Generated Code
The following is c_ida code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 70 entries in the algebraic variable array.
There are a total of 7 entries in each of the rate and state variable arrays.
There are a total of 46 entries in the constant variable array.
*/
/*
* VOI is time in component environment (millisecond).
* STATES[0] is V in component membrane (millivolt).
* ALGEBRAIC[0] is IK in component membrane (femtoA).
* ALGEBRAIC[18] is ICa in component membrane (femtoA).
* ALGEBRAIC[1] is IKCa in component membrane (femtoA).
* ALGEBRAIC[68] is IKATP in component KATP (femtoA).
* CONSTANTS[0] is Cm in component membrane (femtoF).
* CONSTANTS[1] is gK in component membrane (picoS).
* CONSTANTS[2] is VK in component KATP (millivolt).
* STATES[1] is n in component membrane (dimensionless).
* CONSTANTS[3] is gKCa in component membrane (picoS).
* CONSTANTS[4] is kd in component membrane (micromolar).
* STATES[2] is c in component calcium_handling (micromolar).
* CONSTANTS[5] is gCa in component membrane (picoS).
* ALGEBRAIC[2] is minf in component membrane (dimensionless).
* CONSTANTS[6] is VCa in component membrane (millivolt).
* CONSTANTS[7] is taun in component membrane (millisecond).
* ALGEBRAIC[3] is ninf in component membrane (dimensionless).
* STATES[3] is cer in component calcium_handling (micromolar).
* CONSTANTS[8] is fcyt in component calcium_handling (dimensionless).
* ALGEBRAIC[19] is Jmem in component calcium_handling (flux).
* ALGEBRAIC[6] is Jer in component calcium_handling (flux).
* CONSTANTS[9] is fer in component calcium_handling (dimensionless).
* CONSTANTS[10] is sigmaV in component calcium_handling (dimensionless).
* CONSTANTS[11] is pleak in component calcium_handling (first_order_rate_constant).
* CONSTANTS[12] is Kserca in component calcium_handling (first_order_rate_constant).
* CONSTANTS[13] is lambdaer in component calcium_handling (dimensionless).
* CONSTANTS[14] is epser in component calcium_handling (dimensionless).
* CONSTANTS[15] is alpha in component calcium_handling (micromolar_per_femtoA_millisecond).
* CONSTANTS[16] is kpmca in component calcium_handling (first_order_rate_constant).
* ALGEBRAIC[4] is Jserca in component calcium_handling (flux).
* ALGEBRAIC[5] is Jleak in component calcium_handling (flux).
* ALGEBRAIC[8] is rgpdh in component glycolysis (flux).
* CONSTANTS[17] is Rgk in component glycolysis (per_second).
* CONSTANTS[18] is atot in component glycolysis (micromolar).
* CONSTANTS[19] is pfkbas in component glycolysis (dimensionless).
* CONSTANTS[20] is Katpase in component glycolysis (micromolar).
* CONSTANTS[21] is kg in component glycolysis (flux).
* ALGEBRAIC[7] is f6p in component glycolysis (micromolar).
* CONSTANTS[22] is lambda in component glycolysis (dimensionless).
* ALGEBRAIC[69] is pfk in component pfk (micromolar).
* STATES[4] is g6p in component glycolysis (micromolar).
* STATES[5] is fbp in component glycolysis (micromolar).
* CONSTANTS[23] is bottom1 in component pfk (dimensionless).
* CONSTANTS[24] is weight1 in component pfk (dimensionless).
* CONSTANTS[25] is topa1 in component pfk (dimensionless).
* CONSTANTS[26] is k1 in component pfk (micromolar).
* CONSTANTS[27] is k2 in component pfk (micromolar).
* CONSTANTS[28] is k3 in component pfk (micromolar).
* CONSTANTS[29] is k4 in component pfk (micromolar).
* CONSTANTS[30] is cat in component pfk (dimensionless).
* ALGEBRAIC[21] is atp in component nucleotides (micromolar).
* ALGEBRAIC[24] is weight2 in component pfk (dimensionless).
* CONSTANTS[45] is topa2 in component pfk (dimensionless).
* ALGEBRAIC[25] is bottom2 in component pfk (dimensionless).
* ALGEBRAIC[10] is topa3 in component pfk (dimensionless).
* ALGEBRAIC[9] is weight3 in component pfk (dimensionless).
* ALGEBRAIC[26] is bottom3 in component pfk (dimensionless).
* CONSTANTS[31] is famp in component pfk (dimensionless).
* CONSTANTS[32] is fatp in component pfk (dimensionless).
* CONSTANTS[33] is ffbp in component pfk (dimensionless).
* CONSTANTS[34] is fbt in component pfk (dimensionless).
* CONSTANTS[35] is fmt in component pfk (dimensionless).
* ALGEBRAIC[27] is weight4 in component pfk (dimensionless).
* ALGEBRAIC[28] is topa4 in component pfk (dimensionless).
* ALGEBRAIC[29] is bottom4 in component pfk (dimensionless).
* ALGEBRAIC[11] is weight5 in component pfk (dimensionless).
* ALGEBRAIC[30] is topa5 in component pfk (dimensionless).
* ALGEBRAIC[31] is bottom5 in component pfk (dimensionless).
* ALGEBRAIC[32] is weight6 in component pfk (dimensionless).
* ALGEBRAIC[33] is topa6 in component pfk (dimensionless).
* ALGEBRAIC[34] is bottom6 in component pfk (dimensionless).
* ALGEBRAIC[12] is weight7 in component pfk (dimensionless).
* ALGEBRAIC[35] is topa7 in component pfk (dimensionless).
* ALGEBRAIC[36] is bottom7 in component pfk (dimensionless).
* ALGEBRAIC[37] is weight8 in component pfk (dimensionless).
* ALGEBRAIC[38] is topa8 in component pfk (dimensionless).
* ALGEBRAIC[39] is bottom8 in component pfk (dimensionless).
* ALGEBRAIC[40] is weight9 in component pfk (dimensionless).
* ALGEBRAIC[41] is topa9 in component pfk (dimensionless).
* ALGEBRAIC[42] is bottom9 in component pfk (dimensionless).
* ALGEBRAIC[43] is weight10 in component pfk (dimensionless).
* ALGEBRAIC[44] is topa10 in component pfk (dimensionless).
* ALGEBRAIC[45] is bottom10 in component pfk (dimensionless).
* ALGEBRAIC[46] is weight11 in component pfk (dimensionless).
* ALGEBRAIC[47] is topa11 in component pfk (dimensionless).
* ALGEBRAIC[48] is bottom11 in component pfk (dimensionless).
* ALGEBRAIC[49] is weight12 in component pfk (dimensionless).
* ALGEBRAIC[50] is topa12 in component pfk (dimensionless).
* ALGEBRAIC[51] is bottom12 in component pfk (dimensionless).
* ALGEBRAIC[52] is weight13 in component pfk (dimensionless).
* ALGEBRAIC[53] is topa13 in component pfk (dimensionless).
* ALGEBRAIC[54] is bottom13 in component pfk (dimensionless).
* ALGEBRAIC[55] is weight14 in component pfk (dimensionless).
* ALGEBRAIC[56] is topa14 in component pfk (dimensionless).
* ALGEBRAIC[57] is bottom14 in component pfk (dimensionless).
* ALGEBRAIC[58] is weight15 in component pfk (dimensionless).
* ALGEBRAIC[59] is topa15 in component pfk (dimensionless).
* ALGEBRAIC[60] is bottom15 in component pfk (dimensionless).
* ALGEBRAIC[62] is weight16 in component pfk (dimensionless).
* ALGEBRAIC[63] is topa16 in component pfk (dimensionless).
* ALGEBRAIC[64] is bottom16 in component pfk (dimensionless).
* ALGEBRAIC[61] is topb in component pfk (dimensionless).
* ALGEBRAIC[22] is amp in component nucleotides (micromolar).
* ALGEBRAIC[13] is mgadp in component KATP (micromolar).
* ALGEBRAIC[14] is adp3m in component KATP (micromolar).
* ALGEBRAIC[65] is atp4m in component KATP (micromolar).
* ALGEBRAIC[15] is topo in component KATP (dimensionless).
* ALGEBRAIC[66] is bottomo in component KATP (dimensionless).
* ALGEBRAIC[67] is katpo in component KATP (dimensionless).
* CONSTANTS[36] is gkatpbar in component KATP (picoS).
* STATES[6] is adp in component nucleotides (micromolar).
* CONSTANTS[37] is kdd in component KATP (dimensionless).
* CONSTANTS[38] is ktd in component KATP (dimensionless).
* CONSTANTS[39] is ktt in component KATP (dimensionless).
* ALGEBRAIC[20] is fback in component nucleotides (dimensionless).
* CONSTANTS[40] is taua in component nucleotides (dimensionless).
* CONSTANTS[41] is r1 in component nucleotides (micromolar).
* CONSTANTS[42] is r in component nucleotides (dimensionless).
* ALGEBRAIC[16] is y in component nucleotides (dimensionless).
* CONSTANTS[43] is vg in component nucleotides (dimensionless).
* CONSTANTS[44] is kg in component nucleotides (flux).
* ALGEBRAIC[17] is rad in component nucleotides (dimensionless).
* ALGEBRAIC[23] is ratio in component nucleotides (dimensionless).
* RATES[0] is d/dt V in component membrane (millivolt).
* RATES[1] is d/dt n in component membrane (dimensionless).
* RATES[2] is d/dt c in component calcium_handling (micromolar).
* RATES[3] is d/dt cer in component calcium_handling (micromolar).
* RATES[5] is d/dt fbp in component glycolysis (micromolar).
* RATES[4] is d/dt g6p in component glycolysis (micromolar).
* RATES[6] is d/dt adp in component nucleotides (micromolar).
* There are a total of 0 condition variables.
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = -60;
CONSTANTS[0] = 5300;
CONSTANTS[1] = 2700;
CONSTANTS[2] = -75;
STATES[1] = 0;
CONSTANTS[3] = 600;
CONSTANTS[4] = 0.5;
STATES[2] = 0.25;
CONSTANTS[5] = 1000;
CONSTANTS[6] = 25;
CONSTANTS[7] = 20;
STATES[3] = 185;
CONSTANTS[8] = 0.01;
CONSTANTS[9] = 0.01;
CONSTANTS[10] = 31;
CONSTANTS[11] = 0.0002;
CONSTANTS[12] = 0.4;
CONSTANTS[13] = 1;
CONSTANTS[14] = 1;
CONSTANTS[15] = 0.00000450;
CONSTANTS[16] = 0.2;
CONSTANTS[17] = 0.2;
CONSTANTS[18] = 3000;
CONSTANTS[19] = 0.06;
CONSTANTS[20] = 0.0003;
CONSTANTS[21] = 10;
CONSTANTS[22] = 0.005;
STATES[4] = 200;
STATES[5] = 40;
CONSTANTS[23] = 1;
CONSTANTS[24] = 1;
CONSTANTS[25] = 0;
CONSTANTS[26] = 30;
CONSTANTS[27] = 1;
CONSTANTS[28] = 50000;
CONSTANTS[29] = 1000;
CONSTANTS[30] = 2;
CONSTANTS[31] = 0.02;
CONSTANTS[32] = 20;
CONSTANTS[33] = 0.2;
CONSTANTS[34] = 20;
CONSTANTS[35] = 20;
CONSTANTS[36] = 25000;
STATES[6] = 780;
CONSTANTS[37] = 17;
CONSTANTS[38] = 26;
CONSTANTS[39] = 1;
CONSTANTS[40] = 300000;
CONSTANTS[41] = 0.35;
CONSTANTS[42] = 1;
CONSTANTS[43] = 2.2;
CONSTANTS[44] = 10;
CONSTANTS[45] = CONSTANTS[25];
RATES[0] = 0.1001;
RATES[1] = 0.1001;
RATES[2] = 0.1001;
RATES[3] = 0.1001;
RATES[5] = 0.1001;
RATES[4] = 0.1001;
RATES[6] = 0.1001;
}
void
computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES,
double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS)
{
resid[0] = RATES[0] - - (ALGEBRAIC[0]+ALGEBRAIC[18]+ALGEBRAIC[1]+ALGEBRAIC[68])/CONSTANTS[0];
resid[1] = RATES[1] - (ALGEBRAIC[3] - STATES[1])/CONSTANTS[7];
resid[2] = RATES[2] - CONSTANTS[8]*(ALGEBRAIC[19]+ALGEBRAIC[6]);
resid[3] = RATES[3] - - CONSTANTS[9]*CONSTANTS[10]*ALGEBRAIC[6];
resid[4] = RATES[5] - CONSTANTS[22]*(ALGEBRAIC[69] - 0.500000*ALGEBRAIC[8]);
resid[5] = RATES[4] - CONSTANTS[22]*(CONSTANTS[17] - ALGEBRAIC[69]);
resid[6] = RATES[6] - (ALGEBRAIC[21] - STATES[6]*exp( ALGEBRAIC[20]*(1.00000 - STATES[2]/CONSTANTS[41])))/CONSTANTS[40];
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[23] = ALGEBRAIC[21]/STATES[6];
}
void
computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] = CONSTANTS[1]*STATES[1]*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[1] = (CONSTANTS[3]/(1.00000+pow(CONSTANTS[4]/STATES[2], 2.00000)))*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[3] = 1.00000/(1.00000+exp(- (16.0000+STATES[0])/5.00000));
ALGEBRAIC[4] = CONSTANTS[12]*STATES[2];
ALGEBRAIC[5] = CONSTANTS[11]*(STATES[3] - STATES[2]);
ALGEBRAIC[6] = ( CONSTANTS[14]*(ALGEBRAIC[5] - ALGEBRAIC[4]))/CONSTANTS[13];
ALGEBRAIC[8] = 0.200000* pow(fabs(STATES[5]), 1.0 / 2);
ALGEBRAIC[2] = 1.00000/(1.00000+exp(- (20.0000+STATES[0])/12.0000));
ALGEBRAIC[18] = CONSTANTS[5]*ALGEBRAIC[2]*(STATES[0] - CONSTANTS[6]);
ALGEBRAIC[19] = - ( CONSTANTS[15]*ALGEBRAIC[18]+ CONSTANTS[16]*STATES[2]);
ALGEBRAIC[16] = CONSTANTS[43]*(ALGEBRAIC[8]/(CONSTANTS[44]+ALGEBRAIC[8]));
ALGEBRAIC[20] = CONSTANTS[42]+ALGEBRAIC[16];
ALGEBRAIC[17] = pow(fabs(pow(STATES[6] - CONSTANTS[18], 2.00000) - 4.00000*pow(STATES[6], 2.00000)), 1.0 / 2);
ALGEBRAIC[21] = 0.500000*((CONSTANTS[18] - STATES[6])+ALGEBRAIC[17]);
ALGEBRAIC[13] = 0.165000*STATES[6];
ALGEBRAIC[15] = 0.0800000*(1.00000+( 2.00000*ALGEBRAIC[13])/CONSTANTS[37])+ 0.890000*pow(ALGEBRAIC[13]/CONSTANTS[37], 2.00000);
ALGEBRAIC[14] = 0.135000*STATES[6];
ALGEBRAIC[65] = 0.0500000*ALGEBRAIC[21];
ALGEBRAIC[66] = pow(1.00000+ALGEBRAIC[13]/CONSTANTS[37], 2.00000)*(1.00000+ALGEBRAIC[14]/CONSTANTS[38]+ALGEBRAIC[65]/CONSTANTS[39]);
ALGEBRAIC[67] = ALGEBRAIC[15]/ALGEBRAIC[66];
ALGEBRAIC[68] = CONSTANTS[36]*ALGEBRAIC[67]*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[7] = 0.300000*STATES[4];
ALGEBRAIC[9] = pow(ALGEBRAIC[7], 2.00000)/CONSTANTS[28];
ALGEBRAIC[10] = CONSTANTS[45]+ALGEBRAIC[9];
ALGEBRAIC[27] = pow( ALGEBRAIC[7]*ALGEBRAIC[21], 2.00000)/( CONSTANTS[32]*CONSTANTS[28]*CONSTANTS[29]);
ALGEBRAIC[28] = ALGEBRAIC[10]+ALGEBRAIC[27];
ALGEBRAIC[30] = ALGEBRAIC[28];
ALGEBRAIC[33] = ALGEBRAIC[30];
ALGEBRAIC[12] = ( STATES[5]*pow(ALGEBRAIC[7], 2.00000))/( CONSTANTS[27]*CONSTANTS[28]*CONSTANTS[33]);
ALGEBRAIC[35] = ALGEBRAIC[33]+ALGEBRAIC[12];
ALGEBRAIC[37] = ( STATES[5]*pow(ALGEBRAIC[7], 2.00000)*pow(ALGEBRAIC[21], 2.00000))/( CONSTANTS[27]*CONSTANTS[28]*CONSTANTS[29]*CONSTANTS[33]*CONSTANTS[34]*CONSTANTS[32]);
ALGEBRAIC[38] = ALGEBRAIC[35]+ALGEBRAIC[37];
ALGEBRAIC[41] = ALGEBRAIC[38];
ALGEBRAIC[44] = ALGEBRAIC[41];
ALGEBRAIC[22] = ( STATES[6]*STATES[6])/ALGEBRAIC[21];
ALGEBRAIC[46] = ( ALGEBRAIC[22]*pow(ALGEBRAIC[7], 2.00000))/( CONSTANTS[26]*CONSTANTS[28]*CONSTANTS[31]);
ALGEBRAIC[47] = ALGEBRAIC[44]+ALGEBRAIC[46];
ALGEBRAIC[49] = ( ALGEBRAIC[22]*pow(ALGEBRAIC[7], 2.00000)*pow(ALGEBRAIC[21], 2.00000))/( CONSTANTS[26]*CONSTANTS[28]*CONSTANTS[29]*CONSTANTS[31]*CONSTANTS[35]*CONSTANTS[32]);
ALGEBRAIC[50] = ALGEBRAIC[47]+ALGEBRAIC[49];
ALGEBRAIC[53] = ALGEBRAIC[50];
ALGEBRAIC[56] = ALGEBRAIC[53];
ALGEBRAIC[59] = ALGEBRAIC[56];
ALGEBRAIC[62] = ( ALGEBRAIC[22]*STATES[5]*pow(ALGEBRAIC[7], 2.00000)*pow(ALGEBRAIC[21], 2.00000))/( CONSTANTS[26]*CONSTANTS[27]*CONSTANTS[28]*CONSTANTS[29]*CONSTANTS[33]*CONSTANTS[31]*CONSTANTS[34]*CONSTANTS[35]*CONSTANTS[32]);
ALGEBRAIC[63] = ALGEBRAIC[59]+ALGEBRAIC[62];
ALGEBRAIC[24] = pow(ALGEBRAIC[21], 2.00000)/CONSTANTS[29];
ALGEBRAIC[25] = CONSTANTS[23]+ALGEBRAIC[24];
ALGEBRAIC[26] = ALGEBRAIC[25]+ALGEBRAIC[9];
ALGEBRAIC[29] = ALGEBRAIC[26]+ALGEBRAIC[27];
ALGEBRAIC[11] = STATES[5]/CONSTANTS[27];
ALGEBRAIC[31] = ALGEBRAIC[29]+ALGEBRAIC[11];
ALGEBRAIC[32] = ( STATES[5]*pow(ALGEBRAIC[21], 2.00000))/( CONSTANTS[27]*CONSTANTS[29]*CONSTANTS[34]);
ALGEBRAIC[34] = ALGEBRAIC[31]+ALGEBRAIC[32];
ALGEBRAIC[36] = ALGEBRAIC[34]+ALGEBRAIC[12];
ALGEBRAIC[39] = ALGEBRAIC[36]+ALGEBRAIC[37];
ALGEBRAIC[40] = ALGEBRAIC[22]/CONSTANTS[26];
ALGEBRAIC[42] = ALGEBRAIC[39]+ALGEBRAIC[40];
ALGEBRAIC[43] = ( ALGEBRAIC[22]*pow(ALGEBRAIC[21], 2.00000))/( CONSTANTS[26]*CONSTANTS[29]*CONSTANTS[35]);
ALGEBRAIC[45] = ALGEBRAIC[42]+ALGEBRAIC[43];
ALGEBRAIC[48] = ALGEBRAIC[45]+ALGEBRAIC[46];
ALGEBRAIC[51] = ALGEBRAIC[48]+ALGEBRAIC[49];
ALGEBRAIC[52] = ( ALGEBRAIC[22]*STATES[5])/( CONSTANTS[26]*CONSTANTS[27]);
ALGEBRAIC[54] = ALGEBRAIC[51]+ALGEBRAIC[52];
ALGEBRAIC[55] = ( ALGEBRAIC[22]*STATES[5]*pow(ALGEBRAIC[21], 2.00000))/( CONSTANTS[26]*CONSTANTS[27]*CONSTANTS[29]*CONSTANTS[34]*CONSTANTS[35]);
ALGEBRAIC[57] = ALGEBRAIC[54]+ALGEBRAIC[55];
ALGEBRAIC[58] = ( ALGEBRAIC[22]*STATES[5]*pow(ALGEBRAIC[7], 2.00000))/( CONSTANTS[26]*CONSTANTS[27]*CONSTANTS[28]*CONSTANTS[33]*CONSTANTS[31]);
ALGEBRAIC[60] = ALGEBRAIC[57]+ALGEBRAIC[58];
ALGEBRAIC[64] = ALGEBRAIC[60]+ALGEBRAIC[62];
ALGEBRAIC[61] = ALGEBRAIC[58];
ALGEBRAIC[69] = ( CONSTANTS[19]*CONSTANTS[30]*ALGEBRAIC[63]+ CONSTANTS[30]*ALGEBRAIC[61])/ALGEBRAIC[64];
}
void
getStateInformation(double* SI)
{
SI[0] = 1.0;
SI[1] = 1.0;
SI[2] = 1.0;
SI[3] = 1.0;
SI[4] = 1.0;
SI[5] = 1.0;
SI[6] = 1.0;
}
void
computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES,
double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS)
{
}