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Signal Transduction

PMR2 Exposure File Asthagiri, Lauffenburger, 2001
A Compuational Study of Feedback Effects on Signal Dynamics in a Mitogen-Activated Protein Kinase (MAPK) Pathway Model
PMR2 Exposure File Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2006
Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores
PMR2 Exposure File Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008
Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (Model II)
PMR2 Exposure File Bagci, Vodovotz, Billiar, Ermentrout, Bahar, 2008
Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis (Model III)
PMR2 Exposure File Bertram, Arnot, Zamponi, 2002
Role for G protein G-beta-gamma isoform specificity in synaptic signal processing (Pre-Synaptic Cell)
PMR2 Exposure File Bertram, Arnot, Zamponi, 2002
Role for G protein G-beta-gamma isoform specificity in synaptic signal processing (Post-Synaptic Cell)
PMR2 Exposure File Bertram, Smolen, Sherman, Mears, Atwater, Martin, Soria, 1995
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells
PMR2 Exposure File Bhalla, Iyengar, 1999
Complete network of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
Ca-IP3 component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
EGFR pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
MAPK pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
Conversion of PIP to IP3 and DAG component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
PKC pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
PLA2 pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
PLC-gamma pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
RAS pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bhalla, Iyengar, 1999
phospholipase C (PLC) pathway component of the Bhalla-Iyengar model
PMR2 Exposure File Bornheimer, Maurya, Farquhar, Subramaniam, 2004
Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction
PMR2 Exposure File Brightman, Fell, 2000
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells.
PMR2 Exposure File Chen, Popel, 2006
Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
PMR2 Exposure File Chen, Popel, 2007
Vascular and perivascular nitric oxide release and transport (Fe3 = 0.6 micromolar)
PMR2 Exposure File Chen, Popel, 2007
Vascular and perivascular nitric oxide release and transport (Fe3 = 0.9 micromolar)
PMR2 Exposure File Cooling, Hunter, Crampin, 2007
Modeling hypertrophic IP3 transients in the cardiac myocyte
PMR2 Exposure File Cooling, Hunter, Crampin, 2008
Modeling Biological Modularity with CellML
PMR2 Exposure File Cooling, Hunter, Crampin, 2009
Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Shen-derived calcium protocol)
PMR2 Exposure File Cooling, Hunter, Crampin, 2009
Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Dual Calcium Protocol)
PMR2 Exposure File Cooling, Hunter, Crampin, 2009
Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Tomida-derived calcium protocol)
PMR2 Exposure File Cui, Kaandorp, 2008
Simulating Complex Calcium-Calcineurin Signaling Network
PMR2 Exposure File Dawson, Lea, Irvine, 2003
Kinetic model of the inositol trisphosphate receptor that shows both steady-state and quantal patterns of Ca2+ release from intracellular stores
PMR2 Exposure File De Young, Keizer, 1992
A single-pool inositol 1,4,5-triphosphate-receptor-based model for agonist-stimulated oscillations in Ca 2+ concentration
PMR2 Exposure File Demir, Clark, Giles, 1999
Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model
PMR2 Exposure File Dougherty, Wright, Yew, 2005
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons
PMR2 Exposure File Fall, Keizer, 2001
Mitochondrial Modulation of Intracellular Ca2+ Signalling
PMR2 Exposure File Fallon, Lauffenburger, 2000
Computational Model for Effects of Ligand/Receptor Binding Properties on Interleukin-2 Trafficking Dynamics and T Cell Proliferation Response
PMR2 Exposure File Farhy, Bowers, Veldhuis, 2007
Female-specific model and GHRH alone is being injected
PMR2 Exposure File Farhy, Bowers, Veldhuis, 2007
Male-specific model and GHRH alone is being injected
PMR2 Exposure File Goldbeter, Pourquie, 2008
Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways: coupled Notch, Wnt and FGF signalling pathways
PMR2 Exposure File Goldbeter, Pourquie, 2008
Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways: uncoupled Notch, Wnt and FGF signalling pathways
PMR2 Exposure File Gupta, Maurya, Stephens, Dennis, Subramaniam, 2009
An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis
PMR2 Exposure File Hatakeyama, Shirouzu, Yokoyama, Konagaya, Kimura, Naka, Kawasaki, Yumoto, Ichikawa, Kim, Saito, Saeki, 2003
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
PMR2 Exposure File Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005
Control of MAPK signalling: from complexity to what really matters
PMR2 Exposure File Huang, Ferrell, 1996
Ultrasensitivity in the mitogen-activated protein kinase cascade
PMR2 Exposure File Iancu, Jones, Harvey, 2007
Compartmentation of cAMP signaling in cardiac myocytes: a computational study
PMR2 Exposure File Karagiannis, Popel, 2004
A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2
PMR2 Exposure File Karagiannis, Popel, 2006
Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model
PMR2 Exposure File Kholodenko, Demin, Moehren, Hoek, 1999
Quantification of short term signalling by the epidermal growth
PMR2 Exposure File Kirschner, Panetta, 1998
Modeling immunotherapy of the tumor-immune interaction
PMR2 Exposure File LeBeau, Yule, Groblewski, Sneyd, 1999
Agonist-dependent Phosphorylation of the Inositol 1,4,5-Triphosphate Receptor
PMR2 Exposure File Leloup, Goldbeter, 2003
Toward a detailed computational model for the mammalian circadian clock
PMR2 Exposure File Leloup, Goldbeter, 2004
Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms
PMR2 Exposure File Leloup, Gonze, Goldbeter, 1999
Limit Cycle Model for Circadian Rhythms in Drosophila and Neurospora (Drosophila model)
PMR2 Exposure File Leloup, Gonze, Goldbeter, 1999
Limit Cycle Model for Circadian Rhythms in Drosophila and Neurospora (Neurospora model)
PMR2 Exposure File Maly, Wiley, Lauffenburger, 2004
Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis
PMR2 Exposure File Marwan, 2003
Theory of Time-Resolved Somatic Complementation and Its Use to Explore the Sporulation Control Network in Physarum polycephalum
PMR2 Exposure File Maurya, Bornheimer, Venkatasubramanian, Subramaniam, 2005
Reduced-order modelling of biochemical networks: application to the GTPase-cycle signalling module
PMR2 Exposure File Muller, Obeyesekere, Mills, Ram, 2008
Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R
PMR2 Exposure File Proctor, Soti, Boys, Gillespie, Shanley, Wilkinson, Kirkwood, 2005
Modelling the actions of chaperones and their role in ageing.
PMR2 Exposure File Proctor, Tsiringotis, Gray, 2007
An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline
PMR2 Exposure File Rangamani, Sirovich, 2007
Survival and apoptotic pathways initiated by TNF-alpha: modeling and predictions
PMR2 Exposure File Reidl, Borowski, Sensse, Starke, Zapotocky, Eiswirth, 2006
Model of Calcium Oscillations Due to Negative Feedback in Olfactory Cilia
PMR2 Exposure File Riccobene, Omann, Linderman, 1999
Modeling Activation and Desensitisation of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy
PMR2 Exposure File Sachse, Glanzel, Seemann, 2003
Modeling of Protein Interactions Involved in Cardiac Tension Development
PMR2 Exposure File Saftenku, Williams, Sitsapesan, 2001
Markovian Models of Low and High Activity Levals of Cardiac Ryanodine Receptors (Low Model)
PMR2 Exposure File Sarkar, Lauffenburger, 2003
Cell-Level Pharmacokinetic Model of Granulocyte Colony-Stimulating Factor: Implications for Ligand Lifetime and Potency in Vivo
PMR2 Exposure File Saucerman, Brunton, Michailova, McCulloch, 2003
Modeling beta-adrenergic control of cardiac myocyte contractility in silico
PMR2 Exposure File Saucerman, McCulloch, 2004
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation
PMR2 Exposure File Schoeberl, Eichler-Jonsson, Gilles, Muller, 2002
Computational Modeling of the Dynamics of the MAP Kinase Cascade Activated by Surface and Internalized EGF Receptors.
PMR2 Exposure File Schuster, Beny, Meister, 2003
Modelling the electrophysiological endothelial cell response to bradykinin
PMR2 Exposure File Sedaghat, Sherman, Quon, 2002
A mathematical model of metabolic insulin signaling pathways (without feedback)
PMR2 Exposure File Sedaghat, Sherman, Quon, 2002
A mathematical model of metabolic insulin signaling pathways (with feedback)
PMR2 Exposure File Shorten, Robson, McKinnon, Wall, 2000
CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs
PMR2 Exposure File Spiro, Parkinson, Othmer, 1997
A model of excitation and adaptation in bacterial chemotaxis
PMR2 Exposure File St Hilaire, Gronfier, Zeitzer, Klerman, 2007
A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker
PMR2 Exposure File Starbuck, Wiley, Lauffenburger, 1990
Epidermal Growth Factor Binding and Trafficking Dynamics in Fibroblasts: Relationship to Cell Proliferation
PMR2 Exposure File Tabak, Mascagni, Bertram, 2010
Mechanism for the Universal Pattern of Activity in Developing Neuronal Networks
PMR2 Exposure File Thomsen, Neubig, 1989
Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step
PMR2 Exposure File Tolic, Mosekilde, Sturis, 2000
Modelling the Insulin-Glucose Feedback System: The Significance of Pulsatile Insulin Secretion
PMR2 Exposure File Topp, Promislow, de Vries, Miura, Finegood, 2000
A Model of Beta-Cell Mass, Insulin, and Glucose Kinetics: Paythways to Diabetes
PMR2 Exposure File Ueda, Hagiwara, Kitano, 2001
Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
PMR2 Exposure File Vempati, Karagiannis, Popel, 2007
A Biochemical Model of Matrix Metalloproteinase 9 Activation and Inhibition
PMR2 Exposure File Vilar, Jansen, Sander, 2006
Signal processing in the TGF-beta superfamily ligand-receptor network (Standard Form)
PMR2 Exposure File Vilar, Jansen, Sander, 2006
Signal processing in the TGF-beta superfamily ligand-receptor network (Reaction Form)
PMR2 Exposure File Vilar, Kueh, Barkai, Leibler, 2002
Mechanisms of noise-resistance in genetic oscillators
PMR2 Exposure File Wanant, Quon, 2000
Insulin receptor binding kinetics: modeling and simulation studies (Divalent Receptor Model)
PMR2 Exposure File Wanant, Quon, 2000
Insulin receptor binding kinetics: modeling and simulation studies (Receptor Aggregation Model)
PMR2 Exposure File Warashina, Ogura, 2004
Modeling of simulation-secretion coupling in a chromaffin cell
PMR2 Exposure File Warren, Tawhai, Crampin, 2010
Mathematical modelling of calcium wave propagation in mammalian airway epithelium: evidence for regenerative ATP release
PMR2 Exposure File Winograd, Destexhe, Sanchez-Vives, 2008
Hyperpolarization-activated graded persistent activity in the prefrontal cortex
PMR2 Exposure File Wolf, Passarge, Somsen, Snoep, Heinrich, Westerhoff, 2000
Transduction of Intracellular and Intercellular Dynamics in Yeast Glycolytic Oscillations
PMR2 Exposure File Yang, Clark, Bryan, Robertson, 2003
The myogenic response in isolated rat cerebrovascular arteries: smooth muscle cell model
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