42] = CONSTANTS[31]*(STATES[18]+STATES[19])*(STATES[22] - STATES[5]);
ALGEBRAIC[46] = (STATES[5] - STATES[17])/CONSTANTS[48];
ALGEBRAIC[49] = 1.00000/(1.00000+( CONSTANTS[62]*CONSTANTS[59])/pow(CONSTANTS[59]+STATES[5], 2.00000));
RATES[5] = ALGEBRAIC[49]*((( ALGEBRAIC[42]*CONSTANTS[56])/CONSTANTS[58] - ( ALGEBRAIC[46]*CONSTANTS[55])/CONSTANTS[58]) - ( ALGEBRAIC[26]*1.00000)/( 2.00000*CONSTANTS[58]*CONSTANTS[2]));
ALGEBRAIC[50] = 1.00000/(1.00000+( CONSTANTS[63]*CONSTANTS[60])/pow(CONSTANTS[60]+STATES[22], 2.00000));
RATES[22] = ALGEBRAIC[50]*(ALGEBRAIC[47] - ALGEBRAIC[42]);
ALGEBRAIC[51] = CONSTANTS[53]*STATES[17]*(CONSTANTS[50] - STATES[25]) - CONSTANTS[54]*STATES[25];
RATES[25] = ALGEBRAIC[51];
ALGEBRAIC[52] = ALGEBRAIC[48]+ALGEBRAIC[51];
ALGEBRAIC[53] = 1.00000/(1.00000+( CONSTANTS[62]*CONSTANTS[59])/pow(CONSTANTS[59]+STATES[17], 2.00000)+( CONSTANTS[64]*CONSTANTS[61])/pow(CONSTANTS[61]+STATES[17], 2.00000));
RATES[17] = ALGEBRAIC[53]*(ALGEBRAIC[46] - (ALGEBRAIC[45]+ALGEBRAIC[52]+( ((ALGEBRAIC[36] - 2.00000*ALGEBRAIC[41])+ALGEBRAIC[40])*1.00000)/( 2.00000*CONSTANTS[55]*CONSTANTS[2])));
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[6] = 1.00000/(1.00000+STATES[5]/0.0100000);
ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+24.8000)/3.50000));
ALGEBRAIC[11] = 1.00000/(1.00000+exp((STATES[0]+37.6000)/5.90000));
ALGEBRAIC[0] = 1.00000/(1.00000+exp((STATES[0]+45.0000)/- 6.50000));
ALGEBRAIC[14] = 0.00136000/(( 0.320000*(STATES[0]+47.1300))/(1.00000 - exp( - 0.100000*(STATES[0]+47.1300)))+ 0.0800000*exp(- STATES[0]/11.0000));
ALGEBRAIC[1] = 1.00000/(1.00000+exp((STATES[0]+76.1000)/6.07000));
ALGEBRAIC[15] = (STATES[0]>=- 40.0000 ? 0.000453700*(1.00000+exp(- (STATES[0]+10.6600)/11.1000)) : 0.00349000/( 0.135000*exp(- (STATES[0]+80.0000)/6.80000)+ 3.56000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.350000*STATES[0])));
ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+76.1000)/6.07000));
ALGEBRAIC[16] = (STATES[0]>=- 40.0000 ? ( 0.0116300*(1.00000+exp( - 0.100000*(STATES[0]+32.0000))))/exp( - 2.53500e-07*STATES[0]) : 0.00349000/( ((STATES[0]+37.7800)/(1.00000+exp( 0.311000*(STATES[0]+79.2300))))*( - 127140.*exp( 0.244400*STATES[0]) - 3.47400e-05*exp( - 0.0439100*STATES[0]))+( 0.121200*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400)))));
ALGEBRAIC[3] = 1.00000/(1.00000+exp((STATES[0]+15.3000)/- 5.00000));
ALGEBRAIC[17] = 0.00305000*exp( - 0.00450000*pow(STATES[0]+7.00000, 2.00000))+ 0.00105000*exp( - 0.00200000*pow(STATES[0] - 18.0000, 2.00000))+0.000250000;
ALGEBRAIC[4] = 1.00000/(1.00000+exp((STATES[0]+26.7000)/5.40000));
ALGEBRAIC[18] = 0.105000*exp(- pow((STATES[0]+45.0000)/12.0000, 2.00000))+0.0400000/(1.00000+exp((- STATES[0]+25.0000)/25.0000))+0.0150000/(1.00000+exp((STATES[0]+75.0000)/25.0000))+0.00170000;
ALGEBRAIC[5] = 1.00000/(1.00000+exp((STATES[0]+26.7000)/5.40000));
ALGEBRAIC[19] = 0.0410000*exp(- pow((STATES[0]+47.0000)/12.0000, 2.00000))+0.0800000/(1.00000+exp((STATES[0]+55.0000)/- 5.00000))+0.0150000/(1.00000+exp((STATES[0]+75.0000)/25.0000))+0.00170000;
ALGEBRAIC[20] = 1.00000/( 45.1600*exp( 0.0357700*(STATES[0]+50.0000))+ 98.9000*exp( - 0.100000*(STATES[0]+38.0000)));
ALGEBRAIC[7] = 1.00000/(1.00000+exp((STATES[0]+12.5000)/- 7.70000));
ALGEBRAIC[21] = 3.00000/( 45.1600*exp( 0.0357700*(STATES[0]+50.0000))+ 98.9000*exp( - 0.100000*(STATES[0]+38.0000)));
ALGEBRAIC[9] = 1.00000/(1.00000+exp((STATES[0]+12.5000)/- 7.70000));
ALGEBRAIC[22] = 1.00000/( 45.1600*exp( 0.0357700*(STATES[0]+50.0000))+ 98.9000*exp( - 0.100000*(STATES[0]+38.0000)));
ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+12.5000)/- 7.70000));
ALGEBRAIC[23] = 1.00000/( 0.118850*exp((STATES[0]+80.0000)/28.3700)+ 0.562300*exp((STATES[0]+80.0000)/- 14.1900));
ALGEBRAIC[12] = 1.00000/(1.00000+exp((STATES[0]+138.600)/10.4800));
ALGEBRAIC[27] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[13]/STATES[10]);
ALGEBRAIC[28] = CONSTANTS[12]*STATES[11]*STATES[12]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[29] = CONSTANTS[14]*STATES[13]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[31] = ( (48.0000/(exp((STATES[0]+37.0000)/25.0000)+exp((STATES[0]+37.0000)/- 25.0000))+10.0000)*0.00100000)/(1.00000+exp((STATES[0] - (ALGEBRAIC[27]+76.7700))/- 17.0000))+( CONSTANTS[16]*(STATES[0] - (ALGEBRAIC[27]+1.73000)))/( (1.00000+exp(( 1.61300*CONSTANTS[2]*(STATES[0] - (ALGEBRAIC[27]+1.73000)))/( CONSTANTS[0]*CONSTANTS[1])))*(1.00000+exp((CONSTANTS[13] - 0.998800)/- 0.124000)));
ALGEBRAIC[39] = ( (( (( CONSTANTS[24]*1.00000)/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0365000*CONSTANTS[69]*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))))*CONSTANTS[13])/(CONSTANTS[13]+CONSTANTS[25]))*1.00000)/(1.00000+pow(CONSTANTS[26]/STATES[1], 1.50000));
ALGEBRAIC[30] = CONSTANTS[15]*STATES[14]*STATES[15]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[33] = CONSTANTS[17]*STATES[16]*CONSTANTS[68]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[37] = CONSTANTS[21]*(STATES[0] - ALGEBRAIC[27]);
ALGEBRAIC[24] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[8]/STATES[1]);
ALGEBRAIC[25] = CONSTANTS[7]*pow(STATES[2], 3.00000)*STATES[3]*STATES[4]*(STATES[0] - ALGEBRAIC[24]);
ALGEBRAIC[26] = CONSTANTS[9]*STATES[6]*( (0.900000+STATES[9]/10.0000)*STATES[7]+ (0.100000 - STATES[9]/10.0000)*STATES[8])*(STATES[0] - CONSTANTS[10]);
ALGEBRAIC[32] = CONSTANTS[17]*STATES[16]*CONSTANTS[18]*(STATES[0] - ALGEBRAIC[24]);
ALGEBRAIC[34] = ALGEBRAIC[32]+ALGEBRAIC[33];
ALGEBRAIC[35] = CONSTANTS[19]*(STATES[0] - ALGEBRAIC[24]);
ALGEBRAIC[36] = CONSTANTS[20]*(STATES[0] - CONSTANTS[22]);
ALGEBRAIC[38] = ALGEBRAIC[35]+ALGEBRAIC[36]+ALGEBRAIC[37];
ALGEBRAIC[41] = ( CONSTANTS[28]*( pow(STATES[1], 3.00000)*CONSTANTS[23]*exp( 0.0374300*STATES[0]*CONSTANTS[30]) - pow(CONSTANTS[8], 3.00000)*STATES[17]*exp( 0.0374300*STATES[0]*(CONSTANTS[30] - 1.00000))))/(1.00000+ CONSTANTS[29]*( STATES[17]*pow(CONSTANTS[8], 3.00000)+ CONSTANTS[23]*pow(STATES[1], 3.00000)));
ALGEBRAIC[40] = ( CONSTANTS[27]*STATES[17])/(STATES[17]+0.000400000);
ALGEBRAIC[13] = (VOI - floor(VOI/CONSTANTS[4])*CONSTANTS[4]>=0.00000&&VOI - floor(VOI/CONSTANTS[4])*CONSTANTS[4]<=CONSTANTS[5] ? CONSTANTS[6] : 0.00000);
ALGEBRAIC[43] = pow(STATES[17]/CONSTANTS[40], CONSTANTS[45]);
ALGEBRAIC[44] = pow(STATES[23]/CONSTANTS[41], CONSTANTS[46]);
ALGEBRAIC[45] = ( CONSTANTS[44]*( CONSTANTS[42]*ALGEBRAIC[43] - CONSTANTS[43]*ALGEBRAIC[44]))/(1.00000+ALGEBRAIC[43]+ALGEBRAIC[44]);
ALGEBRAIC[47] = (STATES[23] - STATES[22])/CONSTANTS[47];
ALGEBRAIC[48] = CONSTANTS[51]*STATES[17]*(CONSTANTS[49] - STATES[24]) - CONSTANTS[52]*STATES[24];
ALGEBRAIC[42] = CONSTANTS[31]*(STATES[18]+STATES[19])*(STATES[22] - STATES[5]);
ALGEBRAIC[46] = (STATES[5] - STATES[17])/CONSTANTS[48];
ALGEBRAIC[49] = 1.00000/(1.00000+( CONSTANTS[62]*CONSTANTS[59])/pow(CONSTANTS[59]+STATES[5], 2.00000));
ALGEBRAIC[50] = 1.00000/(1.00000+( CONSTANTS[63]*CONSTANTS[60])/pow(CONSTANTS[60]+STATES[22], 2.00000));
ALGEBRAIC[51] = CONSTANTS[53]*STATES[17]*(CONSTANTS[50] - STATES[25]) - CONSTANTS[54]*STATES[25];
ALGEBRAIC[52] = ALGEBRAIC[48]+ALGEBRAIC[51];
ALGEBRAIC[53] = 1.00000/(1.00000+( CONSTANTS[62]*CONSTANTS[59])/pow(CONSTANTS[59]+STATES[17], 2.00000)+( CONSTANTS[64]*CONSTANTS[61])/pow(CONSTANTS[61]+STATES[17], 2.00000));
}