Location: Glucose Uptake in Enterocyte @ 5c28c09a41d3 / CFTR_flux.cellml

Author:

Nima <nafs080@aucklanduni.ac.nz>

Date:

2018-04-09 08:03:37+12:00

Desc:

NHE3

Permanent Source URI:

http://models.cellml.org/workspace/572/rawfile/5c28c09a41d31e690ae34f3455c251650b10ec61/CFTR_flux.cellml

<?xml version='1.0'?>
<!--Original Paper:Hodgkin, Alan L., and Andrew F. Huxley. "A quantitative description of membrane current and its application to conduction and excitation in nerve." The Journal of physiology 117.4 (1952): 500-544.
Link in Exposure:-->
<model name="CFTR_flux" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
    <component name="CFTR">
        <variable name="z_Cl" public_interface="in" units="dimensionless"/>
        <variable name="R" public_interface="in" units="J_per_K_per_mol"/>
        <variable name="T" public_interface="in" units="kelvin"/>
        <variable name="q_Cl_i" public_interface="in" units="M"/>
        <variable name="q_Cl_m" public_interface="in" units="M"/>
        <variable name="v_A_Cl" public_interface="out" units="volt"/>
        <variable name="v_mc" public_interface="in" units="volt"/>
        <variable name="J_CFTR" public_interface="out" units="umol_per_s"/>
        <variable name="I_CFTR" public_interface="out" units="uA"/>
        <variable name="A_Apical" public_interface="in" units="m2"/>
        <variable name="F" public_interface="in" units="C_per_mol"/>
        <variable initial_value="9" name="G_CFTR" public_interface="out" units="S"/>
        <variable initial_value="-1" name="z_HCO3" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.1" name="alpha_CFTR" public_interface="out" units="per_m2"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>J_CFTR</ci>
                <apply>
                    <divide/>
                    <ci>I_CFTR</ci>
                    <ci>F</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>v_A_Cl</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>z_Cl</ci>
                            <ci>F</ci>
                        </apply>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>q_Cl_m</ci>
                            <ci>q_Cl_i</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <!-- 1e6 is for unit consistency in order to change Ampere to MicorAmpere        -->
            <apply>
                <eq/>
                <ci>I_CFTR</ci>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
                    </apply>
                    <ci>G_CFTR</ci>
                    <ci>alpha_CFTR</ci>
                    <ci>A_Apical</ci>
                    <apply>
                        <minus/>
                        <ci>v_mc</ci>
                        <ci>v_A_Cl</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
</model>