- Author:
- Dewan Sarwar <sarwarcse@gmail.com>
- Date:
- 2019-01-22 18:17:02+13:00
- Desc:
- adding UTF-8
- Permanent Source URI:
- http://models.cellml.org/workspace/584/rawfile/771f7cf8dd59d9a21ece87e7966a93d064a6b01a/Hilgemann_1987.cellml
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Hilemann-Noble Atrial Cell Model 1987</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This model is known to run in OpenCell and COR and reproduce the published results.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: Interactions of electrogenic sodium-calcium exchange, calcium channel and sarcoplasmic reticulum in the mammalian heart have been explored by simulation of extracellular calcium transients measured with tetramethylmurexide in rabbit atrium. The approach has been to use the simplest possible formulations of these mechanisms, which together with a minimum number of additional mechanisms allow reconstruction of action potentials, intracellular calcium transients and extracellular calcium transients. A 3:1 sodium-calcium exchange stoichiometry is assumed. Calcium-channel inactivation is assumed to take place by a voltage-dependent mechanism, which is accelerated by a rise in intracellular calcium; intracellular calcium release becomes a major physiological regulator of calcium influx via calcium channels. A calcium release mechanism is assumed, which is both calcium- and voltage-sensitive, and which undergoes prolonged inactivation. 200 microM cytosolic calcium buffer is assumed. For most simulations only instantaneous potassium conductances are simulated so as to study the other mechanisms independently of time- and calcium-dependent outward current. Thus, the model reconstructs extracellular calcium transients and typical action-potential configuration changes during steady-state and non-steady-state stimulation from the mechanisms directly involved in trans-sarcolemmal calcium movements. The model predicts relatively small trans-sarcolemmal calcium movements during regular stimulation (ca. 2 mumol kg-1 fresh mass per excitation); calcium current is fully activated within 2 ms of excitation, inactivation is substantially complete within 30 ms, and sodium-calcium exchange significantly resists repolarization from approximately -30 mV. Net calcium movements many times larger are possible during non-steady-state stimulation. Long action potentials at premature excitations or after inhibition of calcium release can be supported almost exclusively by calcium current (net calcium influx 5-30 mumol kg-1 fresh mass); action potentials during potentiated post-stimulatory contractions can be supported almost exclusively by sodium-calcium exchange (net calcium efflux 4-20 mumol kg-1 fresh mass). Large calcium movements between the extracellular space and the sarcoplasmic reticulum can take place through the cytosol with virtually no contractile activation. The simulations provide integrated explanations of electrical activity, contractile function and trans-sarcolemmal calcium movements, which were outside the explanatory range of previous models.</para>
<para>The original paper reference is cited below:</para>
<para>
Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of the basic cellular mechanisms, Hilemann, D.W. and Noble, D. 1987,
<emphasis>Proc. R. Soc. Lond.</emphasis>
, B230, 163-205.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2884668&dopt=Abstract">PubMed ID: 2884668</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram of the Hilemann-Noble model showing ionic currents across the sarcolemma</title>
</objectinfo>
<imagedata fileref="hilgemann_noble_1987.png" />
</imageobject>
</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Hilemann-Noble model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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<variable cmeta:id="sodium_background_current.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<variable cmeta:id="sodium_background_current.g_b_Na" name="g_b_Na" units="microS" />
<variable cmeta:id="sodium_background_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="sodium_background_current.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="sodium_background_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="sodium_background_current_i_b_Na" name="i_b_Na" public_interface="out" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_Na</ci>
<apply>
<times />
<ci>RTONF</ci>
<apply>
<ln />
<apply>
<divide />
<ci>Na_o</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_b_Na</ci>
<apply>
<times />
<ci>g_b_Na</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
<variable cmeta:id="fast_sodium_current.g_Na" name="g_Na" units="microS" />
<variable cmeta:id="fast_sodium_current.K_i" name="K_i" public_interface="in" units="millimolar" />
<variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="nanoA" />
<variable cmeta:id="fast_sodium_current.m" name="m" private_interface="in" units="dimensionless" />
<variable cmeta:id="fast_sodium_current.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<variable cmeta:id="fast_sodium_current.E_mh" name="E_mh" units="millivolt" />
<variable cmeta:id="fast_sodium_current.time" name="time" public_interface="in" private_interface="out" units="second" />
<variable cmeta:id="fast_sodium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="fast_sodium_current.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="fast_sodium_current.K_c" name="K_c" public_interface="in" units="millimolar" />
<variable cmeta:id="fast_sodium_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="fast_sodium_current.h" name="h" private_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_mh</ci>
<apply>
<times />
<ci>RTONF</ci>
<apply>
<ln />
<apply>
<divide />
<apply>
<plus />
<ci>Na_o</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
<ci>K_c</ci>
</apply>
</apply>
<apply>
<plus />
<ci>Na_i</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.12</cn>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_Na</ci>
<apply>
<times />
<ci>g_Na</ci>
<apply>
<power />
<ci>m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_mh</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_m_gate">
<variable cmeta:id="fast_sodium_current_m_gate.m" name="m" public_interface="out" units="dimensionless" />
<variable cmeta:id="fast_sodium_current_m_gate.beta_m" name="beta_m" units="per_second" />
<variable cmeta:id="fast_sodium_current_m_gate.alpha_m" name="alpha_m" units="per_second" />
<variable cmeta:id="fast_sodium_current_m_gate.E0_m" name="E0_m" units="millivolt" />
<variable cmeta:id="fast_sodium_current_m_gate.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="fast_sodium_current_m_gate.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="fast_sodium_current_m_gate.delta_m" name="delta_m" units="millivolt" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E0_m</ci>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">41</cn>
</apply>
</apply>
<apply>
<eq />
<ci>alpha_m</ci>
<piecewise>
<piece>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">2000</cn>
<apply>
<lt />
<apply>
<abs />
<ci>E0_m</ci>
</apply>
<ci>delta_m</ci>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_second">200</cn>
<ci>E0_m</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
</apply>
<ci>E0_m</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<ci>beta_m</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">8000</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.056</cn>
</apply>
<apply>
<plus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">66</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_m</ci>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_potassium_concentration">
<variable cmeta:id="intracellular_potassium_concentration.i_NaK" name="i_NaK" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.i_siK" name="i_siK" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="intracellular_potassium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="intracellular_potassium_concentration.K_i" name="K_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_potassium_concentration.V_i" name="V_i" public_interface="in" units="micrometre3" />
<variable cmeta:id="intracellular_potassium_concentration.i_b_K" name="i_b_K" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_potassium_concentration.i_K1" name="i_K1" public_interface="in" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>i_K1</ci>
<ci>i_siK</ci>
<ci>i_b_K</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sarcoplasmic_reticulum_calcium_pump">
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.beta_up" name="beta_up" units="millimolar_per_second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.i_up" name="i_up" public_interface="out" units="millimolar_per_second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_srca" name="K_srca" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.Ca_up" name="Ca_up" public_interface="in" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_2" name="K_2" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_1" name="K_1" units="dimensionless" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_cyca" name="K_cyca" units="millimolar" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.alpha_up" name="alpha_up" units="millimolar_per_second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="sarcoplasmic_reticulum_calcium_pump.K_xcs" name="K_xcs" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>K_1</ci>
<apply>
<divide />
<apply>
<times />
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_srca</ci>
</apply>
</apply>
<apply>
<eq />
<ci>K_2</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<apply>
<times />
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<apply>
<times />
<ci>K_cyca</ci>
<ci>K_xcs</ci>
</apply>
<ci>K_cyca</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_up</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>Ca_i</ci>
<ci>K_2</ci>
</apply>
<ci>alpha_up</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>Ca_up</ci>
<ci>K_1</ci>
</apply>
<ci>K_2</ci>
</apply>
<ci>beta_up</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable cmeta:id="calcium_background_current.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_background_current.g_b_Ca" name="g_b_Ca" units="microS" />
<variable cmeta:id="calcium_background_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="calcium_background_current.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_background_current.E_Ca" name="E_Ca" public_interface="out" units="millivolt" />
<variable cmeta:id="calcium_background_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_background_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_background_current_i_b_Ca" name="i_b_Ca" public_interface="out" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_Ca</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.5</cn>
<ci>RTONF</ci>
<apply>
<ln />
<apply>
<divide />
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_b_Ca</ci>
<apply>
<times />
<ci>g_b_Ca</ci>
<apply>
<minus />
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable cmeta:id="membrane.C_m" name="C_m" units="microF" />
<variable cmeta:id="membrane_V" name="V" public_interface="out" units="millivolt" />
<variable cmeta:id="membrane.T" name="T" public_interface="out" units="kelvin" />
<variable cmeta:id="membrane.i_b_K" name="i_b_K" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.R" name="R" public_interface="out" units="joule_per_kilomole_kelvin" />
<variable cmeta:id="membrane.i_si" name="i_si" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.i_NaCa" name="i_NaCa" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.i_Na" name="i_Na" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.stim_duration" name="stim_duration" units="second" />
<variable cmeta:id="membrane.stim_start" name="stim_start" units="second" />
<variable cmeta:id="membrane.F" name="F" public_interface="out" units="coulomb_per_mole" />
<variable cmeta:id="membrane.i_NaK" name="i_NaK" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.i_b_Na" name="i_b_Na" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.stim_amplitude" name="stim_amplitude" units="nanoA" />
<variable cmeta:id="membrane.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="membrane.RTONF" name="RTONF" public_interface="out" units="millivolt" />
<variable cmeta:id="membrane.i_K1" name="i_K1" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.i_Stim" name="i_Stim" units="nanoA" />
<variable cmeta:id="membrane.stim_period" name="stim_period" units="second" />
<variable cmeta:id="membrane.i_b_Ca" name="i_b_Ca" public_interface="in" units="nanoA" />
<variable cmeta:id="membrane.stim_end" name="stim_end" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>RTONF</ci>
<apply>
<divide />
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and />
<apply>
<geq />
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq />
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq />
<apply>
<minus />
<apply>
<minus />
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times />
<apply>
<floor />
<apply>
<divide />
<apply>
<minus />
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="nanoA">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<ci>i_Stim</ci>
<ci>i_K1</ci>
<ci>i_b_Na</ci>
<ci>i_b_Ca</ci>
<ci>i_b_K</ci>
<ci>i_NaK</ci>
<ci>i_NaCa</ci>
<ci>i_Na</ci>
<ci>i_si</ci>
</apply>
</apply>
<ci>C_m</ci>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable cmeta:id="time_independent_potassium_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="time_independent_potassium_current.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="time_independent_potassium_current.K_i" name="K_i" public_interface="in" units="millimolar" />
<variable cmeta:id="time_independent_potassium_current.E_K" name="E_K" public_interface="out" units="millivolt" />
<variable cmeta:id="time_independent_potassium_current.K_m_K1" name="K_m_K1" units="millimolar" />
<variable cmeta:id="time_independent_potassium_current.K_c" name="K_c" public_interface="in" units="millimolar" />
<variable cmeta:id="time_independent_potassium_current.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="nanoA" />
<variable cmeta:id="time_independent_potassium_current.g_K1" name="g_K1" units="microS" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_K</ci>
<apply>
<times />
<ci>RTONF</ci>
<apply>
<ln />
<apply>
<divide />
<ci>K_c</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_K1</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>g_K1</ci>
<ci>K_c</ci>
</apply>
<apply>
<plus />
<ci>K_c</ci>
<ci>K_m_K1</ci>
</apply>
</apply>
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<apply>
<minus />
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_calcium_concentration">
<variable cmeta:id="intracellular_calcium_concentration.V_Cell" name="V_Cell" units="micrometre3" />
<variable cmeta:id="intracellular_calcium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="intracellular_calcium_concentration.beta_Trop" name="beta_Trop" units="per_second" />
<variable cmeta:id="intracellular_calcium_concentration_Ca_i" name="Ca_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.alpha_Trop" name="alpha_Trop" units="per_millimolar_second" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_Calmod" name="Ca_Calmod" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.i_b_Ca" name="i_b_Ca" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_calcium_concentration.Trop" name="Trop" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_rel" name="Ca_rel" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_Trop" name="Ca_Trop" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.dCaTropdt" name="dCaTropdt" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.V_e_ratio" name="V_e_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.i_up" name="i_up" public_interface="in" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.Calmod" name="Calmod" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.i_NaCa" name="i_NaCa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_calcium_concentration.length" name="length" units="micrometre" />
<variable cmeta:id="intracellular_calcium_concentration.alpha_Calmod" name="alpha_Calmod" units="per_millimolar_second" />
<variable cmeta:id="intracellular_calcium_concentration.Ca_up" name="Ca_up" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_calcium_concentration.V_i_ratio" name="V_i_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.V_rel_ratio" name="V_rel_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.V_i" name="V_i" public_interface="out" units="micrometre3" />
<variable cmeta:id="intracellular_calcium_concentration.i_siCa" name="i_siCa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_calcium_concentration.Ve" name="Ve" public_interface="out" units="micrometre3" />
<variable cmeta:id="intracellular_calcium_concentration.radius" name="radius" units="micrometre" />
<variable cmeta:id="intracellular_calcium_concentration.dCaCalmoddt" name="dCaCalmoddt" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.V_up_ratio" name="V_up_ratio" units="dimensionless" />
<variable cmeta:id="intracellular_calcium_concentration.beta_Calmod" name="beta_Calmod" units="per_second" />
<variable cmeta:id="intracellular_calcium_concentration.i_trans" name="i_trans" public_interface="in" units="millimolar_per_second" />
<variable cmeta:id="intracellular_calcium_concentration.i_rel" name="i_rel" public_interface="in" units="millimolar_per_second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>V_Cell</ci>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.141592654</cn>
<apply>
<power />
<ci>radius</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>length</ci>
</apply>
</apply>
<apply>
<eq />
<ci>V_i_ratio</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>V_e_ratio</ci>
</apply>
<ci>V_up_ratio</ci>
</apply>
<ci>V_rel_ratio</ci>
</apply>
</apply>
<apply>
<eq />
<ci>V_i</ci>
<apply>
<times />
<ci>V_Cell</ci>
<ci>V_i_ratio</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Ve</ci>
<apply>
<times />
<ci>V_Cell</ci>
<ci>V_e_ratio</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<plus />
<ci>i_siCa</ci>
<ci>i_b_Ca</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>i_rel</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>V_i_ratio</ci>
</apply>
</apply>
<ci>dCaCalmoddt</ci>
</apply>
<ci>dCaTropdt</ci>
</apply>
<ci>i_up</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_up</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>V_i_ratio</ci>
<ci>V_up_ratio</ci>
</apply>
<ci>i_up</ci>
</apply>
<ci>i_trans</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_rel</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<divide />
<ci>V_up_ratio</ci>
<ci>V_rel_ratio</ci>
</apply>
<ci>i_trans</ci>
</apply>
<ci>i_rel</ci>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calmod</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Calmod</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Trop</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Trop</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dCaCalmoddt</ci>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Calmod</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Calmod</ci>
<ci>Ca_Calmod</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>dCaTropdt</ci>
<apply>
<minus />
<apply>
<times />
<ci>alpha_Trop</ci>
<ci>Ca_i</ci>
<apply>
<minus />
<ci>Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
<apply>
<times />
<ci>beta_Trop</ci>
<ci>Ca_Trop</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_exchanger">
<variable cmeta:id="Na_Ca_exchanger.d_NaCa" name="d_NaCa" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="nanoA" />
<variable cmeta:id="Na_Ca_exchanger.n_NaCa" name="n_NaCa" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.k_NaCa" name="k_NaCa" units="nanoA" />
<variable cmeta:id="Na_Ca_exchanger.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="Na_Ca_exchanger.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="Na_Ca_exchanger.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="Na_Ca_exchanger.gamma" name="gamma" units="dimensionless" />
<variable cmeta:id="Na_Ca_exchanger.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_NaCa</ci>
<apply>
<divide />
<apply>
<times />
<ci>k_NaCa</ci>
<apply>
<minus />
<apply>
<times />
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>gamma</ci>
<apply>
<minus />
<ci>n_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
<apply>
<power />
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times />
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>gamma</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>n_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
<apply>
<power />
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
<apply>
<times />
<ci>d_NaCa</ci>
<apply>
<plus />
<apply>
<times />
<ci>Ca_i</ci>
<apply>
<power />
<ci>Na_o</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<power />
<ci>Na_i</ci>
<ci>n_NaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_sodium_concentration">
<variable cmeta:id="intracellular_sodium_concentration.Na_i" name="Na_i" public_interface="out" units="millimolar" />
<variable cmeta:id="intracellular_sodium_concentration.V_i" name="V_i" public_interface="in" units="micrometre3" />
<variable cmeta:id="intracellular_sodium_concentration.i_Na" name="i_Na" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="intracellular_sodium_concentration.i_NaCa" name="i_NaCa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.F" name="F" public_interface="in" units="coulomb_per_mole" />
<variable cmeta:id="intracellular_sodium_concentration.i_NaK" name="i_NaK" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.i_siNa" name="i_siNa" public_interface="in" units="nanoA" />
<variable cmeta:id="intracellular_sodium_concentration.i_b_Na" name="i_b_Na" public_interface="in" units="nanoA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mA_nA">1</cn>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="litre_micrometre3">1</cn>
<ci>V_i</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<plus />
<ci>i_Na</ci>
<ci>i_b_Na</ci>
<apply>
<times />
<ci>i_NaK</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times />
<ci>i_NaCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
</apply>
<ci>i_siNa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_release">
<variable cmeta:id="calcium_release.K_m_rel" name="K_m_rel" units="per_second" />
<variable cmeta:id="calcium_release.ActFrac" name="ActFrac" units="dimensionless" />
<variable cmeta:id="calcium_release.Ca_i" name="Ca_i" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_release.V" name="V" public_interface="in" units="millivolt" />
<variable cmeta:id="calcium_release.K_leak_rate" name="K_leak_rate" units="per_second" />
<variable cmeta:id="calcium_release.ProdFrac" name="ProdFrac" units="dimensionless" />
<variable cmeta:id="calcium_release_i_rel" name="i_rel" public_interface="out" units="millimolar_per_second" />
<variable cmeta:id="calcium_release.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="calcium_release.VoltDep" name="VoltDep" units="dimensionless" />
<variable cmeta:id="calcium_release.RegBindSite" name="RegBindSite" units="dimensionless" />
<variable cmeta:id="calcium_release.InactRate" name="InactRate" units="per_second" />
<variable cmeta:id="calcium_release.PrecFrac" name="PrecFrac" units="dimensionless" />
<variable cmeta:id="calcium_release.Ca_rel" name="Ca_rel" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_release.ActRate" name="ActRate" units="per_second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PrecFrac</ci>
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>ActFrac</ci>
</apply>
<ci>ProdFrac</ci>
</apply>
</apply>
<apply>
<eq />
<ci>VoltDep</ci>
<apply>
<exp />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08</cn>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>RegBindSite</ci>
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0005</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<eq />
<ci>ActRate</ci>
<apply>
<plus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">600</cn>
<ci>VoltDep</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn>
<ci>RegBindSite</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>InactRate</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">60</cn>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">500</cn>
<ci>RegBindSite</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>ActFrac</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>PrecFrac</ci>
<ci>ActRate</ci>
</apply>
<apply>
<times />
<ci>ActFrac</ci>
<ci>InactRate</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>ProdFrac</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>ActFrac</ci>
<ci>InactRate</ci>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_second">0.6</cn>
<ci>ProdFrac</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_rel</ci>
<apply>
<times />
<apply>
<plus />
<apply>
<times />
<apply>
<power />
<apply>
<divide />
<ci>ActFrac</ci>
<apply>
<plus />
<ci>ActFrac</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.25</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>K_m_rel</ci>
</apply>
<ci>K_leak_rate</ci>
</apply>
<ci>Ca_rel</ci>
</apply>
</apply>
</math>
</component>
<component name="calcium_translocation">
<variable cmeta:id="calcium_translocation.Ca_up" name="Ca_up" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_translocation_i_trans" name="i_trans" public_interface="out" units="millimolar_per_second" />
<variable cmeta:id="calcium_translocation.Ca_rel" name="Ca_rel" public_interface="in" units="millimolar" />
<variable cmeta:id="calcium_translocation.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="calcium_translocation.alpha_tr" name="alpha_tr" units="per_second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_trans</ci>
<apply>
<times />
<apply>
<minus />
<ci>Ca_up</ci>
<ci>Ca_rel</ci>
</apply>
<ci>alpha_tr</ci>
</apply>
</apply>
</math>
</component>
<component name="extracellular_sodium_concentration">
<variable cmeta:id="extracellular_sodium_concentration.Na_o" name="Na_o" public_interface="out" units="millimolar" />
</component>
<component name="second_inward_calcium_current">
<variable cmeta:id="second_inward_calcium_current.i_siNa" name="i_siNa" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.P_si" name="P_si" units="nanoA_per_millimolar" />
<variable cmeta:id="second_inward_calcium_current.i_si" name="i_si" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.i_siK" name="i_siK" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.V" name="V" public_interface="in" private_interface="out" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current.CaChon" name="CaChon" private_interface="in" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current.Ca_o" name="Ca_o" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.K_c" name="K_c" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.RTONF" name="RTONF" public_interface="in" units="millivolt" />
<variable cmeta:id="second_inward_calcium_current.Ca_i" name="Ca_i" public_interface="in" private_interface="out" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.Na_i" name="Na_i" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.Na_o" name="Na_o" public_interface="in" units="millimolar" />
<variable cmeta:id="second_inward_calcium_current.d" name="d" private_interface="in" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current.f_Ca" name="f_Ca" private_interface="in" units="dimensionless" />
<variable cmeta:id="second_inward_calcium_current.i_siCa" name="i_siCa" public_interface="out" units="nanoA" />
<variable cmeta:id="second_inward_calcium_current.time" name="time" public_interface="in" private_interface="out" units="second" />
<variable cmeta:id="second_inward_calcium_current.K_i" name="K_i" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>i_si</ci>
<apply>
<plus />
<ci>i_siCa</ci>
<ci>i_siK</ci>
<ci>i_siNa</ci>
</apply>
</apply>
<apply>
<eq />
<ci>i_siCa</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
<ci>P_si</ci>
<ci>d</ci>
<ci>CaChon</ci>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Ca_i</ci>
<apply>
<exp />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>Ca_o</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_siK</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.002</cn>
<ci>P_si</ci>
<ci>d</ci>
<ci>CaChon</ci>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>K_i</ci>
<apply>
<exp />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>K_c</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>i_siNa</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
<ci>P_si</ci>
<ci>d</ci>
<ci>CaChon</ci>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>Na_i</ci>
<apply>
<exp />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>Na_o</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
</apply>
<apply>
<minus />
<ci>V</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
</apply>
</apply>
<ci>RTONF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate" />
<component_ref component="fast_sodium_current_h_gate" />
</component_ref>
<component_ref component="second_inward_calcium_current">
<component_ref component="second_inward_calcium_current_f_Ca_gate" />
<component_ref component="second_inward_calcium_current_d_gate" />
</component_ref>
</group>
<group>
<relationship_ref relationship="containment" />
<component_ref component="membrane">
<component_ref component="intracellular_potassium_concentration" />
<component_ref component="sarcoplasmic_reticulum_calcium_pump" />
<component_ref component="Na_Ca_exchanger" />
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate" />
<component_ref component="fast_sodium_current_h_gate" />
</component_ref>
<component_ref component="second_inward_calcium_current">
<component_ref component="second_inward_calcium_current_f_Ca_gate" />
<component_ref component="second_inward_calcium_current_d_gate" />
</component_ref>
<component_ref component="intracellular_sodium_concentration" />
<component_ref component="sodium_potassium_pump" />
<component_ref component="intracellular_calcium_concentration" />
<component_ref component="calcium_release" />
<component_ref component="calcium_translocation" />
<component_ref component="extracellular_calcium_concentration" />
<component_ref component="calcium_background_current" />
<component_ref component="extracellular_sodium_concentration" />
<component_ref component="sodium_background_current" />
<component_ref component="potassium_background_current" />
<component_ref component="extracellular_potassium_concentration" />
<component_ref component="time_independent_potassium_current" />
</component_ref>
</group>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="sodium_potassium_pump" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="extracellular_sodium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="time_independent_potassium_current" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="fast_sodium_current_m_gate" component_2="fast_sodium_current" />
<map_variables variable_1="m" variable_2="m" />
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca" />
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcium_background_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="time_independent_potassium_current" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcium_release" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="time_independent_potassium_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="environment" component_2="second_inward_calcium_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="extracellular_calcium_concentration" component_2="calcium_background_current" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="potassium_background_current" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="i_siCa" variable_2="i_siCa" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="intracellular_potassium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="K_i" variable_2="K_i" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="V_i" variable_2="V_i" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="environment" component_2="potassium_background_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="membrane" />
<map_variables variable_1="i_b_Na" variable_2="i_b_Na" />
</connection>
<connection>
<map_components component_1="extracellular_sodium_concentration" component_2="fast_sodium_current" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="sarcoplasmic_reticulum_calcium_pump" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_up" variable_2="i_up" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_siNa" variable_2="i_siNa" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="membrane" />
<map_variables variable_1="i_si" variable_2="i_si" />
</connection>
<connection>
<map_components component_1="environment" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="sodium_background_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="calcium_background_current" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="extracellular_calcium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="membrane" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcium_translocation" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="membrane" />
<map_variables variable_1="i_K1" variable_2="i_K1" />
</connection>
<connection>
<map_components component_1="potassium_background_current" component_2="membrane" />
<map_variables variable_1="i_b_K" variable_2="i_b_K" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="calcium_release" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="Ca_rel" variable_2="Ca_rel" />
</connection>
<connection>
<map_components component_1="intracellular_sodium_concentration" component_2="sodium_background_current" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="membrane" component_2="second_inward_calcium_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="fast_sodium_current_h_gate" component_2="fast_sodium_current" />
<map_variables variable_1="h" variable_2="h" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="Na_Ca_exchanger" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current_f_Ca_gate" component_2="second_inward_calcium_current" />
<map_variables variable_1="CaChon" variable_2="CaChon" />
<map_variables variable_1="f_Ca" variable_2="f_Ca" />
</connection>
<connection>
<map_components component_1="extracellular_sodium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_siK" variable_2="i_siK" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="Ve" variable_2="Ve" />
</connection>
<connection>
<map_components component_1="extracellular_calcium_concentration" component_2="second_inward_calcium_current" />
<map_variables variable_1="Ca_o" variable_2="Ca_o" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_siCa" variable_2="i_siCa" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate" />
<map_variables variable_1="time" variable_2="time" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current_d_gate" component_2="second_inward_calcium_current" />
<map_variables variable_1="d" variable_2="d" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="V_i" variable_2="V_i" />
</connection>
<connection>
<map_components component_1="environment" component_2="sodium_potassium_pump" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="membrane" />
<map_variables variable_1="i_Na" variable_2="i_Na" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="membrane" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="fast_sodium_current" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="potassium_background_current" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_b_K" variable_2="i_b_K" />
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="extracellular_potassium_concentration" component_2="sodium_potassium_pump" />
<map_variables variable_1="K_c" variable_2="K_c" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="sarcoplasmic_reticulum_calcium_pump" />
<map_variables variable_1="Ca_up" variable_2="Ca_up" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_Na" variable_2="i_Na" />
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_K1" variable_2="i_K1" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
</connection>
<connection>
<map_components component_1="environment" component_2="sarcoplasmic_reticulum_calcium_pump" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="membrane" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="calcium_background_current" component_2="membrane" />
<map_variables variable_1="i_b_Ca" variable_2="i_b_Ca" />
</connection>
<connection>
<map_components component_1="intracellular_calcium_concentration" component_2="calcium_translocation" />
<map_variables variable_1="Ca_up" variable_2="Ca_up" />
<map_variables variable_1="Ca_rel" variable_2="Ca_rel" />
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_potassium_concentration" />
<map_variables variable_1="i_NaK" variable_2="i_NaK" />
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="second_inward_calcium_current" component_2="second_inward_calcium_current_f_Ca_gate" />
<map_variables variable_1="Ca_i" variable_2="Ca_i" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="calcium_release" component_2="intracellular_calcium_concentration" />
<map_variables variable_1="i_rel" variable_2="i_rel" />
</connection>
<connection>
<map_components component_1="membrane" component_2="extracellular_calcium_concentration" />
<map_variables variable_1="F" variable_2="F" />
</connection>
<connection>
<map_components component_1="extracellular_sodium_concentration" component_2="sodium_background_current" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current" />
<map_variables variable_1="RTONF" variable_2="RTONF" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<connection>
<map_components component_1="sodium_background_current" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_b_Na" variable_2="i_b_Na" />
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="intracellular_sodium_concentration" />
<map_variables variable_1="i_NaCa" variable_2="i_NaCa" />
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<dc:publisher>Department of Physiology, Anatomy & Genetics, University of Oxford</dc:publisher>
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<dc:creator>
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<vCard:FN>James Lawson</vCard:FN>
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<rdf:value>This version was created by Penny Noble of Oxford University and is known to run in both COR and PCEnv. The integration problems experienced with Version 03 are fixed in this version. A predefined operator diff error produced by PCEnv in the component intracellular_calcium_concentration of Penny Noble's version was fixed by James Lawson on 19/04/07. Due to the small stimulus duration, for this model to produce a train of action potentials, the max step size must be set at 0.001 or below and the number of points per graph must be over 10k.</rdf:value>
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<vCard:Orgname>Oxford University</vCard:Orgname>
<vCard:Orgunit>Department of Physiology, Anatomy & Genetics</vCard:Orgunit>
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</vCard:ORG>
<vCard:EMAIL rdf:resource="rdf:#40a75966-f864-4887-9e5c-aeb89bff221a" rdf:value="penny.noble@dpag.ox.ac.uk" rdf:type="http://imc.org/vCard/3.0#internet" />
<vCard:N rdf:resource="rdf:#abf72336-d61e-48a4-98b5-a93673fcbbfd" vCard:Given="Penny" vCard:Family="Noble" vCard:Other="J" />
</rdf:Description>
</dc:creator>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#20f85be5-33d5-4183-8900-c02eccab3b39">
<dcterms:modified rdf:resource="rdf:#4ae6dde3-74ce-4ca7-b5f7-dc7e62c7db98" dcterms:W3CDTF="2008-01-10T13:06:42+13:00" />
<rdf:value>added cmeta:id's to some variables to facilitate creation of PCEnv session file</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#5385f45f-9928-4da2-9654-e9c8651cbf57">
<vCard:N rdf:resource="rdf:#ad840cb5-5971-40f0-9319-0e4030e77505" vCard:Given="James" vCard:Family="Lawson" vCard:Other="Richard" />
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#0a11824d-79bb-4c95-bf67-f2a0c00a1ab1">
<dcterms:modified rdf:resource="rdf:#eee2dffe-700f-4485-9feb-f7ba7a90abc2" dcterms:W3CDTF="2007-06-20T15:15:35+12:00" />
<rdf:value>Added stimulus protocol to allow simulation of trains of action potentials.</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#7500468a-4c03-4b44-93f7-84fcc577f8d6">
<vCard:N rdf:resource="rdf:#9e7662b0-bfb4-4bb5-9d56-3c5f91e06e18" vCard:Given="James" vCard:Family="Lawson" vCard:Other="Richard" />
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#d134371a-7ca9-4bc9-b15c-8311d6159199">
<dcterms:modified rdf:resource="rdf:#eb2cd150-322c-4782-8f7f-61662395f5f0" dcterms:W3CDTF="2007-09-20T12:40:08+12:00" />
<rdf:value>Made 2 new variables - dCaCalmoddt and dCaTropdt in component "intracellular_calcium_concentration," equated these variables to d(CaCalmod)/d(time) and d(CaTrop)/d(time), respectively. This was done to allow PCEnv 0.2 to run the model.</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#b8bd0ccd-2a3d-467d-a4e8-4baeb73e1139">
<vCard:N rdf:resource="rdf:#53f5e968-5a33-41dc-a08d-abf75f7a4684" vCard:Given="James" vCard:Family="Lawson" vCard:Other="Richard" />
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current_i_b_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#process_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.gamma">
<dcterms:description>Position of energy barrier controlling voltage-dependence of i_NaCa</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.dCaCalmoddt">
<dcterms:description>Redundant and unused codeword</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.R">
<dcterms:description>Boltzmann constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.dCaTropdt">
<dcterms:description>Redundant and unused codeword</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_h_gate.beta_h">
<dcterms:description>Inactivation gate and rate coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.time">
<dcterms:description>Time solution domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Hilgemann_1987" semsim:modelId="hilgemann_noble_1987" semsim:AnnotatorContactInfo="thompsct@umich.edu" semsim:modelName="hilgemann_noble_1987">
<semsim:AnnotatorName>Chris Thompson</semsim:AnnotatorName>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.n_NaCa">
<dcterms:description>Stoichiometry of Na-Ca exchange</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.V_i">
<dcterms:description>Total intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger_i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_67">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-Ca exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_d_gate.d">
<dcterms:description>Activation gating and rate coefficient for fast Ca current channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#time_independent_potassium_current.g_K1">
<dcterms:description>Inward K rectifier conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.radius">
<dcterms:description>radius of preparation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#time_independent_potassium_current.time">
<dcterms:description>Time solution domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.f_Ca">
<dcterms:description>Fraction of channels inactivated by voltage-dependent process.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.Ca_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_89">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular calcium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_70">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Na concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_background_current.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-Ca exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.V_i">
<dcterms:description>Total intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_background_current.g_b_Ca">
<dcterms:description>Calcium background conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.alpha_f_Ca">
<dcterms:description>Inactivation gating and rate coefficient for fast Ca current channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.i_si">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_86">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_10" dcterms:description="">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_14" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_7" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_13" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_13" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_12" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_2" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_14" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_6" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_13" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_11" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_12" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_4" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Secondary channel inward current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total TTX-insensitive inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.F">
<dcterms:description>Faraday Constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Ca concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.i_siK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_87">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_7" dcterms:description="">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_9" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_13" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_9" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_11" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Secondary K channel inward current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Potassium component of fast Ca current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_pump.K_mK">
<dcterms:description>NaK pump K half activation concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_translocation.Ca_rel">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_83">
<semsim:physicalPropertyOf rdf:resource="#entity_19" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ca concentrations in s.r. release store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_pump.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Potassium concentration in the extracellular cleft</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_K1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_46">
<semsim:physicalPropertyOf rdf:resource="#process_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Time independent K current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.E_Na">
<dcterms:description>Sodium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.i_siK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_28">
<semsim:physicalPropertyOf rdf:resource="#process_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Potassium component of fast Ca current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.time">
<dcterms:description>Time solution domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_up_ratio">
<dcterms:description>Ratio of SR uptake component volume and total cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Stim">
<dcterms:description>Experimental stimulation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.time">
<dcterms:description>Time solution domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.i_b_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:physicalPropertyOf rdf:resource="#process_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Background K current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#potassium_background_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.Ca_up">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ca concentration in s.r. uptake store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_up">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_58">
<semsim:physicalPropertyOf rdf:resource="#process_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ca uptake into SR expressed as a current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Ca_up">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_61">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ca concentration in s.r. uptake store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.beta_f_Ca">
<dcterms:description>Inactivation gating and rate coefficient for fast Ca current channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration_Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_52">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Ca concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_66">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_i_ratio">
<dcterms:description>Ratio of intracellular volume and total cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.k_NaCa">
<dcterms:description>scaling factor for i_NaCa</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_potassium_concentration.F">
<dcterms:description>Faraday Constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_b_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_54">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_2" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_1">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_3" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_4" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_3" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_2" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Ca background current across plasma membrane of cardiac myocyte</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.PrecFrac">
<dcterms:description>Activator precursor molecule fraction</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_b_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:physicalPropertyOf rdf:resource="#process_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.f_Ca">
<dcterms:description>Fraction of channels inactivated by voltage-dependent process.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#time_independent_potassium_current.K_m_K1">
<dcterms:description>K half-activation concentration for inward K rectifier</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_m_gate.beta_m">
<dcterms:description>Activation gate and rate coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_Cell">
<dcterms:description>Cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.d_NaCa">
<dcterms:description>Denominator constant for i_NaCa</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_NaCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_60">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-Ca exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.i_rel">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_64">
<semsim:physicalPropertyOf rdf:resource="#process_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00592" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ca release from junctional sarcoplasmic reticulum into cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_release.VoltDep">
<dcterms:description>Voltage dependence of release</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular sodium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_h_gate.h">
<dcterms:description>Gating variable for h gate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_rel_ratio">
<dcterms:description>Ratio of JSR volume and total cell volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.K_srca">
<dcterms:description>SR Ca/enzyme reaction rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Ca_rel">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_56">
<semsim:physicalPropertyOf rdf:resource="#entity_19" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ca concentrations in s.r. release store</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_88">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_72">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_6" dcterms:description="">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_8" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_7" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_8" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_6" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Fast sodium channel current across plasma membrane</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>TTX sensittive fast Na current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.time">
<dcterms:description>Time solution domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:physicalPropertyOf rdf:resource="#process_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>TTX sensittive fast Na current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Ca_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_68">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular calcium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>NaK exchange pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_calcium_concentration.i_siCa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#process_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Calcium component of fast Ca current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#time_independent_potassium_current.E_K">
<dcterms:description>Potassium reversal potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Ca concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_si">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf rdf:resource="#process_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total TTX-insensitive inward current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_calcium_concentration.F">
<dcterms:description>Faraday Constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_translocation.alpha_tr">
<dcterms:description>Rate coefficient for Ca translocation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_background_current_i_b_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:physicalPropertyOf rdf:resource="#process_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_92">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Na concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.g_b_Na">
<dcterms:description>Sodium background conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Trop">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_55">
<semsim:physicalPropertyOf rdf:resource="#entity_18" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total troponin concentration in the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_i_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf rdf:resource="#process_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>TTX sensittive fast Na current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_b_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:physicalPropertyOf rdf:resource="#process_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current.m">
<dcterms:description>Activation gate and rate coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_potassium_pump.time">
<dcterms:description>Time solution domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.alpha_Trop">
<dcterms:description>Ca-troponin binding rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_potassium_concentration.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Potassium concentration in the extracellular cleft</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.i_b_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_40">
<semsim:physicalPropertyOf rdf:resource="#process_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Background K current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_m_gate.m">
<dcterms:description>Activation gate and rate coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_e_ratio">
<dcterms:description>Fraction of volume taken by extracellular space</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#extracellular_calcium_concentration.i_b_Ca">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#process_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Calcium background current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_f_Ca_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.i_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_74">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>NaK exchange pump current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current_d_gate.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Cardiac myocyte membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.V_i">
<dcterms:description>Total intracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.beta_Trop">
<dcterms:description>Ca-troponin dissociation rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.F">
<dcterms:description>Faraday Constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Calmod">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_59">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_22">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:62343" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total calmodulin concentration in the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_65">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular sodium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.Ve">
<dcterms:description>Total extracellular volume</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#membrane.C_m">
<dcterms:description>Membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sarcoplasmic_reticulum_calcium_pump.beta_up">
<dcterms:description>SR Ca uptake back ard reaction rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.alpha_Calmod">
<dcterms:description>Ca-calmodulin binding rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_sodium_concentration.F">
<dcterms:description>Faraday Constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.K_c">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_90">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Potassium concentration in the extracellular cleft</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#sodium_background_current.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Na concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#calcium_translocation.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_Ca_exchanger.Ca_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_69">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular Ca concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#second_inward_calcium_current.CaChon">
<dcterms:description>Active, unbound regulatory states</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#intracellular_calcium_concentration.length">
<dcterms:description>length of preparation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fast_sodium_current_m_gate.alpha_m">
<dcterms:description>Activation gate and rate coefficient</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
