Location: Glucose Uptake in Enterocyte @ c052b0c46028 / SGLT1_Rate_Constants.cellml

Author:
nima <nafs080@aucklanduni.ac.nz>
Date:
2020-09-30 10:48:46+13:00
Desc:
Renamed the files
Permanent Source URI:
http://models.cellml.org/workspace/572/rawfile/c052b0c460280139dad150937fbee4fa6a026505/SGLT1_Rate_Constants.cellml

<?xml version='1.0'?>
<!--Link in Exposure : https://models.physiomeproject.org/exposure/4f0e5558031705df771326fb9bd90c28
 Original Paper: Xing-Zhen Chen, Michael J Coady, Francis Jackson, Alfred Berteloot, and Jean-Yves Lapointe. Thermodynamic determination of the Na+: glucose coupling ratio for the human sglt1 cotransporter.        -->
<model name="SGLT1_Rate_Constants" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
    <component name="SGLT1_rate_constants">
        <variable name="Na_i" public_interface="in" units="M"/>
        <variable name="Na_m" public_interface="in" units="M"/>
        <variable name="glucose_i" public_interface="in" units="M"/>
        <variable name="glucose_m" public_interface="in" units="M"/>
        <variable name="k_12" public_interface="out" units="per_second"/>
        <variable name="ks_12" public_interface="out" units="per_M2_per_second"/>
        <variable name="k_21" public_interface="out" units="per_second"/>
        <variable name="k_32" public_interface="out" units="per_second"/>
        <variable name="k_25" public_interface="out" units="per_second"/>
        <variable name="k_52" public_interface="out" units="per_second"/>
        <variable name="k_34" public_interface="out" units="per_second"/>
        <variable name="k_43" public_interface="out" units="per_second"/>
        <variable name="k_45" public_interface="out" units="per_second"/>
        <variable name="k_54" public_interface="out" units="per_second"/>
        <variable name="k_56" public_interface="out" units="per_second"/>
        <variable name="k_65" public_interface="out" units="per_second"/>
        <variable name="k_61" public_interface="out" units="per_second"/>
        <variable name="k_16" public_interface="out" units="per_second"/>
        <variable name="k0_12" public_interface="in" units="per_M2_per_second"/>
        <variable name="k0_21" public_interface="in" units="per_second"/>
        <variable name="k0_32" public_interface="in" units="per_second"/>
        <variable name="k0_25" public_interface="in" units="per_second"/>
        <variable name="k0_52" public_interface="in" units="per_second"/>
        <variable name="k0_34" public_interface="in" units="per_second"/>
        <variable name="k0_43" public_interface="in" units="per_second"/>
        <variable name="k0_45" public_interface="in" units="per_second"/>
        <variable name="k0_54" public_interface="in" units="per_M_per_second"/>
        <variable name="k0_56" public_interface="in" units="per_second"/>
        <variable name="k0_65" public_interface="in" units="per_M2_per_second"/>
        <variable name="k0_61" public_interface="in" units="per_second"/>
        <variable name="k0_16" public_interface="in" units="per_second"/>
        <variable name="delta" public_interface="in" units="dimensionless"/>
        <variable name="n" public_interface="in" units="dimensionless"/>
        <variable name="z_c" public_interface="in" units="dimensionless"/>
        <variable name="z_Na" public_interface="in" units="dimensionless"/>
        <variable name="alpha_p" public_interface="in" units="dimensionless"/>
        <variable name="mu" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>ks_12</ci>
                <apply>
                    <times/>
                    <ci>k0_12</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>n</ci>
                                </apply>
                                <ci>alpha_p</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_12</ci>
                <apply>
                    <times/>
                    <ci>k0_12</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <ci>alpha_p</ci>
                            </apply>
                            <ci>mu</ci>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <ci>Na_m</ci>
                        <cn cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_21</ci>
                <apply>
                    <times/>
                    <ci>k0_21</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>n</ci>
                                <ci>z_Na</ci>
                                <ci>alpha_p</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_32</ci>
                <ci>k0_32</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_34</ci>
                <ci>k0_34</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_43</ci>
                <ci>k0_43</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_45</ci>
                <ci>k0_45</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_54</ci>
                <apply>
                    <times/>
                    <ci>k0_54</ci>
                    <ci>glucose_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_25</ci>
                <ci>k0_25</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_56</ci>
                <ci>k0_56</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_65</ci>
                <apply>
                    <times/>
                    <ci>k0_65</ci>
                    <apply>
                        <power/>
                        <ci>Na_i</ci>
                        <cn cellml:units="dimensionless">2</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_61</ci>
                <apply>
                    <times/>
                    <ci>k0_61</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>z_c</ci>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_16</ci>
                <apply>
                    <times/>
                    <ci>k0_16</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>z_c</ci>
                                </apply>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_52</ci>
                <ci>k0_52</ci>
            </apply>
        </math>
    </component>
</model>