- Author:
- David Nickerson <david.nickerson@gmail.com>
- Date:
- 2019-11-04 22:25:48+09:00
- Desc:
- adding CellML 2.0 version of this model generated using the CellML1to2 XSL
- Permanent Source URI:
- http://models.cellml.org/w/andre/VPH-MIP/rawfile/bd1651a373bbed124d4bd763a86c32c2bf2f3ff0/cellml-2.0/components/stimulated.xml
<?xml version="1.0" encoding="UTF-8"?><model xmlns="http://www.cellml.org/cellml/2.0#" xmlns:cellml="http://www.cellml.org/cellml/2.0#" xmlns:xlink="http://www.w3.org/1999/xlink" name="stimulated">
<import xlink:href="units.xml">
<units name="mV" units_ref="mV"/>
<units name="ms" units_ref="ms"/>
<units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
<units name="mS_per_cmsq" units_ref="mS_per_cmsq"/>
<units name="uF_per_cmsq" units_ref="uF_per_cmsq"/>
</import>
<import xlink:href="INa.xml">
<component name="INa" component_ref="INa"/>
</import>
<import xlink:href="IK.xml">
<component name="IK" component_ref="IK"/>
</import>
<import xlink:href="Ileak.xml">
<component name="Ileak" component_ref="Ileak"/>
</import>
<component name="action_potential">
<variable name="V_initial" units="mV" interface="public_and_private"/>
<variable name="n_initial" units="dimensionless" interface="public_and_private"/>
<variable name="m_initial" units="dimensionless" interface="public_and_private"/>
<variable name="h_initial" units="dimensionless" interface="public_and_private"/>
<variable name="Istim" units="uA_per_cmsq" interface="public_and_private"/>
<variable name="INa" units="uA_per_cmsq" interface="public_and_private"/>
<variable name="IK" units="uA_per_cmsq" interface="public_and_private"/>
<variable name="Ileak" units="uA_per_cmsq" interface="public_and_private"/>
<variable name="h" units="dimensionless" interface="public_and_private"/>
<variable name="m" units="dimensionless" interface="public_and_private"/>
<variable name="n" units="dimensionless" interface="public_and_private"/>
<variable name="V" units="mV" initial_value="V_initial" interface="public_and_private"/>
<variable name="minus_V" units="mV" interface="public_and_private"/>
<variable name="VNa" units="mV" interface="public_and_private"/>
<variable name="VK" units="mV" interface="public_and_private"/>
<variable name="Vleak" units="mV" interface="public_and_private"/>
<variable name="gNa_max" units="mS_per_cmsq" interface="public_and_private"/>
<variable name="gK_max" units="mS_per_cmsq" interface="public_and_private"/>
<variable name="gleak_max" units="mS_per_cmsq" interface="public_and_private"/>
<variable name="Cm" units="uF_per_cmsq" interface="public_and_private"/>
<variable name="time" units="ms" interface="public_and_private"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_calculation"><eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>V</ci>
</apply>
<apply><divide/>
<apply><minus/>
<ci>Istim</ci>
<apply><plus/>
<ci>INa</ci>
<ci>IK</ci>
<ci>Ileak</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="minus_V_calculation"><eq/>
<ci>minus_V</ci>
<apply><minus/>
<ci>V</ci>
</apply>
</apply>
</math>
</component>
<encapsulation>
<component_ref component="action_potential">
<component_ref component="INa"/>
<component_ref component="IK"/>
<component_ref component="Ileak"/>
</component_ref>
</encapsulation>
<connection component_1="action_potential" component_2="INa">
<map_variables variable_1="INa" variable_2="INa"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="m_initial" variable_2="m_initial"/>
<map_variables variable_1="h_initial" variable_2="h_initial"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="VNa" variable_2="VNa"/>
<map_variables variable_1="gNa_max" variable_2="gNa_max"/>
</connection>
<connection component_1="action_potential" component_2="IK">
<map_variables variable_1="IK" variable_2="IK"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="n_initial" variable_2="n_initial"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="VK" variable_2="VK"/>
<map_variables variable_1="gK_max" variable_2="gK_max"/>
</connection>
<connection component_1="action_potential" component_2="Ileak">
<map_variables variable_1="Ileak" variable_2="Ileak"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Vleak" variable_2="Vleak"/>
<map_variables variable_1="gleak_max" variable_2="gleak_max"/>
</connection>
</model>
