- Author:
- Enrico Ravagli <ravae88@gmail.com>
- Date:
- 2013-06-03 15:40:40+02:00
- Desc:
-
- Permanent Source URI:
- http://models.cellml.org/workspace/593/rawfile/c21ed1c9aa81e4426124cd605b217d7a40562d16/paci_hyttinen_aaltosetala_severi_ventricularVersion.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 03/06/2013 at 15:12:46 using:
COR (0.9.31.1409)
Copyright 2002-2013 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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<ci>time</ci>
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<ci>h</ci>
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<divide/>
<apply>
<minus/>
<ci>h_inf</ci>
<ci>h</ci>
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<ci>tau_h</ci>
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<variable name="alpha_j" units="dimensionless"/>
<variable name="beta_j" units="dimensionless"/>
<variable name="tau_j" units="second"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>j_inf</ci>
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<root/>
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<times/>
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<cn cellml:units="millivolt">72.1</cn>
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<cn cellml:units="millivolt">5.7</cn>
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</apply>
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<apply>
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<ci>alpha_j</ci>
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<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">25428</cn>
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<apply>
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<times/>
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<ci>Vm</ci>
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</apply>
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<apply>
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<cn cellml:units="per_millivolt">6.948</cn>
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<exp/>
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<times/>
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<ci>Vm</ci>
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</apply>
</apply>
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<plus/>
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<times/>
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<cn cellml:units="millivolt">37.78</cn>
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<cn cellml:units="millivolt">79.23</cn>
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</apply>
</apply>
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<apply>
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<ci>beta_j</ci>
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<piece>
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<divide/>
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<cn cellml:units="dimensionless">0.02424</cn>
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<exp/>
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<apply>
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<ci>Vm</ci>
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<times/>
<apply>
<minus/>
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<plus/>
<apply>
<times/>
<ci>Vm</ci>
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<cn cellml:units="millivolt">40.14</cn>
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</apply>
</apply>
</apply>
</apply>
<apply>
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<ci>Vm</ci>
<apply>
<minus/>
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</apply>
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<divide/>
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<times/>
<cn cellml:units="dimensionless">0.6</cn>
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<exp/>
<apply>
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<cn cellml:units="per_millivolt">0.057</cn>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
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<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
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<cn cellml:units="millivolt">32</cn>
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</apply>
</apply>
</apply>
</apply>
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<apply>
<eq/>
<ci>tau_j</ci>
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<divide/>
<cn cellml:units="second">7</cn>
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<times/>
<apply>
<plus/>
<ci>alpha_j</ci>
<ci>beta_j</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
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</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>j</ci>
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<divide/>
<apply>
<minus/>
<ci>j_inf</ci>
<ci>j</ci>
</apply>
<ci>tau_j</ci>
</apply>
</apply>
</math>
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<variable name="i_CaL" units="A_per_F" public_interface="out"/>
<variable name="g_CaL" units="metre_cube_per_F_per_s" initial_value="8.635702e-5"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm" units="volt" public_interface="in" private_interface="out"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Cao" units="millimolar" public_interface="in" private_interface="out"/>
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<variable name="f1" units="dimensionless" private_interface="in"/>
<variable name="f2" units="dimensionless" private_interface="in"/>
<variable name="fCa" units="dimensionless" private_interface="in"/>
<variable name="nifed_3nM" units="dimensionless" public_interface="in"/>
<variable name="nifed_10nM" units="dimensionless" public_interface="in"/>
<variable name="nifed_30nM" units="dimensionless" public_interface="in"/>
<variable name="nifed_100nM" units="dimensionless" public_interface="in"/>
<variable name="nifed_coeff" units="dimensionless"/>
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<apply>
<eq/>
<ci>nifed_coeff</ci>
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<piece>
<cn cellml:units="dimensionless">0.93</cn>
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<eq/>
<ci>nifed_3nM</ci>
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<ci>nifed_10nM</ci>
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<eq/>
<ci>nifed_30nM</ci>
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<eq/>
<ci>nifed_100nM</ci>
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<apply>
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<ci>i_CaL</ci>
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<times/>
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<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_CaL</ci>
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<power/>
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<apply>
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<ci>R</ci>
<ci>T</ci>
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<apply>
<minus/>
<apply>
<times/>
<ci>Cai</ci>
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<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vm</ci>
<ci>F</ci>
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<times/>
<ci>R</ci>
<ci>T</ci>
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</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.341</cn>
<ci>Cao</ci>
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</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vm</ci>
<ci>F</ci>
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<times/>
<ci>R</ci>
<ci>T</ci>
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<cn cellml:units="dimensionless">1</cn>
</apply>
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<ci>d</ci>
<ci>f1</ci>
<ci>f2</ci>
<ci>fCa</ci>
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</apply>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
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<cn cellml:units="millivolt">9.1</cn>
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<cn cellml:units="millivolt">7</cn>
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<apply>
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<ci>alpha_d</ci>
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<apply>
<minus/>
<ci>Vm</ci>
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</apply>
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<apply>
<eq/>
<ci>beta_d</ci>
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<ci>Vm</ci>
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<cn cellml:units="millivolt">5</cn>
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<cn cellml:units="millivolt">5</cn>
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<apply>
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<ci>gamma_d</ci>
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<apply>
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<apply>
<plus/>
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<times/>
<apply>
<minus/>
<ci>Vm</ci>
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<cn cellml:units="millivolt_per_volt">1000</cn>
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<cn cellml:units="millivolt">50</cn>
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<cn cellml:units="millivolt">20</cn>
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</apply>
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</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_d</ci>
<ci>beta_d</ci>
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<ci>gamma_d</ci>
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<cn cellml:units="second">1</cn>
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<apply>
<eq/>
<apply>
<diff/>
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<ci>d</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>d_infinity</ci>
<ci>d</ci>
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<ci>tau_d</ci>
</apply>
</apply>
</math>
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<variable name="constf1" units="dimensionless"/>
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<variable name="Cai" units="millimolar" public_interface="in"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide/>
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<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
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</apply>
<cn cellml:units="millivolt">26</cn>
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<cn cellml:units="millivolt">3</cn>
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</apply>
</apply>
</apply>
</apply>
<apply>
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<ci>tau_f1</ci>
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<times/>
<apply>
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<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
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<cn cellml:units="millivolt">27</cn>
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<cn cellml:units="dimensionless">2</cn>
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</apply>
</apply>
<apply>
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<plus/>
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<apply>
<divide/>
<apply>
<minus/>
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<times/>
<ci>Vm</ci>
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</apply>
<cn cellml:units="millivolt">10</cn>
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<apply>
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<cn cellml:units="millivolt">10</cn>
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<ci>constf1</ci>
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<ci>constf1</ci>
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<piece>
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<times/>
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<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
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<apply>
<gt/>
<apply>
<minus/>
<ci>f1_inf</ci>
<ci>f1</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>f1</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>f1_inf</ci>
<ci>f1</ci>
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<ci>tau_f1</ci>
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</apply>
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<variable name="constf2" units="dimensionless"/>
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<cn cellml:units="millivolt">4</cn>
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<apply>
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<apply>
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<ci>tau_f2</ci>
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<times/>
<apply>
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<apply>
<minus/>
<apply>
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<plus/>
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<times/>
<ci>Vm</ci>
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</apply>
<cn cellml:units="millivolt">25</cn>
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<cn cellml:units="dimensionless">2</cn>
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</apply>
<cn cellml:units="millivolt_square">170</cn>
</apply>
</apply>
</apply>
<apply>
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<plus/>
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<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
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<apply>
<times/>
<ci>Vm</ci>
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</apply>
</apply>
<cn cellml:units="millivolt">10</cn>
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<apply>
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<plus/>
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<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
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<apply>
<times/>
<ci>Vm</ci>
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</apply>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>constf2</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>f2</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>f2_inf</ci>
<ci>f2</ci>
</apply>
<ci>tau_f2</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_CaL_fCa_gate">
<variable name="fCa" units="dimensionless" initial_value="0.998925296531804" public_interface="out"/>
<variable name="constfCa" units="dimensionless"/>
<variable name="alpha_fCa" units="dimensionless"/>
<variable name="beta_fCa" units="dimensionless"/>
<variable name="gamma_fCa" units="dimensionless"/>
<variable name="fCa_inf" units="dimensionless"/>
<variable name="tau_fCa" units="second" initial_value="0.002"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_fCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.0006</cn>
</apply>
<cn cellml:units="dimensionless">8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_fCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.0009</cn>
</apply>
<cn cellml:units="millimolar">0.0001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma_fCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.3</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.00075</cn>
</apply>
<cn cellml:units="millimolar">0.0008</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fCa_inf</ci>
<apply>
<divide/>
<apply>
<plus/>
<ci>alpha_fCa</ci>
<ci>beta_fCa</ci>
<ci>gamma_fCa</ci>
</apply>
<cn cellml:units="dimensionless">1.3156</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>constfCa</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>Vm</ci>
<apply>
<minus/>
<cn cellml:units="volt">0.06</cn>
</apply>
</apply>
<apply>
<gt/>
<ci>fCa_inf</ci>
<ci>fCa</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCa</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>constfCa</ci>
<apply>
<minus/>
<ci>fCa_inf</ci>
<ci>fCa</ci>
</apply>
</apply>
<ci>tau_fCa</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_Kr">
<variable name="i_Kr" units="A_per_F" public_interface="out"/>
<variable name="g_Kr" units="S_per_F" initial_value="29.8667"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm" units="volt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="volt" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Xr1" units="dimensionless" private_interface="in"/>
<variable name="Xr2" units="dimensionless" private_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in" private_interface="out"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in" private_interface="out"/>
<variable name="E4031_30nM" units="dimensionless" public_interface="in"/>
<variable name="E4031_100nM" units="dimensionless" public_interface="in"/>
<variable name="E4031_coeff" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E4031_coeff</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0.77</cn>
<apply>
<eq/>
<ci>E4031_30nM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<eq/>
<ci>E4031_100nM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>E4031_coeff</ci>
<ci>g_Kr</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<ci>Xr1</ci>
<ci>Xr2</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_Kr_Xr1_gate">
<variable name="Xr1" units="dimensionless" initial_value="0.00778547011240132" public_interface="out"/>
<variable name="Xr1_inf" units="dimensionless"/>
<variable name="alpha_Xr1" units="dimensionless"/>
<variable name="beta_Xr1" units="dimensionless"/>
<variable name="tau_Xr1" units="second"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="L0" units="dimensionless" initial_value="0.025"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="V_half" units="millivolt"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Q" units="dimensionless" initial_value="2.3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_half</ci>
<apply>
<times/>
<cn cellml:units="millivolt_per_volt">1000</cn>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>R</ci>
</apply>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>F</ci>
<ci>Q</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cao</ci>
<cn cellml:units="millimolar">2.6</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<times/>
<ci>L0</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cao</ci>
<cn cellml:units="millimolar">0.58</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="volt">0.019</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Xr1_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V_half</ci>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">4.9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Xr1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">450</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">45</cn>
</apply>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Xr1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="millivolt">30</cn>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">11.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xr1</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="second">1</cn>
<ci>alpha_Xr1</ci>
<ci>beta_Xr1</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xr1</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xr1_inf</ci>
<ci>Xr1</ci>
</apply>
<ci>tau_Xr1</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_Kr_Xr2_gate">
<variable name="Xr2" units="dimensionless" initial_value="0.432162576531617" public_interface="out"/>
<variable name="Xr2_infinity" units="dimensionless"/>
<variable name="alpha_Xr2" units="dimensionless"/>
<variable name="beta_Xr2" units="dimensionless"/>
<variable name="tau_Xr2" units="second"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Xr2_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">88</cn>
</apply>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Xr2</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">3</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Xr2</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.12</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xr2</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="second">1</cn>
<ci>alpha_Xr2</ci>
<ci>beta_Xr2</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xr2</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xr2_infinity</ci>
<ci>Xr2</ci>
</apply>
<ci>tau_Xr2</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_Ks">
<variable name="i_Ks" units="A_per_F" public_interface="out"/>
<variable name="g_Ks" units="S_per_F" initial_value="2.041"/>
<variable name="E_Ks" units="volt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm" units="volt" public_interface="in" private_interface="out"/>
<variable name="Xs" units="dimensionless" private_interface="in"/>
<variable name="Chromanol_iKs30" units="dimensionless" public_interface="in"/>
<variable name="Chromanol_iKs50" units="dimensionless" public_interface="in"/>
<variable name="Chromanol_iKs70" units="dimensionless" public_interface="in"/>
<variable name="Chromanol_iKs90" units="dimensionless" public_interface="in"/>
<variable name="Chromanol_coeff" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Chromanol_coeff</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0.7</cn>
<apply>
<eq/>
<ci>Chromanol_iKs30</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<eq/>
<ci>Chromanol_iKs50</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.3</cn>
<apply>
<eq/>
<ci>Chromanol_iKs70</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<piece>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<eq/>
<ci>Chromanol_iKs90</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>Chromanol_coeff</ci>
<ci>g_Ks</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ks</ci>
</apply>
<apply>
<power/>
<ci>Xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millimolar">3.8</cn>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">1.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_Ks_Xs_gate">
<variable name="Xs" units="dimensionless" initial_value="0.0322944866983666" public_interface="out"/>
<variable name="Xs_infinity" units="dimensionless"/>
<variable name="alpha_Xs" units="dimensionless"/>
<variable name="beta_Xs" units="dimensionless"/>
<variable name="tau_Xs" units="second"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Xs_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>Vm</ci>
</apply>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="millivolt">16</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Xs</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1100</cn>
<apply>
<root/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="millivolt">10</cn>
</apply>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Xs</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="millivolt">60</cn>
</apply>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xs</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="second">1</cn>
<ci>alpha_Xs</ci>
<ci>beta_Xs</ci>
</apply>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xs_infinity</ci>
<ci>Xs</ci>
</apply>
<ci>tau_Xs</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_K1">
<variable name="i_K1" units="A_per_F" public_interface="out"/>
<variable name="g_K1" units="S_per_F" initial_value="28.1492"/>
<variable name="XK1_inf" units="dimensionless"/>
<variable name="E_K" units="volt" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm" units="volt" public_interface="in" private_interface="out"/>
<variable name="alpha_K1" units="dimensionless"/>
<variable name="beta_K1" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_K1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">3.91</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.5942</cn>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<apply>
<times/>
<ci>E_K</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">200</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_K1</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.509</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0002</cn>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<apply>
<times/>
<ci>E_K</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">100</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.5886</cn>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<apply>
<times/>
<ci>E_K</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.4547</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<apply>
<times/>
<ci>E_K</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>XK1_inf</ci>
<apply>
<divide/>
<ci>alpha_K1</ci>
<apply>
<plus/>
<ci>alpha_K1</ci>
<ci>beta_K1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>g_K1</ci>
<ci>XK1_inf</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
</apply>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
</math>
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<variable name="i_f" units="A_per_F" public_interface="out"/>
<variable name="g_f" units="S_per_F" initial_value="30.10312"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="E_f" units="volt" initial_value="-0.017"/>
<variable name="Vm" units="volt" public_interface="in" private_interface="out"/>
<variable name="Xf" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>Xf</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_f</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_f_Xf_gate">
<variable name="Xf" units="dimensionless" initial_value="0.100615100568753" public_interface="out"/>
<variable name="Xf_infinity" units="dimensionless"/>
<variable name="tau_Xf" units="second"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Xf_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">77.85</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xf</ci>
<apply>
<divide/>
<apply>
<divide/>
<cn cellml:units="second">1900</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1000</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xf</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>Xf_infinity</ci>
<ci>Xf</ci>
</apply>
<ci>tau_Xf</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_b_Na">
<variable name="i_b_Na" units="A_per_F" public_interface="out"/>
<variable name="g_b_Na" units="S_per_F" initial_value="0.9"/>
<variable name="E_Na" units="volt" public_interface="in"/>
<variable name="Vm" units="volt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Na</ci>
<apply>
<times/>
<ci>g_b_Na</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_b_Ca">
<variable name="i_b_Ca" units="A_per_F" public_interface="out"/>
<variable name="g_b_Ca" units="S_per_F" initial_value="0.69264"/>
<variable name="E_Ca" units="volt" public_interface="in"/>
<variable name="Vm" units="volt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_b_Ca</ci>
<apply>
<times/>
<ci>g_b_Ca</ci>
<apply>
<minus/>
<ci>Vm</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaK">
<variable name="i_NaK" units="A_per_F" public_interface="out"/>
<variable name="E_Na" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Km_K" units="millimolar" initial_value="1"/>
<variable name="Km_Na" units="millimolar" initial_value="40"/>
<variable name="PNaK" units="A_per_F" initial_value="1.841424"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>PNaK</ci>
<ci>Ko</ci>
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<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_K</ci>
</apply>
</apply>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<ci>Nai</ci>
<ci>Km_Na</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
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<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
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<ci>Vm</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
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<apply>
<times/>
<cn cellml:units="dimensionless">0.0353</cn>
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<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Vm</ci>
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<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
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</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaCa">
<variable name="i_NaCa" units="A_per_F" public_interface="out"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="kNaCa" units="A_per_F" initial_value="4900"/>
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<variable name="KmCa" units="millimolar" initial_value="1.38"/>
<variable name="KmNai" units="millimolar" initial_value="87.5"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kNaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
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<ci>F</ci>
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<times/>
<ci>R</ci>
<ci>T</ci>
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<apply>
<power/>
<ci>Nai</ci>
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<ci>Cao</ci>
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<times/>
<apply>
<exp/>
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<divide/>
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<times/>
<apply>
<minus/>
<ci>gamma</ci>
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<ci>Vm</ci>
<ci>F</ci>
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<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
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<apply>
<power/>
<ci>Nao</ci>
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<ci>Cai</ci>
<ci>alpha</ci>
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<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>KmNai</ci>
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<apply>
<power/>
<ci>Nao</ci>
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<apply>
<plus/>
<ci>KmCa</ci>
<ci>Cao</ci>
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<plus/>
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<times/>
<ci>Ksat</ci>
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<exp/>
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<divide/>
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<times/>
<apply>
<minus/>
<ci>gamma</ci>
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<ci>Vm</ci>
<ci>F</ci>
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<times/>
<ci>R</ci>
<ci>T</ci>
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</apply>
</apply>
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</apply>
</apply>
</math>
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<variable name="i_PCa" units="A_per_F" public_interface="out"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
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<variable name="g_PCa" units="A_per_F" initial_value="0.4125"/>
<variable name="KPCa" units="millimolar" initial_value="0.0005"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_PCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_PCa</ci>
<ci>Cai</ci>
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<apply>
<plus/>
<ci>Cai</ci>
<ci>KPCa</ci>
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</math>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_to">
<variable name="i_to" units="A_per_F" public_interface="out"/>
<variable name="g_to" units="S_per_F" initial_value="29.9038"/>
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<variable name="r" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>i_to</ci>
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<times/>
<ci>g_to</ci>
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<minus/>
<ci>Vm</ci>
<ci>E_K</ci>
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<ci>q</ci>
<ci>r</ci>
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<variable name="q" units="dimensionless" initial_value="0.839295925773219" public_interface="out"/>
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<variable name="time" units="second" public_interface="in"/>
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<eq/>
<ci>q_inf</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
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<cn cellml:units="millivolt">53</cn>
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<cn cellml:units="millivolt">13</cn>
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</apply>
<apply>
<eq/>
<ci>tau_q</ci>
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<divide/>
<apply>
<plus/>
<cn cellml:units="second">6.06</cn>
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<divide/>
<cn cellml:units="second">39.102</cn>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.57</cn>
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<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.08</cn>
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<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">44</cn>
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</apply>
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<apply>
<times/>
<cn cellml:units="dimensionless">0.065</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.1</cn>
<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">45.93</cn>
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</apply>
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</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1000</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>q</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>q_inf</ci>
<ci>q</ci>
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<ci>tau_q</ci>
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</apply>
</math>
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<variable name="tau_r" units="second"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
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<cn cellml:units="millivolt">22.3</cn>
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</apply>
<cn cellml:units="millivolt">18.75</cn>
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<apply>
<eq/>
<ci>tau_r</ci>
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<divide/>
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<plus/>
<cn cellml:units="second">2.75352</cn>
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<divide/>
<cn cellml:units="second">14.40516</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.037</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.09</cn>
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<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
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<cn cellml:units="millivolt">30.61</cn>
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</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.369</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.12</cn>
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<apply>
<plus/>
<apply>
<times/>
<ci>Vm</ci>
<cn cellml:units="millivolt_per_volt">1000</cn>
</apply>
<cn cellml:units="millivolt">23.84</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1000</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>r</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>r_inf</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
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</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="model_parameters">
<variable name="Cao" units="millimolar" initial_value="1.8" public_interface="out"/>
<variable name="Nao" units="millimolar" initial_value="151" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="150" public_interface="out"/>
<variable name="Ko" units="millimolar" initial_value="5.4" public_interface="out"/>
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<variable name="Vc" units="micrometre_cube" initial_value="8800" public_interface="out"/>
<variable name="V_SR" units="micrometre_cube" initial_value="583.73" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" initial_value="8.314472" public_interface="out"/>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="sodium_dynamics">
<variable name="Nai" units="millimolar" initial_value="10.9248496211574" public_interface="out"/>
<variable name="Cm" units="farad" public_interface="in"/>
<variable name="Vc" units="micrometre_cube" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
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<variable name="i_b_Na" units="A_per_F" public_interface="in"/>
<variable name="i_NaK" units="A_per_F" public_interface="in"/>
<variable name="i_NaCa" units="A_per_F" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
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<plus/>
<ci>i_Na</ci>
<ci>i_b_Na</ci>
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<times/>
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<ci>i_NaK</ci>
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<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
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<apply>
<times/>
<ci>F</ci>
<ci>Vc</ci>
<cn type="e-notation" cellml:units="metre3_per_um3">1 <sep/>
-18</cn>
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</apply>
</apply>
</math>
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<component xmlns="http://www.cellml.org/cellml/1.0#" name="calcium_dynamics">
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<variable name="Vc" units="micrometre_cube" public_interface="in"/>
<variable name="V_SR" units="micrometre_cube" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Vm" units="volt" public_interface="in"/>
<variable name="Cm" units="farad" public_interface="in"/>
<variable name="i_CaL" units="A_per_F" public_interface="in"/>
<variable name="i_PCa" units="A_per_F" public_interface="in"/>
<variable name="i_b_Ca" units="A_per_F" public_interface="in"/>
<variable name="i_NaCa" units="A_per_F" public_interface="in"/>
<variable name="a_rel" units="millimolar_per_second" initial_value="16.464"/>
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<variable name="tau_g" units="second" initial_value="0.002"/>
<variable name="g_inf" units="dimensionless"/>
<variable name="Kup" units="millimolar" initial_value="0.00025"/>
<variable name="Buf_C" units="millimolar" initial_value="0.25"/>
<variable name="Buf_SR" units="millimolar" initial_value="10"/>
<variable name="Kbuf_C" units="millimolar" initial_value="0.001"/>
<variable name="Kbuf_SR" units="millimolar" initial_value="0.3"/>
<variable name="Cai_bufc" units="dimensionless"/>
<variable name="Ca_SR_bufSR" units="dimensionless"/>
<variable name="d" units="dimensionless" public_interface="in"/>
<variable name="VmaxUp" units="millimolar_per_second" initial_value="0.56064"/>
<variable name="const2" units="dimensionless"/>
<variable name="V_leak" units="per_second" initial_value="0.00044444"/>
<variable name="i_rel" units="millimolar_per_second"/>
<variable name="i_up" units="millimolar_per_second"/>
<variable name="i_leak" units="millimolar_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_rel</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>c_rel</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>a_rel</ci>
<apply>
<power/>
<ci>Ca_SR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>b_rel</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Ca_SR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<ci>d</ci>
<ci>g</ci>
<cn cellml:units="dimensionless">0.0411</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_up</ci>
<apply>
<divide/>
<ci>VmaxUp</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>Kup</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_leak</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Cai</ci>
</apply>
<ci>V_leak</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>g_inf</ci>
<piecewise>
<piece>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</apply>
<apply>
<leq/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<cn cellml:units="millimolar">0.00035</cn>
</apply>
<cn cellml:units="dimensionless">16</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>const2</ci>
<piecewise>
<piece>
<cn cellml:units="dimensionless">0</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>g_inf</ci>
<ci>g</ci>
</apply>
<apply>
<gt/>
<ci>Vm</ci>
<apply>
<minus/>
<cn cellml:units="volt">0.06</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">1</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>g</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>const2</ci>
<apply>
<minus/>
<ci>g_inf</ci>
<ci>g</ci>
</apply>
</apply>
<ci>tau_g</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Cai_bufc</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>Buf_C</ci>
<ci>Kbuf_C</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>Kbuf_C</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ca_SR_bufSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>Buf_SR</ci>
<ci>Kbuf_SR</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Ca_SR</ci>
<ci>Kbuf_SR</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>Cai_bufc</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_leak</ci>
<ci>i_up</ci>
</apply>
<ci>i_rel</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaL</ci>
<ci>i_b_Ca</ci>
<ci>i_PCa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vc</ci>
<ci>F</ci>
<cn type="e-notation" cellml:units="metre3_per_um3">1 <sep/>
-18</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_SR_bufSR</ci>
<ci>Vc</ci>
</apply>
<ci>V_SR</ci>
</apply>
<apply>
<minus/>
<ci>i_up</ci>
<apply>
<plus/>
<ci>i_rel</ci>
<ci>i_leak</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
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<relationship_ref relationship="containment"/>
<component_ref component="Membrane">
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<component_ref component="sodium_dynamics"/>
<component_ref component="model_parameters"/>
<component_ref component="electric_potentials"/>
<component_ref component="i_b_Ca"/>
<component_ref component="i_b_Na"/>
<component_ref component="i_NaK"/>
<component_ref component="i_NaCa"/>
<component_ref component="i_PCa"/>
<component_ref component="i_K1"/>
<component_ref component="stim_mode"/>
<component_ref component="current_blockers"/>
<component_ref component="i_Na">
<component_ref component="i_Na_m_gate"/>
<component_ref component="i_Na_h_gate"/>
<component_ref component="i_Na_j_gate"/>
</component_ref>
<component_ref component="i_CaL">
<component_ref component="i_CaL_d_gate"/>
<component_ref component="i_CaL_f1_gate"/>
<component_ref component="i_CaL_f2_gate"/>
<component_ref component="i_CaL_fCa_gate"/>
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<component_ref component="i_Kr_Xr1_gate"/>
<component_ref component="i_Kr_Xr2_gate"/>
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<component_ref component="i_Ks">
<component_ref component="i_Ks_Xs_gate"/>
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<component_ref component="i_to_q_gate"/>
<component_ref component="i_to_r_gate"/>
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<component_ref component="i_f">
<component_ref component="i_f_Xf_gate"/>
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<component_ref component="i_Na_h_gate"/>
<component_ref component="i_Na_j_gate"/>
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<component_ref component="i_CaL">
<component_ref component="i_CaL_d_gate"/>
<component_ref component="i_CaL_f1_gate"/>
<component_ref component="i_CaL_f2_gate"/>
<component_ref component="i_CaL_fCa_gate"/>
</component_ref>
<component_ref component="i_Kr">
<component_ref component="i_Kr_Xr1_gate"/>
<component_ref component="i_Kr_Xr2_gate"/>
</component_ref>
<component_ref component="i_Ks">
<component_ref component="i_Ks_Xs_gate"/>
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<component_ref component="i_to">
<component_ref component="i_to_q_gate"/>
<component_ref component="i_to_r_gate"/>
</component_ref>
<component_ref component="i_f">
<component_ref component="i_f_Xf_gate"/>
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<map_variables variable_1="nifed_30nM" variable_2="nifed_30nM"/>
<map_variables variable_1="nifed_100nM" variable_2="nifed_100nM"/>
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<map_variables variable_1="Chromanol_iKs50" variable_2="Chromanol_iKs50"/>
<map_variables variable_1="Chromanol_iKs70" variable_2="Chromanol_iKs70"/>
<map_variables variable_1="Chromanol_iKs90" variable_2="Chromanol_iKs90"/>
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<map_variables variable_1="Ki" variable_2="Ki"/>
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<connection xmlns="http://www.cellml.org/cellml/1.0#">
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<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
<map_variables variable_1="V_SR" variable_2="V_SR"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_dynamics" component_2="model_parameters"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Vc" variable_2="Vc"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_dynamics" component_2="i_Na"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_dynamics" component_2="i_NaK"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_dynamics" component_2="i_NaCa"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="calcium_dynamics" component_2="Membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="calcium_dynamics" component_2="electric_potentials"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="sodium_dynamics" component_2="electric_potentials"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Na" component_2="i_Na_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Na" component_2="i_Na_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Na" component_2="i_Na_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_CaL" component_2="i_CaL_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_CaL" component_2="i_CaL_fCa_gate"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="fCa" variable_2="fCa"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_CaL" component_2="i_CaL_f1_gate"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="f1" variable_2="f1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_CaL" component_2="i_CaL_f2_gate"/>
<map_variables variable_1="f2" variable_2="f2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_CaL" component_2="model_parameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Kr" component_2="model_parameters"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_K1" component_2="model_parameters"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Kr" component_2="i_Kr_Xr1_gate"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Xr1" variable_2="Xr1"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Kr" component_2="i_Kr_Xr2_gate"/>
<map_variables variable_1="Xr2" variable_2="Xr2"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_Ks" component_2="i_Ks_Xs_gate"/>
<map_variables variable_1="Xs" variable_2="Xs"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_to" component_2="i_to_q_gate"/>
<map_variables variable_1="q" variable_2="q"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_to" component_2="i_to_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_f" component_2="i_f_Xf_gate"/>
<map_variables variable_1="Xf" variable_2="Xf"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
</model>
