- Author:
- ssaf006 <ssaf006@aucklanduni.ac.nz>
- Date:
- 2019-06-06 20:47:37+12:00
- Desc:
- fixed the nvc model
- Permanent Source URI:
- http://models.cellml.org/workspace/4bd/rawfile/4e32e1754f465d7374b6a52d1371fba0a346c5c4/original/Neuron.cellml
<?xml version='1.0'?>
<model name="Neuron_module" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="per_s" units_ref="per_s"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
<units name="per_mM" units_ref="per_mM"/>
<units name="per_mM_s" units_ref="per_mM_s"/>
</import>
<import xlink:href="NVC_parameters.cellml">
<component component_ref="Parameters" name="Parameters"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="Neuron">
<variable name="t" public_interface="in" units="second"/>
<!-- State variables-->
<variable initial_value="0.0" name="q_Glu" public_interface="in" units="mM"/>
<variable initial_value="0.0" name="q_Ca_Neuro" units="mM"/>
<variable initial_value="0.0" name="q_NO" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="q_cGMP" public_interface="out" units="mM"/>
<variable initial_value="0.0" name="q_S1_cGMP" units="mM"/>
<variable initial_value="0.0" name="q_S2_cGMP" units="mM"/>
<variable initial_value="0.0" name="q_S3_cGMP" units="mM"/>
<!-- Parameters-->
<variable name="k_3" public_interface="in" units="per_s"/>
<variable name="k_10" public_interface="in" units="per_s"/>
<variable name="k_11" public_interface="in" units="per_s"/>
<variable name="k_21" public_interface="in" units="per_s"/>
<variable name="k_22" public_interface="in" units="per_s"/>
<variable name="k_23" public_interface="in" units="per_s"/>
<variable name="k_NO_sink" public_interface="in" units="per_s"/>
<variable name="k_sink_N" public_interface="in" units="per_s"/>
<variable name="k_sink_C" public_interface="in" units="per_s"/>
<variable name="v_Ca_Nbas" public_interface="in" units="mM_per_s"/>
<!-- ODEs-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Ca_Neuro</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>k_3</ci>
<ci>q_Glu</ci>
</apply>
<apply>
<times/>
<ci>q_Ca_Neuro</ci>
<ci>k_sink_N</ci>
</apply>
</apply>
<ci>v_Ca_Nbas</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_NO</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_10</ci>
<ci>q_Ca_Neuro</ci>
</apply>
<apply>
<times/>
<ci>k_NO_sink</ci>
<ci>q_NO</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_cGMP</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_23</ci>
<ci>q_S3_cGMP</ci>
</apply>
<apply>
<times/>
<ci>k_sink_C</ci>
<ci>q_cGMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S1_cGMP</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_11</ci>
<ci>q_NO</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>q_S1_cGMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S2_cGMP</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_21</ci>
<ci>q_S1_cGMP</ci>
</apply>
<apply>
<times/>
<ci>k_22</ci>
<ci>q_S2_cGMP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_S3_cGMP</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_22</ci>
<ci>q_S2_cGMP</ci>
</apply>
<apply>
<times/>
<ci>k_23</ci>
<ci>q_S3_cGMP</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="Neuron"/>
<map_variables variable_1="time" variable_2="t"/>
</connection>
<connection>
<map_components component_1="Neuron" component_2="Parameters"/>
<map_variables variable_1="k_3" variable_2="k_3"/>
<map_variables variable_1="k_10" variable_2="k_10"/>
<map_variables variable_1="k_11" variable_2="k_11"/>
<map_variables variable_1="k_21" variable_2="k_21"/>
<map_variables variable_1="k_22" variable_2="k_22"/>
<map_variables variable_1="k_23" variable_2="k_23"/>
<map_variables variable_1="k_NO_sink" variable_2="k_NO_sink"/>
<map_variables variable_1="k_sink_N" variable_2="k_sink_N"/>
<map_variables variable_1="k_sink_C" variable_2="k_sink_C"/>
<map_variables variable_1="v_Ca_Nbas" variable_2="v_Ca_Nbas"/>
</connection>
</model>
