Location: semantic-annotation @ f42c82f77870 / Hodgkin_Huxley_1952.cellml

Author:
Dewan Sarwar <sarwarcse@gmail.com>
Date:
2019-01-22 15:53:48+13:00
Desc:
adding the removed namepsaces
Permanent Source URI:
http://models.cellml.org/workspace/584/rawfile/f42c82f77870f412e1964b9b0701fec331344c8d/Hodgkin_Huxley_1952.cellml

<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="hodgkin_huxley_squid_axon_1952" cmeta:id="hodgkin_huxley_squid_axon_1952">
  <documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <section id="sec_status">
        <title>Model Status</title>
        <para>This version has had a stimulus protocol component added to allow the model to simulate multiple action potentials, has been unit checked and curated and is known to run in COR and PCEnv.</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>In a series of papers published in 1952, A.L. Hodgkin and A.F. Huxley presented the results of a series of experiments in which they investigated the flow of electric current through the surface membrane of the giant nerve fibre of a squid. In the summary paper of the Hodgkin and Huxley model, the authors developed a mathematical description of the behaviour of the membrane based upon these experiments, which accounts for the conduction and excitation of the fibre. The form of this description has been used as the basis for almost all other ionic current models of excitable tissues, including Purkinje fibres and cardiac atrial and ventricular muscle.</para>
        <para>The summary paper is cited below:</para>
        <para>
          A Quantitative Description of Membrane Current and its Application to Conduction and Excitation in Nerve, A. L. Hodgkin and A. F. Huxley, 1952,
          <emphasis>The Journal of Physiology</emphasis>
          , 117, 500-544.
          <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=12991237&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 12991237</ulink>
        </para>
        <informalfigure float="0" id="fig_circuit_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>Electrical circuit describing the current across the cell membrane</title>
              </objectinfo>
              <imagedata fileref="hodgkin_1952.png" />
            </imageobject>
          </mediaobject>
          <caption>A schematic cell diagram describing the current flows across the cell membrane that are captured in the Hodgkin Huxley model.</caption>
        </informalfigure>
      </sect1>
    </article>
  </documentation>
  <units name="millisecond">
    <unit prefix="milli" units="second" />
  </units>
  <units name="milliS_per_cm2">
    <unit exponent="-2.0" prefix="centi" units="metre" />
    <unit prefix="milli" units="siemens" />
  </units>
  <units name="microF_per_cm2">
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    <unit prefix="micro" units="farad" />
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  <component name="leakage_current">
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    <variable cmeta:id="leakage_current_i_L" name="i_L" public_interface="out" units="microA_per_cm2" />
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      <component_ref component="sodium_channel_h_gate" />
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    <map_variables variable_1="E_R" variable_2="E_R" />
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    <map_variables variable_1="E_R" variable_2="E_R" />
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    <map_components component_1="sodium_channel" component_2="membrane" />
    <map_variables variable_1="i_Na" variable_2="i_Na" />
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    <map_components component_1="environment" component_2="membrane" />
    <map_variables variable_1="time" variable_2="time" />
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    <map_variables variable_1="time" variable_2="time" />
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  <connection>
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