- Author:
- Dewan Sarwar <sarwarcse@gmail.com>
- Date:
- 2019-01-22 15:53:48+13:00
- Desc:
- adding the removed namepsaces
- Permanent Source URI:
- http://models.cellml.org/workspace/584/rawfile/f42c82f77870f412e1964b9b0701fec331344c8d/weinstein_1998.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="weinstein_1998_renal_H_K_ATPase_model" cmeta:id="weinstein_1998_renal_H_K_ATPase_model">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Acid/base Transport in the Inner Medullary Collecting Duct of the Rat</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model variant describes the renal H+/K+ ATPase.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: A mathematical model of the inner medullary collecting duct (IMCD) of the rat has been developed that is suitable for simulating luminal buffer titration and ammonia secretion by this nephron segment. Luminal proton secretion has been assigned to an H-K-ATPase, which has been represented by adapting the kinetic model of the gastric enzyme by Brzezinski et al. (P. Brzezinski, B. G. Malmstrom, P. Lorentzon, and B. Wallmark. Biochim. Biophys. Acta 942: 215-219, 1988). In shifting to a 2 H+:1 ATP stoichiometry, the model enzyme can acidify the tubule lumen approximately 3 pH units below that of the cytosol, when luminal K+ is in abundance. Peritubular base exit is a combination of ammonia recycling and HCO3- flux (either via Cl-/HCO3- exchange or via a Cl- channel). Ammonia recycling involves NH4(+) uptake on the Na-K-ATPase followed by diffusive NH3 exit [S. M. Wall. Am. J. Physiol. 270 (Renal Physiol. 39): F432-F439, 1996]; model calculations suggest that this is the principal mode of base exit. By virtue of this mechanism, the model also suggests that realistic elevations in peritubular K+ concentration will compromise IMCD acid secretion. Although ammonia recycling is insensitive to carbonic anhydrase (CA) inhibition, the base exit linked to HCO3- flux provides a CA-sensitive component to acid secretion. In model simulations, it is observed that increased luminal NaCl entry increases ammonia cycling but decreases peritubular Cl-/HCO3- exchange (due to increased cell Cl-). This parallel system of peritubular base exit stabilizes acid secretion in the face of variable Na+ reabsorption.</para>
<para>The complete original paper reference is cited below:</para>
<para>
A mathematical model of the inner medullary collecting duct of the rat: acid/base transport, Alan M. Weinstein, 1998,
<emphasis>American Journal of Physiology</emphasis>
, 274(5 Pt 2), F856-67.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6496750&dopt=Abstract">PubMed ID: 6496750</ulink>
</para>
<informalfigure float="0" id="fig_pathway_rendering">
<mediaobject>
<imageobject>
<objectinfo>
<title>pathway_rendering</title>
</objectinfo>
<imagedata fileref="weinstein_1998b.png" />
</imageobject>
</mediaobject>
<caption>
Conventional rendering of the renal H-K-ATPase adapted from the gastric H-K-ATPase model. This model has a stoichiometry of two H
<superscript>+</superscript>
and two K
<superscript>+</superscript>
per ATP. E
<subscript>1</subscript>
and E
<subscript>2</subscript>
are the cytosolic- and luminal-facing enzymes, respectively.
</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="millimolar">
<unit exponent="-1.0" units="litre" />
<unit prefix="micro" units="mole" />
</units>
<units name="second_order_rate_constant">
<unit exponent="-1.0" units="millimolar" />
<unit exponent="-1.0" units="second" />
</units>
<units name="first_order_rate_constant">
<unit exponent="-1.0" units="second" />
</units>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="second" />
</component>
<component name="K2_E1" cmeta:id="K2_E1">
<variable cmeta:id="K2_E1.K2_E1" name="K2_E1" public_interface="out" units="millimolar" />
<variable cmeta:id="K2_E1.k1" name="k1" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E1.k1_" name="k1_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1.k9" name="k9" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1.k9_" name="k9_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1.K2_E2" name="K2_E2" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1.K2_E1_ATP" name="K2_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1.ATP" name="ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K2_E1</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k9</ci>
<ci>K2_E2</ci>
</apply>
<apply>
<times />
<ci>k1_</ci>
<ci>K2_E1_ATP</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k9_</ci>
<ci>K2_E1</ci>
</apply>
<apply>
<times />
<ci>k1</ci>
<ci>ATP</ci>
<ci>K2_E1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="K2_E1_ATP" cmeta:id="K2_E1_ATP">
<variable cmeta:id="K2_E1_ATP.K2_E1_ATP" name="K2_E1_ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="K2_E1_ATP.k1" name="k1" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E1_ATP.k1_" name="k1_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1_ATP.k2a" name="k2a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1_ATP.k2a_" name="k2a_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E1_ATP.k11" name="k11" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1_ATP.k11_" name="k11_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E1_ATP.K2_E2_ATP" name="K2_E2_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1_ATP.K2_E1" name="K2_E1" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1_ATP.K_E1_ATP" name="K_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1_ATP.K" name="K" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1_ATP.ATP" name="ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E1_ATP.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K2_E1_ATP</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k1</ci>
<ci>ATP</ci>
<ci>K2_E1</ci>
</apply>
<apply>
<times />
<ci>k11</ci>
<ci>K2_E2_ATP</ci>
</apply>
<apply>
<times />
<ci>k2a_</ci>
<ci>K</ci>
<ci>K_E1_ATP</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k11_</ci>
<ci>K2_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k1_</ci>
<ci>K2_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k2a</ci>
<ci>K2_E1_ATP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="K_E1_ATP" cmeta:id="K_E1_ATP">
<variable cmeta:id="K_E1_ATP.K_E1_ATP" name="K_E1_ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="K_E1_ATP.k2a" name="k2a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K_E1_ATP.k2a_" name="k2a_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K_E1_ATP.k2b" name="k2b" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K_E1_ATP.k2b_" name="k2b_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K_E1_ATP.K2_E1_ATP" name="K2_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K_E1_ATP.E1_ATP" name="E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K_E1_ATP.K" name="K" public_interface="in" units="millimolar" />
<variable cmeta:id="K_E1_ATP.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_E1_ATP</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k2a</ci>
<ci>K2_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k2b_</ci>
<ci>K</ci>
<ci>E1_ATP</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k2a_</ci>
<ci>K_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k2b</ci>
<ci>K_E1_ATP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="E1_ATP" cmeta:id="E1_ATP">
<variable cmeta:id="E1_ATP.E1_ATP" name="E1_ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="E1_ATP.k2b" name="k2b" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="E1_ATP.k2b_" name="k2b_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="E1_ATP.k3a" name="k3a" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="E1_ATP.k3a_" name="k3a_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="E1_ATP.H_E1_ATP" name="H_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="E1_ATP.K_E1_ATP" name="K_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="E1_ATP.K" name="K" public_interface="in" units="millimolar" />
<variable cmeta:id="E1_ATP.H" name="H" public_interface="in" units="millimolar" />
<variable cmeta:id="E1_ATP.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>E1_ATP</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k2b</ci>
<ci>K_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k3a_</ci>
<ci>H_E1_ATP</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k2b_</ci>
<ci>K</ci>
<ci>E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k3a</ci>
<ci>H</ci>
<ci>E1_ATP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H_E1_ATP" cmeta:id="H_E1_ATP">
<variable cmeta:id="H_E1_ATP.H_E1_ATP" name="H_E1_ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="H_E1_ATP.k3a" name="k3a" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H_E1_ATP.k3a_" name="k3a_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H_E1_ATP.k3b" name="k3b" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H_E1_ATP.k3b_" name="k3b_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H_E1_ATP.H2_E1_ATP" name="H2_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="H_E1_ATP.E1_ATP" name="E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="H_E1_ATP.H" name="H" public_interface="in" units="millimolar" />
<variable cmeta:id="H_E1_ATP.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>H_E1_ATP</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k3a</ci>
<ci>H</ci>
<ci>E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k3b_</ci>
<ci>H2_E1_ATP</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k3a_</ci>
<ci>H_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k3b</ci>
<ci>H</ci>
<ci>H_E1_ATP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H2_E1_ATP" cmeta:id="H2_E1_ATP">
<variable cmeta:id="H2_E1_ATP.H2_E1_ATP" name="H2_E1_ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="H2_E1_ATP.k4" name="k4" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E1_ATP.k4_" name="k4_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H2_E1_ATP.k3b" name="k3b" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H2_E1_ATP.k3b_" name="k3b_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E1_ATP.H_E1_ATP" name="H_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_ATP.H2_E1_P" name="H2_E1_P" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_ATP.ADP" name="ADP" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_ATP.H" name="H" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_ATP.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>H2_E1_ATP</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k3b</ci>
<ci>H</ci>
<ci>H_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k4_</ci>
<ci>ADP</ci>
<ci>H2_E1_P</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k3b_</ci>
<ci>H2_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k4</ci>
<ci>H2_E1_ATP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H2_E1_P" cmeta:id="H2_E1_P">
<variable cmeta:id="H2_E1_P.H2_E1_P" name="H2_E1_P" public_interface="out" units="millimolar" />
<variable cmeta:id="H2_E1_P.k4" name="k4" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E1_P.k4_" name="k4_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H2_E1_P.k5" name="k5" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E1_P.k5_" name="k5_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E1_P.H2_E2_P" name="H2_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_P.H2_E1_ATP" name="H2_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_P.ADP" name="ADP" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E1_P.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>H2_E1_P</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k4</ci>
<ci>H2_E1_ATP</ci>
</apply>
<apply>
<times />
<ci>k5_</ci>
<ci>H2_E2_P</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k4_</ci>
<ci>ADP</ci>
<ci>H2_E1_P</ci>
</apply>
<apply>
<times />
<ci>k5</ci>
<ci>H2_E1_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H2_E2_P" cmeta:id="H2_E2_P">
<variable cmeta:id="H2_E2_P.H2_E2_P" name="H2_E2_P" public_interface="out" units="millimolar" />
<variable cmeta:id="H2_E2_P.k6a" name="k6a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E2_P.k6a_" name="k6a_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H2_E2_P.k5" name="k5" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E2_P.k5_" name="k5_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H2_E2_P.H2_E1_P" name="H2_E1_P" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E2_P.H_E2_P" name="H_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E2_P.H" name="H" public_interface="in" units="millimolar" />
<variable cmeta:id="H2_E2_P.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>H2_E2_P</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k6a_</ci>
<ci>H</ci>
<ci>H_E2_P</ci>
</apply>
<apply>
<times />
<ci>k5</ci>
<ci>H2_E1_P</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k6a</ci>
<ci>H2_E2_P</ci>
</apply>
<apply>
<times />
<ci>k5_</ci>
<ci>H2_E2_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H_E2_P" cmeta:id="H_E2_P">
<variable cmeta:id="H_E2_P.H_E2_P" name="H_E2_P" public_interface="out" units="millimolar" />
<variable cmeta:id="H_E2_P.k6a" name="k6a" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H_E2_P.k6a_" name="k6a_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H_E2_P.k6b" name="k6b" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="H_E2_P.k6b_" name="k6b_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="H_E2_P.H2_E2_P" name="H2_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="H_E2_P.E2_P" name="E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="H_E2_P.H" name="H" public_interface="in" units="millimolar" />
<variable cmeta:id="H_E2_P.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>H_E2_P</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k6a</ci>
<ci>H2_E2_P</ci>
</apply>
<apply>
<times />
<ci>k6b_</ci>
<ci>H</ci>
<ci>E2_P</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k6a_</ci>
<ci>H</ci>
<ci>H_E2_P</ci>
</apply>
<apply>
<times />
<ci>k6b</ci>
<ci>H_E2_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="E2_P" cmeta:id="E2_P">
<variable cmeta:id="E2_P.E2_P" name="E2_P" public_interface="out" units="millimolar" />
<variable cmeta:id="E2_P.k6b" name="k6b" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="E2_P.k6b_" name="k6b_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="E2_P.k7a" name="k7a" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="E2_P.k7a_" name="k7a_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="E2_P.H_E2_P" name="H_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="E2_P.K_E2_P" name="K_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="E2_P.H" name="H" public_interface="in" units="millimolar" />
<variable cmeta:id="E2_P.K" name="K" public_interface="in" units="millimolar" />
<variable cmeta:id="E2_P.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>E2_P</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k7a_</ci>
<ci>K_E2_P</ci>
</apply>
<apply>
<times />
<ci>k6b</ci>
<ci>H_E2_P</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k6b_</ci>
<ci>H</ci>
<ci>E2_P</ci>
</apply>
<apply>
<times />
<ci>k7a</ci>
<ci>K</ci>
<ci>E2_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="K_E2_P" cmeta:id="K_E2_P">
<variable cmeta:id="K_E2_P.K_E2_P" name="K_E2_P" public_interface="out" units="millimolar" />
<variable cmeta:id="K_E2_P.k7a" name="k7a" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K_E2_P.k7a_" name="k7a_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K_E2_P.k7b" name="k7b" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K_E2_P.k7b_" name="k7b_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K_E2_P.E2_P" name="E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="K_E2_P.K2_E2_P" name="K2_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="K_E2_P.K" name="K" public_interface="in" units="millimolar" />
<variable cmeta:id="K_E2_P.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_E2_P</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k7a</ci>
<ci>K</ci>
<ci>E2_P</ci>
</apply>
<apply>
<times />
<ci>k7b_</ci>
<ci>K2_E2_P</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k7a_</ci>
<ci>K_E2_P</ci>
</apply>
<apply>
<times />
<ci>k7b</ci>
<ci>K</ci>
<ci>K_E2_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="K2_E2_P" cmeta:id="K2_E2_P">
<variable cmeta:id="K2_E2_P.K2_E2_P" name="K2_E2_P" public_interface="out" units="millimolar" />
<variable cmeta:id="K2_E2_P.k8" name="k8" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2_P.k8_" name="k8_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E2_P.k7b" name="k7b" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E2_P.k7b_" name="k7b_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2_P.K_E2_P" name="K_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_P.K2_E2" name="K2_E2" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_P.P" name="P" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_P.K" name="K" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_P.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K2_E2_P</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k7b</ci>
<ci>K</ci>
<ci>K_E2_P</ci>
</apply>
<apply>
<times />
<ci>k8_</ci>
<ci>P</ci>
<ci>K2_E2</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k8</ci>
<ci>K2_E2_P</ci>
</apply>
<apply>
<times />
<ci>k7b_</ci>
<ci>K2_E2_P</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="K2_E2" cmeta:id="K2_E2">
<variable cmeta:id="K2_E2.K2_E2" name="K2_E2" public_interface="out" units="millimolar" />
<variable cmeta:id="K2_E2.k8" name="k8" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2.k8_" name="k8_" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E2.k9" name="k9" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2.k9_" name="k9_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2.k10" name="k10" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E2.k10_" name="k10_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2.K2_E2_ATP" name="K2_E2_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2.K2_E1" name="K2_E1" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2.K2_E2_P" name="K2_E2_P" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2.P" name="P" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2.ATP" name="ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K2_E2</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k8</ci>
<ci>K2_E2_P</ci>
</apply>
<apply>
<times />
<ci>k10_</ci>
<ci>K2_E2_ATP</ci>
</apply>
<apply>
<times />
<ci>k9_</ci>
<ci>K2_E1</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k8_</ci>
<ci>P</ci>
<ci>K2_E2</ci>
</apply>
<apply>
<times />
<ci>k10</ci>
<ci>ATP</ci>
<ci>K2_E2</ci>
</apply>
<apply>
<times />
<ci>k9</ci>
<ci>K2_E2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="K2_E2_ATP" cmeta:id="K2_E2_ATP">
<variable cmeta:id="K2_E2_ATP.K2_E2_ATP" name="K2_E2_ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="K2_E2_ATP.k11" name="k11" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2_ATP.k11_" name="k11_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2_ATP.k10" name="k10" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="K2_E2_ATP.k10_" name="k10_" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="K2_E2_ATP.K2_E1_ATP" name="K2_E1_ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_ATP.K2_E2" name="K2_E2" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_ATP.ATP" name="ATP" public_interface="in" units="millimolar" />
<variable cmeta:id="K2_E2_ATP.time" name="time" public_interface="in" units="second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K2_E2_ATP</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k10</ci>
<ci>ATP</ci>
<ci>K2_E2</ci>
</apply>
<apply>
<times />
<ci>k11_</ci>
<ci>K2_E1_ATP</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k10_</ci>
<ci>K2_E2_ATP</ci>
</apply>
<apply>
<times />
<ci>k11</ci>
<ci>K2_E2_ATP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="reaction_constants">
<variable cmeta:id="reaction_constants.K" initial_value="20.0" name="K" public_interface="out" units="millimolar" />
<variable cmeta:id="reaction_constants.H" initial_value="4.0" name="H" public_interface="out" units="millimolar" />
<variable cmeta:id="reaction_constants.P" initial_value="5.0" name="P" public_interface="out" units="millimolar" />
<variable cmeta:id="reaction_constants.ATP" initial_value="2.0" name="ATP" public_interface="out" units="millimolar" />
<variable cmeta:id="reaction_constants.ADP" initial_value="0.04" name="ADP" public_interface="out" units="millimolar" />
<variable cmeta:id="reaction_constants.k1" initial_value="1.3E7" name="k1" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k1_" initial_value="6.5" name="k1_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k2a" initial_value="8.9E3" name="k2a" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k2a_" initial_value="7.3E4" name="k2a_" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k2b" initial_value="8.9E3" name="k2b" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k2b_" initial_value="7.3E4" name="k2b_" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k3a" initial_value="5.3E9" name="k3a" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k3a_" initial_value="6.6E2" name="k3a_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k3b" initial_value="5.3E9" name="k3b" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k3b_" initial_value="6.6E2" name="k3b_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k4" initial_value="5E1" name="k4" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k4_" initial_value="2.5E6" name="k4_" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k5" initial_value="4E1" name="k5" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k5_" initial_value="2E2" name="k5_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k6a" initial_value="5E7" name="k6a" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k6a_" initial_value="8E12" name="k6a_" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k6b" initial_value="5E7" name="k6b" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k6b_" initial_value="8E12" name="k6b_" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k7a" initial_value="2.6E10" name="k7a" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k7a_" initial_value="1.5E8" name="k7a_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k7b" initial_value="2.6E10" name="k7b" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k7b_" initial_value="1.5E8" name="k7b_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k8" initial_value="5.4E1" name="k8" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k8_" initial_value="3.2E1" name="k8_" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k9" initial_value="1.75E0" name="k9" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k9_" initial_value="3.5E1" name="k9_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k10" initial_value="5E4" name="k10" public_interface="out" units="second_order_rate_constant" />
<variable cmeta:id="reaction_constants.k10_" initial_value="5E1" name="k10_" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k11" initial_value="5E2" name="k11" public_interface="out" units="first_order_rate_constant" />
<variable cmeta:id="reaction_constants.k11_" initial_value="5E0" name="k11_" public_interface="out" units="first_order_rate_constant" />
</component>
<connection>
<map_components component_1="K2_E2_P" component_2="K2_E2" />
<map_variables variable_1="K2_E2_P" variable_2="K2_E2_P" />
</connection>
<connection>
<map_components component_1="H_E1_ATP" component_2="H2_E1_ATP" />
<map_variables variable_1="H_E1_ATP" variable_2="H_E1_ATP" />
</connection>
<connection>
<map_components component_1="H2_E2_P" component_2="H_E2_P" />
<map_variables variable_1="H2_E2_P" variable_2="H2_E2_P" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="E2_P" />
<map_variables variable_1="k6b" variable_2="k6b" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="k7a_" variable_2="k7a_" />
<map_variables variable_1="k6b_" variable_2="k6b_" />
<map_variables variable_1="k7a" variable_2="k7a" />
<map_variables variable_1="K" variable_2="K" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="H2_E2_P" />
<map_variables variable_1="k5_" variable_2="k5_" />
<map_variables variable_1="k5" variable_2="k5" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="k6a" variable_2="k6a" />
<map_variables variable_1="k6a_" variable_2="k6a_" />
</connection>
<connection>
<map_components component_1="H_E1_ATP" component_2="E1_ATP" />
<map_variables variable_1="H_E1_ATP" variable_2="H_E1_ATP" />
</connection>
<connection>
<map_components component_1="H2_E1_P" component_2="H2_E1_ATP" />
<map_variables variable_1="H2_E1_P" variable_2="H2_E1_P" />
</connection>
<connection>
<map_components component_1="environment" component_2="K2_E2" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K2_E1_ATP" component_2="K_E1_ATP" />
<map_variables variable_1="K2_E1_ATP" variable_2="K2_E1_ATP" />
</connection>
<connection>
<map_components component_1="H2_E1_ATP" component_2="H_E1_ATP" />
<map_variables variable_1="H2_E1_ATP" variable_2="H2_E1_ATP" />
</connection>
<connection>
<map_components component_1="K2_E2_P" component_2="K_E2_P" />
<map_variables variable_1="K2_E2_P" variable_2="K2_E2_P" />
</connection>
<connection>
<map_components component_1="K2_E2" component_2="K2_E1" />
<map_variables variable_1="K2_E2" variable_2="K2_E2" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K_E2_P" />
<map_variables variable_1="k7b_" variable_2="k7b_" />
<map_variables variable_1="k7b" variable_2="k7b" />
<map_variables variable_1="k7a_" variable_2="k7a_" />
<map_variables variable_1="k7a" variable_2="k7a" />
<map_variables variable_1="K" variable_2="K" />
</connection>
<connection>
<map_components component_1="H2_E1_ATP" component_2="H2_E1_P" />
<map_variables variable_1="H2_E1_ATP" variable_2="H2_E1_ATP" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K2_E2_ATP" />
<map_variables variable_1="k11_" variable_2="k11_" />
<map_variables variable_1="ATP" variable_2="ATP" />
<map_variables variable_1="k10_" variable_2="k10_" />
<map_variables variable_1="k10" variable_2="k10" />
<map_variables variable_1="k11" variable_2="k11" />
</connection>
<connection>
<map_components component_1="environment" component_2="K2_E1" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="E1_ATP" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K2_E1_ATP" />
<map_variables variable_1="k1_" variable_2="k1_" />
<map_variables variable_1="k11_" variable_2="k11_" />
<map_variables variable_1="k2a_" variable_2="k2a_" />
<map_variables variable_1="ATP" variable_2="ATP" />
<map_variables variable_1="k2a" variable_2="k2a" />
<map_variables variable_1="k1" variable_2="k1" />
<map_variables variable_1="k11" variable_2="k11" />
<map_variables variable_1="K" variable_2="K" />
</connection>
<connection>
<map_components component_1="H2_E1_P" component_2="H2_E2_P" />
<map_variables variable_1="H2_E1_P" variable_2="H2_E1_P" />
</connection>
<connection>
<map_components component_1="E1_ATP" component_2="K_E1_ATP" />
<map_variables variable_1="E1_ATP" variable_2="E1_ATP" />
</connection>
<connection>
<map_components component_1="E1_ATP" component_2="H_E1_ATP" />
<map_variables variable_1="E1_ATP" variable_2="E1_ATP" />
</connection>
<connection>
<map_components component_1="K_E2_P" component_2="E2_P" />
<map_variables variable_1="K_E2_P" variable_2="K_E2_P" />
</connection>
<connection>
<map_components component_1="environment" component_2="K2_E2_ATP" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K_E1_ATP" component_2="K2_E1_ATP" />
<map_variables variable_1="K_E1_ATP" variable_2="K_E1_ATP" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K2_E2_P" />
<map_variables variable_1="k8_" variable_2="k8_" />
<map_variables variable_1="k8" variable_2="k8" />
<map_variables variable_1="k7b_" variable_2="k7b_" />
<map_variables variable_1="k7b" variable_2="k7b" />
<map_variables variable_1="P" variable_2="P" />
<map_variables variable_1="K" variable_2="K" />
</connection>
<connection>
<map_components component_1="H_E2_P" component_2="E2_P" />
<map_variables variable_1="H_E2_P" variable_2="H_E2_P" />
</connection>
<connection>
<map_components component_1="K2_E2" component_2="K2_E2_ATP" />
<map_variables variable_1="K2_E2" variable_2="K2_E2" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="H_E2_P" />
<map_variables variable_1="k6b" variable_2="k6b" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="k6b_" variable_2="k6b_" />
<map_variables variable_1="k6a" variable_2="k6a" />
<map_variables variable_1="k6a_" variable_2="k6a_" />
</connection>
<connection>
<map_components component_1="environment" component_2="K_E1_ATP" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="H2_E2_P" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K_E1_ATP" component_2="E1_ATP" />
<map_variables variable_1="K_E1_ATP" variable_2="K_E1_ATP" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="H2_E1_ATP" />
<map_variables variable_1="ADP" variable_2="ADP" />
<map_variables variable_1="k3b_" variable_2="k3b_" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="k4" variable_2="k4" />
<map_variables variable_1="k3b" variable_2="k3b" />
<map_variables variable_1="k4_" variable_2="k4_" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="H2_E1_P" />
<map_variables variable_1="ADP" variable_2="ADP" />
<map_variables variable_1="k5_" variable_2="k5_" />
<map_variables variable_1="k5" variable_2="k5" />
<map_variables variable_1="k4" variable_2="k4" />
<map_variables variable_1="k4_" variable_2="k4_" />
</connection>
<connection>
<map_components component_1="K2_E1" component_2="K2_E1_ATP" />
<map_variables variable_1="K2_E1" variable_2="K2_E1" />
</connection>
<connection>
<map_components component_1="K_E2_P" component_2="K2_E2_P" />
<map_variables variable_1="K_E2_P" variable_2="K_E2_P" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K_E1_ATP" />
<map_variables variable_1="k2b_" variable_2="k2b_" />
<map_variables variable_1="k2a_" variable_2="k2a_" />
<map_variables variable_1="k2b" variable_2="k2b" />
<map_variables variable_1="k2a" variable_2="k2a" />
<map_variables variable_1="K" variable_2="K" />
</connection>
<connection>
<map_components component_1="E2_P" component_2="K_E2_P" />
<map_variables variable_1="E2_P" variable_2="E2_P" />
</connection>
<connection>
<map_components component_1="K2_E1" component_2="K2_E2" />
<map_variables variable_1="K2_E1" variable_2="K2_E1" />
</connection>
<connection>
<map_components component_1="H2_E2_P" component_2="H2_E1_P" />
<map_variables variable_1="H2_E2_P" variable_2="H2_E2_P" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="H_E1_ATP" />
<map_variables variable_1="k3b_" variable_2="k3b_" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="k3b" variable_2="k3b" />
<map_variables variable_1="k3a" variable_2="k3a" />
<map_variables variable_1="k3a_" variable_2="k3a_" />
</connection>
<connection>
<map_components component_1="environment" component_2="H2_E1_P" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="H2_E1_ATP" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K2_E2_ATP" component_2="K2_E2" />
<map_variables variable_1="K2_E2_ATP" variable_2="K2_E2_ATP" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K2_E2" />
<map_variables variable_1="k9_" variable_2="k9_" />
<map_variables variable_1="k8_" variable_2="k8_" />
<map_variables variable_1="k8" variable_2="k8" />
<map_variables variable_1="ATP" variable_2="ATP" />
<map_variables variable_1="k10_" variable_2="k10_" />
<map_variables variable_1="k10" variable_2="k10" />
<map_variables variable_1="k9" variable_2="k9" />
<map_variables variable_1="P" variable_2="P" />
</connection>
<connection>
<map_components component_1="H_E2_P" component_2="H2_E2_P" />
<map_variables variable_1="H_E2_P" variable_2="H_E2_P" />
</connection>
<connection>
<map_components component_1="environment" component_2="K2_E1_ATP" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="K2_E1" />
<map_variables variable_1="k9_" variable_2="k9_" />
<map_variables variable_1="k1_" variable_2="k1_" />
<map_variables variable_1="ATP" variable_2="ATP" />
<map_variables variable_1="k1" variable_2="k1" />
<map_variables variable_1="k9" variable_2="k9" />
</connection>
<connection>
<map_components component_1="environment" component_2="H_E2_P" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="E1_ATP" />
<map_variables variable_1="k2b_" variable_2="k2b_" />
<map_variables variable_1="k2b" variable_2="k2b" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="K" variable_2="K" />
<map_variables variable_1="k3a" variable_2="k3a" />
<map_variables variable_1="k3a_" variable_2="k3a_" />
</connection>
<connection>
<map_components component_1="environment" component_2="K_E2_P" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="H_E1_ATP" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K2_E1_ATP" component_2="K2_E1" />
<map_variables variable_1="K2_E1_ATP" variable_2="K2_E1_ATP" />
</connection>
<connection>
<map_components component_1="E2_P" component_2="H_E2_P" />
<map_variables variable_1="E2_P" variable_2="E2_P" />
</connection>
<connection>
<map_components component_1="K2_E2" component_2="K2_E2_P" />
<map_variables variable_1="K2_E2" variable_2="K2_E2" />
</connection>
<connection>
<map_components component_1="environment" component_2="K2_E2_P" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K2_E2_ATP" component_2="K2_E1_ATP" />
<map_variables variable_1="K2_E2_ATP" variable_2="K2_E2_ATP" />
</connection>
<connection>
<map_components component_1="environment" component_2="E2_P" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="K2_E1_ATP" component_2="K2_E2_ATP" />
<map_variables variable_1="K2_E1_ATP" variable_2="K2_E1_ATP" />
</connection>
<rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#" xmlns:j.0="http://imc.org/vCard/3.0#">
<rdf:Description rdf:about="">
<dc:title>A mathematical model of the inner medullary collecting duct of the rat: acid/base transport (Renal H+/K+ ATPase Variant)</dc:title>
<dc:publisher>The University of Auckland, Bioengineering Institute</dc:publisher>
<cmeta:comment>
<rdf:Description rdf:about="rdf:#c5701989-734c-44fb-9a9a-a9329c43cd09">
<dc:creator>
<rdf:Description rdf:about="rdf:#311e4d45-57db-4383-9c4f-72750a39cbdd">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
</dc:creator>
<rdf:value>This CellML model represents only a small part of the model described in Weinstein et al.'s paper - namely, the H+ K+ ATPase pump</rdf:value>
</rdf:Description>
</cmeta:comment>
<dcterms:created rdf:resource="rdf:#1500fab7-6fd2-46fb-943d-ba6d6d60abbb" dcterms:W3CDTF="2007-05-25T00:00:00+00:00" />
<dc:creator>
<rdf:Description rdf:about="rdf:#3e7283b5-f1bc-4a08-bdff-e3debd03664d">
<vCard:ORG>
<rdf:Description rdf:about="rdf:#fe8d3f00-454d-47cb-94aa-e3f30fb5c8e8">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
</vCard:ORG>
<vCard:EMAIL rdf:resource="rdf:#bfec3d24-8fa3-476b-bcf7-fb8a3533c688" rdf:value="c.lloyd@auckland.ac.nz" rdf:type="http://imc.org/vCard/3.0#internet" />
<vCard:N rdf:resource="rdf:#55f3e14f-2c34-4820-a65a-dabcf14028a8" vCard:Given="Catherine" vCard:Family="Lloyd" vCard:Other="May" />
</rdf:Description>
</dc:creator>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#1020e132-994d-4578-b383-b24972a75e48">
<dcterms:modified rdf:resource="rdf:#f9932100-ae1e-4368-b98b-b4e62eec97da" dcterms:W3CDTF="2008-05-13T15:43:04+12:00" />
<rdf:value>Fixed documentation to show proper diagram.</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#2147935c-c415-4142-89bf-649c06b8e5f4">
<vCard:N rdf:resource="rdf:#afd461a5-9ba1-4992-852a-840cb57ecb39" vCard:Given="James" vCard:Family="Lawson" vCard:Other="Richard" />
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#686412fb-dbb7-43fb-a215-85af16e52550">
<dcterms:modified rdf:resource="rdf:#3facc7aa-1a7c-4fb9-938f-4362f8e49103" dcterms:W3CDTF="2008-05-09T14:28:04+12:00" />
<rdf:value>Fixed a minor connection error - units defined for connected variables made consistent.</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#95398056-9ab5-49c9-9f86-175c2630d032">
<vCard:N rdf:resource="rdf:#8be48139-6a99-4bca-9666-333ea3474262" vCard:Given="James" vCard:Family="Lawson" vCard:Other="Richard" />
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
<cmeta:modification>
<rdf:Description rdf:about="rdf:#7322e08b-7903-45a2-aefe-0697d4d8d3ea">
<dcterms:modified rdf:resource="rdf:#89a52636-941a-4ef6-80b9-d7f859cd105f" dcterms:W3CDTF="2007-06-05T09:30:31+12:00" />
<rdf:value>The new version of this model has been re-coded to remove the reaction element and replace it with a simple MathML description of the model reaction kinetics. This is thought to be truer to the original publication, and information regarding the enzyme kinetics etc will later be added to the metadata through use of an ontology.
For some reason I can't open this file in PCEnv - I'm not sure why. It may be something to do with the name of the file? This particular Weinstein publication has two models in it - a gastric and a renal one.</rdf:value>
<cmeta:modifier>
<rdf:Description rdf:about="rdf:#5c3a6043-c982-4ad5-b638-d0ac4d6ec5e0">
<vCard:N rdf:resource="rdf:#5d7bd9ab-b5b7-4882-aa64-6380dd9be145" vCard:Given="Catherine" vCard:Family="Lloyd" vCard:Other="May" />
</rdf:Description>
</cmeta:modifier>
</rdf:Description>
</cmeta:modification>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_4">
<ro:part_of>
<rdf:Description rdf:about="#entity_3">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_74550" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15378" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E2_P.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.ATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15422" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ATP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2_E2_P.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K2_E2_ATP.ATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ATP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2_E1_ATP.ADP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_5">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_16761" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ADP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.ADP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ADP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2_E1_ATP.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K2_E2_P.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#weinstein_1998_renal_H_K_ATPase_model" semsim:PubMedIDofReferencePublication="6496750" semsim:modelId="weinstein_1998_renal_H_K_ATPase_model" semsim:modelName="weinstein_1998_renal_H_K_ATPase_model" />
<rdf:Description rdf:about="#H_E1_ATP.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E1_ATP.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K2_E1.ATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ATP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E1_ATP.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K2_E1_ATP.ATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ATP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_E2_P.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H_E2_P.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of hydrogen in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2_E1_P.ADP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ADP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K2_E1_ATP.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#weinstein_1998_renal_H_K_ATPase_model" cmeta:species="Rat">
<dc:title>The 1998 Weinstein mathematical model of the renal H-K-ATPase.</dc:title>
<cmeta:bio_entity>Renal Medullary Cell</cmeta:bio_entity>
<cmeta:comment>
<rdf:Description rdf:about="rdf:#aebddf7e-88c0-45d0-b875-a56391de6460">
<dc:creator>
<rdf:Description rdf:about="rdf:#921d66c7-7386-41cf-acb2-23a5ff979903">
<vCard:FN>Catherine Lloyd</vCard:FN>
</rdf:Description>
</dc:creator>
<rdf:value>This is the CellML description of Weinstein's 1998 mathematical model of the renal H-K-ATPase in rats.</rdf:value>
</rdf:Description>
</cmeta:comment>
<bqs:reference>
<rdf:Description rdf:about="rdf:#a865ad48-59c3-49f5-800c-7e11b4508f95" bqs:Pubmed_id="9612322">
<bqs:JournalArticle>
<rdf:Description rdf:about="rdf:#3ffd19e0-9bfa-4694-a8e4-190e410a02a1" bqs:volume="274" bqs:first_page="F856" bqs:last_page="F867">
<dc:creator>
<rdf:Seq rdf:about="rdf:#d9f541c8-a0de-4e25-89d9-de145f08381e">
<rdf:li>
<bqs:Person rdf:about="rdf:#b66ec299-f2d2-412a-b1f3-e23bc958de00">
<vCard:N rdf:resource="rdf:#badce4de-bbf5-4905-a1ee-e61f237d6630" vCard:Given="Alan" vCard:Family="Weinstein" vCard:Other="M" />
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>A mathematical model of the inner medullary collecting duct of the 
rat: acid/base transport</dc:title>
<bqs:Journal>
<rdf:Description rdf:about="rdf:#c1d48d2b-7297-4bed-a707-cd74355881f4">
<dc:title>Journal of Physiology</dc:title>
</rdf:Description>
</bqs:Journal>
<dcterms:issued rdf:resource="rdf:#802f90fc-9d11-4d28-83dc-4801497a04ae" dcterms:W3CDTF="1998-05" />
</rdf:Description>
</bqs:JournalArticle>
</rdf:Description>
</bqs:reference>
<bqs:reference>
<rdf:Description rdf:about="rdf:#c4c40ace-ab16-432d-9526-f1b1cab77aa0">
<dc:subject>
<rdf:Description rdf:about="rdf:#cf05e99a-ee9b-4a22-923a-561b3f4177ad" bqs:subject_type="keyword">
<rdf:value>
<rdf:Bag rdf:about="rdf:#9936f30b-e0e9-4d99-94fa-5bb550cd222e">
<rdf:li>acid-base transport</rdf:li>
<rdf:li>renal</rdf:li>
<rdf:li>electrophysiology</rdf:li>
<rdf:li>collecting duct</rdf:li>
<rdf:li>rat</rdf:li>
<rdf:li>kidney</rdf:li>
</rdf:Bag>
</rdf:value>
</rdf:Description>
</dc:subject>
</rdf:Description>
</bqs:reference>
</rdf:Description>
<rdf:Description rdf:about="#E2_P.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K2_E2.ATP">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of ATP in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_E1_ATP.K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the luminal compartment</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
