- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 07:53:41+12:00
- Desc:
- committing version01 of chen_calzone_csikasznagy_cross_novak_tyson_2004
- Permanent Source URI:
- http://models.cellml.org/workspace/369/rawfile/7c59b98100b66a986da171524f440b1165dd17a3/chen_calzone_csikasznagy_cross_novak_tyson_2004.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : chen_model_2004.xml
CREATED : 27th June 2004
LAST MODIFIED : 21st April 2005
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Chen et al.'s 2004 mathematical model of cell cyc1e control in budding yeast.
CHANGES:
21/04/2005 - PJV - Removed unnecessary type
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="chen_calzone_csikasz-nagy_cross_novak_tyson_2004_version01" name="chen_calzone_csikasz-nagy_cross_novak_tyson_2004_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>An Integrative Analysis of Cell Cycle Control in Budding Yeast</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
The mitotic cell cycle can be defined as the sequence of events by which a somatic cell replicates all its components, and then divides them equally between two daughter cells. The end product is two genetically identical daughter cells. Cell division is an essential component of the biological processes of growth, reproduction and development. As might be expected for such an important process, the distinct phases and events of the cell cycle are carefully regulated by specific proteins.
</para>
<para>
The cell cycle regulatory system is most fully understood for budding yeast, <emphasis>Saccharomyces cerevisiae</emphasis>. A hypothetical molecular mechanism, potentially underlying cell cycle control in this organism, is outlined in <xref linkend="fig_reaction_diagram"/> below. However, these networks of interacting proteins are so complex that the functional integration of the network cannot be understood by intuition alone. Mathematical models, which describe molecular interactions and reactions with biochemical rate equations, provide an integrative framework with which the complexities of molecular regulatory networks can be studied. In the Chen <emphasis>et al.</emphasis> 2004 publication described here, the authors develop a mathematical model to analyse cell cycle control in budding yeast. Model simulations reveal that the data generated by the model are in accord with the physiological properties of many genetic strains of budding yeast. The mathematical model is also useful in that it can be used to interpret existing experimental data and help to design new experiments.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Chen <emphasis>et al.</emphasis> 2004 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.molbiolcell.org/cgi/content/abstract/E03-11-0794v1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=chen+KC&andorexactfulltext=and&searchid=1090102867811_525&stored_search=&FIRSTINDEX=0&sortspec=relevance&resourcetype=1&journalcode=molbiolcell">Integrative analysis of cell cycle control in budding yeast</ulink>, Katherine C. Chen, Laurence Calzone, Attila Csikasz-Nagy, Frederick R. Cross, Bela Novak, and John J. Tyson, 2004, <ulink url="http://www.molbiolcell.org/">
<emphasis>Molecular Biology of the Cell</emphasis>
</ulink>. (<ulink url="http://www.molbiolcell.org/cgi/reprint/E03-11-0794">A PDF</ulink> version of the article is available to subscribers ahead of print on the <emphasis>Molecular Biology of the Cell</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15169868&dopt=Abstract">PubMed ID: 15169868</ulink>
</para>
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<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram</title>
</objectinfo>
<imagedata fileref="reaction_diagram.gif"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the cell cycle control mechanism in budding yeast.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<variable units="first_order_rate_constant" public_interface="in" name="kas_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f5"/>
<variable units="dimensionless" public_interface="in" name="Vd_b2"/>
<variable units="dimensionless" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Swi5"/>
<variable units="dimensionless" public_interface="in" name="SBF"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc6P"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc6</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_f6_ </ci>
<apply>
<times/>
<ci> ks_f6__ </ci>
<ci> Swi5 </ci>
</apply>
<apply>
<times/>
<ci> ks_f6___ </ci>
<ci> SBF </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> Vd_b2 </ci>
<ci> kdi_f2 </ci>
</apply>
<ci> F2 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> Vd_b5 </ci>
<ci> kdi_f5 </ci>
</apply>
<ci> F5 </ci>
</apply>
<apply>
<times/>
<ci> kpp_f6 </ci>
<ci> Cdc14 </ci>
<ci> Cdc6P </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> kas_f2 </ci>
<ci> Clb2 </ci>
</apply>
<apply>
<times/>
<ci> kas_f5 </ci>
<ci> Clb5 </ci>
</apply>
<ci> Vkp_f6 </ci>
</apply>
<ci> Cdc6 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6P">
<variable units="dimensionless" public_interface="out" name="Cdc6P" initial_value="0.0155"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vd_b2"/>
<variable units="dimensionless" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc6P</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci> Vkp_f6 </ci>
<ci> Cdc6 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> kpp_f6 </ci>
<ci> Cdc14 </ci>
</apply>
<ci> kd3_f6 </ci>
</apply>
<ci> Cdc6P </ci>
</apply>
</apply>
<apply>
<times/>
<ci> Vd_b2 </ci>
<ci> F2P </ci>
</apply>
<apply>
<times/>
<ci> Vd_b5 </ci>
<ci> F5P </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F2">
<variable units="dimensionless" public_interface="out" name="F2" initial_value="0.2361"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f2"/>
<variable units="dimensionless" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> kas_f2 </ci>
<ci> Clb2 </ci>
<ci> Cdc6 </ci>
</apply>
<apply>
<times/>
<ci> kpp_f6 </ci>
<ci> Cdc14 </ci>
<ci> F2P </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> kdi_f2 </ci>
<ci> Vd_b2 </ci>
<ci> Vkp_f6 </ci>
</apply>
<ci> F2 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Pds1">
<variable units="dimensionless" public_interface="out" name="Pds1" initial_value="0.0256"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_pds_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks1_pds__"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks2_pds__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_esp"/>
<variable units="dimensionless" public_interface="in" name="Vd_pds"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_esp"/>
<variable units="dimensionless" public_interface="in" name="SBF"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="PE"/>
<variable units="dimensionless" public_interface="in" name="Esp1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Pds1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_pds_ </ci>
<apply>
<times/>
<ci> ks1_pds__ </ci>
<ci> SBF </ci>
</apply>
<apply>
<times/>
<ci> ks2_pds__ </ci>
<ci> Mcm1 </ci>
</apply>
<apply>
<times/>
<ci> kdi_esp </ci>
<ci> PE </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> Vd_pds </ci>
<apply>
<times/>
<ci> kas_esp </ci>
<ci> Esp1 </ci>
</apply>
</apply>
<ci> Pds1 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Esp1">
<variable units="dimensionless" public_interface="out" name="Esp1" initial_value="0.3013"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_esp"/>
<variable units="dimensionless" public_interface="in" name="Vd_pds"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_esp"/>
<variable units="dimensionless" public_interface="in" name="Pds1"/>
<variable units="dimensionless" public_interface="in" name="PE"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Esp1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci> kas_esp </ci>
<ci> Pds1 </ci>
<ci> Esp1 </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> kdi_esp </ci>
<ci> Vd_pds </ci>
</apply>
<ci> PE </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ORI">
<variable units="dimensionless" public_interface="out" name="ORI" initial_value="0.0009"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_ori"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_ori"/>
<variable units="dimensionless" public_interface="in" name="epsilon_ori_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_ori_b2"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ORI</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> ks_ori </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> epsilon_ori_b5 </ci>
<ci> Clb5 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_ori_b2 </ci>
<ci> Clb2 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> kd_ori </ci>
<ci> ORI </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="BUD">
<variable units="dimensionless" public_interface="out" name="BUD" initial_value="0.0085"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_bud"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_bud"/>
<variable units="dimensionless" public_interface="in" name="epsilon_bud_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_bud_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_bud_b5"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BUD</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> ks_bud </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> epsilon_bud_n2 </ci>
<ci> Cln2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_bud_n3 </ci>
<ci> Cln3 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_bud_b5 </ci>
<ci> Clb5 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> kd_bud </ci>
<ci> BUD </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SPN">
<variable units="dimensionless" public_interface="out" name="SPN" initial_value="0.0305"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_spn"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_spn"/>
<variable units="dimensionless" public_interface="in" name="Jspn"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SPN</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> ks_spn </ci>
<apply>
<divide/>
<ci> Clb2 </ci>
<apply>
<plus/>
<ci> Jspn </ci>
<ci> Clb2 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> kd_spn </ci>
<ci> SPN </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_sbf">
<variable units="dimensionless" public_interface="out" name="G_sbf"/>
<variable units="dimensionless" public_interface="in" name="Ji_sbf"/>
<variable units="dimensionless" public_interface="in" name="Ja_sbf"/>
<variable units="dimensionless" public_interface="in" name="Vi_sbf"/>
<variable units="dimensionless" public_interface="in" name="Va_sbf"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_sbf</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> Ji_sbf </ci>
<ci> Va_sbf </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Vi_sbf </ci>
<apply>
<times/>
<ci> Ja_sbf </ci>
<ci> Vi_sbf </ci>
</apply>
<apply>
<times/>
<ci> Ji_sbf </ci>
<ci> Va_sbf </ci>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci> Vi_sbf </ci>
<apply>
<times/>
<ci> Ja_sbf </ci>
<ci> Vi_sbf </ci>
</apply>
<apply>
<times/>
<ci> Ji_sbf </ci>
<ci> Va_sbf </ci>
</apply>
</apply>
<ci> Va_sbf </ci>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<apply>
<minus/>
<ci> Vi_sbf </ci>
<ci> Va_sbf </ci>
</apply>
<ci> Ji_sbf </ci>
<ci> Va_sbf </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 0.5 </cn>
</apply>
</apply>
<ci> Va_sbf </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_cdh">
<variable units="dimensionless" public_interface="out" name="G_cdh"/>
<variable units="dimensionless" public_interface="in" name="Ji_cdh"/>
<variable units="dimensionless" public_interface="in" name="Ja_cdh"/>
<variable units="dimensionless" public_interface="in" name="Vi_cdh"/>
<variable units="dimensionless" public_interface="in" name="Va_cdh"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_cdh</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> Ji_cdh </ci>
<ci> Va_cdh </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Vi_cdh </ci>
<apply>
<times/>
<ci> Ja_cdh </ci>
<ci> Vi_cdh </ci>
</apply>
<apply>
<times/>
<ci> Ji_cdh </ci>
<ci> Va_cdh </ci>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci> Vi_cdh </ci>
<apply>
<times/>
<ci> Ja_cdh </ci>
<ci> Vi_cdh </ci>
</apply>
<apply>
<times/>
<ci> Ji_cdh </ci>
<ci> Va_cdh </ci>
</apply>
</apply>
<ci> Va_cdh </ci>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<apply>
<minus/>
<ci> Vi_cdh </ci>
<ci> Va_cdh </ci>
</apply>
<ci> Ji_cdh </ci>
<ci> Va_cdh </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 0.5 </cn>
</apply>
</apply>
<ci> Va_cdh </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="G_mcm">
<variable units="dimensionless" public_interface="out" name="G_mcm"/>
<variable units="dimensionless" public_interface="in" name="Ji_mcm"/>
<variable units="dimensionless" public_interface="in" name="Ja_mcm"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_mcm"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_mcm"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_mcm</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless"> 2.0 </cn>
<ci> Ji_mcm </ci>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ki_mcm </ci>
<apply>
<times/>
<ci> Ja_mcm </ci>
<ci> ki_mcm </ci>
</apply>
<apply>
<times/>
<ci> Ji_mcm </ci>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<apply>
<plus/>
<ci> ki_mcm </ci>
<apply>
<times/>
<ci> Ja_mcm </ci>
<ci> ki_mcm </ci>
</apply>
<apply>
<times/>
<ci> Ji_mcm </ci>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 2.0 </cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless"> 4.0 </cn>
<apply>
<minus/>
<ci> ki_mcm </ci>
<apply>
<times/>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<ci> Ji_mcm </ci>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<cn cellml:units="dimensionless"> 0.5 </cn>
</apply>
</apply>
<apply>
<times/>
<ci> ka_mcm </ci>
<ci> Clb2 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SBF_MBF">
<variable units="dimensionless" public_interface="out" name="SBF"/>
<variable units="dimensionless" public_interface="out" name="MBF"/>
<variable units="dimensionless" public_interface="in" name="G_sbf"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>SBF</ci>
<ci> MBF </ci>
</apply>
<apply>
<eq/>
<ci>MBF</ci>
<ci> G_sbf </ci>
</apply>
</math>
</component>
<component name="Mcm1">
<variable units="dimensionless" public_interface="out" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="G_mcm"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mcm1</ci>
<ci> G_mcm </ci>
</apply>
</math>
</component>
<component name="Cln3">
<variable units="dimensionless" public_interface="out" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="C0"/>
<variable units="dimensionless" public_interface="in" name="Dn3"/>
<variable units="dimensionless" public_interface="in" name="Jn3"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cln3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci> C0 </ci>
<ci> Dn3 </ci>
<ci> mass </ci>
</apply>
<apply>
<plus/>
<ci> Jn3 </ci>
<apply>
<times/>
<ci> Dn3 </ci>
<ci> mass </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Bck2">
<variable units="dimensionless" public_interface="out" name="Bck2"/>
<variable units="dimensionless" public_interface="in" name="B0"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Bck2</ci>
<apply>
<times/>
<ci> B0 </ci>
<ci> mass </ci>
</apply>
</apply>
</math>
</component>
<component name="Clb5_T">
<variable units="dimensionless" public_interface="out" name="Clb5_T"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Clb5_T</ci>
<apply>
<plus/>
<ci> Clb5 </ci>
<ci> C5 </ci>
<ci> C5P </ci>
<ci> F5 </ci>
<ci> F5P </ci>
</apply>
</apply>
</math>
</component>
<component name="Clb2_T">
<variable units="dimensionless" public_interface="out" name="Clb2_T"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Clb2_T</ci>
<apply>
<plus/>
<ci> Clb2 </ci>
<ci> C2 </ci>
<ci> C2P </ci>
<ci> F2 </ci>
<ci> F2P </ci>
</apply>
</apply>
</math>
</component>
<component name="Sic1_T">
<variable units="dimensionless" public_interface="out" name="Sic1_T"/>
<variable units="dimensionless" public_interface="in" name="Sic1"/>
<variable units="dimensionless" public_interface="in" name="Sic1P"/>
<variable units="dimensionless" public_interface="in" name="C2"/>
<variable units="dimensionless" public_interface="in" name="C2P"/>
<variable units="dimensionless" public_interface="in" name="C5"/>
<variable units="dimensionless" public_interface="in" name="C5P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Sic1_T</ci>
<apply>
<plus/>
<ci> Sic1 </ci>
<ci> Sic1P </ci>
<ci> C2 </ci>
<ci> C2P </ci>
<ci> C5 </ci>
<ci> C5P </ci>
</apply>
</apply>
</math>
</component>
<component name="F5">
<variable units="dimensionless" public_interface="out" name="F5" initial_value="7.2E-5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_f5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_f5"/>
<variable units="dimensionless" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> kas_f5 </ci>
<ci> Clb5 </ci>
<ci> Cdc6 </ci>
</apply>
<apply>
<times/>
<ci> kpp_f6 </ci>
<ci> Cdc14 </ci>
<ci> F5P </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> kdi_f5 </ci>
<ci> Vd_b5 </ci>
<ci> Vkp_f6 </ci>
</apply>
<ci> F5 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F2P">
<variable units="dimensionless" public_interface="out" name="F2P" initial_value="0.0274"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vd_b2"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F2P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> Vkp_f6 </ci>
<ci> F2 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> kpp_f6 </ci>
<ci> Cdc14 </ci>
</apply>
<ci> kd3_f6 </ci>
<ci> Vd_b2 </ci>
</apply>
<ci> F2P </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="F5P">
<variable units="dimensionless" public_interface="out" name="F5P" initial_value="7.9E-6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Vd_b5"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>F5P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> Vkp_f6 </ci>
<ci> F5 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> kpp_f6 </ci>
<ci> Cdc14 </ci>
</apply>
<ci> kd3_f6 </ci>
<ci> Vd_b5 </ci>
</apply>
<ci> F5P </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5_T">
<variable units="dimensionless" public_interface="out" name="Swi5_T" initial_value="0.9765"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swi"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swi5_T</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_swi_ </ci>
<apply>
<times/>
<ci> ks_swi__ </ci>
<ci> Mcm1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_swi </ci>
<ci> Swi5_T </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swi5">
<variable units="dimensionless" public_interface="out" name="Swi5" initial_value="0.9562"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_swi__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swi"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_swi"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_swi"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Swi5_T"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swi5</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_swi_ </ci>
<apply>
<times/>
<ci> ks_swi__ </ci>
<ci> Mcm1 </ci>
</apply>
<apply>
<times/>
<ci> ka_swi </ci>
<ci> Cdc14 </ci>
<apply>
<minus/>
<ci> Swi5_T </ci>
<ci> Swi5 </ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> kd_swi </ci>
<apply>
<times/>
<ci> ki_swi </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<ci> Swi5 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="APC_P">
<variable units="dimensionless" public_interface="out" name="APC_P" initial_value="0.1015"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_apc"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_apc"/>
<variable units="dimensionless" public_interface="in" name="Ja_apc"/>
<variable units="dimensionless" public_interface="in" name="Ji_apc"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>APC_P</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ka_apc </ci>
<ci> Clb2 </ci>
<apply>
<minus/>
<cn cellml:units="dimensionless"> 1.0 </cn>
<ci>APC_P</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Ja_apc </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
<ci> APC_P </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ki_apc </ci>
<ci> APC_P </ci>
</apply>
<apply>
<plus/>
<ci> Ji_apc </ci>
<ci> APC_P </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_T">
<variable units="dimensionless" public_interface="out" name="Cdc20_T" initial_value="1.9163"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_20_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_20__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_20"/>
<variable units="dimensionless" public_interface="in" name="Mcm1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_T</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_20_ </ci>
<apply>
<times/>
<ci> ks_20__ </ci>
<ci> Mcm1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_20 </ci>
<ci> Cdc20_T </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_A">
<variable units="dimensionless" public_interface="out" name="Cdc20_A" initial_value="0.4443"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_20_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_20__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_20"/>
<variable units="first_order_rate_constant" public_interface="in" name="kmad2"/>
<variable units="dimensionless" public_interface="in" name="APC_P"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_A</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci> ka_20_ </ci>
<apply>
<times/>
<ci> ka_20__ </ci>
<ci> APC_P </ci>
</apply>
</apply>
<apply>
<minus/>
<ci> Cdc20_T </ci>
<ci> Cdc20_A </ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci> kmad2 </ci>
<ci> kd_20 </ci>
</apply>
<ci> Cdc20_A </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1_T">
<variable units="dimensionless" public_interface="out" name="Cdh1_T" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_cdh"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1_T</ci>
</apply>
<apply>
<minus/>
<ci> ks_cdh </ci>
<apply>
<times/>
<ci> kd_cdh </ci>
<ci> Cdh1_T </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1">
<variable units="dimensionless" public_interface="out" name="Cdh1" initial_value="0.9305"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_cdh"/>
<variable units="dimensionless" public_interface="in" name="Ja_cdh"/>
<variable units="dimensionless" public_interface="in" name="Ji_cdh"/>
<variable units="dimensionless" public_interface="in" name="Va_cdh"/>
<variable units="dimensionless" public_interface="in" name="Vi_cdh"/>
<variable units="dimensionless" public_interface="in" name="Cdh1_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_cdh </ci>
<apply>
<divide/>
<apply>
<times/>
<ci> Va_cdh </ci>
<apply>
<minus/>
<ci> Cdh1_T </ci>
<ci> Cdh1 </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Ja_cdh </ci>
<ci> Cdh1_T </ci>
</apply>
<ci> Cdh1 </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> kd_cdh </ci>
<ci> Cdh1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Vi_cdh </ci>
<ci> Cdh1 </ci>
</apply>
<apply>
<plus/>
<ci> Ji_cdh </ci>
<ci> Cdh1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Tem1">
<variable units="dimensionless" public_interface="out" name="Tem1" initial_value="0.9039"/>
<variable units="dimensionless" name="Va_tem"/>
<variable units="dimensionless" name="Vi_tem"/>
<variable units="first_order_rate_constant" public_interface="in" name="kbub2"/>
<variable units="first_order_rate_constant" public_interface="in" name="klte1"/>
<variable units="dimensionless" public_interface="in" name="Ja_tem"/>
<variable units="dimensionless" public_interface="in" name="Ji_tem"/>
<variable units="dimensionless" public_interface="in" name="Tem1_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Tem1</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> klte1 </ci>
<apply>
<minus/>
<ci> Tem1_T </ci>
<ci> Tem1 </ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> Ja_tem </ci>
<ci> Tem1_T </ci>
</apply>
<ci> Tem1 </ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> kbub2 </ci>
<ci> Tem1 </ci>
</apply>
<apply>
<plus/>
<ci> Ji_tem </ci>
<ci> Tem1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc15">
<variable units="dimensionless" public_interface="out" name="Cdc15" initial_value="0.6565"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_15_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_15__"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_15___"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_15"/>
<variable units="dimensionless" public_interface="in" name="Tem1"/>
<variable units="dimensionless" public_interface="in" name="Tem1_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Cdc15_T"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc15</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> ka_15_ </ci>
<apply>
<minus/>
<ci> Tem1_T </ci>
<ci> Tem1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> ka_15__ </ci>
<ci> Tem1 </ci>
</apply>
<apply>
<times/>
<ci> ka_15___ </ci>
<ci> Cdc14 </ci>
</apply>
</apply>
<apply>
<minus/>
<ci> Cdc15_T </ci>
<ci> Cdc15 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> ki_15 </ci>
<ci> Cdc15 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc14_T">
<variable units="dimensionless" public_interface="out" name="Cdc14_T" initial_value="2.0"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc14_T</ci>
</apply>
<apply>
<minus/>
<ci> ks_14 </ci>
<apply>
<times/>
<ci> kd_14 </ci>
<ci> Cdc14_T </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc14">
<variable units="dimensionless" public_interface="out" name="Cdc14" initial_value="0.4683"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rentp"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rent"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rentp"/>
<variable units="dimensionless" public_interface="in" name="RENT"/>
<variable units="dimensionless" public_interface="in" name="RENTP"/>
<variable units="dimensionless" public_interface="in" name="Net1"/>
<variable units="dimensionless" public_interface="in" name="Net1P"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc14</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_14 </ci>
<apply>
<times/>
<ci> kd_net </ci>
<apply>
<plus/>
<ci> RENT </ci>
<ci> RENTP </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kdi_rent </ci>
<ci> RENT </ci>
</apply>
<apply>
<times/>
<ci> kdi_rentp </ci>
<ci> RENTP </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> kd_14 </ci>
<ci> Cdc14 </ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> kas_rent </ci>
<ci> Net1 </ci>
</apply>
<apply>
<times/>
<ci> kas_rentp </ci>
<ci> Net1P </ci>
</apply>
</apply>
<ci> Cdc14 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Net1_T">
<variable units="dimensionless" public_interface="out" name="Net1_T" initial_value="2.8"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Net1_T</ci>
</apply>
<apply>
<minus/>
<ci> ks_net </ci>
<apply>
<times/>
<ci> kd_net </ci>
<ci> Net1_T </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc6_T">
<variable units="dimensionless" public_interface="out" name="Cdc6_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc6"/>
<variable units="dimensionless" public_interface="in" name="Cdc6P"/>
<variable units="dimensionless" public_interface="in" name="F2"/>
<variable units="dimensionless" public_interface="in" name="F2P"/>
<variable units="dimensionless" public_interface="in" name="F5"/>
<variable units="dimensionless" public_interface="in" name="F5P"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Cdc6_T </ci>
<apply>
<plus/>
<ci> Cdc6 </ci>
<ci> Cdc6P </ci>
<ci> F2 </ci>
<ci> F2P </ci>
<ci> F5 </ci>
<ci> F5P </ci>
</apply>
</apply>
</math>
</component>
<component name="CKI_T">
<variable units="dimensionless" public_interface="out" name="CKI_T"/>
<variable units="dimensionless" public_interface="in" name="Sic1_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc6_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> CKI_T </ci>
<apply>
<plus/>
<ci> Sic1_T </ci>
<ci> Cdc6_T </ci>
</apply>
</apply>
</math>
</component>
<component name="RENTP">
<variable units="dimensionless" public_interface="out" name="RENTP"/>
<variable units="dimensionless" public_interface="in" name="Cdc14_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="RENT"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> RENTP </ci>
<apply>
<minus/>
<ci> Cdc14_T </ci>
<apply>
<plus/>
<ci> RENT </ci>
<ci> Cdc14 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Net1P">
<variable units="dimensionless" public_interface="out" name="Net1P"/>
<variable units="dimensionless" public_interface="in" name="Net1_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14_T"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Net1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Net1P </ci>
<apply>
<minus/>
<apply>
<plus/>
<ci> Net1_T </ci>
<ci> Cdc14 </ci>
</apply>
<apply>
<plus/>
<ci> Net1 </ci>
<ci> Cdc14_T </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PE">
<variable units="dimensionless" public_interface="out" name="PE"/>
<variable units="dimensionless" public_interface="in" name="Esp1_T"/>
<variable units="dimensionless" public_interface="in" name="Esp1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> PE </ci>
<apply>
<plus/>
<ci> Esp1_T </ci>
<ci> Esp1 </ci>
</apply>
</apply>
</math>
</component>
<component name="Vd_b5">
<variable units="dimensionless" public_interface="out" name="Vd_b5"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b5_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b5__"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vd_b5 </ci>
<apply>
<plus/>
<ci> kd_b5_ </ci>
<apply>
<times/>
<ci> kd_b5__ </ci>
<ci> Cdc20_A </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_b2">
<variable units="dimensionless" public_interface="out" name="Vd_b2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b2_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b2__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_b2p"/>
<variable units="dimensionless" public_interface="in" name="Cdh1"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vd_b2 </ci>
<apply>
<plus/>
<ci> kd_b2_ </ci>
<apply>
<times/>
<ci> kd_b2__ </ci>
<ci> Cdh1 </ci>
</apply>
<apply>
<times/>
<ci> kd_b2p </ci>
<ci> Cdc20_A </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Va_sbf">
<variable units="dimensionless" public_interface="out" name="Va_sbf"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_sbf"/>
<variable units="dimensionless" public_interface="in" name="epsilon_sbf_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_sbf_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_sbf_b5"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Bck2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Va_sbf </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> ka_sbf </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> epsilon_sbf_n2 </ci>
<ci> Cln2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_sbf_n3 </ci>
<apply>
<plus/>
<ci> Cln3 </ci>
<ci> Bck2 </ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci> epsilon_sbf_n2 </ci>
<ci> Clb5 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vi_sbf">
<variable units="dimensionless" public_interface="out" name="Vi_sbf"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_sbf_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_sbf__"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vi_sbf </ci>
<apply>
<plus/>
<ci> ki_sbf_ </ci>
<apply>
<times/>
<ci> ki_sbf__ </ci>
<ci> Clb2 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_c1">
<variable units="dimensionless" public_interface="out" name="Vkp_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd1_c1"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd2_c1"/>
<variable units="dimensionless" public_interface="in" name="Jd2_c1"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_k2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_c1_b2"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Bck2"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Sic1_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vkp_c1 </ci>
<apply>
<plus/>
<ci> kd1_c1 </ci>
<apply>
<times/>
<ci> kd2_c1 </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci> epsilon_c1_n3 </ci>
<ci> Cln3 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_c1_k2 </ci>
<ci> Bck2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_c1_n2 </ci>
<ci> Cln2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_c1_b5 </ci>
<ci> Clb5 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_c1_b2 </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> Jd2_c1 </ci>
<ci> Sic1_T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_f6">
<variable units="dimensionless" public_interface="out" name="Vkp_f6"/>
<variable units="dimensionless" public_interface="in" name="Jd2_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd1_f6"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd2_f6"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_k2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_f6_b2"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Bck2"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<variable units="dimensionless" public_interface="in" name="Cdc6_T"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vkp_f6 </ci>
<apply>
<plus/>
<ci> kd1_f6 </ci>
<apply>
<times/>
<ci> kd2_f6 </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci> epsilon_f6_n3 </ci>
<ci> Cln3 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_f6_k2 </ci>
<ci> Bck2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_f6_n2 </ci>
<ci> Cln2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_f6_b5 </ci>
<ci> Clb5 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_f6_b2 </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> Jd2_f6 </ci>
<ci> Cdc6_T </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Va_cdh">
<variable units="dimensionless" public_interface="out" name="Va_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_cdh_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_cdh__"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Va_cdh </ci>
<apply>
<plus/>
<ci> ka_cdh_ </ci>
<apply>
<times/>
<ci> ka_cdh__ </ci>
<ci> Cdc14 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vi_cdh">
<variable units="dimensionless" public_interface="out" name="Vi_cdh"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_cdh_"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_cdh__"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_n2"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_n3"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_b5"/>
<variable units="dimensionless" public_interface="in" name="epsilon_cdh_b2"/>
<variable units="dimensionless" public_interface="in" name="Cln2"/>
<variable units="dimensionless" public_interface="in" name="Clb5"/>
<variable units="dimensionless" public_interface="in" name="Cln3"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vi_cdh </ci>
<apply>
<plus/>
<ci> ki_cdh_ </ci>
<apply>
<times/>
<ci> ki_cdh__ </ci>
<apply>
<plus/>
<apply>
<times/>
<ci> epsilon_cdh_n3 </ci>
<ci> Cln3 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_cdh_n2 </ci>
<ci> Cln2 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_cdh_b5 </ci>
<ci> Clb5 </ci>
</apply>
<apply>
<times/>
<ci> epsilon_cdh_b2 </ci>
<ci> Clb2 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vpp_net">
<variable units="dimensionless" public_interface="out" name="Vpp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_net_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kpp_net__"/>
<variable units="dimensionless" public_interface="in" name="PPX"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vpp_net </ci>
<apply>
<plus/>
<ci> kpp_net_ </ci>
<apply>
<times/>
<ci> kpp_net__ </ci>
<ci> PPX </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vkp_net">
<variable units="dimensionless" public_interface="out" name="Vkp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kkp_net_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kkp_net__"/>
<variable units="dimensionless" public_interface="in" name="Cdc15"/>
<variable units="dimensionless" public_interface="in" name="mass"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vkp_net </ci>
<apply>
<times/>
<apply>
<plus/>
<ci> kkp_net_ </ci>
<apply>
<times/>
<ci> kkp_net__ </ci>
<ci> Cdc15 </ci>
</apply>
</apply>
<ci> mass </ci>
</apply>
</apply>
</math>
</component>
<component name="Net1">
<variable units="dimensionless" public_interface="out" name="Net1" initial_value="0.0186"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rent"/>
<variable units="dimensionless" public_interface="in" name="Vpp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rent"/>
<variable units="dimensionless" public_interface="in" name="Vkp_net"/>
<variable units="dimensionless" public_interface="in" name="RENT"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="Net1P"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Net1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_net </ci>
<apply>
<times/>
<ci> kd_14 </ci>
<ci> RENT </ci>
</apply>
<apply>
<times/>
<ci> kdi_rent </ci>
<ci> RENT </ci>
</apply>
<apply>
<times/>
<ci> Vpp_net </ci>
<ci> Net1P </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> kd_net </ci>
<ci> Net1 </ci>
</apply>
<apply>
<times/>
<ci> kas_rent </ci>
<ci> Cdc14 </ci>
<ci> Net1 </ci>
</apply>
<apply>
<times/>
<ci> Vkp_net </ci>
<ci> Net1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RENT">
<variable units="dimensionless" public_interface="out" name="RENT" initial_value="1.0495"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_14"/>
<variable units="first_order_rate_constant" public_interface="in" name="kdi_rent"/>
<variable units="dimensionless" public_interface="in" name="Vpp_net"/>
<variable units="first_order_rate_constant" public_interface="in" name="kas_rent"/>
<variable units="dimensionless" public_interface="in" name="Vkp_net"/>
<variable units="dimensionless" public_interface="in" name="Net1"/>
<variable units="dimensionless" public_interface="in" name="Cdc14"/>
<variable units="dimensionless" public_interface="in" name="RENTP"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>RENT</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> kas_rent </ci>
<ci> Cdc14 </ci>
<ci> Net1 </ci>
</apply>
<apply>
<times/>
<ci> Vpp_net </ci>
<ci> RENTP </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci> kd_14 </ci>
<ci> kd_net </ci>
</apply>
<ci> RENT </ci>
</apply>
<apply>
<times/>
<ci> kdi_rent </ci>
<ci> RENT </ci>
</apply>
<apply>
<times/>
<ci> Vkp_net </ci>
<ci> RENT </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PPX">
<variable units="dimensionless" public_interface="out" name="PPX" initial_value="0.1232"/>
<variable units="first_order_rate_constant" public_interface="in" name="ks_ppx"/>
<variable units="dimensionless" public_interface="in" name="Vd_ppx"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci> PPX </ci>
</apply>
<apply>
<minus/>
<ci> ks_ppx </ci>
<apply>
<times/>
<ci> Vd_ppx </ci>
<ci> PPX </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_ppx">
<variable units="dimensionless" public_interface="out" name="Vd_ppx"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_ppx_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_ppx__"/>
<variable units="dimensionless" public_interface="in" name="Pds1"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<variable units="dimensionless" public_interface="in" name="Jpds"/>
<variable units="dimensionless" public_interface="in" name="J20_ppx"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vd_ppx </ci>
<apply>
<plus/>
<ci> kd_ppx_ </ci>
<apply>
<times/>
<ci> kd_ppx__ </ci>
<apply>
<plus/>
<ci> J20_ppx </ci>
<ci> Cdc20_A </ci>
</apply>
<apply>
<divide/>
<ci> Jpds </ci>
<apply>
<plus/>
<ci> Jpds </ci>
<ci> Pds1 </ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Vd_pds">
<variable units="dimensionless" public_interface="out" name="Vd_pds"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd1_pds_"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd2_pds__"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd3_pds___"/>
<variable units="dimensionless" public_interface="in" name="Cdh1"/>
<variable units="dimensionless" public_interface="in" name="Cdc20_A"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci> Vd_pds </ci>
<apply>
<plus/>
<ci> kd1_pds_ </ci>
<apply>
<times/>
<ci> kd2_pds__ </ci>
<ci> Cdc20_A </ci>
</apply>
<apply>
<times/>
<ci> kd3_pds___ </ci>
<ci> Cdh1 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="model_parameters">
<variable units="first_order_rate_constant" public_interface="out" name="kg" initial_value="0.007702"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_n2_" initial_value="0.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_n2__" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_n2" initial_value="0.12"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b5_" initial_value="0.0008"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b5__" initial_value="0.005"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b5_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b5__" initial_value="0.16"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b2_" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_b2__" initial_value="0.04"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b2_" initial_value="0.003"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b2__" initial_value="0.4"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_b2p" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_c1_" initial_value="0.012"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_c1__" initial_value="0.12"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd1_c1" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd2_c1" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd3_c1" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_c1" initial_value="4.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_f6_" initial_value="0.024"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_f6__" initial_value="0.12"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_f6___" initial_value="0.004"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd1_f6" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd2_f6" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd3_f6" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_f6" initial_value="4.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_b5" initial_value="50.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_b5" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_f5" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_f5" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_b2" initial_value="50.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_b2" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_f2" initial_value="15.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_f2" initial_value="0.5"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_swi_" initial_value="0.005"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_swi__" initial_value="0.08"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_swi" initial_value="0.08"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_swi" initial_value="2.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_swi" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_apc" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_apc" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_20_" initial_value="0.006"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_20__" initial_value="0.6"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_20" initial_value="0.3"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_20_" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_20__" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_cdh" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_cdh" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_cdh_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_cdh__" initial_value="0.8"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_cdh_" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_cdh__" initial_value="0.08"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_14" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_14" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_net" initial_value="0.084"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_net" initial_value="0.03"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_15_" initial_value="0.002"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_15__" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_15___" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_15" initial_value="0.5"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_net_" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="kpp_net__" initial_value="3.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kkp_net_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kkp_net__" initial_value="0.6"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_rent" initial_value="200.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_rentp" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_rent" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_rentp" initial_value="2.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_ppx" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_ppx_" initial_value="0.17"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_ppx__" initial_value="2.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_pds_" initial_value="0.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks1_pds__" initial_value="0.03"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks2_pds__" initial_value="0.055"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd1_pds_" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd2_pds__" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd3_pds___" initial_value="0.04"/>
<variable units="first_order_rate_constant" public_interface="out" name="kas_esp" initial_value="50.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdi_esp" initial_value="0.5"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_ori" initial_value="2.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_ori" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_bud" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_bud" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="ks_spn" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_spn" initial_value="0.06"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_sbf" initial_value="0.38"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_sbf_" initial_value="0.6"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_sbf__" initial_value="8.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_mcm" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_mcm" initial_value="0.15"/>
<variable units="first_order_rate_constant" public_interface="out" name="kmad2" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kbub2" initial_value="0.2"/>
<variable units="first_order_rate_constant" public_interface="out" name="klte1" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="epsilon_sbf_n2" initial_value="2.0"/>
<variable units="dimensionless" public_interface="out" name="epsilon_sbf_n3" initial_value="10.0"/>
<variable units="dimensionless" public_interface="out" name="epsilon_sbf_b5" initial_value="2.0"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_n3" initial_value="0.3"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_n2" initial_value="0.06"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_k2" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_b5" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="epsilon_c1_b2" initial_value="0.45"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_n3" initial_value="0.3"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_n2" initial_value="0.06"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_k2" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_b5" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="epsilon_f6_b2" initial_value="0.55"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_n2" initial_value="0.25"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_n3" initial_value="0.4"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_b5" initial_value="8.0"/>
<variable units="dimensionless" public_interface="out" name="epsilon_cdh_b2" initial_value="1.2"/>
<variable units="dimensionless" public_interface="out" name="epsilon_ori_b5" initial_value="0.9"/>
<variable units="dimensionless" public_interface="out" name="epsilon_ori_b2" initial_value="0.45"/>
<variable units="dimensionless" public_interface="out" name="epsilon_bud_n3" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="epsilon_bud_n2" initial_value="0.25"/>
<variable units="dimensionless" public_interface="out" name="epsilon_bud_b5" initial_value="1.0"/>
<variable units="dimensionless" public_interface="out" name="C0" initial_value="0.4"/>
<variable units="dimensionless" public_interface="out" name="Dn3" initial_value="1.0"/>
<variable units="dimensionless" public_interface="out" name="B0" initial_value="0.054"/>
<variable units="dimensionless" public_interface="out" name="Tem1_T" initial_value="1.0"/>
<variable units="dimensionless" public_interface="out" name="Cdc15_T" initial_value="1.0"/>
<variable units="dimensionless" public_interface="out" name="Esp1_T" initial_value="1.0"/>
<variable units="dimensionless" public_interface="out" name="Jd2_c1" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Jd2_f6" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Ja_apc" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ji_apc" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ja_cdh" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="Ji_cdh" initial_value="0.03"/>
<variable units="dimensionless" public_interface="out" name="Ja_tem" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ji_tem" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ja_sbf" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Ji_sbf" initial_value="0.01"/>
<variable units="dimensionless" public_interface="out" name="Ja_mcm" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Ji_mcm" initial_value="0.1"/>
<variable units="dimensionless" public_interface="out" name="Jspn" initial_value="0.14"/>
<variable units="dimensionless" public_interface="out" name="Jn3" initial_value="6.0"/>
<variable units="dimensionless" public_interface="out" name="J20_ppx" initial_value="0.15"/>
<variable units="dimensionless" public_interface="out" name="Jpds" initial_value="0.04"/>
<variable units="dimensionless" public_interface="out" name="Kez" initial_value="0.3"/>
<variable units="dimensionless" public_interface="out" name="Kez2" initial_value="0.2"/>
<variable units="dimensionless" public_interface="in" name="ORI"/>
<variable units="dimensionless" public_interface="in" name="SPN"/>
<variable units="dimensionless" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="kmad2_calculation">
<eq/>
<ci> kmad2 </ci>
<piecewise>
<piece>
<cn cellml:units="first_order_rate_constant"> 8.0 </cn>
<apply>
<and/>
<apply>
<gt/>
<ci> ORI </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
<apply>
<lt/>
<ci> SPN </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="first_order_rate_constant"> 0.01 </cn>
</otherwise>
</piecewise>
</apply>
<apply id="kbub2_calculation">
<eq/>
<ci> kbub2 </ci>
<piecewise>
<piece>
<cn cellml:units="first_order_rate_constant"> 1.0 </cn>
<apply>
<and/>
<apply>
<gt/>
<ci> ORI </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
<apply>
<lt/>
<ci> SPN </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="first_order_rate_constant"> 0.2 </cn>
</otherwise>
</piecewise>
</apply>
<apply id="klte1_calculation">
<eq/>
<ci> klte1 </ci>
<piecewise>
<piece>
<cn cellml:units="first_order_rate_constant"> 1.0 </cn>
<apply>
<and/>
<apply>
<gt/>
<ci> SPN </ci>
<cn cellml:units="dimensionless"> 1.0 </cn>
</apply>
<apply>
<gt/>
<ci> Clb2 </ci>
<ci> Kez </ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="first_order_rate_constant"> 0.1 </cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<connection>
<map_components component_2="environment" component_1="mass"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Clb2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cln2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Clb5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Sic1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Sic1P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C2P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="C5P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc6"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc6P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Pds1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Esp1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="ORI"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="BUD"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="SPN"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F2P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="F5P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Swi5_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Swi5"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="APC_P"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc20_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc20_A"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdh1_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdh1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Tem1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc15"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc14_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc14"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Net1_T"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Net1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="RENT"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="PPX"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="mass"/>
<map_variables variable_2="kg" variable_1="kg"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cln2"/>
<map_variables variable_2="ks_n2_" variable_1="ks_n2_"/>
<map_variables variable_2="ks_n2__" variable_1="ks_n2__"/>
<map_variables variable_2="kd_n2" variable_1="kd_n2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Clb5"/>
<map_variables variable_2="ks_b5_" variable_1="ks_b5_"/>
<map_variables variable_2="ks_b5__" variable_1="ks_b5__"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kdi_b5" variable_1="kdi_b5"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kdi_f5" variable_1="kdi_f5"/>
<map_variables variable_2="kas_b5" variable_1="kas_b5"/>
<map_variables variable_2="kas_f5" variable_1="kas_f5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Clb2"/>
<map_variables variable_2="ks_b2_" variable_1="ks_b2_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
<map_variables variable_2="ks_b2__" variable_1="ks_b2__"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kdi_b2" variable_1="kdi_b2"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kdi_f2" variable_1="kdi_f2"/>
<map_variables variable_2="kas_b2" variable_1="kas_b2"/>
<map_variables variable_2="kas_f2" variable_1="kas_f2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Sic1"/>
<map_variables variable_2="ks_c1_" variable_1="ks_c1_"/>
<map_variables variable_2="ks_c1__" variable_1="ks_c1__"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kdi_b2" variable_1="kdi_b2"/>
<map_variables variable_2="kdi_b5" variable_1="kdi_b5"/>
<map_variables variable_2="kas_b2" variable_1="kas_b2"/>
<map_variables variable_2="kas_b5" variable_1="kas_b5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Sic1P"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C2"/>
<map_variables variable_2="kas_b2" variable_1="kas_b2"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kdi_b2" variable_1="kdi_b2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C5"/>
<map_variables variable_2="kas_b5" variable_1="kas_b5"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
<map_variables variable_2="kdi_b5" variable_1="kdi_b5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C2P"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="C5P"/>
<map_variables variable_2="kd3_c1" variable_1="kd3_c1"/>
<map_variables variable_2="kpp_c1" variable_1="kpp_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc6"/>
<map_variables variable_2="ks_f6_" variable_1="ks_f6_"/>
<map_variables variable_2="ks_f6__" variable_1="ks_f6__"/>
<map_variables variable_2="ks_f6___" variable_1="ks_f6___"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kdi_f2" variable_1="kdi_f2"/>
<map_variables variable_2="kdi_f5" variable_1="kdi_f5"/>
<map_variables variable_2="kas_f5" variable_1="kas_f5"/>
<map_variables variable_2="kas_f2" variable_1="kas_f2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc6P"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F2"/>
<map_variables variable_2="kas_f2" variable_1="kas_f2"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kdi_f2" variable_1="kdi_f2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Pds1"/>
<map_variables variable_2="ks_pds_" variable_1="ks_pds_"/>
<map_variables variable_2="ks1_pds__" variable_1="ks1_pds__"/>
<map_variables variable_2="ks2_pds__" variable_1="ks2_pds__"/>
<map_variables variable_2="kdi_esp" variable_1="kdi_esp"/>
<map_variables variable_2="kas_esp" variable_1="kas_esp"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Esp1"/>
<map_variables variable_2="kdi_esp" variable_1="kdi_esp"/>
<map_variables variable_2="kas_esp" variable_1="kas_esp"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="ORI"/>
<map_variables variable_2="ks_ori" variable_1="ks_ori"/>
<map_variables variable_2="ORI" variable_1="ORI"/>
<map_variables variable_2="kd_ori" variable_1="kd_ori"/>
<map_variables variable_2="epsilon_ori_b5" variable_1="epsilon_ori_b5"/>
<map_variables variable_2="epsilon_ori_b2" variable_1="epsilon_ori_b2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="BUD"/>
<map_variables variable_2="ks_bud" variable_1="ks_bud"/>
<map_variables variable_2="kd_bud" variable_1="kd_bud"/>
<map_variables variable_2="epsilon_bud_b5" variable_1="epsilon_bud_b5"/>
<map_variables variable_2="epsilon_bud_n2" variable_1="epsilon_bud_n2"/>
<map_variables variable_2="epsilon_bud_n3" variable_1="epsilon_bud_n3"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="SPN"/>
<map_variables variable_2="ks_spn" variable_1="ks_spn"/>
<map_variables variable_2="SPN" variable_1="SPN"/>
<map_variables variable_2="Jspn" variable_1="Jspn"/>
<map_variables variable_2="kd_spn" variable_1="kd_spn"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="G_sbf"/>
<map_variables variable_2="Ja_sbf" variable_1="Ja_sbf"/>
<map_variables variable_2="Ji_sbf" variable_1="Ji_sbf"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="G_cdh"/>
<map_variables variable_2="Ja_cdh" variable_1="Ja_cdh"/>
<map_variables variable_2="Ji_cdh" variable_1="Ji_cdh"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="G_mcm"/>
<map_variables variable_2="Ja_mcm" variable_1="Ja_mcm"/>
<map_variables variable_2="Ji_mcm" variable_1="Ji_mcm"/>
<map_variables variable_2="ka_mcm" variable_1="ka_mcm"/>
<map_variables variable_2="ki_mcm" variable_1="ki_mcm"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cln3"/>
<map_variables variable_2="C0" variable_1="C0"/>
<map_variables variable_2="Dn3" variable_1="Dn3"/>
<map_variables variable_2="Jn3" variable_1="Jn3"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Bck2"/>
<map_variables variable_2="B0" variable_1="B0"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F5"/>
<map_variables variable_2="kas_f5" variable_1="kas_f5"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
<map_variables variable_2="kdi_f5" variable_1="kdi_f5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F2P"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="F5P"/>
<map_variables variable_2="kd3_f6" variable_1="kd3_f6"/>
<map_variables variable_2="kpp_f6" variable_1="kpp_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Swi5_T"/>
<map_variables variable_2="ks_swi_" variable_1="ks_swi_"/>
<map_variables variable_2="ks_swi__" variable_1="ks_swi__"/>
<map_variables variable_2="kd_swi" variable_1="kd_swi"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Swi5"/>
<map_variables variable_2="ks_swi_" variable_1="ks_swi_"/>
<map_variables variable_2="ks_swi__" variable_1="ks_swi__"/>
<map_variables variable_2="ka_swi" variable_1="ka_swi"/>
<map_variables variable_2="kd_swi" variable_1="kd_swi"/>
<map_variables variable_2="ki_swi" variable_1="ki_swi"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="APC_P"/>
<map_variables variable_2="ka_apc" variable_1="ka_apc"/>
<map_variables variable_2="ki_apc" variable_1="ki_apc"/>
<map_variables variable_2="Ja_apc" variable_1="Ja_apc"/>
<map_variables variable_2="Ji_apc" variable_1="Ji_apc"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc20_T"/>
<map_variables variable_2="ks_20_" variable_1="ks_20_"/>
<map_variables variable_2="ks_20__" variable_1="ks_20__"/>
<map_variables variable_2="kd_20" variable_1="kd_20"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc20_A"/>
<map_variables variable_2="ka_20_" variable_1="ka_20_"/>
<map_variables variable_2="ka_20__" variable_1="ka_20__"/>
<map_variables variable_2="kd_20" variable_1="kd_20"/>
<map_variables variable_2="kmad2" variable_1="kmad2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdh1"/>
<map_variables variable_2="ks_cdh" variable_1="ks_cdh"/>
<map_variables variable_2="kd_cdh" variable_1="kd_cdh"/>
<map_variables variable_2="Ja_cdh" variable_1="Ja_cdh"/>
<map_variables variable_2="Ji_cdh" variable_1="Ji_cdh"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdh1_T"/>
<map_variables variable_2="ks_cdh" variable_1="ks_cdh"/>
<map_variables variable_2="kd_cdh" variable_1="kd_cdh"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Tem1"/>
<map_variables variable_2="klte1" variable_1="klte1"/>
<map_variables variable_2="kbub2" variable_1="kbub2"/>
<map_variables variable_2="Tem1_T" variable_1="Tem1_T"/>
<map_variables variable_2="Ja_tem" variable_1="Ja_tem"/>
<map_variables variable_2="Ji_tem" variable_1="Ji_tem"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc15"/>
<map_variables variable_2="ka_15_" variable_1="ka_15_"/>
<map_variables variable_2="ka_15__" variable_1="ka_15__"/>
<map_variables variable_2="ka_15___" variable_1="ka_15___"/>
<map_variables variable_2="Tem1_T" variable_1="Tem1_T"/>
<map_variables variable_2="Cdc15_T" variable_1="Cdc15_T"/>
<map_variables variable_2="ki_15" variable_1="ki_15"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc14_T"/>
<map_variables variable_2="ks_14" variable_1="ks_14"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="PE"/>
<map_variables variable_2="Esp1_T" variable_1="Esp1_T"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Cdc14"/>
<map_variables variable_2="ks_14" variable_1="ks_14"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
<map_variables variable_2="kdi_rent" variable_1="kdi_rent"/>
<map_variables variable_2="kdi_rentp" variable_1="kdi_rentp"/>
<map_variables variable_2="kas_rent" variable_1="kas_rent"/>
<map_variables variable_2="kas_rentp" variable_1="kas_rentp"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Net1_T"/>
<map_variables variable_2="ks_net" variable_1="ks_net"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_b5"/>
<map_variables variable_2="kd_b5_" variable_1="kd_b5_"/>
<map_variables variable_2="kd_b5__" variable_1="kd_b5__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_b2"/>
<map_variables variable_2="kd_b2_" variable_1="kd_b2_"/>
<map_variables variable_2="kd_b2__" variable_1="kd_b2__"/>
<map_variables variable_2="kd_b2p" variable_1="kd_b2p"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Va_sbf"/>
<map_variables variable_2="ka_sbf" variable_1="ka_sbf"/>
<map_variables variable_2="epsilon_sbf_n2" variable_1="epsilon_sbf_n2"/>
<map_variables variable_2="epsilon_sbf_n3" variable_1="epsilon_sbf_n3"/>
<map_variables variable_2="epsilon_sbf_b5" variable_1="epsilon_sbf_b5"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vi_sbf"/>
<map_variables variable_2="ki_sbf_" variable_1="ki_sbf_"/>
<map_variables variable_2="ki_sbf__" variable_1="ki_sbf__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vkp_c1"/>
<map_variables variable_2="kd1_c1" variable_1="kd1_c1"/>
<map_variables variable_2="kd2_c1" variable_1="kd2_c1"/>
<map_variables variable_2="epsilon_c1_n2" variable_1="epsilon_c1_n2"/>
<map_variables variable_2="epsilon_c1_n3" variable_1="epsilon_c1_n3"/>
<map_variables variable_2="epsilon_c1_k2" variable_1="epsilon_c1_k2"/>
<map_variables variable_2="epsilon_c1_b5" variable_1="epsilon_c1_b5"/>
<map_variables variable_2="epsilon_c1_b2" variable_1="epsilon_c1_b2"/>
<map_variables variable_2="Jd2_c1" variable_1="Jd2_c1"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vkp_f6"/>
<map_variables variable_2="kd1_f6" variable_1="kd1_f6"/>
<map_variables variable_2="kd2_f6" variable_1="kd2_f6"/>
<map_variables variable_2="epsilon_f6_n2" variable_1="epsilon_f6_n2"/>
<map_variables variable_2="epsilon_f6_n3" variable_1="epsilon_f6_n3"/>
<map_variables variable_2="epsilon_f6_k2" variable_1="epsilon_f6_k2"/>
<map_variables variable_2="epsilon_f6_b5" variable_1="epsilon_f6_b5"/>
<map_variables variable_2="epsilon_f6_b2" variable_1="epsilon_f6_b2"/>
<map_variables variable_2="Jd2_f6" variable_1="Jd2_f6"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Va_cdh"/>
<map_variables variable_2="ka_cdh_" variable_1="ka_cdh_"/>
<map_variables variable_2="ka_cdh__" variable_1="ka_cdh__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vi_cdh"/>
<map_variables variable_2="ki_cdh_" variable_1="ki_cdh_"/>
<map_variables variable_2="ki_cdh__" variable_1="ki_cdh__"/>
<map_variables variable_2="epsilon_cdh_n2" variable_1="epsilon_cdh_n2"/>
<map_variables variable_2="epsilon_cdh_n3" variable_1="epsilon_cdh_n3"/>
<map_variables variable_2="epsilon_cdh_b5" variable_1="epsilon_cdh_b5"/>
<map_variables variable_2="epsilon_cdh_b2" variable_1="epsilon_cdh_b2"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vpp_net"/>
<map_variables variable_2="kpp_net_" variable_1="kpp_net_"/>
<map_variables variable_2="kpp_net__" variable_1="kpp_net__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vkp_net"/>
<map_variables variable_2="kkp_net_" variable_1="kkp_net_"/>
<map_variables variable_2="kkp_net__" variable_1="kkp_net__"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Net1"/>
<map_variables variable_2="ks_net" variable_1="ks_net"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
<map_variables variable_2="kdi_rent" variable_1="kdi_rent"/>
<map_variables variable_2="kas_rent" variable_1="kas_rent"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="RENT"/>
<map_variables variable_2="ks_net" variable_1="ks_net"/>
<map_variables variable_2="kd_net" variable_1="kd_net"/>
<map_variables variable_2="kd_14" variable_1="kd_14"/>
<map_variables variable_2="kdi_rent" variable_1="kdi_rent"/>
<map_variables variable_2="kas_rent" variable_1="kas_rent"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="PPX"/>
<map_variables variable_2="ks_ppx" variable_1="ks_ppx"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_ppx"/>
<map_variables variable_2="kd_ppx_" variable_1="kd_ppx_"/>
<map_variables variable_2="kd_ppx__" variable_1="kd_ppx__"/>
<map_variables variable_2="J20_ppx" variable_1="J20_ppx"/>
<map_variables variable_2="Jpds" variable_1="Jpds"/>
</connection>
<connection>
<map_components component_2="model_parameters" component_1="Vd_pds"/>
<map_variables variable_2="kd1_pds_" variable_1="kd1_pds_"/>
<map_variables variable_2="kd2_pds__" variable_1="kd2_pds__"/>
<map_variables variable_2="kd3_pds___" variable_1="kd3_pds___"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="mass"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Cln2"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Clb5"/>
<map_variables variable_2="MBF" variable_1="MBF"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Clb5"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Clb5"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Clb5"/>
<map_variables variable_2="C5" variable_1="C5"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Clb5"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Clb5"/>
<map_variables variable_2="F5" variable_1="F5"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Clb5"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Cdc6" component_1="Clb5"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="G_mcm" component_1="Clb2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Clb2"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Clb2"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Clb2"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Clb2"/>
<map_variables variable_2="C2" variable_1="C2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Clb2"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Clb2"/>
<map_variables variable_2="F2" variable_1="F2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Clb2"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cdc6" component_1="Clb2"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Swi5" component_1="Sic1"/>
<map_variables variable_2="Swi5" variable_1="Swi5"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="Sic1"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="Sic1P"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C2"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C5"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Sic1"/>
<map_variables variable_2="C2" variable_1="C2"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Sic1"/>
<map_variables variable_2="C5" variable_1="C5"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Sic1"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Sic1P" component_1="Sic1"/>
<map_variables variable_2="Sic1P" variable_1="Sic1P"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Sic1P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Sic1P"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Sic1P"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="C2"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="C2"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
<map_variables variable_2="C2" variable_1="C2"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="C5"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="C5"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="Swi5" component_1="Cdc6"/>
<map_variables variable_2="Swi5" variable_1="Swi5"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Cdc6"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Cdc6"/>
<map_variables variable_2="F2" variable_1="F2"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Cdc6"/>
<map_variables variable_2="F5" variable_1="F5"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Cdc6"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc6P" component_1="Cdc6"/>
<map_variables variable_2="Cdc6P" variable_1="Cdc6P"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Cdc6P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Cdc6P"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Cdc6P"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F2"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="F2"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
<map_variables variable_2="F2" variable_1="F2"/>
</connection>
<connection>
<map_components component_2="SBF_MBF" component_1="Pds1"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Pds1"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="PE" component_1="Pds1"/>
<map_variables variable_2="PE" variable_1="PE"/>
</connection>
<connection>
<map_components component_2="Esp1" component_1="Pds1"/>
<map_variables variable_2="Esp1" variable_1="Esp1"/>
<map_variables variable_2="Pds1" variable_1="Pds1"/>
</connection>
<connection>
<map_components component_2="PE" component_1="Esp1"/>
<map_variables variable_2="PE" variable_1="PE"/>
<map_variables variable_2="Esp1" variable_1="Esp1"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="ORI"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="ORI"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="BUD"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="BUD"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="BUD"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="SPN"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="G_sbf" component_1="SBF_MBF"/>
<map_variables variable_2="G_sbf" variable_1="G_sbf"/>
</connection>
<connection>
<map_components component_2="G_mcm" component_1="Mcm1"/>
<map_variables variable_2="G_mcm" variable_1="G_mcm"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Cln3"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Bck2"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Clb5_T"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Clb5_T"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Clb5_T"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Clb5_T"/>
<map_variables variable_2="F5" variable_1="F5"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Clb5_T"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Clb2_T"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Clb2_T"/>
<map_variables variable_2="C2" variable_1="C2"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Clb2_T"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Clb2_T"/>
<map_variables variable_2="F2" variable_1="F2"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Clb2_T"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Sic1_T"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
</connection>
<connection>
<map_components component_2="Sic1P" component_1="Sic1_T"/>
<map_variables variable_2="Sic1P" variable_1="Sic1P"/>
</connection>
<connection>
<map_components component_2="C2" component_1="Sic1_T"/>
<map_variables variable_2="C2" variable_1="C2"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Sic1_T"/>
<map_variables variable_2="C2P" variable_1="C2P"/>
</connection>
<connection>
<map_components component_2="C5" component_1="Sic1_T"/>
<map_variables variable_2="C5" variable_1="C5"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Sic1_T"/>
<map_variables variable_2="C5P" variable_1="C5P"/>
</connection>
<connection>
<map_components component_2="Cdc6" component_1="Cdc6_T"/>
<map_variables variable_2="Cdc6" variable_1="Cdc6"/>
</connection>
<connection>
<map_components component_2="Cdc6P" component_1="Cdc6_T"/>
<map_variables variable_2="Cdc6P" variable_1="Cdc6P"/>
</connection>
<connection>
<map_components component_2="F2" component_1="Cdc6_T"/>
<map_variables variable_2="F2" variable_1="F2"/>
</connection>
<connection>
<map_components component_2="F2P" component_1="Cdc6_T"/>
<map_variables variable_2="F2P" variable_1="F2P"/>
</connection>
<connection>
<map_components component_2="F5" component_1="Cdc6_T"/>
<map_variables variable_2="F5" variable_1="F5"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="Cdc6_T"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
</connection>
<connection>
<map_components component_2="Sic1_T" component_1="CKI_T"/>
<map_variables variable_2="Sic1_T" variable_1="Sic1_T"/>
</connection>
<connection>
<map_components component_2="Cdc6_T" component_1="CKI_T"/>
<map_variables variable_2="Cdc6_T" variable_1="Cdc6_T"/>
</connection>
<connection>
<map_components component_2="Cdc14_T" component_1="RENTP"/>
<map_variables variable_2="Cdc14_T" variable_1="Cdc14_T"/>
</connection>
<connection>
<map_components component_2="RENT" component_1="RENTP"/>
<map_variables variable_2="RENT" variable_1="RENT"/>
<map_variables variable_2="RENTP" variable_1="RENTP"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="RENTP"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
<map_variables variable_2="RENTP" variable_1="RENTP"/>
</connection>
<connection>
<map_components component_2="Net1_T" component_1="Net1P"/>
<map_variables variable_2="Net1_T" variable_1="Net1_T"/>
</connection>
<connection>
<map_components component_2="Net1" component_1="Net1P"/>
<map_variables variable_2="Net1P" variable_1="Net1P"/>
<map_variables variable_2="Net1" variable_1="Net1"/>
</connection>
<connection>
<map_components component_2="Cdc14_T" component_1="Net1P"/>
<map_variables variable_2="Cdc14_T" variable_1="Cdc14_T"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Net1P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
<map_variables variable_2="Net1P" variable_1="Net1P"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F5"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="F5P" component_1="F5"/>
<map_variables variable_2="F5P" variable_1="F5P"/>
<map_variables variable_2="F5" variable_1="F5"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F2P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="F5P"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Swi5_T"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Swi5"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Swi5"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Swi5_T" component_1="Swi5"/>
<map_variables variable_2="Swi5_T" variable_1="Swi5_T"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Swi5"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="APC_P"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Mcm1" component_1="Cdc20_T"/>
<map_variables variable_2="Mcm1" variable_1="Mcm1"/>
</connection>
<connection>
<map_components component_2="APC_P" component_1="Cdc20_A"/>
<map_variables variable_2="APC_P" variable_1="APC_P"/>
</connection>
<connection>
<map_components component_2="Cdc20_T" component_1="Cdc20_A"/>
<map_variables variable_2="Cdc20_T" variable_1="Cdc20_T"/>
</connection>
<connection>
<map_components component_2="Cdh1_T" component_1="Cdh1"/>
<map_variables variable_2="Cdh1_T" variable_1="Cdh1_T"/>
</connection>
<connection>
<map_components component_2="Tem1" component_1="Cdc15"/>
<map_variables variable_2="Tem1" variable_1="Tem1"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Cdc15"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="RENT" component_1="Cdc14"/>
<map_variables variable_2="RENT" variable_1="RENT"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Net1" component_1="Cdc14"/>
<map_variables variable_2="Net1" variable_1="Net1"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_b5"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_b2"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Cdh1" component_1="Vd_b2"/>
<map_variables variable_2="Cdh1" variable_1="Cdh1"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Va_sbf"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Va_sbf"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Bck2" component_1="Va_sbf"/>
<map_variables variable_2="Bck2" variable_1="Bck2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Va_sbf"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vi_sbf"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Vkp_c1"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Vkp_c1"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Bck2" component_1="Vkp_c1"/>
<map_variables variable_2="Bck2" variable_1="Bck2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Vkp_c1"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vkp_c1"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Sic1_T" component_1="Vkp_c1"/>
<map_variables variable_2="Sic1_T" variable_1="Sic1_T"/>
</connection>
<connection>
<map_components component_2="Cdc14" component_1="Va_cdh"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cdc15" component_1="Vkp_net"/>
<map_variables variable_2="Cdc15" variable_1="Cdc15"/>
</connection>
<connection>
<map_components component_2="mass" component_1="Vkp_net"/>
<map_variables variable_2="mass" variable_1="mass"/>
</connection>
<connection>
<map_components component_2="RENT" component_1="Net1"/>
<map_variables variable_2="RENT" variable_1="RENT"/>
<map_variables variable_2="Net1" variable_1="Net1"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_ppx"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Pds1" component_1="Vd_ppx"/>
<map_variables variable_2="Pds1" variable_1="Pds1"/>
</connection>
<connection>
<map_components component_2="Cdc20_A" component_1="Vd_pds"/>
<map_variables variable_2="Cdc20_A" variable_1="Cdc20_A"/>
</connection>
<connection>
<map_components component_2="Cdh1" component_1="Vd_pds"/>
<map_variables variable_2="Cdh1" variable_1="Cdh1"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Sic1P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Sic1P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Clb5"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Clb2"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Sic1"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Sic1"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="C2"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="C5"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C2P"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="C2P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vkp_c1" component_1="C5P"/>
<map_variables variable_2="Vkp_c1" variable_1="Vkp_c1"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="C5P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Cdc6"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Cdc6"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="Cdc6"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="Cdc6P"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="Cdc6P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="Cdc6P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="F2"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F2"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vd_pds" component_1="Pds1"/>
<map_variables variable_2="Vd_pds" variable_1="Vd_pds"/>
</connection>
<connection>
<map_components component_2="Vd_pds" component_1="Esp1"/>
<map_variables variable_2="Vd_pds" variable_1="Vd_pds"/>
</connection>
<connection>
<map_components component_2="Va_sbf" component_1="G_sbf"/>
<map_variables variable_2="Va_sbf" variable_1="Va_sbf"/>
</connection>
<connection>
<map_components component_2="Vi_sbf" component_1="G_sbf"/>
<map_variables variable_2="Vi_sbf" variable_1="Vi_sbf"/>
</connection>
<connection>
<map_components component_2="Va_cdh" component_1="G_cdh"/>
<map_variables variable_2="Va_cdh" variable_1="Va_cdh"/>
</connection>
<connection>
<map_components component_2="Vi_cdh" component_1="G_cdh"/>
<map_variables variable_2="Vi_cdh" variable_1="Vi_cdh"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="F5"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F5"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F5P"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vkp_f6" component_1="F2P"/>
<map_variables variable_2="Vkp_f6" variable_1="Vkp_f6"/>
</connection>
<connection>
<map_components component_2="Vd_b2" component_1="F2P"/>
<map_variables variable_2="Vd_b2" variable_1="Vd_b2"/>
</connection>
<connection>
<map_components component_2="Vd_b5" component_1="F5P"/>
<map_variables variable_2="Vd_b5" variable_1="Vd_b5"/>
</connection>
<connection>
<map_components component_2="Va_cdh" component_1="Cdh1"/>
<map_variables variable_2="Va_cdh" variable_1="Va_cdh"/>
</connection>
<connection>
<map_components component_2="Vi_cdh" component_1="Cdh1"/>
<map_variables variable_2="Vi_cdh" variable_1="Vi_cdh"/>
</connection>
<connection>
<map_components component_2="Vpp_net" component_1="Net1"/>
<map_variables variable_2="Vpp_net" variable_1="Vpp_net"/>
</connection>
<connection>
<map_components component_2="Vkp_net" component_1="Net1"/>
<map_variables variable_2="Vkp_net" variable_1="Vkp_net"/>
</connection>
<connection>
<map_components component_2="Vpp_net" component_1="RENT"/>
<map_variables variable_2="Vpp_net" variable_1="Vpp_net"/>
</connection>
<connection>
<map_components component_2="Vkp_net" component_1="RENT"/>
<map_variables variable_2="Vkp_net" variable_1="Vkp_net"/>
</connection>
<connection>
<map_components component_2="Vd_ppx" component_1="PPX"/>
<map_variables variable_2="Vd_ppx" variable_1="Vd_ppx"/>
</connection>
<connection>
<map_components component_2="C2P" component_1="Cdc14"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="C5P" component_1="Cdc14"/>
<map_variables variable_2="Cdc14" variable_1="Cdc14"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Vkp_f6"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Vi_cdh"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<connection>
<map_components component_2="Cln2" component_1="Vi_cdh"/>
<map_variables variable_2="Cln2" variable_1="Cln2"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vi_cdh"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Vi_cdh"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Cdc6_T" component_1="Vkp_f6"/>
<map_variables variable_2="Cdc6_T" variable_1="Cdc6_T"/>
</connection>
<connection>
<map_components component_2="PPX" component_1="Vpp_net"/>
<map_variables variable_2="PPX" variable_1="PPX"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Vkp_f6"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Bck2" component_1="Vkp_f6"/>
<map_variables variable_2="Bck2" variable_1="Bck2"/>
</connection>
<connection>
<map_components component_2="Cln3" component_1="Vkp_f6"/>
<map_variables variable_2="Cln3" variable_1="Cln3"/>
</connection>
<connection>
<map_components component_2="Clb5" component_1="Vkp_f6"/>
<map_variables variable_2="Clb5" variable_1="Clb5"/>
</connection>
<rdf:RDF>
<rdf:Bag rdf:about="rdf:#5171a8e5-a07e-4dd3-a4d0-a377a1edf4dc">
<rdf:li>cell cyc1e</rdf:li>
<rdf:li>yeast</rdf:li>
<rdf:li>cell cycle</rdf:li>
</rdf:Bag>
<rdf:Seq rdf:about="rdf:#7006f677-a710-4a2f-8b3a-8c18f4194aa4">
<rdf:li rdf:resource="rdf:#29420f26-c3c2-42cd-a833-e33afd410977"/>
<rdf:li rdf:resource="rdf:#fd4a516c-1833-4f7b-8e3f-a285010aee1c"/>
<rdf:li rdf:resource="rdf:#352fe27a-f0a7-4ea2-8b5c-192586d502cc"/>
<rdf:li rdf:resource="rdf:#4c2f6994-f1d4-49aa-b785-35993dd51523"/>
<rdf:li rdf:resource="rdf:#8c6696b9-cf16-42e0-a9da-fa3514f997f0"/>
<rdf:li rdf:resource="rdf:#55db0589-7d14-423f-aa22-8c8926c54394"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#9a47ba18-861f-4814-8fe2-2c3e2452d734">
<vCard:Given>Bela</vCard:Given>
<vCard:Family>Novak</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4101a0bb-f4c6-4b86-8f21-243e40dcd5bf">
<vCard:Given>Katherine</vCard:Given>
<vCard:Family>Chen</vCard:Family>
<vCard:Other>C</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4755a4bd-209c-45a0-9436-efd9183adcb2">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#55db0589-7d14-423f-aa22-8c8926c54394">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
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