Location: mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: A population-based simulation study @ b4e719b237a8 / index.html

Author:: David Nickerson <nickerso@users.sourceforge.net>
Date:: 2011-11-17 17:19:50+13:00
Desc:: update stimulus protocol to allow offset of applied stimulus from time 0
Permanent Source URI:: http://models.cellml.org/w/miller/Walmsley_Rodriguez_2013/rawfile/b4e719b237a8d183ab7c7ab54db304722f726b0b/index.html

This workspace houses a CellML 1.0 encoding of the 2011 O'Hara, VirÃ¡g, VarrÃ³, & Rudy 2011 human cardiac ventricular action potential model (ORd). The original article is available at: http://www.ncbi.nlm.nih.gov/pubmed/21637795. This model was encoded based on the Matlab version of the code available from: http://rudylab.wustl.edu/research/cell/.

The CellML 1.0 encoding of the ORd model was contributed by Steven Niederer. While the units in the CellML encoding are not yet perfect, it is a match for the Matlab code and matches the simulation output for a single beat perfectly. The figure below shows the output of the simulation experiment action-potential.xml encoded in SED-ML using the original version of the model from Steve. This output is generated by running the simulation experiment using the SED-ML Web Tools.