Location: 12 L Platform 1 model codes @ f517ddde5404 / Airway_FTU / cellml2_version / experiment1 / ca2.cellml
- Author:
- aram148 <a.rampadarath@auckland.ac.nz>
- Date:
- 2021-06-29 14:36:26+12:00
- Desc:
- updated working agonist driven FTU
- Permanent Source URI:
- http://models.cellml.org/workspace/6b0/rawfile/f517ddde5404c765afb80b982714243bc9eddcf6/Airway_FTU/cellml2_version/experiment1/ca2.cellml
<model xmlns="http://www.cellml.org/cellml/2.0#" xmlns:cellml="http://www.cellml.org/cellml/2.0#" xmlns:xlink="http://www.w3.org/1999/xlink" name="ca2">
<units name="per_sec">
<unit exponent="-1" units="second"/>
</units>
<units name="mM">
<unit prefix="micro" units="mole"/>
</units>
<component name="environment">
<variable name="time" units="second" interface="public"/>
</component>
<component name="calcium">
<variable name="time" units="second" interface="public"/>
<variable name="k1" units="per_sec" interface="public"/>
<variable name="k2" units="per_sec" interface="public"/>
<variable initial_value="0.5962" name="k1a" units="per_sec"/>
<variable name="c" units="dimensionless"/>
<variable initial_value="1.35" name="k1b" units="mM"/>
<variable initial_value="156.9" name="tau" units="second"/>
<variable initial_value="0" name="P" units="dimensionless"/>
<variable name="kon" units="dimensionless"/>
<variable name="koff" units="dimensionless"/>
<variable initial_value="242.14" name="k2b" units="per_sec"/>
<variable initial_value="0.000125" name="kon1" units="dimensionless"/>
<variable initial_value="0.8988" name="kon2" units="mM"/>
<variable initial_value="0.4629" name="koff1" units="dimensionless"/>
<variable initial_value="20.035" name="koff2" units="dimensionless"/>
<variable initial_value="0.1" name="a" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>kon</ci>
<apply>
<plus/>
<ci>kon1</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>c</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>kon2</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>c</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<!-- -->
<apply>
<eq/>
<ci>koff</ci>
<apply>
<plus/>
<ci>koff1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>koff2</ci>
<ci>a</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>tau</ci>
</apply>
<ci>kon</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>P</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff</ci>
<ci>P</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k2</ci>
<apply>
<times/>
<ci>k2b</ci>
<apply>
<power/>
<ci>P</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k1a</ci>
<apply>
<power/>
<ci>c</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>k1b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
<apply>
<power/>
<ci>c</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>c</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<leq/>
<ci>time</ci>
<cn cellml:units="second">5</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<cn cellml:units="second">5</cn>
</apply>
<apply>
<leq/>
<ci>time</ci>
<cn cellml:units="second">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection component_1="environment" component_2="calcium">
<map_variables variable_1="time" variable_2="time"/>
</connection>
</model>