- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2008-12-10 04:47:08+13:00
- Desc:
- committing version03 of chen_calzone_csikasznagy_cross_novak_tyson_2004
- Permanent Source URI:
- http://models.cellml.org/workspace/369/rawfile/19818edd102cb0c193419be5830bc456ddda98b1/chen_calzone_csikasznagy_cross_novak_tyson_2004.cellml
<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 10/12/2008 at 3:53:27 at p.m. using:
COR (0.9.31.1125)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="chen_calzone_csikasz-nagy_cross_novak_tyson_2004_version01" name="chen_calzone_csikasznagy_cross_novak_tyson_2004_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>An Integrative Analysis of Cell Cycle Control in Budding Yeast</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML version of the model has been checked in COR and PCEnv and the model runs to replicate the results in the original published paper. The units have been checked and are consistent.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
The mitotic cell cycle can be defined as the sequence of events by which a somatic cell replicates all its components, and then divides them equally between two daughter cells. The end product is two genetically identical daughter cells. Cell division is an essential component of the biological processes of growth, reproduction and development. As might be expected for such an important process, the distinct phases and events of the cell cycle are carefully regulated by specific proteins.
</para>
<para>
The cell cycle regulatory system is most fully understood for budding yeast, <emphasis>Saccharomyces cerevisiae</emphasis>. A hypothetical molecular mechanism, potentially underlying cell cycle control in this organism, is outlined in <xref linkend="fig_reaction_diagram"/> below. However, these networks of interacting proteins are so complex that the functional integration of the network cannot be understood by intuition alone. Mathematical models, which describe molecular interactions and reactions with biochemical rate equations, provide an integrative framework with which the complexities of molecular regulatory networks can be studied. In the Chen <emphasis>et al.</emphasis> 2004 publication described here, the authors develop a mathematical model to analyse cell cycle control in budding yeast. Model simulations reveal that the data generated by the model are in accord with the physiological properties of many genetic strains of budding yeast. The mathematical model is also useful in that it can be used to interpret existing experimental data and help to design new experiments.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Chen <emphasis>et al.</emphasis> 2004 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.molbiolcell.org/cgi/content/abstract/E03-11-0794v1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=chen+KC&andorexactfulltext=and&searchid=1090102867811_525&stored_search=&FIRSTINDEX=0&sortspec=relevance&resourcetype=1&journalcode=molbiolcell">Integrative analysis of cell cycle control in budding yeast</ulink>, Katherine C. Chen, Laurence Calzone, Attila Csikasz-Nagy, Frederick R. Cross, Bela Novak, and John J. Tyson, 2004, <ulink url="http://www.molbiolcell.org/">
<emphasis>Molecular Biology of the Cell</emphasis>
</ulink>. (<ulink url="http://www.molbiolcell.org/cgi/reprint/E03-11-0794">A PDF</ulink> version of the article is available to subscribers ahead of print on the <emphasis>Molecular Biology of the Cell</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15169868&dopt=Abstract">PubMed ID: 15169868</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram</title>
</objectinfo>
<imagedata fileref="chen_2004.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the cell cycle control mechanism in budding yeast.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="minute">
<unit units="second" multiplier="60"/>
</units>
<units name="first_order_rate_constant">
<unit units="minute" exponent="-1"/>
</units>
<component name="environment">
<variable units="minute" public_interface="out" name="time"/>
</component>
<component name="mass">
<variable units="dimensionless" public_interface="out" name="mass" initial_value="1.206"/>
<variable units="first_order_rate_constant" public_interface="in" name="kg"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>mass</ci>
</apply>
<apply>
<times/>
<ci>mass</ci>
<ci>kg</ci>
</apply>
</apply>
</math>
</component>
<component name="Cln2">
<variable units="dimensionless" public_interface="out" name="Cln2" initial_value="0.0652"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_n2_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_n2__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_n2"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<variable units="dimensionless" public_interface="in" name="SBF"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cln2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>ks_n2_</ci>
<apply>
<times/>
<ci>ks_n2__</ci>
<ci>SBF</ci>
</apply>
</apply>
<ci>mass</ci>
</apply>
<apply>
<times/>
<ci>kd_n2</ci>
<ci>Cln2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Clb5">
<variable units="dimensionless" public_interface="out" name="Clb5" initial_value="0.0518"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_b5_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_b5__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<variable units="dimensionless" public_interface="in" name="MBF"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Clb5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>ks_b5_</ci>
<apply>
<times/>
<ci>ks_b5__</ci>
<ci>MBF</ci>
</apply>
</apply>
<ci>mass</ci>
</apply>
<apply>
<times/>
<ci>kd3_c1</ci>
<ci>C5P</ci>
</apply>
<apply>
<times/>
<ci>kdi_b5</ci>
<ci>C5</ci>
</apply>
<apply>
<times/>
<ci>kd3_f6</ci>
<ci>F5P</ci>
</apply>
<apply>
<times/>
<ci>kdi_f5</ci>
<ci>F5</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b5</ci>
<apply>
<times/>
<ci>kas_b5</ci>
<ci>Sic1</ci>
</apply>
<apply>
<times/>
<ci>kas_f5</ci>
<ci>Cdc6</ci>
</apply>
</apply>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Clb2">
<variable units="dimensionless" public_interface="out" name="Clb2" initial_value="0.1469"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_b2_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_b2__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Clb2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>ks_b2_</ci>
<apply>
<times/>
<ci>ks_b2__</ci>
<ci>Mcm1</ci>
</apply>
</apply>
<ci>mass</ci>
</apply>
<apply>
<times/>
<ci>kd3_c1</ci>
<ci>C2P</ci>
</apply>
<apply>
<times/>
<ci>kdi_b2</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>kd3_f6</ci>
<ci>F2P</ci>
</apply>
<apply>
<times/>
<ci>kdi_f2</ci>
<ci>F2</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b2</ci>
<apply>
<times/>
<ci>kas_b2</ci>
<ci>Sic1</ci>
</apply>
<apply>
<times/>
<ci>kas_f2</ci>
<ci>Cdc6</ci>
</apply>
</apply>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Sic1">
<variable units="dimensionless" public_interface="out" name="Sic1" initial_value="0.0229"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_c1_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_c1__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_c1"/>
<variable units="dimensionless" public_interface="in" name="Swi5"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Sic1P"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Sic1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_c1_</ci>
<apply>
<times/>
<ci>ks_c1__</ci>
<ci>Swi5</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b2</ci>
<ci>kdi_b2</ci>
</apply>
<ci>C2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b5</ci>
<ci>kdi_b5</ci>
</apply>
<ci>C5</ci>
</apply>
<apply>
<times/>
<ci>kpp_c1</ci>
<ci>Cdc14</ci>
<ci>Sic1P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_b2</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>kas_b5</ci>
<ci>Clb5</ci>
</apply>
<ci>Vkp_c1</ci>
</apply>
<ci>Sic1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Sic1P">
<variable units="dimensionless" public_interface="out" name="Sic1P" initial_value="0.0064"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_c1"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Sic1P</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_c1</ci>
<ci>Sic1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_c1</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_c1</ci>
</apply>
<ci>Sic1P</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vd_b2</ci>
<ci>C2P</ci>
</apply>
<apply>
<times/>
<ci>Vd_b5</ci>
<ci>C5P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C2">
<variable units="dimensionless" public_interface="out" name="C2" initial_value="0.2384"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_c1"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_b2</ci>
<ci>Clb2</ci>
<ci>Sic1</ci>
</apply>
<apply>
<times/>
<ci>kpp_c1</ci>
<ci>Cdc14</ci>
<ci>C2P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_b2</ci>
<ci>Vd_b2</ci>
<ci>Vkp_c1</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C5">
<variable units="dimensionless" public_interface="out" name="C5" initial_value="0.0701"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_c1"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_b5</ci>
<ci>Clb5</ci>
<ci>Sic1</ci>
</apply>
<apply>
<times/>
<ci>kpp_c1</ci>
<ci>Cdc14</ci>
<ci>C5P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_b5</ci>
<ci>Vd_b5</ci>
<ci>Vkp_c1</ci>
</apply>
<ci>C5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C2P">
<variable units="dimensionless" public_interface="out" name="C2P" initial_value="0.024"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_c1"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_c1</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_c1</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_c1</ci>
<ci>Vd_b2</ci>
</apply>
<ci>C2P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="C5P">
<variable units="dimensionless" public_interface="out" name="C5P" initial_value="0.0069"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_c1"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C5P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_c1</ci>
<ci>C5</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_c1</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_c1</ci>
<ci>Vd_b5</ci>
</apply>
<ci>C5P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6">
<variable units="dimensionless" public_interface="out" name="Cdc6" initial_value="0.1076"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_f6_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_f6__"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_f6___"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Swi5"/>
<variable units="dimensionless" public_interface="in" name="SBF"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc6P"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc6</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_f6_</ci>
<apply>
<times/>
<ci>ks_f6__</ci>
<ci>Swi5</ci>
</apply>
<apply>
<times/>
<ci>ks_f6___</ci>
<ci>SBF</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b2</ci>
<ci>kdi_f2</ci>
</apply>
<ci>F2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_b5</ci>
<ci>kdi_f5</ci>
</apply>
<ci>F5</ci>
</apply>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
<ci>Cdc6P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_f2</ci>
<ci>Clb2</ci>
</apply>
<apply>
<times/>
<ci>kas_f5</ci>
<ci>Clb5</ci>
</apply>
<ci>Vkp_f6</ci>
</apply>
<ci>Cdc6</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6P">
<variable units="dimensionless" public_interface="out" name="Cdc6P" initial_value="0.0155"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc6P</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_f6</ci>
<ci>Cdc6</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_f6</ci>
</apply>
<ci>Cdc6P</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vd_b2</ci>
<ci>F2P</ci>
</apply>
<apply>
<times/>
<ci>Vd_b5</ci>
<ci>F5P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F2">
<variable units="dimensionless" public_interface="out" name="F2" initial_value="0.2361"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_f2</ci>
<ci>Clb2</ci>
<ci>Cdc6</ci>
</apply>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
<ci>F2P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_f2</ci>
<ci>Vd_b2</ci>
<ci>Vkp_f6</ci>
</apply>
<ci>F2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Pds1">
<variable units="dimensionless" public_interface="out" name="Pds1" initial_value="0.0256"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_pds_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks1_pds__"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks2_pds__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_esp"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_pds"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_esp"/>
<variable units="dimensionless" public_interface="in" name="SBF"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="PE"/>
<variable units="dimensionless" public_interface="in" name="Esp1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Pds1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_pds_</ci>
<apply>
<times/>
<ci>ks1_pds__</ci>
<ci>SBF</ci>
</apply>
<apply>
<times/>
<ci>ks2_pds__</ci>
<ci>Mcm1</ci>
</apply>
<apply>
<times/>
<ci>kdi_esp</ci>
<ci>PE</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Vd_pds</ci>
<apply>
<times/>
<ci>kas_esp</ci>
<ci>Esp1</ci>
</apply>
</apply>
<ci>Pds1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Esp1">
<variable units="dimensionless" public_interface="out" name="Esp1" initial_value="0.3013"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_esp"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_pds"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_esp"/>
<variable units="dimensionless" public_interface="in" name="Pds1"/>
<variable units="dimensionless" public_interface="in" name="PE"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Esp1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>kas_esp</ci>
</apply>
<ci>Pds1</ci>
<ci>Esp1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_esp</ci>
<ci>Vd_pds</ci>
</apply>
<ci>PE</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ORI">
<variable units="dimensionless" public_interface="out" name="ORI" initial_value="0.0009"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_ori"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_ori"/>
<variable units="dimensionless" public_interface="in" name="epsilon_ori_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_ori_b2"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ORI</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ks_ori</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_ori_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_ori_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kd_ori</ci>
<ci>ORI</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="BUD">
<variable units="dimensionless" public_interface="out" name="BUD" initial_value="0.0085"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_bud"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_bud"/>
<variable units="dimensionless" public_interface="in" name="epsilon_bud_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_bud_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_bud_b5"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BUD</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>ks_bud</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_bud_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_bud_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_bud_b5</ci>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>kd_bud</ci>
<ci>BUD</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SPN">
<variable units="dimensionless" public_interface="out" name="SPN" initial_value="0.0305"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_spn"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_spn"/>
<variable units="dimensionless" public_interface="in" name="Jspn"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SPN</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>ks_spn</ci>
<ci>Clb2</ci>
</apply>
<apply>
<plus/>
<ci>Jspn</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_spn</ci>
<ci>SPN</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_sbf">
<variable units="dimensionless" public_interface="out" name="G_sbf"/>
<variable units="dimensionless" public_interface="in" name="Ji_sbf"/>
<variable units="dimensionless" public_interface="in" name="Ja_sbf"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vi_sbf"/>
<variable units="first_order_rate_constant" public_interface="in" name="Va_sbf"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_sbf</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vi_sbf</ci>
<apply>
<times/>
<ci>Ja_sbf</ci>
<ci>Vi_sbf</ci>
</apply>
<apply>
<times/>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vi_sbf</ci>
<apply>
<times/>
<ci>Ja_sbf</ci>
<ci>Vi_sbf</ci>
</apply>
<apply>
<times/>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<ci>Vi_sbf</ci>
<ci>Va_sbf</ci>
</apply>
<ci>Ji_sbf</ci>
<ci>Va_sbf</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Va_sbf</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_mcm">
<variable units="dimensionless" public_interface="out" name="G_mcm"/>
<variable units="dimensionless" public_interface="in" name="Ji_mcm"/>
<variable units="dimensionless" public_interface="in" name="Ja_mcm"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_mcm"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_mcm"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_mcm</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>Ja_mcm</ci>
<ci>ki_mcm</ci>
</apply>
<apply>
<times/>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>Ja_mcm</ci>
<ci>ki_mcm</ci>
</apply>
<apply>
<times/>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<ci>ki_mcm</ci>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Ji_mcm</ci>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>ka_mcm</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SBF_MBF">
<variable units="dimensionless" public_interface="out" name="SBF"/>
<variable units="dimensionless" public_interface="out" name="MBF"/>
<variable units="dimensionless" public_interface="in" name="G_sbf"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>SBF</ci>
<ci>MBF</ci>
</apply>
<apply>
<eq/>
<ci>MBF</ci>
<ci>G_sbf</ci>
</apply>
</math>
</component>
<component name="Mcm1">
<variable units="dimensionless" public_interface="out" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="G_mcm"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mcm1</ci>
<ci>G_mcm</ci>
</apply>
</math>
</component>
<component name="Cln3">
<variable units="dimensionless" public_interface="out" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="C0"/>
<variable units="dimensionless" public_interface="in" name="Dn3"/>
<variable units="dimensionless" public_interface="in" name="Jn3"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cln3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C0</ci>
<ci>Dn3</ci>
<ci>mass</ci>
</apply>
<apply>
<plus/>
<ci>Jn3</ci>
<apply>
<times/>
<ci>Dn3</ci>
<ci>mass</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Bck2">
<variable units="dimensionless" public_interface="out" name="Bck2"/>
<variable units="dimensionless" public_interface="in" name="B0"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Bck2</ci>
<apply>
<times/>
<ci>B0</ci>
<ci>mass</ci>
</apply>
</apply>
</math>
</component>
<component name="Clb5_T">
<variable units="dimensionless" public_interface="out" name="Clb5_T"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Clb5_T</ci>
<apply>
<plus/>
<ci>Clb5</ci>
<ci>C5</ci>
<ci>C5P</ci>
<ci>F5</ci>
<ci>F5P</ci>
</apply>
</apply>
</math>
</component>
<component name="Clb2_T">
<variable units="dimensionless" public_interface="out" name="Clb2_T"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Clb2_T</ci>
<apply>
<plus/>
<ci>Clb2</ci>
<ci>C2</ci>
<ci>C2P</ci>
<ci>F2</ci>
<ci>F2P</ci>
</apply>
</apply>
</math>
</component>
<component name="Sic1_T">
<variable units="dimensionless" public_interface="out" name="Sic1_T"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="dimensionless" public_interface="in" name="Sic1P"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Sic1_T</ci>
<apply>
<plus/>
<ci>Sic1</ci>
<ci>Sic1P</ci>
<ci>C2</ci>
<ci>C2P</ci>
<ci>C5</ci>
<ci>C5P</ci>
</apply>
</apply>
</math>
</component>
<component name="F5">
<variable units="dimensionless" public_interface="out" name="F5" initial_value="7.2e-5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_f5</ci>
<ci>Clb5</ci>
<ci>Cdc6</ci>
</apply>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
<ci>F5P</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kdi_f5</ci>
<ci>Vd_b5</ci>
<ci>Vkp_f6</ci>
</apply>
<ci>F5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F2P">
<variable units="dimensionless" public_interface="out" name="F2P" initial_value="0.0274"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b2"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F2P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_f6</ci>
<ci>F2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_f6</ci>
<ci>Vd_b2</ci>
</apply>
<ci>F2P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F5P">
<variable units="dimensionless" public_interface="out" name="F5P" initial_value="7.9e-6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F5P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Vkp_f6</ci>
<ci>F5</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kpp_f6</ci>
<ci>Cdc14</ci>
</apply>
<ci>kd3_f6</ci>
<ci>Vd_b5</ci>
</apply>
<ci>F5P</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5_T">
<variable units="dimensionless" public_interface="out" name="Swi5_T" initial_value="0.9765"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swi"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swi5_T</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_swi_</ci>
<apply>
<times/>
<ci>ks_swi__</ci>
<ci>Mcm1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_swi</ci>
<ci>Swi5_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5">
<variable units="dimensionless" public_interface="out" name="Swi5" initial_value="0.9562"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swi"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_swi"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_swi"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Swi5_T"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swi5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_swi_</ci>
<apply>
<times/>
<ci>ks_swi__</ci>
<ci>Mcm1</ci>
</apply>
<apply>
<times/>
<ci>ka_swi</ci>
<ci>Cdc14</ci>
<apply>
<minus/>
<ci>Swi5_T</ci>
<ci>Swi5</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kd_swi</ci>
<apply>
<times/>
<ci>ki_swi</ci>
<ci>Clb2</ci>
</apply>
</apply>
<ci>Swi5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="APC_P">
<variable units="dimensionless" public_interface="out" name="APC_P" initial_value="0.1015"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_apc"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_apc"/>
<variable units="dimensionless" public_interface="in" name="Ja_apc"/>
<variable units="dimensionless" public_interface="in" name="Ji_apc"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>APC_P</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>ka_apc</ci>
<ci>Clb2</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_apc</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>ki_apc</ci>
<ci>APC_P</ci>
</apply>
<apply>
<plus/>
<ci>Ji_apc</ci>
<ci>APC_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_T">
<variable units="dimensionless" public_interface="out" name="Cdc20_T" initial_value="1.9163"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_20_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_20__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_20"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_T</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_20_</ci>
<apply>
<times/>
<ci>ks_20__</ci>
<ci>Mcm1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kd_20</ci>
<ci>Cdc20_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_A">
<variable units="dimensionless" public_interface="out" name="Cdc20_A" initial_value="0.4443"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_20_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_20__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_20"/>
<variable units="first_order_rate_constant" public_interface="in" name="kmad2"/>
<variable units="dimensionless" public_interface="in" name="APC_P"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_A</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>ka_20_</ci>
<apply>
<times/>
<ci>ka_20__</ci>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Cdc20_T</ci>
<ci>Cdc20_A</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>kmad2</ci>
<ci>kd_20</ci>
</apply>
<ci>Cdc20_A</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1_T">
<variable units="dimensionless" public_interface="out" name="Cdh1_T" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_cdh"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1_T</ci>
</apply>
<apply>
<minus/>
<ci>ks_cdh</ci>
<apply>
<times/>
<ci>kd_cdh</ci>
<ci>Cdh1_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1">
<variable units="dimensionless" public_interface="out" name="Cdh1" initial_value="0.9305"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_cdh"/>
<variable units="dimensionless" public_interface="in" name="Ja_cdh"/>
<variable units="dimensionless" public_interface="in" name="Ji_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="Va_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vi_cdh"/>
<variable units="dimensionless" public_interface="in" name="Cdh1_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_cdh</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Va_cdh</ci>
<apply>
<minus/>
<ci>Cdh1_T</ci>
<ci>Cdh1</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_cdh</ci>
<ci>Cdh1_T</ci>
</apply>
<ci>Cdh1</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kd_cdh</ci>
<ci>Cdh1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Vi_cdh</ci>
<ci>Cdh1</ci>
</apply>
<apply>
<plus/>
<ci>Ji_cdh</ci>
<ci>Cdh1</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Tem1">
<variable units="dimensionless" public_interface="out" name="Tem1" initial_value="0.9039"/>
<variable units="first_order_rate_constant" public_interface="in" name="kbub2"/>
<variable units="first_order_rate_constant" public_interface="in" name="klte1"/>
<variable units="dimensionless" public_interface="in" name="Ja_tem"/>
<variable units="dimensionless" public_interface="in" name="Ji_tem"/>
<variable units="dimensionless" public_interface="in" name="Tem1_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Tem1</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>klte1</ci>
<apply>
<minus/>
<ci>Tem1_T</ci>
<ci>Tem1</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>Ja_tem</ci>
<ci>Tem1_T</ci>
</apply>
<ci>Tem1</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>kbub2</ci>
<ci>Tem1</ci>
</apply>
<apply>
<plus/>
<ci>Ji_tem</ci>
<ci>Tem1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc15">
<variable units="dimensionless" public_interface="out" name="Cdc15" initial_value="0.6565"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_15_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_15__"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_15___"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_15"/>
<variable units="dimensionless" public_interface="in" name="Tem1"/>
<variable units="dimensionless" public_interface="in" name="Tem1_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc15_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc15</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>ka_15_</ci>
<apply>
<minus/>
<ci>Tem1_T</ci>
<ci>Tem1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ka_15__</ci>
<ci>Tem1</ci>
</apply>
<apply>
<times/>
<ci>ka_15___</ci>
<ci>Cdc14</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Cdc15_T</ci>
<ci>Cdc15</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ki_15</ci>
<ci>Cdc15</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc14_T">
<variable units="dimensionless" public_interface="out" name="Cdc14_T" initial_value="2"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc14_T</ci>
</apply>
<apply>
<minus/>
<ci>ks_14</ci>
<apply>
<times/>
<ci>kd_14</ci>
<ci>Cdc14_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc14">
<variable units="dimensionless" public_interface="out" name="Cdc14" initial_value="0.4683"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rentp"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rentp"/>
<variable units="dimensionless" public_interface="in" name="RENT"/>
<variable units="dimensionless" public_interface="in" name="RENTP"/>
<variable units="dimensionless" public_interface="in" name="Net1"/>
<variable units="dimensionless" public_interface="in" name="Net1P"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc14</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_14</ci>
<apply>
<times/>
<ci>kd_net</ci>
<apply>
<plus/>
<ci>RENT</ci>
<ci>RENTP</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kdi_rent</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>kdi_rentp</ci>
<ci>RENTP</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kd_14</ci>
<ci>Cdc14</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_rent</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>kas_rentp</ci>
<ci>Net1P</ci>
</apply>
</apply>
<ci>Cdc14</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Net1_T">
<variable units="dimensionless" public_interface="out" name="Net1_T" initial_value="2.8"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Net1_T</ci>
</apply>
<apply>
<minus/>
<ci>ks_net</ci>
<apply>
<times/>
<ci>kd_net</ci>
<ci>Net1_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6_T">
<variable units="dimensionless" public_interface="out" name="Cdc6_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="dimensionless" public_interface="in" name="Cdc6P"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cdc6_T</ci>
<apply>
<plus/>
<ci>Cdc6</ci>
<ci>Cdc6P</ci>
<ci>F2</ci>
<ci>F2P</ci>
<ci>F5</ci>
<ci>F5P</ci>
</apply>
</apply>
</math>
</component>
<component name="CKI_T">
<variable units="dimensionless" public_interface="out" name="CKI_T"/>
<variable units="dimensionless" public_interface="in" name="Sic1_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc6_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>CKI_T</ci>
<apply>
<plus/>
<ci>Sic1_T</ci>
<ci>Cdc6_T</ci>
</apply>
</apply>
</math>
</component>
<component name="RENTP">
<variable units="dimensionless" public_interface="out" name="RENTP"/>
<variable units="dimensionless" public_interface="in" name="Cdc14_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="RENT"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RENTP</ci>
<apply>
<minus/>
<ci>Cdc14_T</ci>
<apply>
<plus/>
<ci>RENT</ci>
<ci>Cdc14</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Net1P">
<variable units="dimensionless" public_interface="out" name="Net1P"/>
<variable units="dimensionless" public_interface="in" name="Net1_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Net1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Net1P</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>Net1_T</ci>
<ci>Cdc14</ci>
</apply>
<apply>
<plus/>
<ci>Net1</ci>
<ci>Cdc14_T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PE">
<variable units="dimensionless" public_interface="out" name="PE"/>
<variable units="dimensionless" public_interface="in" name="Esp1_T"/>
<variable units="dimensionless" public_interface="in" name="Esp1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PE</ci>
<apply>
<minus/>
<ci>Esp1_T</ci>
<ci>Esp1</ci>
</apply>
</apply>
</math>
</component>
<component name="Vd_b5">
<variable units="first_order_rate_constant" public_interface="out" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b5_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b5__"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_b5</ci>
<apply>
<plus/>
<ci>kd_b5_</ci>
<apply>
<times/>
<ci>kd_b5__</ci>
<ci>Cdc20_A</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_b2">
<variable units="first_order_rate_constant" public_interface="out" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b2_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b2__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b2p"/>
<variable units="dimensionless" public_interface="in" name="Cdh1"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_b2</ci>
<apply>
<plus/>
<ci>kd_b2_</ci>
<apply>
<times/>
<ci>kd_b2__</ci>
<ci>Cdh1</ci>
</apply>
<apply>
<times/>
<ci>kd_b2p</ci>
<ci>Cdc20_A</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Va_sbf">
<variable units="first_order_rate_constant" public_interface="out" name="Va_sbf"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_sbf"/>
<variable units="dimensionless" public_interface="in" name="epsilon_sbf_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_sbf_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_sbf_b5"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Bck2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Va_sbf</ci>
<apply>
<times/>
<ci>ka_sbf</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_sbf_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_sbf_n3</ci>
<apply>
<plus/>
<ci>Cln3</ci>
<ci>Bck2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>epsilon_sbf_b5</ci>
<ci>Clb5</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vi_sbf">
<variable units="first_order_rate_constant" public_interface="out" name="Vi_sbf"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_sbf_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_sbf__"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vi_sbf</ci>
<apply>
<plus/>
<ci>ki_sbf_</ci>
<apply>
<times/>
<ci>ki_sbf__</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_c1">
<variable units="first_order_rate_constant" public_interface="out" name="Vkp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd1_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd2_c1"/>
<variable units="dimensionless" public_interface="in" name="Jd2_c1"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_k2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_b2"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Bck2"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Sic1_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vkp_c1</ci>
<apply>
<plus/>
<ci>kd1_c1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kd2_c1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_c1_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_k2</ci>
<ci>Bck2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_c1_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Jd2_c1</ci>
<ci>Sic1_T</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_f6">
<variable units="first_order_rate_constant" public_interface="out" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Jd2_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd1_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd2_f6"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_k2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_b2"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Bck2"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Cdc6_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vkp_f6</ci>
<apply>
<plus/>
<ci>kd1_f6</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kd2_f6</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_f6_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_k2</ci>
<ci>Bck2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_f6_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>Jd2_f6</ci>
<ci>Cdc6_T</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Va_cdh">
<variable units="first_order_rate_constant" public_interface="out" name="Va_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_cdh_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_cdh__"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Va_cdh</ci>
<apply>
<plus/>
<ci>ka_cdh_</ci>
<apply>
<times/>
<ci>ka_cdh__</ci>
<ci>Cdc14</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vi_cdh">
<variable units="first_order_rate_constant" public_interface="out" name="Vi_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_cdh_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_cdh__"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_b2"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vi_cdh</ci>
<apply>
<plus/>
<ci>ki_cdh_</ci>
<apply>
<times/>
<ci>ki_cdh__</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon_cdh_n3</ci>
<ci>Cln3</ci>
</apply>
<apply>
<times/>
<ci>epsilon_cdh_n2</ci>
<ci>Cln2</ci>
</apply>
<apply>
<times/>
<ci>epsilon_cdh_b5</ci>
<ci>Clb5</ci>
</apply>
<apply>
<times/>
<ci>epsilon_cdh_b2</ci>
<ci>Clb2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vpp_net">
<variable units="first_order_rate_constant" public_interface="out" name="Vpp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_net_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_net__"/>
<variable units="dimensionless" public_interface="in" name="PPX"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vpp_net</ci>
<apply>
<plus/>
<ci>kpp_net_</ci>
<apply>
<times/>
<ci>kpp_net__</ci>
<ci>PPX</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_net">
<variable units="first_order_rate_constant" public_interface="out" name="Vkp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kkp_net_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kkp_net__"/>
<variable units="dimensionless" public_interface="in" name="Cdc15"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vkp_net</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>kkp_net_</ci>
<apply>
<times/>
<ci>kkp_net__</ci>
<ci>Cdc15</ci>
</apply>
</apply>
<ci>mass</ci>
</apply>
</apply>
</math>
</component>
<component name="Net1">
<variable units="dimensionless" public_interface="out" name="Net1" initial_value="0.0186"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vpp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_net"/>
<variable units="dimensionless" public_interface="in" name="RENT"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Net1P"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Net1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>ks_net</ci>
<apply>
<times/>
<ci>kd_14</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>kdi_rent</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>Vpp_net</ci>
<ci>Net1P</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kd_net</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>kas_rent</ci>
<ci>Cdc14</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>Vkp_net</ci>
<ci>Net1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RENT">
<variable units="dimensionless" public_interface="out" name="RENT" initial_value="1.0495"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vpp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vkp_net"/>
<variable units="dimensionless" public_interface="in" name="Net1"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="RENTP"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RENT</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kas_rent</ci>
<ci>Cdc14</ci>
<ci>Net1</ci>
</apply>
<apply>
<times/>
<ci>Vpp_net</ci>
<ci>RENTP</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>kd_14</ci>
<ci>kd_net</ci>
</apply>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>kdi_rent</ci>
<ci>RENT</ci>
</apply>
<apply>
<times/>
<ci>Vkp_net</ci>
<ci>RENT</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PPX">
<variable units="dimensionless" public_interface="out" name="PPX" initial_value="0.1232"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_ppx"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vd_ppx"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PPX</ci>
</apply>
<apply>
<minus/>
<ci>ks_ppx</ci>
<apply>
<times/>
<ci>Vd_ppx</ci>
<ci>PPX</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_ppx">
<variable units="first_order_rate_constant" public_interface="out" name="Vd_ppx"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_ppx_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_ppx__"/>
<variable units="dimensionless" public_interface="in" name="Pds1"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<variable units="dimensionless" public_interface="in" name="Jpds"/>
<variable units="dimensionless" public_interface="in" name="J20_ppx"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_ppx</ci>
<apply>
<plus/>
<ci>kd_ppx_</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kd_ppx__</ci>
<apply>
<plus/>
<ci>J20_ppx</ci>
<ci>Cdc20_A</ci>
</apply>
<ci>Jpds</ci>
</apply>
<apply>
<plus/>
<ci>Jpds</ci>
<ci>Pds1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_pds">
<variable units="first_order_rate_constant" public_interface="out" name="Vd_pds"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd1_pds_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd2_pds__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_pds__"/>
<variable units="dimensionless" public_interface="in" name="Cdh1"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vd_pds</ci>
<apply>
<plus/>
<ci>kd1_pds_</ci>
<apply>
<times/>
<ci>kd2_pds__</ci>
<ci>Cdc20_A</ci>
</apply>
<apply>
<times/>
<ci>kd3_pds__</ci>
<ci>Cdh1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="model_parameters">
<variable units="first_order_rate_constant" public_interface="out" name="kg" initial_value="0.007702"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_n2_" initial_value="0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_n2__" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_n2" initial_value="0.12"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b5_" initial_value="0.0008"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b5__" initial_value="0.005"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b5_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b5__" initial_value="0.16"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b2_" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b2__" initial_value="0.04"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b2_" initial_value="0.003"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b2__" initial_value="0.4"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b2p" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_c1_" initial_value="0.012"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_c1__" initial_value="0.12"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd1_c1" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd2_c1" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd3_c1" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_c1" initial_value="4"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_f6_" initial_value="0.024"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_f6__" initial_value="0.12"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_f6___" initial_value="0.004"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd1_f6" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd2_f6" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd3_f6" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_f6" initial_value="4"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_b5" initial_value="50"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_b5" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_f5" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_f5" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_b2" initial_value="50"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_b2" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_f2" initial_value="15"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_f2" initial_value="0.5"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_swi_" initial_value="0.005"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_swi__" initial_value="0.08"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_swi" initial_value="0.08"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_swi" initial_value="2"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_swi" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_apc" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_apc" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_20_" initial_value="0.006"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_20__" initial_value="0.6"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_20" initial_value="0.3"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_20_" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_20__" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_cdh" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_cdh" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_cdh_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_cdh__" initial_value="0.8"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_cdh_" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_cdh__" initial_value="0.08"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_14" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_14" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_net" initial_value="0.084"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_net" initial_value="0.03"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_15_" initial_value="0.002"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_15__" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_15___" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_15" initial_value="0.5"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_net_" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_net__" initial_value="3"/>
<variable units="first_order_rate_constant" public_interface="out" name="kkp_net_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kkp_net__" initial_value="0.6"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_rent" initial_value="200"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_rentp" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_rent" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_rentp" initial_value="2"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_ppx" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_ppx_" initial_value="0.17"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_ppx__" initial_value="2"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_pds_" initial_value="0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks1_pds__" initial_value="0.03"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks2_pds__" initial_value="0.055"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd1_pds_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd2_pds__" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd3_pds__" initial_value="0.04"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_esp" initial_value="50"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_esp" initial_value="0.5"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_ori" initial_value="2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_ori" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_bud" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_bud" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_spn" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_spn" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_sbf" initial_value="0.38"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_sbf_" initial_value="0.6"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_sbf__" initial_value="8"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_mcm" initial_value="1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_mcm" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="kmad2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kbub2"/>
<variable units="first_order_rate_constant" public_interface="out" name="klte1"/>
<variable units="dimensionless" public_interface="out" name="epsilon_sbf_n2" initial_value="2"/>
<variable units="dimensionless" public_interface="out" name="epsilon_sbf_n3" initial_value="10"/>
<variable units="dimensionless" public_interface="out" name="epsilon_sbf_b5" initial_value="2"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_n3" initial_value="0.3"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_n2" initial_value="0.06"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_k2" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_b5" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_b2" initial_value="0.45"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_n3" initial_value="0.3"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_n2" initial_value="0.06"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_k2" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_b5" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_b2" initial_value="0.55"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_n2" initial_value="0.4"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_n3" initial_value="0.25"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_b5" initial_value="8"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_b2" initial_value="1.2"/>
<variable units="dimensionless" public_interface="out" name="epsilon_ori_b5" initial_value="0.9"/>
<variable units="dimensionless" public_interface="out" name="epsilon_ori_b2" initial_value="0.45"/>
<variable units="dimensionless" public_interface="out" name="epsilon_bud_n3" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="epsilon_bud_n2" initial_value="0.25"/>
<variable units="dimensionless" public_interface="out" name="epsilon_bud_b5" initial_value="1"/>
<variable units="dimensionless" public_interface="out" name="C0" initial_value="0.4"/>
<variable units="dimensionless" public_interface="out" name="Dn3" initial_value="1"/>
<variable units="dimensionless" public_interface="out" name="B0" initial_value="0.054"/>
<variable units="dimensionless" public_interface="out" name="Tem1_T" initial_value="1"/>
<variable units="dimensionless" public_interface="out" name="Cdc15_T" initial_value="1"/>
<variable units="dimensionless" public_interface="out" name="Esp1_T" initial_value="1"/>
<variable units="dimensionless" public_interface="out" name="Jd2_c1" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Jd2_f6" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Ja_apc" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ji_apc" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ja_cdh" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="Ji_cdh" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="Ja_tem" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ji_tem" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ja_sbf" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Ji_sbf" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Ja_mcm" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ji_mcm" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Jspn" initial_value="0.14"/>
<variable units="dimensionless" public_interface="out" name="Jn3" initial_value="6"/>
<variable units="dimensionless" public_interface="out" name="J20_ppx" initial_value="0.15"/>
<variable units="dimensionless" public_interface="out" name="Jpds" initial_value="0.04"/>
<variable units="dimensionless" public_interface="out" name="Kez" initial_value="0.3"/>
<variable units="dimensionless" public_interface="out" name="Kez2" initial_value="0.2"/>
<variable units="dimensionless" public_interface="in" name="ORI"/>
<variable units="dimensionless" public_interface="in" name="SPN"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>kmad2</ci>
<piecewise>
<piece>
<cn cellml:units="first_order_rate_constant">8</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>ORI</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<lt/>
<ci>SPN</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="first_order_rate_constant">0.01</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>kbub2</ci>
<piecewise>
<piece>
<cn cellml:units="first_order_rate_constant">1</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>ORI</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<lt/>
<ci>SPN</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="first_order_rate_constant">0.2</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>klte1</ci>
<piecewise>
<piece>
<cn cellml:units="first_order_rate_constant">1</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>SPN</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<gt/>
<ci>Clb2</ci>
<ci>Kez</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="first_order_rate_constant">0.1</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<connection>
<map_components component_2="environment" component_1="mass"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Clb2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cln2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Clb5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Sic1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Sic1P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C2P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C5P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc6"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc6P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Pds1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Esp1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="ORI"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="BUD"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="SPN"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F2P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F5P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Swi5_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Swi5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="APC_P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc20_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc20_A"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdh1_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdh1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Tem1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc15"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc14_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc14"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Net1_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Net1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="RENT"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="PPX"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="mass"/>
<map_variables variable_2="kg" variable_1="kg"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cln2"/>
<map_variables variable_2="ks_n2_" variable_1="ks_n2_"/>
<map_variables variable_2="ks_n2__" variable_1="ks_n2__"/>
<map_variables variable_2="kd_n2" variable_1="kd_n2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Clb5"/>
<map_variables variable_2="ks_b5_" variable_1="ks_b5_"/>
<map_variables variable_2="ks_b5__" variable_1="ks_b5__"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kdi_b5" variable_1="kdi_b5"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kdi_f5" variable_1="kdi_f5"/>
<map_variables variable_2="kas_b5" variable_1="kas_b5"/>
<map_variables variable_2="kas_f5" variable_1="kas_f5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Clb2"/>
<map_variables variable_2="ks_b2_" variable_1="ks_b2_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
<map_variables variable_2="ks_b2__" variable_1="ks_b2__"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kdi_b2" variable_1="kdi_b2"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kdi_f2" variable_1="kdi_f2"/>
<map_variables variable_2="kas_b2" variable_1="kas_b2"/>
<map_variables variable_2="kas_f2" variable_1="kas_f2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Sic1"/>
<map_variables variable_2="ks_c1_" variable_1="ks_c1_"/>
<map_variables variable_2="ks_c1__" variable_1="ks_c1__"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kdi_b2" variable_1="kdi_b2"/>
<map_variables variable_2="kdi_b5" variable_1="kdi_b5"/>
<map_variables variable_2="kas_b2" variable_1="kas_b2"/>
<map_variables variable_2="kas_b5" variable_1="kas_b5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Sic1P"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C2"/>
<map_variables variable_2="kas_b2" variable_1="kas_b2"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kdi_b2" variable_1="kdi_b2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C5"/>
<map_variables variable_2="kas_b5" variable_1="kas_b5"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kdi_b5" variable_1="kdi_b5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C2P"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C5P"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc6"/>
<map_variables variable_2="ks_f6_" variable_1="ks_f6_"/>
<map_variables variable_2="ks_f6__" variable_1="ks_f6__"/>
<map_variables variable_2="ks_f6___" variable_1="ks_f6___"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kdi_f2" variable_1="kdi_f2"/>
<map_variables variable_2="kdi_f5" variable_1="kdi_f5"/>
<map_variables variable_2="kas_f5" variable_1="kas_f5"/>
<map_variables variable_2="kas_f2" variable_1="kas_f2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc6P"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F2"/>
<map_variables variable_2="kas_f2" variable_1="kas_f2"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kdi_f2" variable_1="kdi_f2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Pds1"/>
<map_variables variable_2="ks_pds_" variable_1="ks_pds_"/>
<map_variables variable_2="ks1_pds__" variable_1="ks1_pds__"/>
<map_variables variable_2="ks2_pds__" variable_1="ks2_pds__"/>
<map_variables variable_2="kdi_esp" variable_1="kdi_esp"/>
<map_variables variable_2="kas_esp" variable_1="kas_esp"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Esp1"/>
<map_variables variable_2="kdi_esp" variable_1="kdi_esp"/>
<map_variables variable_2="kas_esp" variable_1="kas_esp"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="ORI"/>
<map_variables variable_2="ks_ori" variable_1="ks_ori"/>
<map_variables variable_2="ORI" variable_1="ORI"/>
<map_variables variable_2="kd_ori" variable_1="kd_ori"/>
<map_variables variable_2="epsilon_ori_b5" variable_1="epsilon_ori_b5"/>
<map_variables variable_2="epsilon_ori_b2" variable_1="epsilon_ori_b2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="BUD"/>
<map_variables variable_2="ks_bud" variable_1="ks_bud"/>
<map_variables variable_2="kd_bud" variable_1="kd_bud"/>
<map_variables variable_2="epsilon_bud_b5" variable_1="epsilon_bud_b5"/>
<map_variables variable_2="epsilon_bud_n2" variable_1="epsilon_bud_n2"/>
<map_variables variable_2="epsilon_bud_n3" variable_1="epsilon_bud_n3"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="SPN"/>
<map_variables variable_2="ks_spn" variable_1="ks_spn"/>
<map_variables variable_2="SPN" variable_1="SPN"/>
<map_variables variable_2="Jspn" variable_1="Jspn"/>
<map_variables variable_2="kd_spn" variable_1="kd_spn"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="G_sbf"/>
<map_variables variable_2="Ja_sbf" variable_1="Ja_sbf"/>
<map_variables variable_2="Ji_sbf" variable_1="Ji_sbf"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="G_mcm"/>
<map_variables variable_2="Ja_mcm" variable_1="Ja_mcm"/>
<map_variables variable_2="Ji_mcm" variable_1="Ji_mcm"/>
<map_variables variable_2="ka_mcm" variable_1="ka_mcm"/>
<map_variables variable_2="ki_mcm" variable_1="ki_mcm"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cln3"/>
<map_variables variable_2="C0" variable_1="C0"/>
<map_variables variable_2="Dn3" variable_1="Dn3"/>
<map_variables variable_2="Jn3" variable_1="Jn3"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Bck2"/>
<map_variables variable_2="B0" variable_1="B0"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F5"/>
<map_variables variable_2="kas_f5" variable_1="kas_f5"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kdi_f5" variable_1="kdi_f5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F2P"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F5P"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Swi5_T"/>
<map_variables variable_2="ks_swi_" variable_1="ks_swi_"/>
<map_variables variable_2="ks_swi__" variable_1="ks_swi__"/>
<map_variables variable_2="kd_swi" variable_1="kd_swi"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Swi5"/>
<map_variables variable_2="ks_swi_" variable_1="ks_swi_"/>
<map_variables variable_2="ks_swi__" variable_1="ks_swi__"/>
<map_variables variable_2="ka_swi" variable_1="ka_swi"/>
<map_variables variable_2="kd_swi" variable_1="kd_swi"/>
<map_variables variable_2="ki_swi" variable_1="ki_swi"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="APC_P"/>
<map_variables variable_2="ka_apc" variable_1="ka_apc"/>
<map_variables variable_2="ki_apc" variable_1="ki_apc"/>
<map_variables variable_2="Ja_apc" variable_1="Ja_apc"/>
<map_variables variable_2="Ji_apc" variable_1="Ji_apc"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc20_T"/>
<map_variables variable_2="ks_20_" variable_1="ks_20_"/>
<map_variables variable_2="ks_20__" variable_1="ks_20__"/>
<map_variables variable_2="kd_20" variable_1="kd_20"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc20_A"/>
<map_variables variable_2="ka_20_" variable_1="ka_20_"/>
<map_variables variable_2="ka_20__" variable_1="ka_20__"/>
<map_variables variable_2="kd_20" variable_1="kd_20"/>
<map_variables variable_2="kmad2" variable_1="kmad2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdh1"/>
<map_variables variable_2="ks_cdh" variable_1="ks_cdh"/>
<map_variables variable_2="kd_cdh" variable_1="kd_cdh"/>
<map_variables variable_2="Ja_cdh" variable_1="Ja_cdh"/>
<map_variables variable_2="Ji_cdh" variable_1="Ji_cdh"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdh1_T"/>
<map_variables variable_2="ks_cdh" variable_1="ks_cdh"/>
<map_variables variable_2="kd_cdh" variable_1="kd_cdh"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Tem1"/>
<map_variables variable_2="klte1" variable_1="klte1"/>
<map_variables variable_2="kbub2" variable_1="kbub2"/>
<map_variables variable_2="Tem1_T" variable_1="Tem1_T"/>
<map_variables variable_2="Ja_tem" variable_1="Ja_tem"/>
<map_variables variable_2="Ji_tem" variable_1="Ji_tem"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc15"/>
<map_variables variable_2="ka_15_" variable_1="ka_15_"/>
<map_variables variable_2="ka_15__" variable_1="ka_15__"/>
<map_variables variable_2="ka_15___" variable_1="ka_15___"/>
<map_variables variable_2="Tem1_T" variable_1="Tem1_T"/>
<map_variables variable_2="Cdc15_T" variable_1="Cdc15_T"/>
<map_variables variable_2="ki_15" variable_1="ki_15"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc14_T"/>
<map_variables variable_2="ks_14" variable_1="ks_14"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="PE"/>
<map_variables variable_2="Esp1_T" variable_1="Esp1_T"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc14"/>
<map_variables variable_2="ks_14" variable_1="ks_14"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
<map_variables variable_2="kdi_rent" variable_1="kdi_rent"/>
<map_variables variable_2="kdi_rentp" variable_1="kdi_rentp"/>
<map_variables variable_2="kas_rent" variable_1="kas_rent"/>
<map_variables variable_2="kas_rentp" variable_1="kas_rentp"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Net1_T"/>
<map_variables variable_2="ks_net" variable_1="ks_net"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_b5"/>
<map_variables variable_2="kd_b5_" variable_1="kd_b5_"/>
<map_variables variable_2="kd_b5__" variable_1="kd_b5__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_b2"/>
<map_variables variable_2="kd_b2_" variable_1="kd_b2_"/>
<map_variables variable_2="kd_b2__" variable_1="kd_b2__"/>
<map_variables variable_2="kd_b2p" variable_1="kd_b2p"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Va_sbf"/>
<map_variables variable_2="ka_sbf" variable_1="ka_sbf"/>
<map_variables variable_2="epsilon_sbf_n2" variable_1="epsilon_sbf_n2"/>
<map_variables variable_2="epsilon_sbf_n3" variable_1="epsilon_sbf_n3"/>
<map_variables variable_2="epsilon_sbf_b5" variable_1="epsilon_sbf_b5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vi_sbf"/>
<map_variables variable_2="ki_sbf_" variable_1="ki_sbf_"/>
<map_variables variable_2="ki_sbf__" variable_1="ki_sbf__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vkp_c1"/>
<map_variables variable_2="kd1_c1" variable_1="kd1_c1"/>
<map_variables variable_2="kd2_c1" variable_1="kd2_c1"/>
<map_variables variable_2="epsilon_c1_n2" variable_1="epsilon_c1_n2"/>
<map_variables variable_2="epsilon_c1_n3" variable_1="epsilon_c1_n3"/>
<map_variables variable_2="epsilon_c1_k2" variable_1="epsilon_c1_k2"/>
<map_variables variable_2="epsilon_c1_b5" variable_1="epsilon_c1_b5"/>
<map_variables variable_2="epsilon_c1_b2" variable_1="epsilon_c1_b2"/>
<map_variables variable_2="Jd2_c1" variable_1="Jd2_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vkp_f6"/>
<map_variables variable_2="kd1_f6" variable_1="kd1_f6"/>
<map_variables variable_2="kd2_f6" variable_1="kd2_f6"/>
<map_variables variable_2="epsilon_f6_n2" variable_1="epsilon_f6_n2"/>
<map_variables variable_2="epsilon_f6_n3" variable_1="epsilon_f6_n3"/>
<map_variables variable_2="epsilon_f6_k2" variable_1="epsilon_f6_k2"/>
<map_variables variable_2="epsilon_f6_b5" variable_1="epsilon_f6_b5"/>
<map_variables variable_2="epsilon_f6_b2" variable_1="epsilon_f6_b2"/>
<map_variables variable_2="Jd2_f6" variable_1="Jd2_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Va_cdh"/>
<map_variables variable_2="ka_cdh_" variable_1="ka_cdh_"/>
<map_variables variable_2="ka_cdh__" variable_1="ka_cdh__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vi_cdh"/>
<map_variables variable_2="ki_cdh_" variable_1="ki_cdh_"/>
<map_variables variable_2="ki_cdh__" variable_1="ki_cdh__"/>
<map_variables variable_2="epsilon_cdh_n2" variable_1="epsilon_cdh_n2"/>
<map_variables variable_2="epsilon_cdh_n3" variable_1="epsilon_cdh_n3"/>
<map_variables variable_2="epsilon_cdh_b5" variable_1="epsilon_cdh_b5"/>
<map_variables variable_2="epsilon_cdh_b2" variable_1="epsilon_cdh_b2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vpp_net"/>
<map_variables variable_2="kpp_net_" variable_1="kpp_net_"/>
<map_variables variable_2="kpp_net__" variable_1="kpp_net__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vkp_net"/>
<map_variables variable_2="kkp_net_" variable_1="kkp_net_"/>
<map_variables variable_2="kkp_net__" variable_1="kkp_net__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Net1"/>
<map_variables variable_2="ks_net" variable_1="ks_net"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
<map_variables variable_2="kdi_rent" variable_1="kdi_rent"/>
<map_variables variable_2="kas_rent" variable_1="kas_rent"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="RENT"/>
<map_variables variable_2="ks_net" variable_1="ks_net"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
<map_variables variable_2="kdi_rent" variable_1="kdi_rent"/>
<map_variables variable_2="kas_rent" variable_1="kas_rent"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="PPX"/>
<map_variables variable_2="ks_ppx" variable_1="ks_ppx"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_ppx"/>
<map_variables variable_2="kd_ppx_" variable_1="kd_ppx_"/>
<map_variables variable_2="kd_ppx__" variable_1="kd_ppx__"/>
<map_variables variable_2="J20_ppx" variable_1="J20_ppx"/>
<map_variables variable_2="Jpds" variable_1="Jpds"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_pds"/>
<map_variables variable_2="kd1_pds_" variable_1="kd1_pds_"/>
<map_variables variable_2="kd2_pds__" variable_1="kd2_pds__"/>
<map_variables variable_2="kd3_pds__" variable_1="kd3_pds__"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="mass"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Cln2"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Clb5"/>
<map_variables variable_2="MBF" variable_1="MBF"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Clb5"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Clb5"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Clb5"/>
<map_variables variable_2="C5" variable_1="C5"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Clb5"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Clb5"/>
<map_variables variable_2="F5" variable_1="F5"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Clb5"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Cdc6" component_1="Clb5"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="G_mcm" component_1="Clb2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Clb2"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Clb2"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Clb2"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Clb2"/>
<map_variables variable_2="C2" variable_1="C2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Clb2"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Clb2"/>
<map_variables variable_2="F2" variable_1="F2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Clb2"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cdc6" component_1="Clb2"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Swi5" component_1="Sic1"/>
<map_variables variable_2="Swi5" variable_1="Swi5"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="Sic1"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="Sic1P"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C2"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C5"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Sic1"/>
<map_variables variable_2="C2" variable_1="C2"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Sic1"/>
<map_variables variable_2="C5" variable_1="C5"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Sic1"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Sic1P" component_1="Sic1"/>
<map_variables variable_2="Sic1P" variable_1="Sic1P"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Sic1P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Sic1P"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Sic1P"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="C2"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="C2"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
<map_variables variable_2="C2" variable_1="C2"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="C5"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="C5"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="Swi5" component_1="Cdc6"/>
<map_variables variable_2="Swi5" variable_1="Swi5"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Cdc6"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Cdc6"/>
<map_variables variable_2="F2" variable_1="F2"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Cdc6"/>
<map_variables variable_2="F5" variable_1="F5"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Cdc6"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc6P" component_1="Cdc6"/>
<map_variables variable_2="Cdc6P" variable_1="Cdc6P"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Cdc6P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Cdc6P"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Cdc6P"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F2"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="F2"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
<map_variables variable_2="F2" variable_1="F2"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Pds1"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Pds1"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="PE" component_1="Pds1"/>
<map_variables variable_2="PE" variable_1="PE"/>
</connection>
<connection>
<map_components component_2="Esp1" component_1="Pds1"/>
<map_variables variable_2="Esp1" variable_1="Esp1"/>
<map_variables variable_2="Pds1" variable_1="Pds1"/>
</connection>
<connection>
<map_components component_2="PE" component_1="Esp1"/>
<map_variables variable_2="PE" variable_1="PE"/>
<map_variables variable_2="Esp1" variable_1="Esp1"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="ORI"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="ORI"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="BUD"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="BUD"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="BUD"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="SPN"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="G_sbf" component_1="SBF_MBF"/>
<map_variables variable_2="G_sbf" variable_1="G_sbf"/>
</connection>
<connection>
<map_components component_2="G_mcm" component_1="Mcm1"/>
<map_variables variable_2="G_mcm" variable_1="G_mcm"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Cln3"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Bck2"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Clb5_T"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Clb5_T"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Clb5_T"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Clb5_T"/>
<map_variables variable_2="F5" variable_1="F5"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Clb5_T"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Clb2_T"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Clb2_T"/>
<map_variables variable_2="C2" variable_1="C2"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Clb2_T"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Clb2_T"/>
<map_variables variable_2="F2" variable_1="F2"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Clb2_T"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Sic1_T"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="Sic1P" component_1="Sic1_T"/>
<map_variables variable_2="Sic1P" variable_1="Sic1P"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Sic1_T"/>
<map_variables variable_2="C2" variable_1="C2"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Sic1_T"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Sic1_T"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Sic1_T"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="Cdc6" component_1="Cdc6_T"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="Cdc6P" component_1="Cdc6_T"/>
<map_variables variable_2="Cdc6P" variable_1="Cdc6P"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Cdc6_T"/>
<map_variables variable_2="F2" variable_1="F2"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Cdc6_T"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Cdc6_T"/>
<map_variables variable_2="F5" variable_1="F5"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Cdc6_T"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="Sic1_T" component_1="CKI_T"/>
<map_variables variable_2="Sic1_T" variable_1="Sic1_T"/>
</connection>
<connection>
<map_components component_2="Cdc6_T" component_1="CKI_T"/>
<map_variables variable_2="Cdc6_T" variable_1="Cdc6_T"/>
</connection>
<connection>
<map_components component_2="Cdc14_T" component_1="RENTP"/>
<map_variables variable_2="Cdc14_T" variable_1="Cdc14_T"/>
</connection>
<connection>
<map_components component_2="RENT" component_1="RENTP"/>
<map_variables variable_2="RENT" variable_1="RENT"/>
<map_variables variable_2="RENTP" variable_1="RENTP"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="RENTP"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
<map_variables variable_2="RENTP" variable_1="RENTP"/>
</connection>
<connection>
<map_components component_2="Net1_T" component_1="Net1P"/>
<map_variables variable_2="Net1_T" variable_1="Net1_T"/>
</connection>
<connection>
<map_components component_2="Net1" component_1="Net1P"/>
<map_variables variable_2="Net1P" variable_1="Net1P"/>
<map_variables variable_2="Net1" variable_1="Net1"/>
</connection>
<connection>
<map_components component_2="Cdc14_T" component_1="Net1P"/>
<map_variables variable_2="Cdc14_T" variable_1="Cdc14_T"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Net1P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
<map_variables variable_2="Net1P" variable_1="Net1P"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F5"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="F5"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
<map_variables variable_2="F5" variable_1="F5"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F2P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F5P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Swi5_T"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Swi5"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Swi5"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Swi5_T" component_1="Swi5"/>
<map_variables variable_2="Swi5_T" variable_1="Swi5_T"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Swi5"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="APC_P"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Cdc20_T"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="APC_P" component_1="Cdc20_A"/>
<map_variables variable_2="APC_P" variable_1="APC_P"/>
</connection>
<connection>
<map_components component_2="Cdc20_T" component_1="Cdc20_A"/>
<map_variables variable_2="Cdc20_T" variable_1="Cdc20_T"/>
</connection>
<connection>
<map_components component_2="Cdh1_T" component_1="Cdh1"/>
<map_variables variable_2="Cdh1_T" variable_1="Cdh1_T"/>
</connection>
<connection>
<map_components component_2="Tem1" component_1="Cdc15"/>
<map_variables variable_2="Tem1" variable_1="Tem1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Cdc15"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="RENT" component_1="Cdc14"/>
<map_variables variable_2="RENT" variable_1="RENT"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Net1" component_1="Cdc14"/>
<map_variables variable_2="Net1" variable_1="Net1"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_b5"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_b2"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Cdh1" component_1="Vd_b2"/>
<map_variables variable_2="Cdh1" variable_1="Cdh1"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Va_sbf"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Va_sbf"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Bck2" component_1="Va_sbf"/>
<map_variables variable_2="Bck2" variable_1="Bck2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Va_sbf"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vi_sbf"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Vkp_c1"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Vkp_c1"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Bck2" component_1="Vkp_c1"/>
<map_variables variable_2="Bck2" variable_1="Bck2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Vkp_c1"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vkp_c1"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Sic1_T" component_1="Vkp_c1"/>
<map_variables variable_2="Sic1_T" variable_1="Sic1_T"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Va_cdh"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc15" component_1="Vkp_net"/>
<map_variables variable_2="Cdc15" variable_1="Cdc15"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Vkp_net"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="RENT" component_1="Net1"/>
<map_variables variable_2="RENT" variable_1="RENT"/>
<map_variables variable_2="Net1" variable_1="Net1"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_ppx"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Pds1" component_1="Vd_ppx"/>
<map_variables variable_2="Pds1" variable_1="Pds1"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_pds"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Cdh1" component_1="Vd_pds"/>
<map_variables variable_2="Cdh1" variable_1="Cdh1"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Sic1P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Sic1P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Clb5"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Clb2"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Sic1"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Sic1"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="C2"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="C5"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C2P"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="C2P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C5P"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="C5P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Cdc6"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Cdc6"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="Cdc6"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="Cdc6P"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Cdc6P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Cdc6P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="F2"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F2"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vd_pds" component_1="Pds1"/>
<map_variables variable_2="Vd_pds" variable_1="Vd_pds"/>
</connection>
<connection>
<map_components component_2="Vd_pds" component_1="Esp1"/>
<map_variables variable_2="Vd_pds" variable_1="Vd_pds"/>
</connection>
<connection>
<map_components component_2="Va_sbf" component_1="G_sbf"/>
<map_variables variable_2="Va_sbf" variable_1="Va_sbf"/>
</connection>
<connection>
<map_components component_2="Vi_sbf" component_1="G_sbf"/>
<map_variables variable_2="Vi_sbf" variable_1="Vi_sbf"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="F5"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F5"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F5P"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F2P"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="F2P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="F5P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Va_cdh" component_1="Cdh1"/>
<map_variables variable_2="Va_cdh" variable_1="Va_cdh"/>
</connection>
<connection>
<map_components component_2="Vi_cdh" component_1="Cdh1"/>
<map_variables variable_2="Vi_cdh" variable_1="Vi_cdh"/>
</connection>
<connection>
<map_components component_2="Vpp_net" component_1="Net1"/>
<map_variables variable_2="Vpp_net" variable_1="Vpp_net"/>
</connection>
<connection>
<map_components component_2="Vkp_net" component_1="Net1"/>
<map_variables variable_2="Vkp_net" variable_1="Vkp_net"/>
</connection>
<connection>
<map_components component_2="Vpp_net" component_1="RENT"/>
<map_variables variable_2="Vpp_net" variable_1="Vpp_net"/>
</connection>
<connection>
<map_components component_2="Vkp_net" component_1="RENT"/>
<map_variables variable_2="Vkp_net" variable_1="Vkp_net"/>
</connection>
<connection>
<map_components component_2="Vd_ppx" component_1="PPX"/>
<map_variables variable_2="Vd_ppx" variable_1="Vd_ppx"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Cdc14"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Cdc14"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Vkp_f6"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Vi_cdh"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Vi_cdh"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vi_cdh"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Vi_cdh"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Cdc6_T" component_1="Vkp_f6"/>
<map_variables variable_2="Cdc6_T" variable_1="Cdc6_T"/>
</connection>
<connection>
<map_components component_2="PPX" component_1="Vpp_net"/>
<map_variables variable_2="PPX" variable_1="PPX"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vkp_f6"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Bck2" component_1="Vkp_f6"/>
<map_variables variable_2="Bck2" variable_1="Bck2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Vkp_f6"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Vkp_f6"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<rdf:RDF>
<rdf:Bag rdf:about="rdf:#5171a8e5-a07e-4dd3-a4d0-a377a1edf4dc">
<rdf:li>cell cyc1e</rdf:li>
<rdf:li>yeast</rdf:li>
<rdf:li>cell cycle</rdf:li>
</rdf:Bag>
<rdf:Seq rdf:about="rdf:#cdbfe632-c4fe-4a66-9cd5-840c6b2cf6c0">
<rdf:li rdf:resource="rdf:#cdb4e896-1294-497c-b841-be883ce8e72f"/>
<rdf:li rdf:resource="rdf:#3378d5a3-08ba-4dba-8704-28d86dce6c68"/>
<rdf:li rdf:resource="rdf:#da337810-3318-4953-a2c8-f547fc2f4c79"/>
<rdf:li rdf:resource="rdf:#eb58e436-ea53-4503-972c-a59c6f0b892a"/>
<rdf:li rdf:resource="rdf:#3fc56b7a-065a-4ead-80ec-0378b1c3fcdb"/>
<rdf:li rdf:resource="rdf:#7a4608c1-c09b-4e75-b317-deb6d3e8c7fa"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#82d7f10e-1aa9-4ab9-9826-30a64fa8b8e2">
<dc:creator rdf:resource="rdf:#bc1b179b-7f4b-4108-85eb-7d0ffd44ff6a"/>
<rdf:value>This is the CellML description of Chen et al.'s 2004 mathematical model of cell cyc1e control in budding yeast.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#983144ce-d79a-4f43-a6b6-d4374ca00448">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>The University of Auckland, Bioengineering Institute</dc:publisher>
<cmeta:comment rdf:resource="rdf:#7ef3d635-274a-4158-93cf-5d263e4061ac"/>
<dcterms:created rdf:resource="rdf:#467e5269-11f2-4bb9-b485-1aecb77f20e3"/>
<dc:creator rdf:resource="rdf:#c3cc1d98-4b00-4b1e-be7c-32d8124d51d4"/>
<cmeta:modification rdf:resource="rdf:#58dcf761-8da3-4511-89f5-2a73707b56f6"/>
<cmeta:modification rdf:resource="rdf:#d0c1c185-9dc0-4325-a232-c06c90f1f120"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7ef3d635-274a-4158-93cf-5d263e4061ac">
<dc:creator rdf:resource="rdf:#b265f467-2791-48c1-868e-5924ca2aac4c"/>
<rdf:value>This CellML version of the model has been checked in COR and PCEnv and the model runs to replicate the results in the original published paper. The units have been checked and are consistent.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#467e5269-11f2-4bb9-b485-1aecb77f20e3">
<dcterms:W3CDTF>2004-06-27T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#bc1b179b-7f4b-4108-85eb-7d0ffd44ff6a">
<vCard:FN>Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7a4608c1-c09b-4e75-b317-deb6d3e8c7fa">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#2cd1534a-5e10-4abb-ac79-f7cbad0e9da0"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#39149564-623c-4c38-8a5d-b217b4dcbc00">
<dcterms:W3CDTF>2008-01-14T13:00:52+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#954940d3-6759-4cc9-a7c3-de5d59e8feb2">
<bqs:Pubmed_id>15169868</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#a384d847-1d1d-4c7a-89c6-8ab7a9ab9a9c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#eb58e436-ea53-4503-972c-a59c6f0b892a">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#026e4657-3fce-42a2-8945-b08481ef73b4"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3fc56b7a-065a-4ead-80ec-0378b1c3fcdb">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#af16b831-e967-49b8-b8ed-5cf2835a74f0"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cdb4e896-1294-497c-b841-be883ce8e72f">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#172ccee7-e462-4988-b82a-b76370174ad6"/>
</rdf:Description>
<rdf:Description rdf:about="#chen_calzone_csikasz-nagy_cross_novak_tyson_2004_version01">
<dc:title>Chen et al.'s 2004 mathematical model of cell cyc1e control in budding yeast.</dc:title>
<cmeta:comment rdf:resource="rdf:#82d7f10e-1aa9-4ab9-9826-30a64fa8b8e2"/>
<bqs:reference rdf:resource="rdf:#954940d3-6759-4cc9-a7c3-de5d59e8feb2"/>
<bqs:reference rdf:resource="rdf:#d7a3abbd-959e-4db6-a5fd-d2ca2cbcab0a"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d7a3abbd-959e-4db6-a5fd-d2ca2cbcab0a">
<dc:subject rdf:resource="rdf:#a96d60ae-bb0d-4efa-bd1c-b529a74ec3dc"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#fcbfe616-407b-42f5-bc4f-f8d2f3ba66f5">
<dcterms:W3CDTF>2004-05-28</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c62a8890-0693-4b76-afa4-a86b19b7ecfb">
<vCard:Given>Attila</vCard:Given>
<vCard:Family>Csikasz-Nagy</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b265f467-2791-48c1-868e-5924ca2aac4c">
<vCard:FN>Jeelean Lim</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#172ccee7-e462-4988-b82a-b76370174ad6">
<vCard:Given>Katherine</vCard:Given>
<vCard:Family>Chen</vCard:Family>
<vCard:Other>C</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#da337810-3318-4953-a2c8-f547fc2f4c79">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#c62a8890-0693-4b76-afa4-a86b19b7ecfb"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2cd1534a-5e10-4abb-ac79-f7cbad0e9da0">
<vCard:Given>John</vCard:Given>
<vCard:Family>Tyson</vCard:Family>
<vCard:Other>J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a96d60ae-bb0d-4efa-bd1c-b529a74ec3dc">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value rdf:resource="rdf:#5171a8e5-a07e-4dd3-a4d0-a377a1edf4dc"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#026e4657-3fce-42a2-8945-b08481ef73b4">
<vCard:Given>Frederick</vCard:Given>
<vCard:Family>Cross</vCard:Family>
<vCard:Other>R</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2fa4b5af-8d07-4328-bbc9-f95f8f3dac56">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a384d847-1d1d-4c7a-89c6-8ab7a9ab9a9c">
<dc:creator rdf:resource="rdf:#cdbfe632-c4fe-4a66-9cd5-840c6b2cf6c0"/>
<dc:title>Integrative Analysis of Cell Cycle Control in Budding Yeast</dc:title>
<bqs:volume/>
<bqs:first_page/>
<bqs:Journal rdf:resource="rdf:#acea03ea-da82-43e7-b3be-d2cc0b6afb83"/>
<dcterms:issued rdf:resource="rdf:#fcbfe616-407b-42f5-bc4f-f8d2f3ba66f5"/>
<bqs:last_page/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#01f6f623-1d50-4578-affc-17925351a087">
<vCard:N rdf:resource="rdf:#2d3b3a78-837b-49fb-8c68-f70d58f9083a"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d0c1c185-9dc0-4325-a232-c06c90f1f120">
<dcterms:modified rdf:resource="rdf:#39149564-623c-4c38-8a5d-b217b4dcbc00"/>
<rdf:value>Removed initial values conflicting with values of variables defined by piecewise equations. </rdf:value>
<cmeta:modifier rdf:resource="rdf:#52e68ffd-f838-4a2d-8819-f402174facb8"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c3cc1d98-4b00-4b1e-be7c-32d8124d51d4">
<vCard:ORG rdf:resource="rdf:#5ba58894-d095-49d2-b8db-06f7fbdba2ea"/>
<vCard:EMAIL rdf:resource="rdf:#983144ce-d79a-4f43-a6b6-d4374ca00448"/>
<vCard:N rdf:resource="rdf:#2fa4b5af-8d07-4328-bbc9-f95f8f3dac56"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#acea03ea-da82-43e7-b3be-d2cc0b6afb83">
<dc:title>Molecular Biology of the Cell</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5ba58894-d095-49d2-b8db-06f7fbdba2ea">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#af16b831-e967-49b8-b8ed-5cf2835a74f0">
<vCard:Given>Bela</vCard:Given>
<vCard:Family>Novak</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e3b63460-8397-4747-a2e9-741b8454c9b9">
<dcterms:W3CDTF>2008-12-10T16:45:51+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d995a687-fc15-4901-a5c6-eaf6cfc2b936">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ad9592bd-3501-4918-8348-fa7a79c93ea2">
<vCard:Given>Laurence</vCard:Given>
<vCard:Family>Calzone</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3378d5a3-08ba-4dba-8704-28d86dce6c68">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#ad9592bd-3501-4918-8348-fa7a79c93ea2"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2d3b3a78-837b-49fb-8c68-f70d58f9083a">
<vCard:Given>Jeelean</vCard:Given>
<vCard:Family>Lim</vCard:Family>
<vCard:Other/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#52e68ffd-f838-4a2d-8819-f402174facb8">
<vCard:N rdf:resource="rdf:#d995a687-fc15-4901-a5c6-eaf6cfc2b936"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#58dcf761-8da3-4511-89f5-2a73707b56f6">
<dcterms:modified rdf:resource="rdf:#e3b63460-8397-4747-a2e9-741b8454c9b9"/>
<rdf:value>Several initial values and equations were corrected. The units were made consistent.
The model produces results that replicate the FIRST cycle of the graphs in the research paper but does not correctly demonstrate the cyclical nature of the graphs.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#01f6f623-1d50-4578-affc-17925351a087"/>
</rdf:Description>
</rdf:RDF>
</model>
