- Author:
- Michael Clerx <michael.clerx@cs.ox.ac.uk>
- Date:
- 2020-12-01 19:40:08+00:00
- Desc:
- Adding model file
- Permanent Source URI:
- http://models.cellml.org/workspace/630/rawfile/dbf305e925d3f801fc2e71fccd8177dbb21fcc7f/koivumaki-2011-pmr.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="koivumaki_2011"
xmlns="http://www.cellml.org/cellml/1.0#"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:cellml="http://www.cellml.org/cellml/1.0#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
cmeta:id="koivumaki_2011">
<units name="C_per_mol">
<unit units="second"/>
<unit units="ampere"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="dimensionless_times_1e6">
<unit units="dimensionless" multiplier="1000000"/>
</units>
<units name="kat_times_1e_minus_12">
<unit units="second" exponent="-1" multiplier="1e-12"/>
<unit units="mole"/>
</units>
<units name="m12_A_per_mol4_times_1e_minus_12">
<unit units="metre" exponent="12" multiplier="1e-12"/>
<unit units="ampere"/>
<unit units="mole" exponent="-4"/>
</units>
<units name="m12_per_mol4">
<unit units="metre" exponent="12"/>
<unit units="mole" exponent="-4"/>
</units>
<units name="m2_per_s_times_1e_minus_12">
<unit units="metre" exponent="2" multiplier="1e-12"/>
<unit units="second" exponent="-1"/>
</units>
<units name="m3_per_mol">
<unit units="metre" exponent="3"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="m3_per_s_times_1e_minus_12">
<unit units="metre" exponent="3" multiplier="1e-12"/>
<unit units="second" exponent="-1"/>
</units>
<units name="m6_per_s_per_mol2">
<unit units="metre" exponent="6"/>
<unit units="second" exponent="-1"/>
<unit units="mole" exponent="-2"/>
</units>
<units name="mJ_per_mol_per_K">
<unit units="gram"/>
<unit units="metre" exponent="2"/>
<unit units="second" exponent="-2"/>
<unit units="kelvin" exponent="-1"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="mM">
<unit units="metre" exponent="-3"/>
<unit units="mole"/>
</units>
<units name="mV">
<unit units="gram"/>
<unit units="metre" exponent="2"/>
<unit units="second" exponent="-3"/>
<unit units="ampere" exponent="-1"/>
</units>
<units name="nF">
<unit units="gram" exponent="-1" multiplier="1e-12"/>
<unit units="metre" exponent="-2"/>
<unit units="second" exponent="4"/>
<unit units="ampere" exponent="2"/>
</units>
<units name="nL">
<unit units="metre" exponent="3" multiplier="1e-12"/>
</units>
<units name="nS">
<unit units="gram" exponent="-1" multiplier="1e-12"/>
<unit units="metre" exponent="-2"/>
<unit units="second" exponent="3"/>
<unit units="ampere" exponent="2"/>
</units>
<units name="pA">
<unit units="ampere" multiplier="1e-12"/>
</units>
<units name="per_mV">
<unit units="gram" exponent="-1"/>
<unit units="metre" exponent="-2"/>
<unit units="second" exponent="3"/>
<unit units="ampere"/>
</units>
<units name="um">
<unit units="metre" multiplier="1e-06"/>
</units>
<units name="um2">
<unit units="metre" exponent="2" multiplier="1e-12"/>
</units>
<component name="calcium">
<variable name="Aj_nj" units="um2" public_interface="in"/>
<variable name="BCa" units="mM" initial_value="0.024"/>
<variable name="CSQN" units="mM" initial_value="6.7"/>
<variable name="CaSR1" units="mM" public_interface="out" initial_value="0.6189225"/>
<variable name="CaSR2" units="mM" public_interface="out" initial_value="0.6076289"/>
<variable name="CaSR3" units="mM" public_interface="out" initial_value="0.5905266"/>
<variable name="CaSR4" units="mM" public_interface="out" initial_value="0.5738108"/>
<variable name="Cai1" units="mM" public_interface="out" initial_value="1.35496500000000013e-04"/>
<variable name="Cai2" units="mM" public_interface="out" initial_value="1.38142100000000014e-04"/>
<variable name="Cai3" units="mM" public_interface="out" initial_value="1.44208699999999994e-04"/>
<variable name="Cai4" units="mM" initial_value="1.56184399999999995e-04"/>
<variable name="Cass" units="mM" public_interface="out" initial_value="1.61937700000000013e-04"/>
<variable name="DCa" units="m2_per_s_times_1e_minus_12" initial_value="780.0"/>
<variable name="DCaBm" units="m2_per_s_times_1e_minus_12" initial_value="25.0"/>
<variable name="DCaSR" units="m2_per_s_times_1e_minus_12" initial_value="44.0"/>
<variable name="F" units="C_per_mol" public_interface="in"/>
<variable name="ICaL" units="pA" public_interface="in"/>
<variable name="ICaP" units="pA" public_interface="in"/>
<variable name="ICab" units="pA" public_interface="in"/>
<variable name="INaCa" units="pA" public_interface="in"/>
<variable name="JCa1" units="kat_times_1e_minus_12"/>
<variable name="JCa2" units="kat_times_1e_minus_12"/>
<variable name="JCa3" units="kat_times_1e_minus_12"/>
<variable name="JCa4" units="kat_times_1e_minus_12"/>
<variable name="JCass" units="kat_times_1e_minus_12"/>
<variable name="JSRCa1" units="kat_times_1e_minus_12"/>
<variable name="JSRCa2" units="kat_times_1e_minus_12"/>
<variable name="JSRCa3" units="kat_times_1e_minus_12"/>
<variable name="JSRCa4" units="kat_times_1e_minus_12"/>
<variable name="JSRCaleak1" units="kat_times_1e_minus_12"/>
<variable name="JSRCaleak2" units="kat_times_1e_minus_12"/>
<variable name="JSRCaleak3" units="kat_times_1e_minus_12"/>
<variable name="JSRCaleakss" units="kat_times_1e_minus_12"/>
<variable name="J_SERCASR1" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_SERCASR2" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_SERCASR3" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_SERCASRss" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_bulkSERCA1" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_bulkSERCA2" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_bulkSERCA3" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="J_bulkSERCAss" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="Jj_nj" units="kat_times_1e_minus_12"/>
<variable name="Jrel1" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="Jrel2" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="Jrel3" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="Jrelss" units="kat_times_1e_minus_12" public_interface="in"/>
<variable name="KdBCa" units="mM" initial_value="0.00238"/>
<variable name="KdCSQN" units="mM" initial_value="0.8"/>
<variable name="KdSLhigh" units="mM" initial_value="0.013"/>
<variable name="KdSLlow" units="mM" initial_value="1.1"/>
<variable name="SLhigh" units="mM" initial_value="13.0"/>
<variable name="SLlow" units="mM" initial_value="165.0"/>
<variable name="VSR1" units="nL" public_interface="in"/>
<variable name="VSR2" units="nL" public_interface="in"/>
<variable name="VSR3" units="nL" public_interface="in"/>
<variable name="VSR4" units="nL" public_interface="in"/>
<variable name="Vnonjunct1" units="nL" public_interface="in"/>
<variable name="Vnonjunct2" units="nL" public_interface="in"/>
<variable name="Vnonjunct3" units="nL" public_interface="in"/>
<variable name="Vnonjunct4" units="nL" public_interface="in"/>
<variable name="Vss" units="nL" public_interface="in"/>
<variable name="calcium_CaSR1_beta" units="dimensionless"/>
<variable name="calcium_CaSR2_beta" units="dimensionless"/>
<variable name="calcium_CaSR3_beta" units="dimensionless"/>
<variable name="calcium_CaSR4_beta" units="dimensionless"/>
<variable name="calcium_Cai1_beta" units="dimensionless"/>
<variable name="calcium_Cai1_gamma" units="dimensionless"/>
<variable name="calcium_Cai2_beta" units="dimensionless"/>
<variable name="calcium_Cai2_gamma" units="dimensionless"/>
<variable name="calcium_Cai3_beta" units="dimensionless"/>
<variable name="calcium_Cai3_gamma" units="dimensionless"/>
<variable name="calcium_Cai4_beta" units="dimensionless"/>
<variable name="calcium_Cai4_gamma" units="dimensionless"/>
<variable name="calcium_Cass_beta" units="dimensionless"/>
<variable name="calcium_Cass_i_tot" units="pA"/>
<variable name="dx" units="um" public_interface="in"/>
<variable name="kSRleak" units="hertz" initial_value="0.006"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="xj_nj" units="um" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSR1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_CaSR1_beta</ci>
<ci>DCaSR</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>CaSR2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>CaSR1</ci>
</apply>
</apply>
<ci>CaSR1</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSR2</ci>
<ci>CaSR1</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JSRCa1</ci>
<ci>VSR1</ci>
</apply>
<ci>calcium_CaSR1_beta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSR2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_CaSR2_beta</ci>
<ci>DCaSR</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>CaSR3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>CaSR2</ci>
</apply>
</apply>
<ci>CaSR1</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSR3</ci>
<ci>CaSR1</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JSRCa2</ci>
<ci>VSR2</ci>
</apply>
<ci>calcium_CaSR2_beta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSR3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_CaSR3_beta</ci>
<ci>DCaSR</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>CaSR4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>CaSR3</ci>
</apply>
</apply>
<ci>CaSR2</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSR4</ci>
<ci>CaSR2</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JSRCa3</ci>
<ci>VSR3</ci>
</apply>
<ci>calcium_CaSR3_beta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSR4</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_CaSR4_beta</ci>
<ci>DCaSR</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>CaSR4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>CaSR4</ci>
</apply>
</apply>
<ci>CaSR3</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSR4</ci>
<ci>CaSR3</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JSRCa4</ci>
<ci>VSR4</ci>
</apply>
<ci>calcium_CaSR4_beta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_Cai1_beta</ci>
<apply>
<plus/>
<ci>DCa</ci>
<apply>
<times/>
<ci>calcium_Cai1_gamma</ci>
<ci>DCaBm</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>Cai2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>Cai1</ci>
</apply>
</apply>
<ci>Cai1</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai2</ci>
<ci>Cai1</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>calcium_Cai1_beta</ci>
</apply>
<ci>calcium_Cai1_gamma</ci>
</apply>
<ci>DCaBm</ci>
</apply>
<apply>
<plus/>
<ci>KdBCa</ci>
<ci>Cai1</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai2</ci>
<ci>Cai1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>dx</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JCa1</ci>
<ci>Vnonjunct1</ci>
</apply>
<ci>calcium_Cai1_beta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_Cai2_beta</ci>
<apply>
<plus/>
<ci>DCa</ci>
<apply>
<times/>
<ci>calcium_Cai2_gamma</ci>
<ci>DCaBm</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>Cai3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>Cai2</ci>
</apply>
</apply>
<ci>Cai1</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai3</ci>
<ci>Cai1</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>calcium_Cai2_beta</ci>
</apply>
<ci>calcium_Cai2_gamma</ci>
</apply>
<ci>DCaBm</ci>
</apply>
<apply>
<plus/>
<ci>KdBCa</ci>
<ci>Cai2</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai3</ci>
<ci>Cai1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>dx</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JCa2</ci>
<ci>Vnonjunct2</ci>
</apply>
<ci>calcium_Cai2_beta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai3</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>calcium_Cai3_beta</ci>
<apply>
<plus/>
<ci>DCa</ci>
<apply>
<times/>
<ci>calcium_Cai3_gamma</ci>
<ci>DCaBm</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>Cai4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>Cai3</ci>
</apply>
</apply>
<ci>Cai2</ci>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai4</ci>
<ci>Cai2</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<apply>
<power/>
<ci>dx</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>calcium_Cai3_beta</ci>
</apply>
<ci>calcium_Cai3_gamma</ci>
</apply>
<ci>DCaBm</ci>
</apply>
<apply>
<plus/>
<ci>KdBCa</ci>
<ci>Cai3</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cai4</ci>
<ci>Cai2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>dx</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>JCa3</ci>
<ci>Vnonjunct3</ci>
</apply>
<ci>calcium_Cai3_beta</ci>
</apply>
</apply>
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<component name="extra">
<variable name="Cao" units="mM" public_interface="out" initial_value="1.8"/>
<variable name="Ko" units="mM" public_interface="out" initial_value="5.4"/>
<variable name="Nao" units="mM" public_interface="out" initial_value="130.0"/>
</component>
<component name="icab">
<variable name="ECa" units="mV" public_interface="in"/>
<variable name="ICab" units="pA" public_interface="out"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="gCab" units="nS" initial_value="0.0952"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICab</ci>
<apply>
<times/>
<ci>gCab</ci>
<apply>
<minus/>
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<variable name="ECa_app" units="mV" initial_value="60.0"/>
<variable name="ICaL" units="pA" public_interface="out"/>
<variable name="V" units="mV" public_interface="in"/>
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<apply>
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<exp/>
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<power/>
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<apply>
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<apply>
<plus/>
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<minus/>
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<apply>
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<ci>Cass</ci>
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</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="icap">
<variable name="Cass" units="mM" public_interface="in"/>
<variable name="ICaP" units="pA" public_interface="out"/>
<variable name="ICaPmax" units="pA" initial_value="2.0"/>
<variable name="kCaP" units="mM" initial_value="0.0005"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICaP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>ICaPmax</ci>
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<apply>
<plus/>
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</apply>
</apply>
</math>
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<component name="if">
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<variable name="ENa" units="mV" public_interface="in"/>
<variable name="If" units="pA" public_interface="out"/>
<variable name="IfK" units="pA" public_interface="out"/>
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<variable name="V" units="mV" public_interface="in"/>
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<variable name="if_y_tau" units="second"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
<plus/>
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<ci>IfNa</ci>
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<ci>IfK</ci>
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<times/>
<apply>
<times/>
<ci>gIf</ci>
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<apply>
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<diff/>
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</math>
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<variable name="FRT" units="per_mV" public_interface="in"/>
<variable name="IK1" units="pA" public_interface="out"/>
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<variable name="gK1" units="nS"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide/>
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<variable name="IKr" units="pA" public_interface="out"/>
<variable name="V" units="mV" public_interface="in"/>
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<minus/>
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<times/>
<apply>
<times/>
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<ci>ikur_s_tau</ci>
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<plus/>
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<divide/>
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<plus/>
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<exp/>
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<divide/>
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<plus/>
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</apply>
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<eq/>
<apply>
<diff/>
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<ci>time</ci>
</bvar>
<ci>r</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>ikur_r_inf</ci>
<ci>r</ci>
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<ci>ikur_r_tau</ci>
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<apply>
<eq/>
<apply>
<diff/>
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<ci>time</ci>
</bvar>
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<apply>
<divide/>
<apply>
<minus/>
<ci>ikur_s_inf</ci>
<ci>s</ci>
</apply>
<ci>ikur_s_tau</ci>
</apply>
</apply>
</math>
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<variable name="F" units="C_per_mol" public_interface="in"/>
<variable name="FRT" units="per_mV" public_interface="in"/>
<variable name="INa" units="pA" public_interface="out"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="PNa" units="m3_per_s_times_1e_minus_12" initial_value="0.0018"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="h1" units="hertz" initial_value="0.90391"/>
<variable name="h2" units="hertz" initial_value="0.9039673"/>
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<variable name="ina_h1_tau" units="second"/>
<variable name="ina_h2_tau" units="second"/>
<variable name="ina_m_inf" units="dimensionless"/>
<variable name="ina_m_tau" units="second"/>
<variable name="m" units="hertz" initial_value="2.77581199999999990e-03"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INa</ci>
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<divide/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
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<apply>
<times/>
<apply>
<times/>
<ci>PNa</ci>
<apply>
<power/>
<ci>m</ci>
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<plus/>
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<apply>
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</apply>
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</apply>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<ci>FRT</ci>
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<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
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<ci>FRT</ci>
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</apply>
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<times/>
<ci>V</ci>
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</apply>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
</apply>
</apply>
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<eq/>
<apply>
<diff/>
<bvar>
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</bvar>
<ci>h1</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>h_inf</ci>
<ci>h1</ci>
</apply>
<ci>ina_h1_tau</ci>
</apply>
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<eq/>
<apply>
<diff/>
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</bvar>
<ci>h2</ci>
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<apply>
<divide/>
<apply>
<minus/>
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<ci>h2</ci>
</apply>
<ci>ina_h2_tau</ci>
</apply>
</apply>
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<eq/>
<ci>h_inf</ci>
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<divide/>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
<cn cellml:units="mV">5.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
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<eq/>
<ci>ina_h1_tau</ci>
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<plus/>
<apply>
<divide/>
<cn cellml:units="second">0.03</cn>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">35.1</cn>
</apply>
<cn cellml:units="mV">3.2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0003</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ina_h2_tau</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="second">0.12</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">35.1</cn>
</apply>
<cn cellml:units="mV">3.2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.003</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ina_m_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
<apply>
<minus/>
<cn cellml:units="mV">8.21</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ina_m_tau</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">4.2e-05</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
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<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
<cn cellml:units="mV">28.8</cn>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">2.4e-05</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>ina_m_inf</ci>
<ci>m</ci>
</apply>
<ci>ina_m_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="inab">
<variable name="ENa" units="mV" public_interface="in"/>
<variable name="INab" units="pA" public_interface="out"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="gNab" units="nS" initial_value="0.060599"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INab</ci>
<apply>
<times/>
<ci>gNab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="inaca">
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="Cass" units="mM" public_interface="in"/>
<variable name="FRT" units="per_mV" public_interface="in"/>
<variable name="INaCa" units="pA" public_interface="out"/>
<variable name="Nao" units="mM" public_interface="in"/>
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<variable name="V" units="mV" public_interface="in"/>
<variable name="dNaCa" units="m12_per_mol4" initial_value="0.0003"/>
<variable name="fCaNCX" units="dimensionless" initial_value="1.0"/>
<variable name="gam" units="dimensionless" initial_value="0.45"/>
<variable name="kNaCa" units="m12_A_per_mol4_times_1e_minus_12" initial_value="0.0084"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kNaCa</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<times/>
<ci>gam</ci>
<ci>V</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nass</ci>
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</apply>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>gam</ci>
<cn cellml:units="dimensionless">1.0</cn>
</apply>
<ci>V</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>Cass</ci>
</apply>
<ci>fCaNCX</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<times/>
<ci>dNaCa</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
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</apply>
<ci>Cass</ci>
</apply>
<ci>fCaNCX</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nass</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>Cao</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="inak">
<variable name="INaK" units="pA" public_interface="out"/>
<variable name="INaKmax" units="pA" initial_value="70.8253"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nass" units="mM" public_interface="in"/>
<variable name="Nass15" units="dimensionless"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="kNaKK" units="mM" initial_value="1.0"/>
<variable name="kNaKNa" units="dimensionless" initial_value="11.0"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>INaKmax</ci>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>kNaKK</ci>
</apply>
</apply>
<ci>Nass15</ci>
</apply>
<apply>
<plus/>
<ci>Nass15</ci>
<apply>
<power/>
<ci>kNaKNa</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">150.0</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">200.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Nass15</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Nass</ci>
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</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</math>
</component>
<component name="it">
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<variable name="It" units="pA" public_interface="out"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="gt" units="nS"/>
<variable name="it_r_inf" units="dimensionless"/>
<variable name="it_r_tau" units="second"/>
<variable name="it_s_inf" units="dimensionless"/>
<variable name="it_s_tau" units="second"/>
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<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>It</ci>
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<times/>
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<times/>
<apply>
<times/>
<ci>gt</ci>
<ci>r</ci>
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<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
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<apply>
<eq/>
<ci>gt</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1.09</cn>
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<eq/>
<ci>it_r_inf</ci>
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<divide/>
<cn cellml:units="dimensionless">1.0</cn>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">1.0</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">11.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>it_r_tau</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.0035</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">0.0</cn>
</apply>
<cn cellml:units="mV">30.0</cn>
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<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.0015</cn>
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<apply>
<eq/>
<ci>it_s_inf</ci>
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<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">40.5</cn>
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<cn cellml:units="mV">11.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>it_s_tau</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="second">0.025635</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">52.45</cn>
</apply>
<cn cellml:units="mV">15.8827</cn>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="second">0.01414</cn>
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</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>it_r_inf</ci>
<ci>r</ci>
</apply>
<ci>it_r_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>it_s_inf</ci>
<ci>s</ci>
</apply>
<ci>it_s_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="membrane">
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<variable name="ICaL" units="pA" public_interface="in"/>
<variable name="ICaP" units="pA" public_interface="in"/>
<variable name="ICab" units="pA" public_interface="in"/>
<variable name="IK1" units="pA" public_interface="in"/>
<variable name="IKr" units="pA" public_interface="in"/>
<variable name="IKs" units="pA" public_interface="in"/>
<variable name="IKur" units="pA" public_interface="in"/>
<variable name="INa" units="pA" public_interface="in"/>
<variable name="INaCa" units="pA" public_interface="in"/>
<variable name="INaK" units="pA" public_interface="in"/>
<variable name="INab" units="pA" public_interface="in"/>
<variable name="If" units="pA" public_interface="in"/>
<variable name="It" units="pA" public_interface="in"/>
<variable name="V" units="mV" public_interface="out" initial_value="-75.42786"/>
<variable name="i_ion" units="pA"/>
<variable name="i_stim" units="pA" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
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<ci>V</ci>
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<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_ion</ci>
<ci>i_stim</ci>
</apply>
</apply>
<ci>Cm</ci>
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</apply>
<apply>
<eq/>
<ci>i_ion</ci>
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<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>INa</ci>
</apply>
<ci>ICaL</ci>
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<ci>It</ci>
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<ci>IKur</ci>
</apply>
<ci>IK1</ci>
</apply>
<ci>IKr</ci>
</apply>
<ci>IKs</ci>
</apply>
<ci>INab</ci>
</apply>
<ci>ICab</ci>
</apply>
<ci>INaK</ci>
</apply>
<ci>ICaP</ci>
</apply>
<ci>INaCa</ci>
</apply>
<ci>If</ci>
</apply>
</apply>
</math>
</component>
<component name="nernst">
<variable name="Cao" units="mM" public_interface="in"/>
<variable name="Cass" units="mM" public_interface="in"/>
<variable name="ECa" units="mV" public_interface="out"/>
<variable name="EK" units="mV" public_interface="out"/>
<variable name="ENa" units="mV" public_interface="out"/>
<variable name="Ki" units="mM" public_interface="in"/>
<variable name="Ko" units="mM" public_interface="in"/>
<variable name="Nao" units="mM" public_interface="in"/>
<variable name="Nass" units="mM" public_interface="in"/>
<variable name="RTF" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ECa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cass</ci>
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</apply>
<cn cellml:units="dimensionless">2.0</cn>
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</apply>
<apply>
<eq/>
<ci>EK</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nass</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phys">
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<variable name="FRT" units="per_mV" public_interface="out"/>
<variable name="R" units="mJ_per_mol_per_K" initial_value="8314.0"/>
<variable name="RTF" units="mV" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="306.15"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FRT</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>RTF</ci>
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</apply>
<apply>
<eq/>
<ci>RTF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="potassium">
<variable name="F" units="C_per_mol" public_interface="in"/>
<variable name="IK1" units="pA" public_interface="in"/>
<variable name="IKr" units="pA" public_interface="in"/>
<variable name="IKs" units="pA" public_interface="in"/>
<variable name="IKur" units="pA" public_interface="in"/>
<variable name="INaK" units="pA" public_interface="in"/>
<variable name="IfK" units="pA" public_interface="in"/>
<variable name="It" units="pA" public_interface="in"/>
<variable name="Ki" units="mM" public_interface="out" initial_value="134.6313"/>
<variable name="Vcytosol" units="nL" public_interface="in"/>
<variable name="i_stim" units="pA" public_interface="in"/>
<variable name="i_tot" units="pA"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<apply>
<diff/>
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<ci>Ki</ci>
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<divide/>
<apply>
<minus/>
<ci>i_tot</ci>
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<times/>
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<ci>i_tot</ci>
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<plus/>
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<plus/>
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<plus/>
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<plus/>
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<plus/>
<ci>It</ci>
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<ci>IK1</ci>
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<ci>IKr</ci>
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<ci>IKs</ci>
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<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>INaK</ci>
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<ci>IfK</ci>
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<ci>i_stim</ci>
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</apply>
</math>
</component>
<component name="ryr">
<variable name="CaSR1" units="mM" public_interface="in"/>
<variable name="CaSR2" units="mM" public_interface="in"/>
<variable name="CaSR3" units="mM" public_interface="in"/>
<variable name="CaSR4" units="mM" public_interface="in"/>
<variable name="Cai1" units="mM" public_interface="in"/>
<variable name="Cai2" units="mM" public_interface="in"/>
<variable name="Cai3" units="mM" public_interface="in"/>
<variable name="Cass" units="mM" public_interface="in"/>
<variable name="Jrel1" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="Jrel2" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="Jrel3" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="Jrelss" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="SRCa1" units="dimensionless"/>
<variable name="SRCa2" units="dimensionless"/>
<variable name="SRCa3" units="dimensionless"/>
<variable name="SRCass" units="dimensionless"/>
<variable name="Vnonjunct1" units="nL" public_interface="in"/>
<variable name="Vnonjunct2" units="nL" public_interface="in"/>
<variable name="Vnonjunct3" units="nL" public_interface="in"/>
<variable name="Vss" units="nL" public_interface="in"/>
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<variable name="a3" units="hertz" initial_value="0.2163122"/>
<variable name="ainf1" units="dimensionless"/>
<variable name="ainf2" units="dimensionless"/>
<variable name="ainf3" units="dimensionless"/>
<variable name="ainfss" units="dimensionless"/>
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<variable name="cinf2" units="dimensionless"/>
<variable name="cinf3" units="dimensionless"/>
<variable name="cinfss" units="dimensionless"/>
<variable name="css" units="hertz" initial_value="0.9999717"/>
<variable name="nu1" units="m3_per_s_times_1e_minus_12"/>
<variable name="nu2" units="m3_per_s_times_1e_minus_12"/>
<variable name="nu3" units="m3_per_s_times_1e_minus_12"/>
<variable name="nuss" units="m3_per_s_times_1e_minus_12"/>
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<variable name="oinf2" units="dimensionless"/>
<variable name="oinf3" units="dimensionless"/>
<variable name="oinfss" units="dimensionless"/>
<variable name="oss" units="hertz" initial_value="3.97509699999999973e-05"/>
<variable name="tau_act" units="second" initial_value="0.01875"/>
<variable name="tau_actss" units="second" initial_value="0.005"/>
<variable name="tau_adapt" units="second" initial_value="1.0"/>
<variable name="tau_inact" units="second" initial_value="0.0875"/>
<variable name="tau_inactss" units="second" initial_value="0.015"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Jrel1</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>nu1</ci>
<ci>o1</ci>
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<ci>c1</ci>
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<ci>SRCa1</ci>
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<apply>
<minus/>
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<ci>Cai1</ci>
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<apply>
<eq/>
<ci>Jrel2</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>nu2</ci>
<ci>o2</ci>
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<ci>c2</ci>
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<ci>SRCa2</ci>
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<apply>
<minus/>
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<ci>Cai2</ci>
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<apply>
<eq/>
<ci>Jrel3</ci>
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<times/>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>nu3</ci>
<ci>o3</ci>
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<ci>c3</ci>
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<ci>SRCa3</ci>
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<apply>
<minus/>
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<ci>Cai3</ci>
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<eq/>
<ci>Jrelss</ci>
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<times/>
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<times/>
<apply>
<times/>
<apply>
<times/>
<ci>nuss</ci>
<ci>oss</ci>
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<ci>css</ci>
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<ci>SRCass</ci>
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<apply>
<minus/>
<ci>CaSR4</ci>
<ci>Cass</ci>
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<eq/>
<ci>SRCa1</ci>
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<minus/>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
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<minus/>
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<cn cellml:units="mM">0.1</cn>
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<apply>
<eq/>
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<minus/>
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<minus/>
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<apply>
<eq/>
<ci>SRCa3</ci>
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<minus/>
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<divide/>
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<minus/>
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<ci>SRCass</ci>
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<minus/>
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<divide/>
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<minus/>
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<diff/>
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<divide/>
<apply>
<minus/>
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<ci>a1</ci>
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<ci>tau_adapt</ci>
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<eq/>
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<diff/>
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<ci>time</ci>
</bvar>
<ci>a2</ci>
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<divide/>
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<minus/>
<ci>ainf2</ci>
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<ci>tau_adapt</ci>
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<divide/>
<apply>
<minus/>
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<ci>a3</ci>
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<ci>tau_adapt</ci>
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<eq/>
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<minus/>
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<minus/>
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<times/>
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<minus/>
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<divide/>
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<exp/>
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<divide/>
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<minus/>
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<times/>
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<cn cellml:units="dimensionless">0.082</cn>
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<minus/>
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<divide/>
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<minus/>
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<ci>ainfss</ci>
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<minus/>
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<divide/>
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<minus/>
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<ci>Cass</ci>
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<diff/>
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<ci>ass</ci>
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<divide/>
<apply>
<minus/>
<ci>ainfss</ci>
<ci>ass</ci>
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<ci>tau_adapt</ci>
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<diff/>
<bvar>
<ci>time</ci>
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<ci>c1</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>cinf1</ci>
<ci>c1</ci>
</apply>
<ci>tau_inact</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>c2</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>cinf2</ci>
<ci>c2</ci>
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<ci>tau_inact</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>c3</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>cinf3</ci>
<ci>c3</ci>
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<ci>tau_inact</ci>
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<eq/>
<ci>cinf1</ci>
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<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>Cai1</ci>
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</apply>
<apply>
<plus/>
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<apply>
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<ci>cinf2</ci>
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<divide/>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
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<minus/>
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<times/>
<ci>Cai2</ci>
<cn cellml:units="m3_per_mol">1000.0</cn>
</apply>
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<plus/>
<ci>a2</ci>
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<cn cellml:units="dimensionless">0.01</cn>
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<eq/>
<ci>cinf3</ci>
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<divide/>
<cn cellml:units="dimensionless">1.0</cn>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>Cai3</ci>
<cn cellml:units="m3_per_mol">1000.0</cn>
</apply>
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<plus/>
<ci>a3</ci>
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<eq/>
<ci>cinfss</ci>
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<divide/>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
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<divide/>
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<minus/>
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<times/>
<ci>Cass</ci>
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<plus/>
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<cn cellml:units="dimensionless">0.01</cn>
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<eq/>
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<diff/>
<bvar>
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</bvar>
<ci>css</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>cinfss</ci>
<ci>css</ci>
</apply>
<ci>tau_inactss</ci>
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<apply>
<eq/>
<ci>nu1</ci>
<apply>
<times/>
<cn cellml:units="hertz">1.0</cn>
<ci>Vnonjunct1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nu2</ci>
<apply>
<times/>
<cn cellml:units="hertz">1.0</cn>
<ci>Vnonjunct2</ci>
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</apply>
<apply>
<eq/>
<ci>nu3</ci>
<apply>
<times/>
<cn cellml:units="hertz">1.0</cn>
<ci>Vnonjunct3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nuss</ci>
<apply>
<times/>
<cn cellml:units="hertz">625.0</cn>
<ci>Vss</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>o1</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>oinf1</ci>
<ci>o1</ci>
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<ci>tau_act</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>o2</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>oinf2</ci>
<ci>o2</ci>
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<ci>tau_act</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
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<ci>o3</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>oinf3</ci>
<ci>o3</ci>
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<ci>tau_act</ci>
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<minus/>
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<exp/>
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<divide/>
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<minus/>
<apply>
<times/>
<ci>Cai1</ci>
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<plus/>
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<minus/>
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<cn cellml:units="dimensionless">1.0</cn>
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<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>Cai2</ci>
<cn cellml:units="m3_per_mol">1000.0</cn>
</apply>
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<plus/>
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<cn cellml:units="dimensionless">0.03</cn>
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<apply>
<eq/>
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<minus/>
<cn cellml:units="dimensionless">1.0</cn>
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<divide/>
<cn cellml:units="dimensionless">1.0</cn>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>Cai3</ci>
<cn cellml:units="m3_per_mol">1000.0</cn>
</apply>
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<plus/>
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<cn cellml:units="dimensionless">0.03</cn>
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<apply>
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<ci>oinfss</ci>
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<minus/>
<cn cellml:units="dimensionless">1.0</cn>
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<divide/>
<cn cellml:units="dimensionless">1.0</cn>
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<plus/>
<cn cellml:units="dimensionless">1.0</cn>
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<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>Cass</ci>
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</apply>
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<plus/>
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<cn cellml:units="dimensionless">0.03</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
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<ci>oss</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>oinfss</ci>
<ci>oss</ci>
</apply>
<ci>tau_actss</ci>
</apply>
</apply>
</math>
</component>
<component name="serca">
<variable name="CaSR1" units="mM" public_interface="in"/>
<variable name="CaSR2" units="mM" public_interface="in"/>
<variable name="CaSR3" units="mM" public_interface="in"/>
<variable name="CaSR4" units="mM" public_interface="in"/>
<variable name="Cai1" units="mM" public_interface="in"/>
<variable name="Cai2" units="mM" public_interface="in"/>
<variable name="Cai3" units="mM" public_interface="in"/>
<variable name="Cass" units="mM" public_interface="in"/>
<variable name="J_SERCASR1" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_SERCASR2" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_SERCASR3" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_SERCASRss" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_bulkSERCA1" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_bulkSERCA2" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_bulkSERCA3" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="J_bulkSERCAss" units="kat_times_1e_minus_12" public_interface="out"/>
<variable name="SERCAKmf" units="mM" initial_value="0.00025"/>
<variable name="SERCAKmr" units="mM" initial_value="1.8"/>
<variable name="Vnonjunct1" units="nL" public_interface="in"/>
<variable name="Vnonjunct2" units="nL" public_interface="in"/>
<variable name="Vnonjunct3" units="nL" public_interface="in"/>
<variable name="Vss" units="nL" public_interface="in"/>
<variable name="a1" units="mM" initial_value="4.63856499999999988e-03"/>
<variable name="a2" units="mM" initial_value="4.51207800000000010e-03"/>
<variable name="a3" units="mM" initial_value="4.32640899999999981e-03"/>
<variable name="ass" units="mM" initial_value="4.25044500000000026e-03"/>
<variable name="cpumps" units="mM" initial_value="0.04"/>
<variable name="k1" units="m6_per_s_per_mol2"/>
<variable name="k2" units="hertz"/>
<variable name="k3" units="m6_per_s_per_mol2"/>
<variable name="k4" units="hertz" initial_value="7.5"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_SERCASR1</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>k3</ci>
</apply>
<apply>
<power/>
<ci>CaSR1</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>a1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>a1</ci>
</apply>
</apply>
<ci>Vnonjunct1</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_SERCASR2</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>k3</ci>
</apply>
<apply>
<power/>
<ci>CaSR2</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>a2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>a2</ci>
</apply>
</apply>
<ci>Vnonjunct2</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_SERCASR3</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>k3</ci>
</apply>
<apply>
<power/>
<ci>CaSR3</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>a3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>a3</ci>
</apply>
</apply>
<ci>Vnonjunct3</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_SERCASRss</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<ci>k3</ci>
</apply>
<apply>
<power/>
<ci>CaSR4</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>ass</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k4</ci>
<ci>ass</ci>
</apply>
</apply>
<ci>Vss</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_bulkSERCA1</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>Cai1</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>a1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>a1</ci>
</apply>
</apply>
<ci>Vnonjunct1</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_bulkSERCA2</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>Cai2</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>a2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>a2</ci>
</apply>
</apply>
<ci>Vnonjunct2</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_bulkSERCA3</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>Cai3</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>a3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>a3</ci>
</apply>
</apply>
<ci>Vnonjunct3</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_bulkSERCAss</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>Cass</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>cpumps</ci>
<ci>ass</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k2</ci>
<ci>ass</ci>
</apply>
</apply>
<ci>Vss</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a1</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SERCASR1</ci>
</apply>
<ci>J_bulkSERCA1</ci>
</apply>
</apply>
<ci>Vnonjunct1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a2</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SERCASR2</ci>
</apply>
<ci>J_bulkSERCA2</ci>
</apply>
</apply>
<ci>Vnonjunct2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>a3</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SERCASR3</ci>
</apply>
<ci>J_bulkSERCA3</ci>
</apply>
</apply>
<ci>Vnonjunct3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ass</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_SERCASRss</ci>
</apply>
<ci>J_bulkSERCAss</ci>
</apply>
</apply>
<ci>Vss</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<times/>
<apply>
<power/>
<cn cellml:units="m3_per_mol">1000.0</cn>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
<ci>k4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>SERCAKmf</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k3</ci>
<apply>
<divide/>
<ci>k4</ci>
<apply>
<power/>
<ci>SERCAKmr</ci>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium">
<variable name="Aj_nj" units="um2" public_interface="in"/>
<variable name="BNa" units="mM"/>
<variable name="DNa" units="m2_per_s_times_1e_minus_12" initial_value="0.12"/>
<variable name="F" units="C_per_mol" public_interface="in"/>
<variable name="INa" units="pA" public_interface="in"/>
<variable name="INaCa" units="pA" public_interface="in"/>
<variable name="INaK" units="pA" public_interface="in"/>
<variable name="INab" units="pA" public_interface="in"/>
<variable name="IfNa" units="pA" public_interface="in"/>
<variable name="JNa" units="kat_times_1e_minus_12"/>
<variable name="KdBNa" units="mM" initial_value="10.0"/>
<variable name="Nai" units="mM" initial_value="9.28686"/>
<variable name="Nass" units="mM" public_interface="out" initial_value="8.691504"/>
<variable name="Vnonjunct_Nai" units="nL" public_interface="in"/>
<variable name="Vss" units="nL" public_interface="in"/>
<variable name="betaNass" units="dimensionless"/>
<variable name="i_ss" units="pA"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="xj_nj_Nai" units="um" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>BNa</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.49</cn>
<cn cellml:units="mM">2.31</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>JNa</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>DNa</ci>
<ci>Aj_nj</ci>
</apply>
<ci>xj_nj_Nai</ci>
</apply>
<apply>
<minus/>
<ci>Nass</ci>
<ci>Nai</ci>
</apply>
</apply>
<cn cellml:units="dimensionless_times_1e6">1e-06</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<ci>JNa</ci>
<ci>Vnonjunct_Nai</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nass</ci>
</apply>
<apply>
<times/>
<ci>betaNass</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<minus/>
<ci>JNa</ci>
</apply>
<ci>Vss</ci>
</apply>
<apply>
<divide/>
<ci>i_ss</ci>
<apply>
<times/>
<ci>Vss</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>betaNass</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>BNa</ci>
<ci>KdBNa</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Nass</ci>
<ci>KdBNa</ci>
</apply>
<cn cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ss</ci>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<apply>
<plus/>
<ci>INa</ci>
</apply>
<ci>INab</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>INaK</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>INaCa</ci>
</apply>
</apply>
<ci>IfNa</ci>
</apply>
</apply>
</math>
</component>
<component name="stimulus">
<variable name="amplitude" units="pA" cmeta:id="amplitude"/>
<variable name="duration" units="second" initial_value="0.001" cmeta:id="duration"/>
<variable name="i_stim" units="pA" public_interface="out"/>
<variable name="offset" units="second" initial_value="0.01" cmeta:id="offset"/>
<variable name="period" units="second" initial_value="1.0" cmeta:id="period"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>amplitude</ci>
<apply>
<minus/>
<cn cellml:units="pA">2500.0</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_stim</ci>
<apply>
<times/>
<piecewise>
<piece>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<lt/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>offset</ci>
</apply>
<apply>
<times/>
<ci>period</ci>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>offset</ci>
</apply>
<ci>period</ci>
</apply>
</apply>
</apply>
</apply>
<ci>duration</ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="dimensionless">0.0</cn>
</otherwise>
</piecewise>
<ci>amplitude</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="calcium" component_2="cell"/>
<map_variables variable_1="Aj_nj" variable_2="Aj_nj"/>
<map_variables variable_1="VSR1" variable_2="VSR1"/>
<map_variables variable_1="VSR2" variable_2="VSR2"/>
<map_variables variable_1="VSR3" variable_2="VSR3"/>
<map_variables variable_1="VSR4" variable_2="VSR4"/>
<map_variables variable_1="Vnonjunct1" variable_2="Vnonjunct1"/>
<map_variables variable_1="Vnonjunct2" variable_2="Vnonjunct2"/>
<map_variables variable_1="Vnonjunct3" variable_2="Vnonjunct3"/>
<map_variables variable_1="Vnonjunct4" variable_2="Vnonjunct4"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
<map_variables variable_1="dx" variable_2="dx"/>
<map_variables variable_1="xj_nj" variable_2="xj_nj"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="engine"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="icab"/>
<map_variables variable_1="ICab" variable_2="ICab"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ical"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="ICaL" variable_2="ICaL"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="icap"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="ICaP" variable_2="ICaP"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="inaca"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="nernst"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="ryr"/>
<map_variables variable_1="CaSR1" variable_2="CaSR1"/>
<map_variables variable_1="CaSR2" variable_2="CaSR2"/>
<map_variables variable_1="CaSR3" variable_2="CaSR3"/>
<map_variables variable_1="CaSR4" variable_2="CaSR4"/>
<map_variables variable_1="Cai1" variable_2="Cai1"/>
<map_variables variable_1="Cai2" variable_2="Cai2"/>
<map_variables variable_1="Cai3" variable_2="Cai3"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="Jrel1" variable_2="Jrel1"/>
<map_variables variable_1="Jrel2" variable_2="Jrel2"/>
<map_variables variable_1="Jrel3" variable_2="Jrel3"/>
<map_variables variable_1="Jrelss" variable_2="Jrelss"/>
</connection>
<connection>
<map_components component_1="calcium" component_2="serca"/>
<map_variables variable_1="CaSR1" variable_2="CaSR1"/>
<map_variables variable_1="CaSR2" variable_2="CaSR2"/>
<map_variables variable_1="CaSR3" variable_2="CaSR3"/>
<map_variables variable_1="CaSR4" variable_2="CaSR4"/>
<map_variables variable_1="Cai1" variable_2="Cai1"/>
<map_variables variable_1="Cai2" variable_2="Cai2"/>
<map_variables variable_1="Cai3" variable_2="Cai3"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="J_SERCASR1" variable_2="J_SERCASR1"/>
<map_variables variable_1="J_SERCASR2" variable_2="J_SERCASR2"/>
<map_variables variable_1="J_SERCASR3" variable_2="J_SERCASR3"/>
<map_variables variable_1="J_SERCASRss" variable_2="J_SERCASRss"/>
<map_variables variable_1="J_bulkSERCA1" variable_2="J_bulkSERCA1"/>
<map_variables variable_1="J_bulkSERCA2" variable_2="J_bulkSERCA2"/>
<map_variables variable_1="J_bulkSERCA3" variable_2="J_bulkSERCA3"/>
<map_variables variable_1="J_bulkSERCAss" variable_2="J_bulkSERCAss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="membrane"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="cell" component_2="potassium"/>
<map_variables variable_1="Vcytosol" variable_2="Vcytosol"/>
</connection>
<connection>
<map_components component_1="cell" component_2="ryr"/>
<map_variables variable_1="Vnonjunct1" variable_2="Vnonjunct1"/>
<map_variables variable_1="Vnonjunct2" variable_2="Vnonjunct2"/>
<map_variables variable_1="Vnonjunct3" variable_2="Vnonjunct3"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="serca"/>
<map_variables variable_1="Vnonjunct1" variable_2="Vnonjunct1"/>
<map_variables variable_1="Vnonjunct2" variable_2="Vnonjunct2"/>
<map_variables variable_1="Vnonjunct3" variable_2="Vnonjunct3"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
</connection>
<connection>
<map_components component_1="cell" component_2="sodium"/>
<map_variables variable_1="Aj_nj" variable_2="Aj_nj"/>
<map_variables variable_1="Vnonjunct_Nai" variable_2="Vnonjunct_Nai"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
<map_variables variable_1="xj_nj_Nai" variable_2="xj_nj_Nai"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ical"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="if"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ikr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="iks"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ikur"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ina"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="it"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="membrane"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="potassium"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="ryr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="serca"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="sodium"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="engine" component_2="stimulus"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ik1"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="ina"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="extra" component_2="inaca"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="extra" component_2="inak"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="extra" component_2="nernst"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="icab" component_2="membrane"/>
<map_variables variable_1="ICab" variable_2="ICab"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="icab" component_2="nernst"/>
<map_variables variable_1="ECa" variable_2="ECa"/>
</connection>
<connection>
<map_components component_1="ical" component_2="membrane"/>
<map_variables variable_1="ICaL" variable_2="ICaL"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="icap" component_2="membrane"/>
<map_variables variable_1="ICaP" variable_2="ICaP"/>
</connection>
<connection>
<map_components component_1="if" component_2="membrane"/>
<map_variables variable_1="If" variable_2="If"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="if" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="if" component_2="potassium"/>
<map_variables variable_1="IfK" variable_2="IfK"/>
</connection>
<connection>
<map_components component_1="if" component_2="sodium"/>
<map_variables variable_1="IfNa" variable_2="IfNa"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="membrane"/>
<map_variables variable_1="IK1" variable_2="IK1"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="ik1" component_2="potassium"/>
<map_variables variable_1="IK1" variable_2="IK1"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="membrane"/>
<map_variables variable_1="IKr" variable_2="IKr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ikr" component_2="potassium"/>
<map_variables variable_1="IKr" variable_2="IKr"/>
</connection>
<connection>
<map_components component_1="iks" component_2="membrane"/>
<map_variables variable_1="IKs" variable_2="IKs"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="iks" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="iks" component_2="potassium"/>
<map_variables variable_1="IKs" variable_2="IKs"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="membrane"/>
<map_variables variable_1="IKur" variable_2="IKur"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="ikur" component_2="potassium"/>
<map_variables variable_1="IKur" variable_2="IKur"/>
</connection>
<connection>
<map_components component_1="ina" component_2="membrane"/>
<map_variables variable_1="INa" variable_2="INa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ina" component_2="nernst"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="ina" component_2="phys"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="ina" component_2="sodium"/>
<map_variables variable_1="INa" variable_2="INa"/>
</connection>
<connection>
<map_components component_1="inab" component_2="membrane"/>
<map_variables variable_1="INab" variable_2="INab"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="inab" component_2="nernst"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
</connection>
<connection>
<map_components component_1="inab" component_2="sodium"/>
<map_variables variable_1="INab" variable_2="INab"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="membrane"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="phys"/>
<map_variables variable_1="FRT" variable_2="FRT"/>
</connection>
<connection>
<map_components component_1="inaca" component_2="sodium"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
<map_variables variable_1="Nass" variable_2="Nass"/>
</connection>
<connection>
<map_components component_1="inak" component_2="membrane"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="inak" component_2="potassium"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
</connection>
<connection>
<map_components component_1="inak" component_2="sodium"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
<map_variables variable_1="Nass" variable_2="Nass"/>
</connection>
<connection>
<map_components component_1="it" component_2="membrane"/>
<map_variables variable_1="It" variable_2="It"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="it" component_2="nernst"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="it" component_2="potassium"/>
<map_variables variable_1="It" variable_2="It"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="stimulus"/>
<map_variables variable_1="i_stim" variable_2="i_stim"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="phys"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="potassium"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="nernst" component_2="sodium"/>
<map_variables variable_1="Nass" variable_2="Nass"/>
</connection>
<connection>
<map_components component_1="phys" component_2="potassium"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="phys" component_2="sodium"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="potassium" component_2="stimulus"/>
<map_variables variable_1="i_stim" variable_2="i_stim"/>
</connection>
<rdf:RDF>
<rdf:Description rdf:about="#amplitude">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_amplitude"/>
</rdf:Description>
<rdf:Description rdf:about="#duration">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_duration"/>
</rdf:Description>
<rdf:Description rdf:about="#offset">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_offset"/>
</rdf:Description>
<rdf:Description rdf:about="#period">
<bqbiol:is rdf:resource="https://chaste.comlab.ox.ac.uk/cellml/ns/oxford-metadata#membrane_stimulus_current_period"/>
</rdf:Description>
<rdf:Description rdf:about="#koivumaki_2011">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>electrophysiology</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>