Location: VPH-MIP case study on CellML @ eeb193d348e7 / experiments / INa-gating-kinetics.xml

Author:
David Nickerson <nickerso@users.sourceforge.net>
Date:
2012-09-26 15:21:03+12:00
Desc:
renaming the tutorial web page to work around a bug in making PMR2 exposures with files named index.html
Permanent Source URI:
http://models.cellml.org/w/andre/VPH-MIP/rawfile/eeb193d348e735266eae6b9948908adc88bc4c00/experiments/INa-gating-kinetics.xml

<?xml version="1.0" encoding="iso-8859-1"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" name="INa_gating_kinetics" cmeta:id="INa_gating_kinetics_model">
  

  <import xlink:href="../components/units.xml">
    <units name="ms" units_ref="ms"/>
    <units name="mV_per_ms" units_ref="mV_per_ms"/>
    <units name="mV" units_ref="mV"/>
  </import>
  <import xlink:href="../components/INa-gating-rates.xml">
    <component name="alpha_m" component_ref="alpha_m"/>
    <component name="beta_m" component_ref="beta_m"/>
    <component name="alpha_h" component_ref="alpha_h"/>
    <component name="beta_h" component_ref="beta_h"/>
  </import>
  <import xlink:href="../components/gating-variable.xml">
    <component name="m_gate" component_ref="hh_gating_variable_steady_state"/>
  </import>
  <connection>
    <map_components component_1="m_gate" component_2="alpha_m"/>
    <map_variables variable_1="alpha" variable_2="alpha"/>
  </connection>
  <connection>
    <map_components component_1="m_gate" component_2="beta_m"/>
    <map_variables variable_1="beta" variable_2="beta"/>
  </connection>
  <import xlink:href="../components/gating-variable.xml">
    <component name="h_gate" component_ref="hh_gating_variable_steady_state"/>
  </import>
  <connection>
    <map_components component_1="h_gate" component_2="alpha_h"/>
    <map_variables variable_1="alpha" variable_2="alpha"/>
  </connection>
  <connection>
    <map_components component_1="h_gate" component_2="beta_h"/>
    <map_variables variable_1="beta" variable_2="beta"/>
  </connection>
  
  <import xlink:href="potential-ramp.xml">
    <component name="V" component_ref="ramp"/>
  </import>
  <import xlink:href="../components/default-variable-values.xml">
    <component name="default_parameters" component_ref="parameters"/>
    <component name="default_initial_conditions" component_ref="initial_conditions"/>
  </import>
  
  <component name="time" cmeta:id="time_component">
    
    <variable cmeta:id="time" name="time" initial_value="0.0" public_interface="out" units="ms"/>
  </component>
  <connection>
    <map_components component_1="m_gate" component_2="time"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="h_gate" component_2="time"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="time" component_2="V"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>

  <component name="V_parameters" cmeta:id="V_parameters">
    
    <variable name="k" initial_value="1.0" public_interface="out" units="mV_per_ms"/>
    <variable cmeta:id="V" name="V" public_interface="in" units="mV"/>
    <variable cmeta:id="m_inf" name="m_inf" public_interface="in" units="dimensionless"/>
    <variable cmeta:id="h_inf" name="h_inf" public_interface="in" units="dimensionless"/>
  </component>
  <connection>
    <map_components component_1="V_parameters" component_2="V"/>
    <map_variables variable_1="k" variable_2="k"/>
    <map_variables variable_1="V" variable_2="y"/>
  </connection>
  <connection>
    <map_components component_1="alpha_m" component_2="V"/>
    <map_variables variable_1="V" variable_2="y"/>
  </connection>
  <connection>
    <map_components component_1="beta_m" component_2="V"/>
    <map_variables variable_1="V" variable_2="y"/>
  </connection>
  <connection>
    <map_components component_1="alpha_h" component_2="V"/>
    <map_variables variable_1="V" variable_2="y"/>
  </connection>
  <connection>
    <map_components component_1="beta_h" component_2="V"/>
    <map_variables variable_1="V" variable_2="y"/>
  </connection>
  <connection>
    <map_components component_1="m_gate" component_2="V_parameters"/>
    <map_variables variable_1="gate_inf" variable_2="m_inf"/>
  </connection>
  <connection>
    <map_components component_1="h_gate" component_2="V_parameters"/>
    <map_variables variable_1="gate_inf" variable_2="h_inf"/>
  </connection>

  <component name="parameters" cmeta:id="parameters">
    
  </component>
  <connection>
    <map_components component_1="alpha_m" component_2="default_parameters"/>
    <map_variables variable_1="Tref" variable_2="Tref_rates"/>
    <map_variables variable_1="T" variable_2="T"/>
    <map_variables variable_1="Q10" variable_2="Q10_rates"/>
  </connection>
  <connection>
    <map_components component_1="beta_m" component_2="default_parameters"/>
    <map_variables variable_1="Tref" variable_2="Tref_rates"/>
    <map_variables variable_1="T" variable_2="T"/>
    <map_variables variable_1="Q10" variable_2="Q10_rates"/>
  </connection>
  <connection>
    <map_components component_1="alpha_h" component_2="default_parameters"/>
    <map_variables variable_1="Tref" variable_2="Tref_rates"/>
    <map_variables variable_1="T" variable_2="T"/>
    <map_variables variable_1="Q10" variable_2="Q10_rates"/>
  </connection>
  <connection>
    <map_components component_1="beta_h" component_2="default_parameters"/>
    <map_variables variable_1="Tref" variable_2="Tref_rates"/>
    <map_variables variable_1="T" variable_2="T"/>
    <map_variables variable_1="Q10" variable_2="Q10_rates"/>
  </connection>
  
  <component name="initial_conditions" cmeta:id="initial_conditions">
    
    <variable cmeta:id="V_initial" name="V_initial" public_interface="out" units="mV" initial_value="-120.0"/>
  </component>
  <connection>
    <map_components component_1="m_gate" component_2="default_initial_conditions"/>
    <map_variables variable_1="gate_initial" variable_2="m_initial"/>
  </connection>
  <connection>
    <map_components component_1="h_gate" component_2="default_initial_conditions"/>
    <map_variables variable_1="gate_initial" variable_2="h_initial"/>
  </connection>
  <connection>
    <map_components component_1="V" component_2="initial_conditions"/>
    <map_variables variable_1="y_initial" variable_2="V_initial"/>
  </connection>
</model>