- Author:
- Dewan Sarwar <sarwarcse@gmail.com>
- Date:
- 2019-01-22 18:17:02+13:00
- Desc:
- adding UTF-8
- Permanent Source URI:
- http://models.cellml.org/workspace/584/rawfile/771f7cf8dd59d9a21ece87e7966a93d064a6b01a/SEDML/eskandari_2005/eskandari_2005.cellml
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<article>
<articleinfo>
<title>Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter</title>
<author>
<firstname>Jonna</firstname>
<surname>Terkildsen</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<sect1 id="sec_status">
<title>Model Status</title>
<para>This CellML model is in the process of being curated, the units are consistent and the model runs in COR and PCEnv. This model does not yet recreate all the published results.</para>
</sect1>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>Abstract: This study investigates the reverse mode of the Na/glucose cotransporter (SGLT1). In giant excised inside-out membrane patches from Xenopus laevis oocytes expressing rabbit SGLT1, application of a-methyl-D-glucopyranoside (aMDG) to the cytoplasmic solution induced an outward current from cytosolic to external membrane surface. The outward current was Na- and sugar-dependent, and was blocked by phlorizin, a specific inhibitor of SGLT1. The current-voltage relationship saturated at positive membrane voltages (30-50 mV), and approached zero at -150 mV. The half-maximal concentration for aMDG-evoked outward current (K_0.5_aMDG) was 35 mM (at 0 mV). In comparison, K_0.5_aMDG for forward sugar transport was 0.15 mM (at 0 mV). K_0.5_Na was similar for forward and reverse transport (~ 35mM at 0 mV). Specificity of SGLT1 for reverse transport was: aMDG (1.0) > D-galactose (0.84) > 3-O-methyl-glucose (0.55) > D-glucose (0.38), whereas for forward transport, specificity was: aMDG ~ D-glucose ~ D-galactose > 3-O-methylglucose. Thus there is an asymmetry in sugar kinetics and specificity between forward and reverse modes. Computer simulations showed that a 6-state kinetic model for SGLT1 can account for Na/sugar cotransport and its voltage dependence in both the forward and reverse modes at saturating sodium concentrations. Our data indicate that under physiological conditions, the transporter is poised to accumulate sugar efficiently in the enterocyte.</para>
<para>The original paper reference is cited below:</para>
<para>
Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter, S.Eskandari, E.M. Wright and D.D.F. Loo, 2005,
<emphasis>Journal of Membrane Biology</emphasis>
, 204, 23-32.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16007500&query_hl=1&itool=pubmed_docsum">PubMed ID: 16007500</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="eskandari_2005.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the Eskandari et al 2005 SGLT1 model. C' represents the external-facing carrier. C'' represents the internal-facing carrier.</caption>
</informalfigure>
</sect1>
</article>
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<apply>
<times />
<apply>
<minus />
<ci>n</ci>
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<ci>z_Na</ci>
<ci>alpha_pp</ci>
<ci>mu</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
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<apply>
<eq />
<ci>k_65</ci>
<apply>
<times />
<ci>k0_65</ci>
<apply>
<power />
<ci>Na_i</ci>
<ci>n</ci>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_pp</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
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<apply>
<eq />
<ci>k_61</ci>
<apply>
<times />
<ci>k0_61</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>z_c</ci>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
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<apply>
<eq />
<ci>k_16</ci>
<apply>
<times />
<ci>k0_16</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>z_c</ci>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
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<apply>
<eq />
<ci>k_52</ci>
<apply>
<divide />
<apply>
<times />
<ci>k0_12</ci>
<ci>k_25</ci>
<ci>k0_56</ci>
<ci>k0_61</ci>
</apply>
<apply>
<times />
<ci>k0_21</ci>
<ci>k0_16</ci>
<ci>k0_65</ci>
</apply>
</apply>
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<apply>
<eq />
<ci>k0_54_temp</ci>
<apply>
<divide />
<apply>
<times />
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>k_32</ci>
<ci>k_25</ci>
</apply>
</apply>
</apply>
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<variable cmeta:id="kinetic_equations.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_23" name="k_23" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_32" name="k_32" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_45" name="k_45" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_54" name="k_54" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.C_1" initial_value="0" name="C_1" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_2" initial_value="0" name="C_2" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_3" initial_value="0" name="C_3" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_4" initial_value="0" name="C_4" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_5" initial_value="0" name="C_5" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_6" name="C_6" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_6_temp" initial_value="0" name="C_6_temp" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="kinetic_equations.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_1</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_21</ci>
<ci>C_2</ci>
</apply>
<apply>
<times />
<ci>k_61</ci>
<ci>C_6</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_12</ci>
<ci>k_16</ci>
</apply>
<ci>C_1</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_2</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_12</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_32</ci>
<ci>C_3</ci>
</apply>
<apply>
<times />
<ci>k_52</ci>
<ci>C_5</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_21</ci>
<ci>k_23</ci>
<ci>k_25</ci>
</apply>
<ci>C_2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_3</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_23</ci>
<ci>C_2</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>C_4</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_32</ci>
<ci>k_34</ci>
</apply>
<ci>C_3</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_4</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_34</ci>
<ci>C_3</ci>
</apply>
<apply>
<times />
<ci>k_54</ci>
<ci>C_5</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_45</ci>
<ci>k_43</ci>
</apply>
<ci>C_4</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_5</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_45</ci>
<ci>C_4</ci>
</apply>
<apply>
<times />
<ci>k_65</ci>
<ci>C_6</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>C_2</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_54</ci>
<ci>k_52</ci>
<ci>k_56</ci>
</apply>
<ci>C_5</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_6_temp</ci>
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<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_56</ci>
<ci>C_5</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_61</ci>
<ci>k_65</ci>
</apply>
<ci>C_6_temp</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C_6</ci>
<apply>
<minus />
<ci>C_T</ci>
<apply>
<plus />
<ci>C_1</ci>
<ci>C_2</ci>
<ci>C_3</ci>
<ci>C_4</ci>
<ci>C_5</ci>
</apply>
</apply>
</apply>
</math>
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<component name="king_altman_states">
<variable cmeta:id="king_altman_states.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_23" name="k_23" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_32" name="k_32" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_45" name="k_45" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_54" name="k_54" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.C1_sum" name="C1_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C2_sum" name="C2_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C3_sum" name="C3_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C4_sum" name="C4_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C5_sum" name="C5_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C6_sum" name="C6_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C_sum" name="C_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="king_altman_states.C1" name="C1" public_interface="out" units="umol" />
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<variable cmeta:id="king_altman_states.C5" name="C5" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.C6" name="C6" public_interface="out" units="umol" />
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<eq />
<ci>C1_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
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<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
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<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
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<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
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<times />
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C2_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C3_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C4_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C5_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C6_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C_sum</ci>
<apply>
<plus />
<ci>C1_sum</ci>
<ci>C2_sum</ci>
<ci>C3_sum</ci>
<ci>C4_sum</ci>
<ci>C5_sum</ci>
<ci>C6_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C1</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C1_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C2</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C2_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C3_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C4</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C4_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C5</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C5_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C6</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C6_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
</math>
</component>
<component name="NBC_current">
<variable cmeta:id="NBC_current.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.C_1" name="C_1" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_2" name="C_2" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_3" name="C_3" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_4" name="C_4" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_5" name="C_5" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_6" name="C_6" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C1" name="C1" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C2" name="C2" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C3" name="C3" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C4" name="C4" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C5" name="C5" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C6" name="C6" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.delta" name="delta" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.alpha_p" name="alpha_p" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.alpha_pp" name="alpha_pp" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.n" name="n" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.z_c" name="z_c" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.z_Na" name="z_Na" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.F" name="F" public_interface="in" units="C_per_mol" />
<variable cmeta:id="NBC_current.I_NaGl_pSS" name="I_NaGl_pSS" public_interface="out" units="uA" />
<variable cmeta:id="NBC_current.I_NaGl_SS" name="I_NaGl_SS" public_interface="out" units="uA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_NaGl_pSS</ci>
<apply>
<times />
<apply>
<minus />
<ci>F</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_p</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_12</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>C_2</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>z_c</ci>
<ci>delta</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_16</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_61</ci>
<ci>C_6</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_pp</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_56</ci>
<ci>C_5</ci>
</apply>
<apply>
<times />
<ci>k_65</ci>
<ci>C_6</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>I_NaGl_SS</ci>
<apply>
<times />
<apply>
<minus />
<ci>F</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>z_c</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_16</ci>
<ci>C1</ci>
</apply>
<apply>
<times />
<ci>k_61</ci>
<ci>C6</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>z_c</ci>
<apply>
<times />
<ci>z_Na</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_25</ci>
<ci>C2</ci>
</apply>
<apply>
<times />
<ci>k_52</ci>
<ci>C5</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>z_c</ci>
<apply>
<times />
<ci>z_Na</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_34</ci>
<ci>C3</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phenomonological_constants">
<variable cmeta:id="phenomonological_constants.epsilon" name="epsilon" public_interface="out" units="per_second" />
<variable cmeta:id="phenomonological_constants.lambda" name="lambda" public_interface="out" units="per_M3_per_second5" />
<variable cmeta:id="phenomonological_constants.chi" name="chi" public_interface="out" units="M" />
<variable cmeta:id="phenomonological_constants.alpha" name="alpha" public_interface="out" units="M3" />
<variable cmeta:id="phenomonological_constants.beta" name="beta" public_interface="out" units="M2" />
<variable cmeta:id="phenomonological_constants.gamma" name="gamma" public_interface="out" units="M3_per_second" />
<variable cmeta:id="phenomonological_constants.phi" name="phi" public_interface="out" units="M_per_second" />
<variable cmeta:id="phenomonological_constants.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_23" name="k_23" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_32" name="k_32" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_45" name="k_45" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_54" name="k_54" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.ks_12" name="ks_12" public_interface="in" units="per_M2_per_second" />
<variable cmeta:id="phenomonological_constants.k0_23" name="k0_23" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="phenomonological_constants.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="phenomonological_constants.F" name="F" public_interface="in" units="C_per_mol" />
<variable cmeta:id="phenomonological_constants.Na_o" name="Na_o" public_interface="in" units="M" />
<variable cmeta:id="phenomonological_constants.glucose_o" name="glucose_o" public_interface="in" units="M" />
<variable cmeta:id="phenomonological_constants.Imax_Na" name="Imax_Na" public_interface="out" units="uA" />
<variable cmeta:id="phenomonological_constants.Imax_gluc" name="Imax_gluc" public_interface="out" units="uA" />
<variable cmeta:id="phenomonological_constants.Khalf_Na_sq" name="Khalf_Na_sq" public_interface="out" units="M2" />
<variable cmeta:id="phenomonological_constants.Khalf_Na" name="Khalf_Na" public_interface="out" units="M" />
<variable cmeta:id="phenomonological_constants.Khalf_gluc" name="Khalf_gluc" public_interface="out" units="M" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>lambda</ci>
<apply>
<plus />
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>chi</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>alpha</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>gamma</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>phi</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<apply>
<minus />
<ci>ks_12</ci>
</apply>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>epsilon</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<minus />
<ci>ks_12</ci>
</apply>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Imax_gluc</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>C_T</ci>
<ci>epsilon</ci>
<apply>
<power />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus />
<ci>beta</ci>
<apply>
<power />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Imax_Na</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>C_T</ci>
<apply>
<plus />
<ci>phi</ci>
<apply>
<times />
<ci>epsilon</ci>
<ci>glucose_o</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<ci>chi</ci>
<ci>glucose_o</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Khalf_gluc</ci>
<apply>
<divide />
<apply>
<plus />
<ci>alpha</ci>
<apply>
<times />
<ci>chi</ci>
<apply>
<power />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<ci>beta</ci>
<apply>
<power />
<ci>Na_o</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Khalf_Na_sq</ci>
<apply>
<divide />
<apply>
<plus />
<ci>alpha</ci>
<apply>
<times />
<ci>beta</ci>
<ci>glucose_o</ci>
</apply>
</apply>
<apply>
<plus />
<ci>chi</ci>
<ci>glucose_o</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Khalf_Na</ci>
<apply>
<root />
<ci>Khalf_Na_sq</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="ion_concentrations" component_2="phenomonological_constants" />
<map_variables variable_1="glucose_o" variable_2="glucose_o" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="rate_constants" component_2="kinetic_equations" />
<map_variables variable_1="k_52" variable_2="k_52" />
<map_variables variable_1="k_25" variable_2="k_25" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_65" variable_2="k_65" />
<map_variables variable_1="k_23" variable_2="k_23" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_32" variable_2="k_32" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_54" variable_2="k_54" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_45" variable_2="k_45" />
<map_variables variable_1="k_16" variable_2="k_16" />
</connection>
<connection>
<map_components component_1="parameters" component_2="rate_constants" />
<map_variables variable_1="C_T" variable_2="C_T" />
<map_variables variable_1="k0_21" variable_2="k0_21" />
<map_variables variable_1="k0_56" variable_2="k0_56" />
<map_variables variable_1="k0_65" variable_2="k0_65" />
<map_variables variable_1="k0_16" variable_2="k0_16" />
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<map_variables variable_1="k0_52" variable_2="k0_52" />
<map_variables variable_1="k0_34" variable_2="k0_34" />
<map_variables variable_1="mu" variable_2="mu" />
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<map_variables variable_1="k0_45" variable_2="k0_45" />
<map_variables variable_1="alpha_pp" variable_2="alpha_pp" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="z_Na" variable_2="z_Na" />
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<connection>
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<connection>
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<map_variables variable_1="glucose_i" variable_2="glucose_i" />
</connection>
<connection>
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<map_variables variable_1="k_23" variable_2="k_23" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_32" variable_2="k_32" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_54" variable_2="k_54" />
<map_variables variable_1="k_56" variable_2="k_56" />
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</connection>
<connection>
<map_components component_1="rate_constants" component_2="NBC_current" />
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<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_65" variable_2="k_65" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_12" variable_2="k_12" />
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</connection>
<connection>
<map_components component_1="rate_constants" component_2="king_altman_states" />
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<map_variables variable_1="k_25" variable_2="k_25" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_65" variable_2="k_65" />
<map_variables variable_1="k_23" variable_2="k_23" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_32" variable_2="k_32" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_54" variable_2="k_54" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_45" variable_2="k_45" />
<map_variables variable_1="k_16" variable_2="k_16" />
</connection>
<connection>
<map_components component_1="ion_concentrations" component_2="parameters" />
<map_variables variable_1="V" variable_2="V" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="kinetic_equations" component_2="NBC_current" />
<map_variables variable_1="C_1" variable_2="C_1" />
<map_variables variable_1="C_4" variable_2="C_4" />
<map_variables variable_1="C_2" variable_2="C_2" />
<map_variables variable_1="C_5" variable_2="C_5" />
<map_variables variable_1="C_3" variable_2="C_3" />
<map_variables variable_1="C_6" variable_2="C_6" />
</connection>
<connection>
<map_components component_1="king_altman_states" component_2="NBC_current" />
<map_variables variable_1="C3" variable_2="C3" />
<map_variables variable_1="C4" variable_2="C4" />
<map_variables variable_1="C5" variable_2="C5" />
<map_variables variable_1="C6" variable_2="C6" />
<map_variables variable_1="C2" variable_2="C2" />
<map_variables variable_1="C1" variable_2="C1" />
</connection>
<connection>
<map_components component_1="environment" component_2="kinetic_equations" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="parameters" component_2="kinetic_equations" />
<map_variables variable_1="C_T" variable_2="C_T" />
</connection>
<connection>
<map_components component_1="parameters" component_2="king_altman_states" />
<map_variables variable_1="C_T" variable_2="C_T" />
</connection>
<connection>
<map_components component_1="parameters" component_2="NBC_current" />
<map_variables variable_1="alpha_pp" variable_2="alpha_pp" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="z_Na" variable_2="z_Na" />
<map_variables variable_1="z_c" variable_2="z_c" />
<map_variables variable_1="delta" variable_2="delta" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="n" variable_2="n" />
</connection>
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<dcterms:description>k_34 is the rate of transition from state 3 to 4 from luminal to cytosol compartment</dcterms:description>
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<dcterms:description>k_23 is the rate of transition from state 2 to 3 in the luminal compartment</dcterms:description>
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<dcterms:description>k_34 is the rate of transition from state 3 to 4 from luminal to cytosol compartment</dcterms:description>
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<rdf:Description rdf:about="#parameters.alpha_pp">
<dcterms:description>fraction of elctrical field sensed by the Na+ binding in the cytosol compartment</dcterms:description>
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<rdf:Description rdf:about="#NBC_current.C2">
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<semsim:name>Concentration of C2 of the 6-state SGLT1 cotransporter</semsim:name>
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<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
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<semsim:name>Transition rate from state 5 to 4</semsim:name>
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<dcterms:description>k_54 is the rate of transition from state 5 to 4 in the cytosol compartment</dcterms:description>
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<rdf:Description rdf:about="#entity_6">
<ro:part_of rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17234" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of glucose in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_87">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_11" dcterms:description="">
<ro:part_of rdf:resource="#entity_2" />
<semsim:name>Concentration of C1 of the 6-state SGLT1 cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C1 in the cytosol compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Imax_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_113">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_16" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_16">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_18" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_18" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Max current of Na+</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Maximum current of Na+ from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_17" dcterms:description="" />
<rdf:Description rdf:about="#NBC_current.z_Na">
<dcterms:description>valence of Na+ in the luminal compartment and cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.area">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00295" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.z_c">
<dcterms:description>valence of ion binding site on the empty carrier from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_3">
<ro:part_of rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of Na+ in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_56">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_60">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_10" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_10">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_10" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_10" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Transition rate from state 5 to 6</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_56 is the rate of transition from state 5 to 6 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_25">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_36">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_8" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_8">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_8" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_8" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Transition rate from state 2 to 5</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_25 is the rate of transition from state 2 to 5 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_32">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_53">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_3" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_3">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_3" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_3" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Transition rate from state 3 to 2</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_32 is the rate of transition from state 3 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_56">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#process_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_56 is the rate of transition from state 5 to 6 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_32">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf rdf:resource="#process_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_32 is the rate of transition from state 3 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_21">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_97">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_21 is the rate of transition from state 2 to 1 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.alpha_pp">
<dcterms:description>fraction of elctrical field sensed by the Na+ binding in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_45">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_102">
<semsim:physicalPropertyOf rdf:resource="#process_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_45 is the arte of transition from state 4 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#entity_0" dcterms:description="" />
<rdf:Description rdf:about="#phenomonological_constants.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_110">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0" dcterms:description="">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<ro:part_of rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_74550" />
</rdf:Description>
</ro:part_of>
<semsim:name>Total concentration of the 6-state SGLT1 cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of 6-state carrier in the luminal and cytosol compartmets of SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_16" dcterms:description="" />
<rdf:Description rdf:about="#kinetic_equations.time" dcterms:description="Time">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_43">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_55">
<semsim:physicalPropertyOf rdf:resource="#process_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_43 is the rate of transition from state 4 to 3 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_45">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#process_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_45 is the arte of transition from state 4 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_9" dcterms:description="" />
<rdf:Description rdf:about="#rate_constants.k_21">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_21 is the rate of transition from state 2 to 1 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_32">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_99">
<semsim:physicalPropertyOf rdf:resource="#process_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_32 is the rate of transition from state 3 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_56">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_106">
<semsim:physicalPropertyOf rdf:resource="#process_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_56 is the rate of transition from state 5 to 6 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_15" dcterms:description="" />
<rdf:Description rdf:about="#phenomonological_constants.chi">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_95">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Khalf_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_115">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>luminal concentration of Na+ at which the half-maximal current from cytosol to luminal compartment is evoked</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_69">
<semsim:physicalPropertyOf rdf:resource="#entity_15" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C5 in the luminal compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_0" dcterms:description="" />
<rdf:Description rdf:about="#NBC_current.k_52">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_78">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_9" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_9">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_9" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_9" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Transition rate from state 5 to 2</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_52 is the rate of transition from state 5 to 2 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.alpha_pp">
<dcterms:description>fraction of elctrical field sensed by the Na+ binding in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_54">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_57">
<semsim:physicalPropertyOf rdf:resource="#process_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_54 is the rate of transition from state 5 to 4 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_54">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf rdf:resource="#process_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_54 is the rate of transition from state 5 to 4 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_82">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C2 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_23">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_98">
<semsim:physicalPropertyOf rdf:resource="#process_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_23 is the rate of transition from state 2 to 3 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_14" dcterms:description="" />
<rdf:Description rdf:about="#king_altman_states.C4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_68">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14" dcterms:description="">
<ro:part_of rdf:resource="#entity_4" />
<semsim:name>Concentration of C4 of the 6-state SGLT1 cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C4 in the luminal compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_65">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_74">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_11" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_11">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_11" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_11" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Transition rate from state 6 to 5</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_65 is the rate of transition from state 6 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_65">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_61">
<semsim:physicalPropertyOf rdf:resource="#process_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_65 is the rate of transition from state 6 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.I_NaGl_pSS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_93">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_14" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_14">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_15" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_14" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_15" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_14" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Current as a transfer of net charge</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>presteady state current is given by sum of all translocation steps involving the transfer of a net charge in the cell membrane of SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_5">
<ro:part_of rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of Na+ in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_43">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#process_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_43 is the rate of transition from state 4 to 3 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#eskandari_2005" semsim:PubMedIDofReferencePublication="16007500" semsim:modelId="eskandari_2005" semsim:modelName="eskandari_2005" />
<rdf:Description rdf:about="#kinetic_equations.k_16">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_13" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_13">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_13" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_13" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Transition rate from state 1 to 6</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_16 is the rate of transition from state 1 to 6 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time" dcterms:description="Time">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_34">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_100">
<semsim:physicalPropertyOf rdf:resource="#process_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_34 is the rate of transition from state 3 to 4 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_81">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C1 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_13" dcterms:description="" />
<rdf:Description rdf:about="#phenomonological_constants.glucose_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_112">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_7">
<ro:part_of rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_17234" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of glucose in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.glucose_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of glucose in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_52">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_59">
<semsim:physicalPropertyOf rdf:resource="#process_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_52 is the rate of transition from state 5 to 2 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_25">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_104">
<semsim:physicalPropertyOf rdf:resource="#process_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_25 is the rate of transition from state 2 to 5 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_84">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C4 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_52">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf rdf:resource="#process_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_52 is the rate of transition from state 5 to 2 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_12" dcterms:description="" />
<rdf:Description rdf:about="#king_altman_states.C6">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_70">
<semsim:physicalPropertyOf rdf:resource="#entity_16" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C6 in the luminal compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_61">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_40">
<semsim:physicalPropertyOf rdf:resource="#process_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_61 is the rate of transition from state 6 to 1 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_43">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_76">
<semsim:physicalPropertyOf rdf:resource="#process_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_43 is the rate of transition from state 4 to 3 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.glucose_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of glucose in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_65">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#process_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_65 is the rate of transition from state 6 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_83">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_13" dcterms:description="">
<ro:part_of rdf:resource="#entity_2" />
<semsim:name>Concentration of C3 of the 6-state SGLT1 cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C3 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_12">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_96">
<semsim:physicalPropertyOf rdf:resource="#process_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_12 is the rate of transition from state 1 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_11" dcterms:description="" />
<rdf:Description rdf:about="#ion_concentrations.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of Na+ in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_65">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C1 in the cytosol compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_46">
<semsim:physicalPropertyOf rdf:resource="#entity_15" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C5 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_56">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_73">
<semsim:physicalPropertyOf rdf:resource="#process_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_56 is the rate of transition from state 5 to 6 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of Na+ in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_4" dcterms:description="" />
<rdf:Description rdf:about="#process_10" dcterms:description="" />
<rdf:Description rdf:about="#rate_constants.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of 6-state carrier in the luminal and cytosol compartmets of SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.delta">
<dcterms:description>fraction of elctrical field sensed by the empty ion binding site from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_21">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_72">
<semsim:physicalPropertyOf rdf:resource="#process_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_21 is the rate of transition from state 2 to 1 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_6">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:physicalPropertyOf rdf:resource="#entity_16" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C6 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_61">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_62">
<semsim:physicalPropertyOf rdf:resource="#process_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_61 is the rate of transition from state 6 to 1 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_52">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf rdf:resource="#process_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_52 is the rate of transition from state 5 to 2 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_3" dcterms:description="" />
<rdf:Description rdf:about="#king_altman_states.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_64">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of 6-state carrier in the luminal and cytosol compartmets of SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_6_temp">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_48">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_16">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf rdf:resource="#process_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_16 is the rate of transition from state 1 to 6 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.alpha_p">
<dcterms:description>fraction of elctrical field sensed by the Na+ binding in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_67">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C3 in the cytosol compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_65">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:physicalPropertyOf rdf:resource="#process_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_65 is the rate of transition from state 6 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_2" dcterms:description="" />
<rdf:Description rdf:about="#NBC_current.k_34">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_75">
<semsim:physicalPropertyOf rdf:resource="#process_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_34 is the rate of transition from state 3 to 4 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.mu">
<dcterms:description>electrochemical potential which is measured in the cell membrane from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_16">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_63">
<semsim:physicalPropertyOf rdf:resource="#process_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_16 is the rate of transition from state 1 to 6 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_61">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_108">
<semsim:physicalPropertyOf rdf:resource="#process_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_61 is the rate of transition from state 6 to 1 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_111">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of Na+ in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_49">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of 6-state carrier in the luminal and cytosol compartments of SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C3 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00378" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_66">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C2 in the cytosol compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of Na+ in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_54">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_35">
<semsim:physicalPropertyOf rdf:resource="#process_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_54 is the rate of transition from state 5 to 4 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_1" dcterms:description="" />
<rdf:Description rdf:about="#phenomonological_constants.k_16">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_109">
<semsim:physicalPropertyOf rdf:resource="#process_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_16 is the rate of transition from state 1 to 6 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.z_c">
<dcterms:description>valence of ion binding site on the empty carrier from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
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<dcterms:description>Concentration of C4 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#eskandari_2005" dcterms:keyword="SGLT1">
<vCard:FN>D.D.F. Loo</vCard:FN>
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<dcterms:abstract>This study investigates the reverse mode of the Na/glucose cotransporter (SGLT1). In giant excised inside-out membrane patches from Xenopus laevis oocytes expressing rabbit SGLT1, application of a-methyl-D-glucopyranoside (aMDG) to the cytoplasmic solution induced an outward current from cytosolic to external membrane surface. The outward current was Na- and sugar-dependent, and was blocked by phlorizin, a specific inhibitor of SGLT1. The current-voltage relationship saturated at positive membrane voltages (30-50 mV), and approached zero at -150 mV. The half-maximal concentration for aMDG-evoked outward current (K_0.5_aMDG) was 35 mM (at 0 mV). In comparison, K_0.5_aMDG for forward sugar transport was 0.15 mM (at 0 mV). K_0.5_Na was similar for forward and reverse transport (~ 35mM at 0 mV). Specificity of SGLT1 for reverse transport was: aMDG (1.0) > D-galactose (0.84) > 3-O-methyl-glucose (0.55) > D-glucose (0.38), whereas for forward transport, specificity was: aMDG ~ D-glucose ~ D-galactose > 3-O-methylglucose. Thus there is an asymmetry in sugar kinetics and specificity between forward and reverse modes. Computer simulations showed that a 6-state kinetic model for SGLT1 can account for Na/sugar cotransport and its voltage dependence in both the forward and reverse modes at saturating sodium concentrations. Our data indicate that under physiological conditions, the transporter is poised to accumulate sugar efficiently in the enterocyte.</dcterms:abstract>
<dcterms:keyword>Xenopus oocyte</dcterms:keyword>
<ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_17716" />
<dcterms:keyword>Reverse sugar transport</dcterms:keyword>
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<bqmodel:isDescribedBy rdf:resource="https://dx.doi.org/10.1007/s00232-005-0743-x" />
<vCard:FN>S. Eskandari</vCard:FN>
<vCard:FN>E.M. Wright</vCard:FN>
<dcterms:title>Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter</dcterms:title>
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<dcterms:description>k_61 is the rate of transition from state 6 to 1 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.alpha_p">
<dcterms:description>fraction of elctrical field sensed by the Na+ binding in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C6">
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<dcterms:description>Concentration of C6 in the luminal compartment (Parent paper)</dcterms:description>
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<dcterms:description>k_43 is the rate of transition from state 4 to 3 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_12">
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_12 is the rate of transition from state 1 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_8" dcterms:description="" />
<rdf:Description rdf:about="#entity_16" dcterms:description="" />
<rdf:Description rdf:about="#kinetic_equations.C_1">
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</rdf:Description>
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<dcterms:description>Concentration of C1 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.z_Na">
<dcterms:description>valence of Na+ in the luminal compartment and cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Khalf_gluc">
<semsim:isComputationalComponentFor>
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>luminal concentration of sugar at which the half-maximal current from cytosol to luminal compartment is evoked</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.mu">
<dcterms:description>electrochemical potential which is measured in the cell membrane from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_32">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_31">
<semsim:physicalPropertyOf rdf:resource="#process_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_32 is the rate of transition from state 3 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_91">
<semsim:physicalPropertyOf rdf:resource="#entity_15" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C5 in the luminal compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_25">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_77">
<semsim:physicalPropertyOf rdf:resource="#process_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_25 is the rate of transition from state 2 to 5 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.z_Na">
<dcterms:description>valence of Na+ in the luminal compartment and cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_56">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:physicalPropertyOf rdf:resource="#process_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_56 is the rate of transition from state 5 to 6 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.glucose_i">
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of glucose in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_7" dcterms:description="" />
<rdf:Description rdf:about="#king_altman_states.k_25">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_58">
<semsim:physicalPropertyOf rdf:resource="#process_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_25 is the rate of transition from state 2 to 5 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#entity_15" dcterms:description="" />
<rdf:Description rdf:about="#parameters.z_c">
<dcterms:description>valence of ion binding site on the empty carrier from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C2 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.I_NaGl_SS">
<semsim:isComputationalComponentFor>
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<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_15">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_17" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_16" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_17" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_16" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Current dependedent on sugar</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>steady state sugar dependent carrier current is given by sum of all possible membrane translocation in SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Imax_gluc">
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<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_19" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_19" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Max current of glucose</semsim:name>
</rdf:Description>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
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<dcterms:description>Maximum current of glucose from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_21">
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<rdf:Description rdf:about="#property_29">
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_21 is the rate of transition from state 2 to 1 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C4">
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<rdf:Description rdf:about="#property_90">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C4 in the luminal compartment (Parent paper)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_12">
<semsim:isComputationalComponentFor>
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_12 is the rate of transition from state 1 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_45">
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<dcterms:description>k_45 is the arte of transition from state 4 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_12">
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<dcterms:description>k_12 is the rate of transition from state 1 to 2 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#entity_14" dcterms:description="" />
<rdf:Description rdf:about="#phenomonological_constants.k_65">
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<dcterms:description>k_65 is the rate of transition from state 6 to 5 in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.delta">
<dcterms:description>fraction of elctrical field sensed by the empty ion binding site from luminal to cytosol compartment and cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#process_6" dcterms:description="" />
<rdf:Description rdf:about="#rate_constants.k_25">
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<rdf:Description rdf:about="#property_21">
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<dcterms:description>k_25 is the rate of transition from state 2 to 5 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
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<dcterms:description>Concentration of 6-state carrier in the luminal and cytosol compartmets of SGLT1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_16">
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<rdf:Description rdf:about="#property_80">
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_16 is the rate of transition from state 1 to 6 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_23">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_52">
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
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<dcterms:description>k_23 is the rate of transition from state 2 to 3 in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_34">
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<rdf:Description rdf:about="#property_32">
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</rdf:Description>
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<dcterms:description>k_34 is the rate of transition from state 3 to 4 from luminal to cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_52">
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<rdf:Description rdf:about="#property_105">
<semsim:physicalPropertyOf rdf:resource="#process_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>k_52 is the rate of transition from state 5 to 2 from cytosol to luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#entity_13" dcterms:description="" />
<rdf:Description rdf:about="#ion_concentrations.time" dcterms:description="Time">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_89">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Concentration of C3 in the cytosol compartment (Parent paper)</dcterms:description>
</rdf:Description>
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</rdf:RDF>
</model>
