- Author:
- Hanne Nielsen <hnie010@aucklanduni.ac.nz>
- Date:
- 2011-08-23 09:54:25+12:00
- Desc:
- Added HTML file
- Permanent Source URI:
- http://models.cellml.org/w/hnielsen/saez_rodriguez_2004/rawfile/a8daf3bf5f6a7964e04e5cc6a1437430d2d99417/saez_rodriguez_2004_2.cellml
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COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
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<title>Modular Analysis of Signal Transduction Networks, Seaz-Rodriguez, 2004</title>
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<firstname>Hanne</firstname>
<surname>Nielsen</surname>
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<shortaffil>Bioengineering Institute, The University of Auckland</shortaffil>
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<section id="sec_status">
<title>Model Status</title>
<para>
This model has does not run in COR, PCEnv and OpenCell to replicate results from the original matlab code as we were missing initial values. It is based on the original published paper. </para>
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT:This paper introduces compelling problems of biological systems and signaling networks to show how engineering tools can be applied to the analysis of the cellular machinery. The mechanisms that cells have developed to process information are described, and the decomposition of signalling networks into subsystems is discussed. A novel criterion for defining modules based on the absence of retroactivity is also presented, and some simple criteria for the analysis of the resulting units are introduced. Two simple examples, two-component signaling and MAPK cascade, and a more complicated example, EGF signaling, were reviewed. An important point to discuss in model analysis for cellular system is the availability of experimental data that is sufficient to verify the model structure and model parameters.
</para>
<para>
The original paper reference is cited below:
</para>
<para>Modular Analysis of Signal Transduction Networks, Julio Saez-Rodriguez, Andreas Kremling, Holger Conzelmann, Katja Bettenbrock and Ernst Dieter Gilles, 2004, <emphasis>IEEE Control Systems Magazine</emphasis>, (24:4) August 2004. <ulink url="http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=1316652&tag=1">PubMed ID: unknown</ulink>
</para>
<para>
Illustration of the Model:
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Modular Analysis of Signal Transduction Networks
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